GREMLIN Database
Sas10 - Sas10 C-terminal domain
PFAM: PF09368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (73)
Sequences: 618 (415)
Seq/√Len: 48.6
META: 0.451

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_R47_V3.2551.00
7_I12_E3.0821.00
42_K45_G2.6451.00
34_K37_E2.4891.00
9_Y15_K2.4641.00
33_R37_E2.3311.00
24_E34_K2.3291.00
37_E41_K2.3241.00
32_K35_K2.0551.00
48_R70_K1.9850.99
44_K49_V1.8180.99
36_Y40_K1.8170.99
43_R49_V1.8130.99
44_K51_R1.7990.99
27_N30_V1.7630.99
25_V31_K1.7530.99
9_Y13_K1.6250.98
52_K56_G1.6150.98
58_G61_A1.5390.97
15_K26_R1.5330.97
57_Y60_E1.4910.96
15_K55_G1.4480.95
39_A42_K1.4460.95
28_P32_K1.2830.91
15_K18_T1.2690.91
62_T65_K1.2340.90
69_V73_K1.2040.89
65_K68_V1.1940.88
21_R26_R1.1160.84
45_G48_R1.0570.81
18_T21_R1.0510.81
19_P26_R1.0450.80
3_G7_I1.0270.79
43_R46_Q1.0250.79
7_I11_I1.0220.79
8_T12_E1.0040.78
4_K9_Y0.9860.76
38_K42_K0.9840.76
46_Q66_A0.9630.75
26_R30_V0.9030.70
22_K25_V0.8750.67
32_K41_K0.8600.66
6_A12_E0.8300.63
7_I56_G0.8240.63
45_G50_Y0.8170.62
2_D7_I0.8080.61
56_G65_K0.8010.60
19_P28_P0.7900.59
9_Y26_R0.7810.58
14_N39_A0.7770.58
60_E63_G0.7630.57
37_E66_A0.7600.56
8_T56_G0.7500.55
68_V71_S0.7370.54
24_E31_K0.7360.54
8_T11_I0.7350.54
40_K43_R0.7310.53
71_S74_L0.7290.53
33_R72_V0.7290.53
32_K36_Y0.7180.52
48_R51_R0.7120.51
16_G21_R0.7110.51
28_P72_V0.6920.49
25_V28_P0.6810.48
54_E74_L0.6800.48
62_T70_K0.6770.48
57_Y63_G0.6690.47
42_K46_Q0.6680.47
19_P25_V0.6600.46
22_K61_A0.6560.46
11_I33_R0.6520.45
8_T40_K0.6520.45
11_I71_S0.6510.45
11_I73_K0.6430.45
12_E25_V0.6370.44
57_Y64_I0.6360.44
31_K35_K0.6330.44
66_A70_K0.6310.43
30_V36_Y0.6310.43
13_K68_V0.6240.43
37_E40_K0.6240.43
52_K55_G0.6080.41
14_N57_Y0.6020.40
66_A72_V0.6010.40
62_T68_V0.5910.39
20_H36_Y0.5910.39
53_E61_A0.5890.39
4_K7_I0.5810.38
19_P74_L0.5810.38
6_A39_A0.5680.37
26_R39_A0.5670.37
5_R11_I0.5620.37
13_K22_K0.5620.37
24_E27_N0.5580.36
15_K25_V0.5580.36
63_G71_S0.5530.36
46_Q65_K0.5330.34
15_K23_K0.5300.34
17_L29_R0.5270.33
52_K66_A0.5200.33
25_V32_K0.5180.33
13_K57_Y0.5110.32
26_R31_K0.5070.32
19_P32_K0.5060.32
31_K34_K0.5050.31
35_K54_E0.5050.31
26_R32_K0.5040.31
52_K61_A0.5040.31
29_R60_E0.5010.31
8_T20_H0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ksrA 3 0.2297 1.6 0.93 Contact Map
1vptA 2 0 1.3 0.933 Contact Map
3bboI 1 0 1.1 0.936 Contact Map
2uxwA 2 0.3378 1.1 0.936 Contact Map
2c1mB 1 0.3108 1.1 0.936 Contact Map
1bxnI 3 0.2027 1 0.939 Contact Map
3zeyY 1 0.7162 0.9 0.939 Contact Map
1lkoA 3 0.4459 0.8 0.941 Contact Map
4ar2A 10 0.3514 0.8 0.942 Contact Map
3zey1 1 0.0946 0.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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