GREMLIN Database
DUF1996 - Domain of unknown function (DUF1996)
PFAM: PF09362 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 211 (207)
Sequences: 3269 (2317)
Seq/√Len: 161.1
META: 0.628

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_D143_N7.9241.00
148_D151_S5.8321.00
145_D149_H4.4331.00
89_A155_Y3.9171.00
13_L52_A3.3991.00
137_S156_P3.2621.00
153_M173_I3.0461.00
131_A203_A2.6841.00
79_T171_V2.4261.00
21_S35_G2.3581.00
178_Y205_A2.3541.00
5_F8_Q2.3411.00
15_T52_A2.3321.00
16_F22_T2.2811.00
81_F173_I2.2591.00
87_M153_M2.1891.00
86_R145_D2.1501.00
27_T30_S2.0821.00
108_C125_C2.0221.00
2_P16_F2.0181.00
133_V205_A2.0091.00
85_L153_M1.9831.00
195_S202_T1.9811.00
5_F10_A1.9561.00
146_S149_H1.9311.00
28_Y32_R1.8981.00
28_Y208_F1.8531.00
62_V65_V1.8481.00
31_L210_G1.8461.00
192_V195_S1.8431.00
17_F50_V1.8221.00
89_A135_F1.8081.00
9_P24_A1.7981.00
26_S30_S1.7581.00
81_F85_L1.7341.00
21_S30_S1.7231.00
191_F196_G1.7131.00
146_S152_H1.7131.00
191_F195_S1.7071.00
31_L47_A1.6661.00
13_L54_Y1.6451.00
22_T47_A1.6251.00
134_T175_Q1.6041.00
50_V180_V1.5771.00
106_W193_L1.5651.00
192_V197_D1.5441.00
193_L196_G1.5221.00
134_T177_F1.5211.00
116_T119_I1.4891.00
130_R181_R1.4271.00
36_C39_C1.3831.00
107_S132_H1.3801.00
197_D202_T1.3761.00
9_P25_F1.3751.00
84_G144_L1.3711.00
87_M135_F1.3631.00
105_S132_H1.3551.00
188_G191_F1.3391.00
98_Q101_N1.3351.00
50_V182_Y1.3161.00
20_T35_G1.3041.00
91_D150_K1.2971.00
20_T38_T1.2901.00
73_K175_Q1.2891.00
55_D59_N1.2801.00
22_T26_S1.2641.00
17_F70_V1.2631.00
86_R149_H1.2481.00
5_F11_S1.2431.00
26_S31_L1.2181.00
138_C165_C1.1771.00
89_A133_V1.1521.00
50_V205_A1.1421.00
44_D207_F1.1411.00
191_F194_S1.1161.00
145_D150_K1.1121.00
55_D61_T1.1071.00
192_V196_G1.1051.00
139_W142_K1.0961.00
98_Q103_A1.0770.99
28_Y83_P1.0770.99
86_R208_F1.0710.99
32_R83_P1.0600.99
11_S24_A1.0580.99
145_D148_D1.0480.99
136_P155_Y1.0450.99
135_F205_A1.0410.99
19_N26_S1.0270.99
20_T36_C1.0270.99
29_A33_A1.0180.99
190_P195_S1.0160.99
14_H206_D1.0090.99
139_W171_V1.0050.99
70_V178_Y0.9930.99
26_S47_A0.9850.99
19_N34_A0.9680.99
189_S192_V0.9660.99
19_N35_G0.9610.99
19_N22_T0.9540.99
139_W173_I0.9530.99
183_P186_G0.9370.98
83_P210_G0.9320.98
61_T64_P0.9320.98
107_S130_R0.9190.98
3_I208_F0.9190.98
190_P193_L0.9180.98
191_F197_D0.8980.98
154_A169_H0.8960.98
81_F176_L0.8950.98
75_R175_Q0.8950.98
5_F88_I0.8930.98
27_T31_L0.8910.98
109_G181_R0.8830.98
146_S150_K0.8810.98
100_A103_A0.8790.98
49_W206_D0.8790.98
14_H204_H0.8790.98
131_A193_L0.8780.98
4_V12_H0.8710.98
3_I206_D0.8690.98
146_S151_S0.8670.97
21_S31_L0.8630.97
164_A167_A0.8620.97
193_L197_D0.8620.97
50_V203_A0.8620.97
105_S115_D0.8610.97
8_Q11_S0.8570.97
17_F68_A0.8560.97
46_S210_G0.8510.97
94_A98_Q0.8460.97
166_P169_H0.8410.97
197_D200_G0.8390.97
194_S197_D0.8380.97
19_N30_S0.8380.97
118_T121_T0.8370.97
106_W131_A0.8300.97
45_R210_G0.8270.97
70_V176_L0.8270.97
4_V149_H0.8220.97
139_W143_N0.8180.96
136_P153_M0.8090.96
199_T202_T0.8010.96
3_I88_I0.8000.96
26_S210_G0.7980.96
28_Y31_L0.7930.96
149_H152_H0.7860.96
132_H177_F0.7850.96
49_W71_Y0.7830.95
7_G25_F0.7780.95
32_R210_G0.7710.95
157_S162_G0.7690.95
143_N146_S0.7660.95
17_F180_V0.7630.95
34_A45_R0.7600.95
104_V203_A0.7560.95
15_T50_V0.7550.94
196_G200_G0.7530.94
133_V203_A0.7510.94
21_S26_S0.7420.94
44_D176_L0.7380.94
120_P125_C0.7330.94
190_P194_S0.7320.94
156_P161_G0.7300.93
193_L203_A0.7270.93
92_A202_T0.7230.93
130_R179_E0.7180.93
109_G128_G0.7140.93
9_P13_L0.7130.93
140_D144_L0.7010.92
154_A168_S0.6990.92
75_R137_S0.6970.92
55_D184_V0.6950.92
75_R172_A0.6890.91
108_C165_C0.6890.91
21_S33_A0.6870.91
74_R78_V0.6840.91
32_R45_R0.6830.91
157_S161_G0.6820.91
157_S160_D0.6820.91
189_S194_S0.6810.91
108_C138_C0.6750.90
36_C61_T0.6730.90
117_A121_T0.6720.90
196_G199_T0.6710.90
112_G127_S0.6670.90
148_D152_H0.6630.90
156_P160_D0.6630.90
119_I125_C0.6600.89
144_L149_H0.6570.89
67_G181_R0.6570.89
68_A180_V0.6550.89
23_N35_G0.6540.89
46_S208_F0.6530.89
69_T178_Y0.6450.88
29_A32_R0.6420.88
36_C45_R0.6410.88
27_T32_R0.6390.88
96_T99_P0.6390.88
14_H18_G0.6380.88
31_L208_F0.6350.88
83_P209_N0.6330.87
74_R172_A0.6320.87
105_S134_T0.6320.87
116_T121_T0.6290.87
29_A83_P0.6290.87
140_D171_V0.6280.87
14_H49_W0.6270.87
96_T101_N0.6250.87
12_H206_D0.6240.87
16_F26_S0.6230.87
35_G45_R0.6220.87
19_N47_A0.6220.87
184_V191_F0.6190.86
69_T181_R0.6180.86
16_F19_N0.6170.86
96_T100_A0.6160.86
66_G69_T0.6160.86
25_F29_A0.6080.85
21_S34_A0.6060.85
58_G61_T0.6030.85
161_G164_A0.6020.85
114_R117_A0.6010.85
98_Q102_A0.6000.85
46_S209_N0.5980.84
118_T201_Y0.5970.84
28_Y210_G0.5970.84
128_G181_R0.5970.84
49_W84_G0.5950.84
137_S155_Y0.5920.84
53_L182_Y0.5870.83
19_N210_G0.5870.83
143_N171_V0.5860.83
159_G162_G0.5850.83
44_D48_Y0.5840.83
23_N26_S0.5830.83
94_A201_Y0.5820.83
89_A205_A0.5810.83
166_P170_P0.5800.82
36_C42_P0.5790.82
107_S111_G0.5780.82
95_T199_T0.5770.82
137_S175_Q0.5760.82
134_T137_S0.5710.82
111_G127_S0.5710.82
152_H169_H0.5700.81
92_A150_K0.5690.81
16_F47_A0.5620.80
78_V172_A0.5620.80
107_S180_V0.5610.80
190_P196_G0.5580.80
55_D190_P0.5570.80
8_Q147_P0.5560.80
187_F190_P0.5540.80
172_A175_Q0.5540.80
135_F176_L0.5530.79
132_H181_R0.5520.79
37_T44_D0.5500.79
60_G63_E0.5500.79
30_S33_A0.5500.79
97_P100_A0.5490.79
75_R109_G0.5480.79
94_A101_N0.5470.79
119_I122_T0.5460.79
156_P175_Q0.5420.78
7_G29_A0.5410.78
138_C166_P0.5380.78
96_T201_Y0.5360.77
107_S179_E0.5350.77
176_L179_E0.5340.77
141_G152_H0.5330.77
118_T122_T0.5330.77
141_G144_L0.5330.77
145_D152_H0.5310.77
91_D94_A0.5300.77
198_P201_Y0.5280.76
72_Y211_W0.5280.76
47_A208_F0.5270.76
79_T172_A0.5260.76
88_I206_D0.5230.76
113_T116_T0.5210.75
54_Y61_T0.5190.75
52_A194_S0.5160.75
195_S198_P0.5160.75
68_A178_Y0.5150.74
140_D170_P0.5150.74
52_A176_L0.5150.74
26_S45_R0.5140.74
153_M169_H0.5140.74
154_A166_P0.5110.74
188_G194_S0.5100.74
70_V74_R0.5100.74
206_D211_W0.5070.73
119_I200_G0.5070.73
184_V187_F0.5070.73
207_F210_G0.5060.73
87_M136_P0.5050.73
12_H18_G0.5040.73
20_T40_R0.5030.73
61_T65_V0.5020.73
53_L106_W0.5020.73
30_S47_A0.5020.73
66_G183_P0.5020.73
192_V198_P0.5020.73
160_D163_G0.5010.72
95_T197_D0.5010.72
144_L171_V0.5010.72
22_T25_F0.5000.72
149_H154_A0.5000.72
40_R43_G0.5000.72
128_G132_H0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x3mA 1 0.0474 2.5 0.971 Contact Map
2mioA 1 0.2322 2 0.972 Contact Map
4zf5A 1 0.2227 1.7 0.973 Contact Map
3lazA 2 0.1517 1.3 0.975 Contact Map
1negA 1 0.1706 1.2 0.975 Contact Map
3wmqA 4 0.3507 1.2 0.976 Contact Map
3n75A 4 0.2512 1.1 0.976 Contact Map
1jo8A 1 0.1659 1 0.977 Contact Map
2qp2A 1 0.4502 1 0.977 Contact Map
1q1lA 4 0.2654 1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.