GREMLIN Database
Phasin_2 - Phasin protein
PFAM: PF09361 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (96)
Sequences: 34496 (19973)
Seq/√Len: 2038.4
META: 0.943

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E30_A2.2591.00
68_R72_E2.2541.00
61_E65_E2.2491.00
37_K41_E2.0951.00
31_K80_E2.0431.00
42_A73_K1.9711.00
48_K52_G1.8161.00
55_S58_E1.7911.00
23_K26_E1.7781.00
58_E61_E1.7751.00
57_Q61_E1.7131.00
38_A73_K1.6851.00
83_E87_K1.6771.00
87_K91_E1.6321.00
49_A62_L1.6211.00
49_A65_E1.6061.00
35_A77_Q1.5741.00
76_A79_R1.5321.00
65_E68_R1.5201.00
72_E76_A1.4971.00
30_A34_E1.4561.00
41_E45_A1.4361.00
5_A9_A1.4291.00
78_A82_A1.3911.00
79_R83_E1.3841.00
47_A51_L1.3731.00
69_K72_E1.3661.00
94_K98_A1.3451.00
4_A8_K1.3441.00
24_G88_A1.3371.00
25_A29_A1.3321.00
23_K27_A1.3301.00
27_A87_K1.3151.00
18_A21_A1.3141.00
74_A78_A1.2971.00
87_K90_A1.2361.00
8_K12_E1.2331.00
42_A69_K1.2321.00
45_A49_A1.2291.00
65_E69_K1.1361.00
69_K73_K1.1341.00
12_E16_K1.1331.00
19_S23_K1.1301.00
32_Q36_A1.1251.00
5_A8_K1.1251.00
15_E19_S1.1021.00
94_K97_E1.0971.00
38_A42_A1.0841.00
63_Q66_F1.0831.00
14_L18_A1.0811.00
34_E38_A1.0701.00
39_N43_A1.0611.00
16_K20_A1.0571.00
89_A92_A1.0421.00
29_A32_Q1.0411.00
7_A10_N1.0401.00
86_A90_A1.0341.00
10_N13_A1.0221.00
53_A59_A1.0141.00
31_K84_L1.0001.00
35_A39_N0.9991.00
34_E37_K0.9971.00
31_K34_E0.9701.00
91_E94_K0.9661.00
53_A62_L0.9581.00
76_A80_E0.9581.00
81_L85_A0.9551.00
42_A45_A0.9371.00
10_N14_L0.9371.00
9_A12_E0.9351.00
46_A66_F0.9271.00
93_A97_E0.9081.00
43_A47_A0.9081.00
27_A30_A0.9011.00
46_A49_A0.8721.00
80_E83_E0.8621.00
90_A94_K0.8591.00
29_A33_L0.8581.00
66_F70_A0.8571.00
39_N77_Q0.8531.00
64_T68_R0.8481.00
56_P59_A0.8271.00
20_A91_E0.8161.00
45_A48_K0.8061.00
12_E15_E0.7801.00
20_A23_K0.7601.00
84_L88_A0.7581.00
46_A62_L0.7541.00
21_A24_G0.7501.00
85_A89_A0.7491.00
44_F47_A0.7461.00
70_A74_A0.7391.00
63_Q67_A0.7361.00
44_F48_K0.7281.00
28_L81_L0.7071.00
18_A22_A0.7061.00
60_V63_Q0.6971.00
17_S95_P0.6971.00
16_K98_A0.6951.00
6_A10_N0.6941.00
54_K58_E0.6911.00
16_K19_S0.6891.00
39_N42_A0.6881.00
58_E62_L0.6791.00
23_K91_E0.6791.00
77_Q81_L0.6791.00
15_E18_A0.6761.00
83_E86_A0.6691.00
38_A41_E0.6601.00
6_A9_A0.6531.00
8_K15_E0.6501.00
3_F7_A0.6431.00
75_V79_R0.6411.00
40_L44_F0.6391.00
36_A40_L0.6361.00
39_N74_A0.6341.00
4_A7_A0.6331.00
26_E29_A0.6251.00
89_A93_A0.6241.00
41_E44_F0.6241.00
49_A52_G0.6141.00
82_A86_A0.6141.00
70_A73_K0.6111.00
19_S22_A0.6011.00
31_K77_Q0.5911.00
3_F6_A0.5891.00
73_K76_A0.5871.00
62_L65_E0.5771.00
61_E64_T0.5771.00
33_L37_K0.5651.00
75_V78_A0.5641.00
71_F75_V0.5601.00
31_K35_A0.5561.00
85_A88_A0.5541.00
56_P60_V0.5531.00
92_A96_I0.5361.00
38_A77_Q0.5331.00
30_A37_K0.5301.00
17_S21_A0.5291.00
27_A31_K0.5281.00
54_K59_A0.5251.00
56_P63_Q0.5041.00
82_A85_A0.5011.00
21_A25_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a01A 1 0.99 11.1 0.818 Contact Map
3s84A 2 0.99 8.6 0.827 Contact Map
2ca5A 1 0.67 8.1 0.829 Contact Map
3ok8A 2 0.78 7.6 0.83 Contact Map
2j6yA 2 0.82 6.2 0.838 Contact Map
1eq1A 1 1 6.1 0.839 Contact Map
3r2pA 2 0.99 5.7 0.84 Contact Map
2lemA 1 0.99 5.5 0.842 Contact Map
2yktA 2 0.78 4.9 0.845 Contact Map
4ui9I 1 1 4.9 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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