GREMLIN Database
RteC - RteC protein
PFAM: PF09357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 218 (216)
Sequences: 1610 (1254)
Seq/√Len: 85.3
META: 0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_D207_K4.3121.00
142_G159_V4.2601.00
198_S204_D3.9151.00
153_A206_L3.8291.00
199_R214_M3.7571.00
159_V202_F3.4451.00
142_G146_A2.9651.00
151_I171_A2.9501.00
171_A185_Y2.6121.00
150_L154_L2.6061.00
151_I174_F2.5931.00
187_R190_L2.5641.00
173_Y177_V2.5161.00
200_T204_D2.5111.00
141_T161_N2.4711.00
27_R118_E2.4661.00
199_R215_D2.3671.00
53_N101_K2.1891.00
165_A170_I2.1691.00
193_K217_D2.0991.00
7_K99_D2.0721.00
145_T188_T2.0121.00
167_I186_Y2.0041.00
156_A213_R1.9751.00
36_K119_L1.9701.00
143_S146_A1.9671.00
23_I39_L1.9671.00
154_L160_I1.9651.00
56_F102_V1.9461.00
141_T163_G1.8561.00
43_L112_Q1.8231.00
47_K51_D1.8181.00
24_E27_R1.8151.00
197_K201_K1.7791.00
210_L214_M1.7751.00
199_R211_L1.7641.00
27_R35_Q1.7421.00
160_I173_Y1.7331.00
23_I115_L1.7281.00
15_I107_A1.7281.00
138_L165_A1.6821.00
118_E121_K1.6741.00
2_F7_K1.6641.00
138_L160_I1.5781.00
160_I170_I1.5691.00
148_I188_T1.5621.00
175_E181_D1.5231.00
154_L202_F1.5211.00
3_F74_R1.5131.00
182_L185_Y1.5101.00
35_Q39_L1.5071.00
60_Y102_V1.4880.99
187_R191_E1.4790.99
61_R109_E1.4750.99
13_K110_L1.4590.99
157_S206_L1.4490.99
192_I214_M1.4270.99
192_I201_K1.4010.99
148_I182_L1.3960.99
7_K94_F1.3590.99
207_K211_L1.3240.99
74_R96_T1.3160.99
3_F7_K1.3140.99
175_E182_L1.3060.99
190_L193_K1.3020.99
212_K216_E1.3010.99
152_Y189_F1.2790.98
147_L182_L1.2760.98
74_R91_D1.2610.98
172_E175_E1.2530.98
67_L70_K1.2420.98
149_E195_R1.2330.98
2_F94_F1.2060.98
189_F217_D1.1720.97
71_Y98_H1.1640.97
36_K123_E1.1520.97
6_I10_F1.1450.97
152_Y186_Y1.1450.97
49_F101_K1.1380.97
142_G202_F1.1370.97
28_P38_Y1.1310.96
34_A44_K1.1280.96
193_K214_M1.1250.96
139_K179_N1.1250.96
208_E212_K1.1200.96
175_E183_G1.1160.96
20_I114_Y1.1070.96
184_D190_L1.0990.96
146_A159_V1.0980.96
66_Y71_Y1.0890.96
148_I185_Y1.0790.95
84_D101_K1.0700.95
11_L103_A1.0680.95
12_S106_L1.0620.95
42_E45_K1.0530.95
151_I170_I1.0530.95
94_F99_D1.0470.94
138_L170_I1.0330.94
213_R217_D1.0300.94
150_L153_A1.0220.94
33_K37_K1.0090.93
13_K17_Y1.0090.93
151_I185_Y1.0070.93
189_F214_M1.0060.93
12_S15_I1.0030.93
157_S209_S0.9930.93
50_F57_Y0.9910.93
24_E118_E0.9880.93
153_A203_L0.9860.92
139_K161_N0.9840.92
27_R39_L0.9770.92
200_T210_L0.9570.91
188_T192_I0.9530.91
196_K199_R0.9430.91
102_V106_L0.9380.91
171_A186_Y0.9360.90
32_K122_L0.9350.90
209_S212_K0.9270.90
155_H213_R0.9130.89
203_L206_L0.9100.89
170_I178_F0.9080.89
12_S110_L0.9060.89
47_K57_Y0.9040.89
148_I192_I0.9030.89
203_L207_K0.8940.88
11_L18_N0.8930.88
145_T187_R0.8900.88
155_H158_G0.8870.88
16_Y20_I0.8710.87
184_D187_R0.8480.85
57_Y105_I0.8470.85
100_Y104_K0.8360.85
168_K186_Y0.8360.85
49_F53_N0.8290.84
89_E100_Y0.8290.84
89_E95_S0.8240.84
166_D186_Y0.8200.84
157_S160_I0.8190.83
24_E115_L0.8130.83
47_K112_Q0.8110.83
173_Y178_F0.8060.82
144_K182_L0.8010.82
189_F193_K0.7980.82
108_N111_L0.7970.82
96_T99_D0.7970.82
147_L174_F0.7950.82
26_K38_Y0.7910.81
23_I111_L0.7860.81
170_I173_Y0.7850.81
145_T192_I0.7850.81
202_F206_L0.7820.81
39_L115_L0.7800.80
56_F71_Y0.7710.80
10_F184_D0.7680.79
2_F99_D0.7680.79
3_F91_D0.7670.79
204_D211_L0.7640.79
127_S131_S0.7620.79
108_N114_Y0.7620.79
152_Y167_I0.7620.79
71_Y96_T0.7610.79
174_F182_L0.7570.78
50_F61_R0.7550.78
157_S205_K0.7530.78
141_T162_N0.7530.78
89_E112_Q0.7420.77
19_K111_L0.7410.77
142_G157_S0.7400.77
211_L214_M0.7380.77
142_G158_G0.7370.76
205_K209_S0.7370.76
31_S34_A0.7330.76
91_D96_T0.7310.76
139_K164_N0.7260.75
12_S103_A0.7170.74
161_N179_N0.7160.74
140_W147_L0.7150.74
4_K65_T0.7130.74
167_I191_E0.7110.74
189_F213_R0.7100.74
187_R217_D0.7100.74
147_L151_I0.7080.74
138_L173_Y0.7020.73
32_K116_E0.6990.73
151_I167_I0.6970.72
66_Y108_N0.6940.72
140_W159_V0.6910.72
174_F177_V0.6910.72
25_T92_P0.6910.72
19_K102_V0.6870.71
185_Y188_T0.6840.71
23_I119_L0.6840.71
28_P61_R0.6830.71
118_E184_D0.6820.71
168_K172_E0.6810.71
7_K28_P0.6780.70
69_E73_L0.6780.70
66_Y70_K0.6750.70
156_A209_S0.6720.70
148_I180_I0.6710.70
186_Y190_L0.6710.70
56_F97_S0.6710.70
171_A175_E0.6700.69
24_E114_Y0.6690.69
148_I171_A0.6680.69
170_I174_F0.6680.69
194_N197_K0.6620.68
118_E122_L0.6620.68
193_K210_L0.6610.68
144_K153_A0.6590.68
46_L108_N0.6520.67
120_E123_E0.6510.67
109_E113_V0.6510.67
53_N199_R0.6390.66
191_E201_K0.6320.65
160_I178_F0.6300.65
42_E46_L0.6240.64
187_R192_I0.6240.64
117_K121_K0.6190.63
40_E121_K0.6150.63
164_N194_N0.6140.63
3_F96_T0.6130.63
25_T52_K0.6120.62
153_A159_V0.6090.62
190_L194_N0.6070.62
20_I24_E0.6070.62
139_K173_Y0.6060.62
183_G191_E0.6050.62
111_L115_L0.6050.62
19_K108_N0.6040.61
7_K114_Y0.6020.61
147_L203_L0.6010.61
27_R102_V0.6010.61
126_N129_S0.6000.61
42_E61_R0.5990.61
125_K135_K0.5970.61
114_Y118_E0.5940.60
183_G193_K0.5930.60
186_Y198_S0.5920.60
191_E202_F0.5920.60
160_I177_V0.5910.60
21_Y89_E0.5910.60
134_P137_K0.5900.60
134_P138_L0.5900.60
144_K180_I0.5890.59
148_I202_F0.5890.59
7_K95_S0.5870.59
137_K169_E0.5850.59
136_S176_K0.5840.59
182_L188_T0.5830.59
198_S201_K0.5830.59
5_E40_E0.5820.59
155_H170_I0.5810.58
56_F98_H0.5800.58
70_K90_I0.5800.58
21_Y25_T0.5800.58
93_E132_S0.5800.58
128_K131_S0.5790.58
12_S105_I0.5760.58
26_K71_Y0.5740.58
11_L39_L0.5740.58
16_Y111_L0.5730.57
167_I189_F0.5720.57
139_K162_N0.5710.57
142_G154_L0.5700.57
191_E196_K0.5690.57
102_V105_I0.5680.57
47_K114_Y0.5670.57
166_D183_G0.5660.56
193_K213_R0.5650.56
3_F99_D0.5640.56
148_I152_Y0.5640.56
132_S135_K0.5630.56
193_K199_R0.5600.56
33_K63_G0.5570.55
35_Q122_L0.5570.55
126_N130_S0.5560.55
78_D81_L0.5540.55
198_S205_K0.5480.54
121_K125_K0.5480.54
137_K179_N0.5480.54
130_S176_K0.5470.54
159_V170_I0.5460.54
66_Y69_E0.5450.54
57_Y60_Y0.5410.53
67_L71_Y0.5400.53
22_N101_K0.5360.53
15_I108_N0.5360.53
20_I111_L0.5340.52
62_S101_K0.5310.52
41_K119_L0.5310.52
73_L81_L0.5280.51
23_I27_R0.5280.51
38_Y46_L0.5270.51
148_I170_I0.5260.51
34_A39_L0.5220.51
46_L112_Q0.5220.51
184_D197_K0.5210.51
140_W144_K0.5190.50
50_F108_N0.5180.50
12_S161_N0.5160.50
8_P12_S0.5140.50
30_G50_F0.5130.49
3_F94_F0.5130.49
30_G61_R0.5130.49
55_D71_Y0.5110.49
24_E39_L0.5100.49
77_F87_Y0.5100.49
31_S35_Q0.5090.49
130_S133_K0.5090.49
199_R210_L0.5090.49
55_D88_F0.5070.49
102_V109_E0.5060.48
25_T62_S0.5060.48
57_Y112_Q0.5050.48
32_K35_Q0.5050.48
22_N31_S0.5050.48
99_D191_E0.5040.48
151_I187_R0.5020.48
77_F98_H0.5020.48
154_L159_V0.5010.48
95_S99_D0.5010.48
143_S188_T0.5010.48
186_Y189_F0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ujpE 1 0.5229 34.5 0.946 Contact Map
4bpeC 1 0.5229 28.3 0.948 Contact Map
3zeyX 1 0.5183 25.1 0.95 Contact Map
4w23D 1 0.5275 22.5 0.951 Contact Map
3j7aD 1 0.3257 18.3 0.953 Contact Map
1iufA 1 0.3807 15.3 0.954 Contact Map
3wtsC 1 0.3716 9.1 0.959 Contact Map
3j20C 1 0.5046 8.5 0.959 Contact Map
2pmyA 4 0.3211 7.5 0.96 Contact Map
2g1pA 1 0.367 7.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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