GREMLIN Database
Phage_BR0599 - Phage conserved hypothetical protein BR0599
PFAM: PF09356 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (79)
Sequences: 8428 (6704)
Seq/√Len: 754.3
META: 0.91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_F67_A4.4171.00
54_D59_T3.4001.00
56_T59_T2.2781.00
57_F75_H1.9711.00
20_R37_L1.9141.00
61_R67_A1.8761.00
31_L49_L1.8491.00
7_R19_S1.8391.00
53_C60_C1.8351.00
24_S32_T1.8101.00
9_T48_T1.7631.00
51_A63_K1.7181.00
2_W51_A1.7071.00
10_W37_L1.6751.00
66_N69_N1.6551.00
4_A24_S1.6521.00
25_H29_G1.5831.00
2_W63_K1.5571.00
1_G4_A1.4911.00
11_T48_T1.4881.00
42_A45_D1.4851.00
70_F74_P1.4511.00
9_T19_S1.4451.00
58_A62_A1.4291.00
11_T46_T1.3481.00
8_L47_F1.3021.00
12_S46_T1.2831.00
15_N39_F1.2621.00
9_T50_T1.2521.00
23_K34_W1.2401.00
57_F74_P1.2351.00
18_L38_P1.2321.00
51_A64_F1.2241.00
33_L37_L1.1931.00
7_R50_T1.1551.00
57_F61_R1.1451.00
73_F76_I1.1091.00
26_T30_T1.0721.00
59_T63_K1.0471.00
10_W15_N1.0471.00
21_E34_W1.0271.00
12_S16_A1.0181.00
10_W47_F1.0081.00
6_G52_G1.0071.00
14_A42_A1.0061.00
5_G52_G1.0021.00
41_I45_D0.9691.00
11_T16_A0.9281.00
60_C66_N0.9061.00
10_W45_D0.8961.00
14_A39_F0.8931.00
14_A45_D0.8911.00
4_A25_H0.8681.00
59_T64_F0.8541.00
8_L49_L0.8441.00
12_S45_D0.8131.00
37_L41_I0.7981.00
8_L33_L0.7971.00
10_W20_R0.7671.00
25_H31_L0.7631.00
15_N18_L0.7631.00
53_C66_N0.7531.00
54_D58_A0.7521.00
4_A54_D0.7441.00
11_T17_G0.7441.00
14_A40_P0.7171.00
15_N37_L0.7171.00
67_A74_P0.7061.00
26_T32_T0.7031.00
18_L37_L0.6971.00
59_T62_A0.6961.00
13_G17_G0.6921.00
5_G21_E0.6901.00
61_R65_N0.6781.00
23_K32_T0.6731.00
58_A61_R0.6691.00
25_H28_G0.6551.00
15_N20_R0.6541.00
21_E35_L0.6511.00
1_G25_H0.6481.00
3_F49_L0.6451.00
20_R33_L0.6441.00
25_H63_K0.6441.00
10_W41_I0.6421.00
76_I79_N0.6321.00
55_K70_F0.6261.00
22_I47_F0.6151.00
31_L47_F0.6101.00
15_N41_I0.5951.00
40_P45_D0.5831.00
21_E78_G0.5791.00
15_N38_P0.5781.00
8_L20_R0.5761.00
20_R38_P0.5741.00
15_N40_P0.5721.00
12_S17_G0.5711.00
52_G63_K0.5711.00
15_N45_D0.5701.00
13_G16_A0.5671.00
12_S15_N0.5641.00
53_C59_T0.5621.00
62_A65_N0.5621.00
20_R23_K0.5561.00
68_V73_F0.5521.00
23_K52_G0.5501.00
25_H30_T0.5441.00
17_G22_I0.5411.00
52_G78_G0.5361.00
3_F25_H0.5341.00
65_N68_V0.5321.00
7_R48_T0.5281.00
10_W18_L0.5231.00
73_F77_P0.5081.00
11_T47_F0.5071.00
32_T35_L0.5061.00
71_R75_H0.5041.00
34_W38_P0.5021.00
16_A46_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gp4A 2 0.775 9.6 0.884 Contact Map
3myxA 1 0.8125 5.4 0.896 Contact Map
1brvA 1 0.0625 4.5 0.9 Contact Map
2yvlA 4 0.5125 4.4 0.901 Contact Map
1f2nA 12 0.5375 3.9 0.903 Contact Map
2ed6A 3 0.975 2.9 0.909 Contact Map
1ng0A 12 0.5375 2.8 0.91 Contact Map
2k9nA 1 0.7375 2.5 0.912 Contact Map
3vkgA 2 1 2.5 0.912 Contact Map
4akgA 2 1 2.5 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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