GREMLIN Database
Phage_Gp19 - Phage protein Gp19/Gp15/Gp42
PFAM: PF09355 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (111)
Sequences: 736 (605)
Seq/√Len: 57.4
META: 0.772

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_D47_S3.7501.00
39_I49_V2.7711.00
45_Y49_V2.7591.00
73_E82_Y2.7531.00
17_L21_S2.5141.00
29_K42_D2.3191.00
37_A41_A2.2861.00
24_L35_L2.1391.00
74_S83_S2.0551.00
21_S53_T2.0221.00
3_R9_E2.0211.00
22_D44_A2.0141.00
76_S81_S1.9831.00
24_L95_I1.9611.00
21_S25_R1.9591.00
94_F99_E1.8971.00
25_R36_D1.8811.00
39_I42_D1.8621.00
7_P10_Q1.8451.00
33_K38_M1.8270.99
56_V95_I1.7480.99
59_R99_E1.7020.99
64_S68_E1.6970.99
17_L53_T1.6310.99
75_E82_Y1.6170.99
42_D45_Y1.5750.98
27_E30_K1.5460.98
19_D51_S1.4610.97
5_L9_E1.4490.97
72_Q85_T1.4340.97
96_K99_E1.4260.97
71_T85_T1.4070.97
70_M84_G1.3750.96
62_M67_R1.3460.96
29_K36_D1.2810.94
39_I45_Y1.2750.94
23_S27_E1.2690.94
13_A61_L1.2600.94
26_V42_D1.2430.93
77_A80_Y1.2430.93
26_V48_V1.2310.93
26_V30_K1.2220.93
23_S51_S1.1980.92
74_S81_S1.1910.92
2_W58_A1.1820.92
97_K106_R1.1800.92
2_W12_R1.1530.91
2_W5_L1.1220.89
11_E14_E1.1210.89
15_A18_P1.1100.89
44_A47_S1.1090.89
19_D47_S1.0940.88
5_L13_A1.0870.88
15_A19_D1.0600.86
63_T69_P1.0030.83
51_S102_R0.9820.82
72_Q83_S0.9810.82
26_V44_A0.9560.80
4_P11_E0.9530.80
89_P92_G0.9420.79
48_V51_S0.9360.79
57_V60_A0.9160.77
20_A56_V0.9080.77
51_S55_D0.9000.76
58_A61_L0.8870.75
39_I46_A0.8870.75
46_A50_K0.8840.75
20_A55_D0.8790.74
4_P7_P0.8680.73
62_M65_T0.8680.73
17_L20_A0.8540.72
36_D39_I0.8460.71
62_M66_D0.8400.71
34_D37_A0.8370.71
63_T99_E0.8350.70
8_E11_E0.8320.70
28_A35_L0.8210.69
60_A93_L0.8200.69
6_T18_P0.8180.69
37_A49_V0.8160.69
58_A62_M0.7940.66
14_E18_P0.7890.66
65_T68_E0.7810.65
79_G84_G0.7800.65
88_V92_G0.7660.64
95_I100_L0.7610.63
11_E110_Y0.7510.62
85_T88_V0.7490.62
73_E86_Y0.7440.61
47_S50_K0.7440.61
63_T93_L0.7430.61
25_R28_A0.7210.59
29_K44_A0.7200.59
20_A23_S0.7170.59
97_K101_K0.7160.58
27_E31_V0.7000.57
96_K100_L0.6950.56
78_G81_S0.6940.56
40_A46_A0.6880.55
75_E80_Y0.6870.55
23_S56_V0.6850.55
87_L96_K0.6830.55
20_A53_T0.6750.54
27_E102_R0.6740.54
88_V101_K0.6740.54
86_Y89_P0.6730.54
10_Q13_A0.6730.54
7_P43_P0.6670.53
26_V29_K0.6620.53
67_R85_T0.6570.52
97_K112_V0.6550.52
11_E18_P0.6530.52
54_V59_R0.6440.51
52_V59_R0.6390.50
70_M73_E0.6370.50
28_A38_M0.6330.49
80_Y84_G0.6210.48
3_R13_A0.6180.48
53_T95_I0.6160.48
68_E71_T0.6110.47
54_V61_L0.6100.47
82_Y86_Y0.6090.47
19_D23_S0.6070.47
23_S102_R0.6060.46
77_A82_Y0.6020.46
97_K107_R0.6000.46
21_S49_V0.5960.45
7_P14_E0.5930.45
76_S79_G0.5900.45
2_W61_L0.5900.45
69_P96_K0.5820.44
24_L28_A0.5820.44
35_L95_I0.5780.43
84_G90_G0.5750.43
28_A33_K0.5710.43
109_R112_V0.5710.43
12_R16_L0.5700.43
37_A43_P0.5650.42
85_T90_G0.5630.42
76_S83_S0.5620.42
12_R55_D0.5620.42
31_V35_L0.5610.42
16_L74_S0.5580.41
95_I103_L0.5570.41
77_A83_S0.5570.41
7_P15_A0.5530.41
90_G94_F0.5530.41
55_D91_G0.5470.40
75_E100_L0.5420.40
31_V100_L0.5390.39
45_Y48_V0.5390.39
88_V94_F0.5370.39
59_R80_Y0.5300.38
47_S57_V0.5250.38
88_V102_R0.5220.38
77_A89_P0.5180.37
87_L99_E0.5110.36
20_A57_V0.5090.36
71_T74_S0.5080.36
19_D54_V0.5070.36
35_L49_V0.5060.36
42_D46_A0.5050.36
27_E100_L0.5040.36
64_S69_P0.5020.35
18_P21_S0.5010.35
32_G100_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xn8A 1 0.9224 65.4 0.885 Contact Map
5a21C 2 0.8103 58.1 0.89 Contact Map
4qolA 4 0.4655 12.3 0.923 Contact Map
4b7hA 4 0.4483 11 0.924 Contact Map
2eqzA 1 0.2759 9.1 0.927 Contact Map
1gweA 4 0.569 8.9 0.927 Contact Map
4qr9A 2 0.2845 8.9 0.928 Contact Map
3neaA 1 0.3362 8.4 0.928 Contact Map
2mrcA 1 0.319 8.1 0.929 Contact Map
4cabA 4 0.6207 7.2 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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