GREMLIN Database
DUF1995 - Domain of unknown function (DUF1995)
PFAM: PF09353 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 197 (192)
Sequences: 927 (698)
Seq/√Len: 50.4
META: 0.544

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L146_V4.5271.00
10_Q147_Y4.4531.00
21_D165_Y4.4471.00
100_E138_R4.0581.00
163_R166_P3.4691.00
25_R142_T3.4431.00
86_F109_R3.2121.00
161_L171_V3.0161.00
191_S194_E2.9081.00
91_P116_P2.6471.00
103_C111_V2.5141.00
67_K83_D2.4941.00
87_L112_V2.4181.00
19_L110_P2.2941.00
168_P187_P2.2861.00
88_F102_L2.2841.00
171_V195_L2.2121.00
88_F99_V2.2051.00
115_N149_L2.2011.00
70_F79_A2.1611.00
152_L159_G2.0581.00
162_F170_Q2.0551.00
25_R143_F2.0251.00
14_A164_C2.0141.00
41_G45_R1.8990.99
175_T181_E1.8890.99
186_F194_E1.8290.99
27_E116_P1.7150.99
182_L185_E1.6830.98
3_S6_E1.6500.98
74_G77_A1.6240.98
42_E45_R1.5940.98
170_Q185_E1.5820.98
21_D25_R1.5390.97
50_A114_L1.5160.97
42_E46_L1.5040.97
83_D109_R1.4640.96
28_V82_E1.4600.96
88_F113_L1.4560.96
168_P185_E1.4290.96
140_L145_P1.3850.95
191_S195_L1.3780.95
74_G136_R1.3690.94
46_L50_A1.3540.94
109_R147_Y1.3440.94
10_Q164_C1.3430.94
99_V113_L1.3180.93
145_P163_R1.3110.93
51_L55_R1.3090.93
161_L181_E1.3080.93
127_G131_R1.2850.92
63_G182_L1.2810.92
36_M39_Y1.2760.92
3_S62_S1.2730.92
128_Y134_Q1.2680.92
106_A111_V1.2550.91
66_L87_L1.2450.91
2_K6_E1.2320.91
14_A18_A1.2250.90
106_A109_R1.2210.90
18_A21_D1.2150.90
74_G78_L1.2150.90
15_T146_V1.2030.89
84_D194_E1.1980.89
113_L116_P1.1880.89
50_A89_V1.1860.89
51_L179_G1.1760.88
190_P195_L1.1710.88
144_E165_Y1.1680.88
117_R161_L1.1530.87
70_F76_A1.1340.86
84_D105_A1.1280.86
134_Q137_E1.1280.86
46_L49_L1.1270.86
167_G170_Q1.1200.86
188_Q194_E1.0890.84
45_R48_P1.0750.83
124_V130_A1.0670.83
100_E104_E1.0620.83
147_Y162_F1.0570.82
27_E30_L1.0550.82
17_A21_D1.0530.82
126_I129_A1.0490.82
19_L183_V1.0490.82
14_A21_D1.0430.81
24_T146_V1.0350.81
142_T152_L1.0270.80
155_G158_S1.0220.80
180_Y194_E1.0210.80
29_E70_F1.0210.80
74_G79_A1.0170.80
185_E188_Q1.0110.79
177_D191_S1.0080.79
112_V196_E1.0030.79
8_I162_F1.0020.79
17_A20_A0.9990.79
15_T25_R0.9960.78
25_R116_P0.9890.78
134_Q138_R0.9830.77
99_V140_L0.9780.77
53_F72_D0.9660.76
116_P120_D0.9650.76
32_F149_L0.9480.75
20_A104_E0.9480.75
1_P6_E0.9480.75
171_V186_F0.9450.75
101_K104_E0.9390.74
91_P190_P0.9280.73
172_W182_L0.9220.73
51_L54_L0.9210.73
160_A180_Y0.9190.72
23_K146_V0.9070.71
77_A127_G0.8950.70
178_G181_E0.8870.70
127_G130_A0.8850.70
10_Q162_F0.8780.69
72_D138_R0.8780.69
16_Q20_A0.8770.69
147_Y190_P0.8750.69
120_D136_R0.8690.68
24_T110_P0.8670.68
46_L90_A0.8620.68
42_E52_Q0.8610.67
69_L76_A0.8570.67
76_A80_R0.8490.66
153_S156_G0.8400.66
11_A117_R0.8290.64
11_A30_L0.8260.64
112_V184_A0.8240.64
11_A163_R0.8230.64
120_D123_S0.8190.64
125_G136_R0.8180.63
61_G110_P0.8110.63
56_L59_E0.8080.62
162_F173_L0.8080.62
73_A77_A0.8080.62
9_A12_A0.8050.62
48_P52_Q0.8010.62
151_P169_W0.8000.62
84_D188_Q0.7980.62
149_L162_F0.7930.61
16_Q62_S0.7920.61
95_E118_L0.7830.60
45_R52_Q0.7800.60
15_T53_F0.7690.59
20_A49_L0.7680.59
13_E20_A0.7580.58
136_R157_I0.7550.57
40_D43_A0.7530.57
152_L161_L0.7510.57
65_R84_D0.7430.56
187_P194_E0.7430.56
15_T29_E0.7250.54
13_E101_K0.7200.54
118_L139_F0.7140.53
61_G64_A0.7130.53
75_A78_L0.7100.53
131_R136_R0.7080.52
107_G112_V0.7080.52
3_S52_Q0.7050.52
21_D104_E0.7030.52
67_K70_F0.7020.52
5_E52_Q0.6980.51
92_S141_S0.6950.51
187_P195_L0.6950.51
25_R103_C0.6950.51
41_G44_L0.6940.51
10_Q14_A0.6920.51
66_L71_P0.6900.51
27_E154_E0.6880.50
13_E17_A0.6870.50
69_L161_L0.6860.50
16_Q21_D0.6850.50
71_P75_A0.6810.50
100_E141_S0.6800.50
145_P148_Y0.6780.49
54_L88_F0.6770.49
29_E148_Y0.6690.48
138_R148_Y0.6690.48
148_Y169_W0.6690.48
49_L87_L0.6660.48
43_A47_L0.6650.48
59_E84_D0.6580.47
135_L171_V0.6550.47
91_P113_L0.6550.47
92_S160_A0.6540.47
41_G46_L0.6510.47
69_L88_F0.6510.47
72_D95_E0.6490.46
20_A107_G0.6430.46
151_P158_S0.6420.46
128_Y131_R0.6410.46
42_E48_P0.6390.45
120_D124_V0.6380.45
17_A23_K0.6370.45
144_E163_R0.6320.45
2_K183_V0.6310.45
42_E54_L0.6290.44
13_E191_S0.6260.44
20_A63_G0.6250.44
91_P143_F0.6250.44
2_K194_E0.6230.44
50_A130_A0.6210.44
32_F71_P0.6210.44
119_E122_A0.6190.43
13_E22_G0.6160.43
42_E57_L0.6150.43
66_L194_E0.6130.43
104_E107_G0.6100.42
63_G113_L0.6040.42
147_Y186_F0.6030.42
67_K71_P0.6020.42
60_L63_G0.6000.41
32_F93_A0.6000.41
78_L81_R0.5980.41
33_P95_E0.5980.41
35_L160_A0.5970.41
11_A28_V0.5930.41
173_L177_D0.5920.41
173_L186_F0.5890.40
86_F110_P0.5890.40
75_A79_A0.5880.40
60_L101_K0.5870.40
45_R51_L0.5860.40
188_Q195_L0.5850.40
135_L138_R0.5850.40
82_E181_E0.5850.40
2_K13_E0.5820.40
5_E143_F0.5780.39
39_Y43_A0.5770.39
43_A78_L0.5740.39
75_A131_R0.5730.39
95_E100_E0.5720.39
170_Q182_L0.5710.39
130_A135_L0.5690.38
51_L57_L0.5680.38
16_Q88_F0.5670.38
44_L48_P0.5660.38
84_D115_N0.5660.38
50_A138_R0.5650.38
5_E11_A0.5650.38
43_A46_L0.5620.38
16_Q19_L0.5610.38
153_S159_G0.5610.38
183_V186_F0.5600.38
115_N167_G0.5580.37
24_T115_N0.5580.37
35_L39_Y0.5540.37
51_L101_K0.5530.37
126_I189_R0.5500.37
94_V163_R0.5490.36
127_G136_R0.5460.36
147_Y166_P0.5460.36
15_T19_L0.5440.36
10_Q15_T0.5420.36
4_L149_L0.5410.36
16_Q113_L0.5410.36
60_L88_F0.5400.36
92_S95_E0.5400.36
3_S96_L0.5370.35
22_G165_Y0.5360.35
42_E49_L0.5320.35
89_V114_L0.5320.35
45_R49_L0.5290.35
45_R58_A0.5290.35
162_F172_W0.5290.35
128_Y135_L0.5280.34
13_E164_C0.5280.34
183_V188_Q0.5270.34
70_F118_L0.5260.34
31_L159_G0.5260.34
71_P80_R0.5260.34
5_E96_L0.5250.34
125_G137_E0.5250.34
88_F111_V0.5240.34
96_L179_G0.5220.34
5_E177_D0.5210.34
28_V144_E0.5190.34
69_L188_Q0.5190.34
53_F95_E0.5180.34
39_Y42_E0.5130.33
145_P183_V0.5120.33
26_L110_P0.5040.32
115_N143_F0.5040.32
93_A149_L0.5030.32
79_A100_E0.5020.32
77_A97_E0.5000.32
13_E16_Q0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x7fA 1 0.8782 6.6 0.947 Contact Map
3me7A 1 0.6802 6 0.948 Contact Map
3ia1A 2 0.665 5.8 0.948 Contact Map
4txoD 1 0.6396 5.2 0.949 Contact Map
2xz3A 3 0.5381 5.2 0.949 Contact Map
3txvA 2 0.934 4.7 0.95 Contact Map
3hhlA 3 0.5482 4.5 0.951 Contact Map
4bpyA 1 0.6954 4.4 0.951 Contact Map
2vtwA 3 0.3452 4.3 0.951 Contact Map
2k6vA 1 0.7208 3.3 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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