GREMLIN Database
DUF1992 - Domain of unknown function (DUF1992)
PFAM: PF09350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 70 (67)
Sequences: 10211 (5563)
Seq/√Len: 679.7
META: 0.871

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_E12_R2.8721.00
59_R63_E2.6111.00
7_R11_E2.5001.00
44_R48_N2.4681.00
4_R8_E2.2621.00
7_R10_M2.1701.00
16_D21_A1.8081.00
53_P56_L1.7981.00
39_L43_Y1.7881.00
1_L5_R1.6221.00
10_M16_D1.6221.00
54_P57_E1.5871.00
64_A68_L1.5771.00
64_A67_E1.5701.00
17_N21_A1.4501.00
52_L60_K1.4421.00
9_A14_E1.4361.00
37_E40_R1.3981.00
40_R43_Y1.3781.00
32_D35_V1.3571.00
3_E7_R1.3411.00
5_R8_E1.3271.00
57_E61_E1.2791.00
20_G24_P1.2741.00
52_L57_E1.2621.00
9_A15_F1.2481.00
4_R7_R1.2321.00
32_D44_R1.2001.00
63_E67_E1.1811.00
41_L44_R1.1801.00
6_I10_M1.1781.00
20_G23_K1.1631.00
63_E66_E1.1211.00
52_L56_L1.1211.00
55_E59_R1.0701.00
2_A5_R1.0531.00
10_M15_F1.0151.00
54_P58_L1.0021.00
36_P40_R0.9721.00
29_D33_P0.9451.00
39_L42_A0.9111.00
35_V40_R0.9041.00
58_L66_E0.8941.00
28_D47_K0.8781.00
20_G26_P0.8741.00
62_I66_E0.8411.00
62_I65_L0.8371.00
47_K50_G0.8371.00
13_G16_D0.8341.00
60_K64_A0.8231.00
35_V43_Y0.8191.00
56_L63_E0.8141.00
15_F18_L0.8081.00
4_R11_E0.7861.00
36_P39_L0.7841.00
34_L37_E0.7791.00
56_L59_R0.7651.00
65_L68_L0.7621.00
2_A10_M0.7481.00
43_Y55_E0.7391.00
27_L32_D0.7241.00
40_R44_R0.7181.00
29_D44_R0.7131.00
17_N20_G0.6951.00
42_A45_I0.6891.00
18_L21_A0.6711.00
57_E60_K0.6681.00
26_P33_P0.6651.00
29_D40_R0.6601.00
10_M14_E0.6521.00
55_E65_L0.6361.00
35_V38_E0.6351.00
46_L51_F0.6261.00
18_L22_G0.6151.00
65_L69_L0.6121.00
8_E11_E0.6111.00
8_E14_E0.6051.00
45_I50_G0.6031.00
45_I49_A0.6021.00
46_L49_A0.5981.00
48_N51_F0.5961.00
18_L23_K0.5831.00
66_E69_L0.5811.00
3_E6_I0.5631.00
10_M21_A0.5551.00
59_R68_L0.5441.00
27_L39_L0.5431.00
58_L61_E0.5431.00
15_F21_A0.5301.00
61_E64_A0.5271.00
60_K63_E0.5251.00
20_G25_L0.5241.00
46_L52_L0.5170.99
52_L55_E0.5170.99
58_L62_I0.5150.99
46_L54_P0.5120.99
61_E65_L0.5090.99
2_A46_L0.5030.99
39_L45_I0.5010.99
5_R12_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jadA 5 0.9571 49.7 0.817 Contact Map
4tvmA 2 0.5143 44.6 0.822 Contact Map
3msuA 2 0.9571 43.6 0.824 Contact Map
1a59A 2 0.9286 42.9 0.824 Contact Map
4xghA 5 0.5857 42.6 0.825 Contact Map
2h12A 4 0.9714 40.8 0.827 Contact Map
3hwkA 5 0.9286 38.7 0.829 Contact Map
3tqgA 2 0.9286 31.4 0.837 Contact Map
1vgmA 2 0.9571 31 0.837 Contact Map
1o7xA 2 0.9429 30.8 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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