GREMLIN Database
DUF1990 - Domain of unknown function (DUF1990)
PFAM: PF09348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 154 (152)
Sequences: 4753 (3477)
Seq/√Len: 282.0
META: 0.842

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_R44_R3.2281.00
82_Y93_A3.1451.00
112_W116_G3.1421.00
62_T79_R2.8391.00
27_E31_E2.8251.00
22_R117_S2.6151.00
103_R127_R2.5951.00
22_R119_W2.4291.00
77_P99_G2.3201.00
23_L29_V2.2561.00
38_R90_F2.2121.00
55_A61_T2.2091.00
58_E61_T2.0871.00
34_R90_F2.0641.00
35_A39_R2.0481.00
18_H121_D2.0101.00
10_L16_V1.9671.00
69_H74_S1.9651.00
120_Y151_S1.9531.00
88_R112_W1.9481.00
69_H72_L1.9191.00
27_E112_W1.8891.00
37_L110_V1.8801.00
88_R114_P1.8451.00
133_A140_A1.7911.00
20_R121_D1.7751.00
18_H123_R1.7341.00
34_R38_R1.7271.00
111_E121_D1.7251.00
22_R25_R1.7231.00
20_R119_W1.6071.00
81_V93_A1.5991.00
89_R111_E1.5941.00
84_V91_G1.5521.00
4_E14_Y1.5501.00
113_D119_W1.5131.00
143_L146_R1.5011.00
7_A125_F1.4821.00
9_R82_Y1.4741.00
76_N101_P1.4411.00
113_D117_S1.4371.00
4_E7_A1.4311.00
102_E140_A1.4151.00
129_A133_A1.3861.00
95_G105_E1.3811.00
147_F151_S1.3391.00
49_R66_L1.3351.00
130_H133_A1.3341.00
132_L136_G1.3301.00
36_A41_R1.3071.00
145_R148_A1.2761.00
47_W150_R1.2571.00
25_R116_G1.2471.00
10_L123_R1.2121.00
84_V109_L1.2061.00
103_R129_A1.2021.00
137_Y140_A1.1891.00
81_V95_G1.1321.00
32_R36_A1.1301.00
67_A101_P1.1301.00
107_R121_D1.1241.00
111_E119_W1.1141.00
21_V152_L1.0861.00
28_A32_R1.0841.00
63_V78_C1.0841.00
106_E124_A1.0681.00
19_N149_R1.0651.00
76_N147_F1.0561.00
99_G129_A1.0461.00
69_H101_P1.0221.00
26_G118_V1.0201.00
35_A56_P1.0151.00
148_A152_L1.0091.00
89_R109_L1.0081.00
3_P14_Y1.0061.00
45_L48_V1.0031.00
95_G125_F1.0011.00
87_P114_P0.9981.00
93_A107_R0.9981.00
91_G109_L0.9861.00
48_V76_N0.9821.00
66_L75_L0.9791.00
138_P142_R0.9631.00
19_N148_A0.9601.00
7_A10_L0.9571.00
67_A76_N0.9571.00
57_I80_V0.9231.00
57_I83_V0.9131.00
42_M120_Y0.9031.00
84_V89_R0.8931.00
31_E34_R0.8901.00
85_D90_F0.8691.00
30_F34_R0.8691.00
81_V105_E0.8691.00
82_Y105_E0.8651.00
4_E125_F0.8601.00
109_L121_D0.8561.00
17_D124_A0.8501.00
15_R102_E0.8311.00
139_L142_R0.8291.00
38_R85_D0.8281.00
34_R85_D0.8281.00
70_L139_L0.8221.00
51_F66_L0.8130.99
59_P83_V0.8090.99
28_A31_E0.8070.99
82_Y107_R0.8000.99
146_R150_R0.7990.99
24_G118_V0.7940.99
142_R145_R0.7910.99
16_V123_R0.7820.99
19_N152_L0.7760.99
51_F54_D0.7740.99
20_R113_D0.7710.99
23_L112_W0.7660.99
14_Y103_R0.7620.99
86_E89_R0.7580.99
38_R56_P0.7580.99
44_R47_W0.7570.99
63_V94_Y0.7510.99
33_A110_V0.7490.99
48_V67_A0.7460.99
4_E10_L0.7430.99
143_L147_F0.7430.99
24_G29_V0.7420.99
46_G150_R0.7420.99
4_E103_R0.7420.99
110_V118_V0.7340.99
122_I148_A0.7330.99
139_L143_L0.7320.99
144_Q148_A0.7320.99
82_Y95_G0.7310.99
65_V78_C0.7300.99
35_A38_R0.7250.99
17_D141_R0.7190.99
23_L33_A0.7100.99
57_I90_F0.7080.99
109_L113_D0.7000.98
37_L42_M0.6980.98
59_P82_Y0.6940.98
54_D58_E0.6870.98
94_Y100_H0.6840.98
31_E35_A0.6830.98
43_F65_V0.6830.98
94_Y126_S0.6800.98
149_R153_R0.6780.98
93_A105_E0.6780.98
25_R117_S0.6780.98
79_R97_L0.6750.98
65_V76_N0.6740.98
102_E133_A0.6730.98
107_R123_R0.6700.98
2_Y6_G0.6680.98
15_R137_Y0.6670.98
19_N145_R0.6630.98
40_W52_P0.6600.98
30_F112_W0.6590.98
102_E124_A0.6570.98
146_R149_R0.6510.98
148_A151_S0.6480.97
66_L73_W0.6460.97
42_M92_F0.6420.97
2_Y8_T0.6420.97
149_R152_L0.6370.97
136_G139_L0.6360.97
54_D61_T0.6350.97
13_G127_R0.6310.97
42_M57_I0.6300.97
27_E116_G0.6290.97
40_W94_Y0.6280.97
136_G140_A0.6280.97
129_A140_A0.6270.97
33_A42_M0.6250.97
44_R48_V0.6240.97
43_F151_S0.6170.97
20_R111_E0.6130.96
150_R153_R0.6090.96
21_V120_Y0.6040.96
17_D148_A0.6020.96
87_P113_D0.6020.96
66_L69_H0.6000.96
7_A16_V0.5940.96
133_A136_G0.5930.96
15_R145_R0.5870.95
64_A77_P0.5860.95
37_L91_G0.5820.95
101_P130_H0.5820.95
85_D88_R0.5800.95
26_G112_W0.5770.95
57_I61_T0.5760.95
4_E8_T0.5760.95
2_Y5_V0.5710.95
43_F78_C0.5670.95
14_Y127_R0.5670.95
140_A148_A0.5660.94
132_L137_Y0.5610.94
105_E125_F0.5600.94
17_D126_S0.5590.94
69_H75_L0.5560.94
51_F64_A0.5550.94
61_T80_V0.5550.94
64_A75_L0.5530.94
15_R19_N0.5530.94
50_V53_P0.5500.94
144_Q147_F0.5460.93
65_V94_Y0.5410.93
110_V120_Y0.5380.93
4_E16_V0.5360.93
140_A143_L0.5310.92
27_E88_R0.5290.92
52_P55_A0.5240.92
32_R35_A0.5210.92
40_W92_F0.5200.92
62_T98_P0.5180.91
83_V90_F0.5170.91
85_D91_G0.5140.91
42_M52_P0.5130.91
30_F37_L0.5110.91
124_A141_R0.5110.91
43_F47_W0.5080.91
133_A137_Y0.5070.91
14_Y125_F0.5060.91
141_R145_R0.5060.91
2_Y95_G0.5050.90
88_R113_D0.5040.90
26_G29_V0.5040.90
109_L123_R0.5000.90
145_R149_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r7kA 4 0.9026 33.5 0.925 Contact Map
2m47A 1 0.8766 29.4 0.927 Contact Map
2d4rA 4 0.8636 13.4 0.937 Contact Map
1xuvA 2 0.8896 13.1 0.938 Contact Map
3ggnA 2 0.7597 11.8 0.939 Contact Map
3p9vA 2 0.8766 11.3 0.939 Contact Map
2pcsA 1 0.8636 10.4 0.94 Contact Map
3k3kA 4 0.9351 9.8 0.941 Contact Map
2ns9A 2 0.9091 8.2 0.943 Contact Map
1t17A 1 0.8571 7.6 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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