GREMLIN Database
DUF1987 - Domain of unknown function (DUF1987)
PFAM: PF09345 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (99)
Sequences: 10474 (7564)
Seq/√Len: 760.2
META: 0.959

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_N82_N3.9441.00
35_D68_K3.3761.00
46_T82_N2.8781.00
44_K78_K2.7301.00
18_S27_Y2.4111.00
13_E48_N2.3721.00
38_L72_I2.2991.00
6_D9_T2.2261.00
17_R52_E2.1891.00
15_S50_K2.1461.00
85_Y93_L2.1401.00
54_F95_A2.1341.00
5_F12_L1.9461.00
2_E15_S1.8971.00
50_K84_Y1.8791.00
44_K80_K1.8241.00
48_N84_Y1.7861.00
18_S58_S1.7311.00
11_I48_N1.7101.00
37_Y45_T1.6901.00
28_E32_D1.6791.00
93_L97_E1.6361.00
2_E13_E1.6061.00
46_T80_K1.4821.00
41_P45_T1.4781.00
11_I46_T1.4451.00
24_A61_C1.3771.00
54_F59_S1.3641.00
4_I13_E1.3311.00
3_V30_V1.2611.00
61_C64_D1.2171.00
23_A57_S1.2081.00
10_G37_Y1.2071.00
32_D36_E1.2071.00
5_F30_V1.2051.00
60_K64_D1.1811.00
12_L47_V1.1761.00
34_L65_I1.1601.00
70_E73_H1.1471.00
49_F66_L1.1401.00
22_N25_E1.1271.00
47_V69_L1.0821.00
31_L61_C1.0421.00
43_E77_K1.0321.00
51_L62_L1.0081.00
36_E39_K0.9971.00
7_P33_W0.9881.00
5_F14_I0.9801.00
34_L69_L0.9521.00
94_E97_E0.9461.00
13_E50_K0.9451.00
67_K71_E0.9201.00
37_Y41_P0.9101.00
24_A28_E0.9011.00
6_D11_I0.8871.00
54_F62_L0.8871.00
25_E28_E0.8641.00
7_P42_N0.8621.00
12_L45_T0.8601.00
24_A64_D0.8571.00
54_F58_S0.8551.00
19_I61_C0.8511.00
10_G43_E0.8471.00
41_P77_K0.8441.00
38_L68_K0.8341.00
56_T95_A0.8281.00
91_D95_A0.8251.00
7_P40_N0.8001.00
69_L79_V0.7921.00
95_A99_F0.7921.00
89_D92_M0.7851.00
70_E74_K0.7831.00
55_N58_S0.7751.00
68_K71_E0.7741.00
26_F30_V0.7741.00
23_A27_Y0.7641.00
72_I77_K0.7621.00
73_H78_K0.7561.00
49_F62_L0.7561.00
63_L67_K0.7531.00
32_D35_D0.7461.00
31_L35_D0.7371.00
68_K72_I0.7241.00
27_Y58_S0.7131.00
85_Y96_G0.7091.00
51_L58_S0.6981.00
70_E79_V0.6941.00
31_L65_I0.6901.00
53_Y56_T0.6871.00
31_L68_K0.6831.00
4_I7_P0.6781.00
20_P58_S0.6771.00
56_T91_D0.6751.00
42_N77_K0.6701.00
73_H76_G0.6701.00
5_F33_W0.6631.00
23_A61_C0.6621.00
45_T72_I0.6561.00
14_I49_F0.6551.00
42_N45_T0.6531.00
45_T77_K0.6481.00
60_K63_L0.6471.00
72_I75_K0.6421.00
33_W37_Y0.6411.00
66_L81_V0.6411.00
18_S51_L0.6311.00
29_P32_D0.6301.00
56_T59_S0.6291.00
92_M96_G0.6261.00
10_G45_T0.6221.00
21_E56_T0.6161.00
59_S63_L0.6091.00
62_L66_L0.6051.00
64_D67_K0.6001.00
34_L68_K0.5991.00
20_P23_A0.5941.00
20_P57_S0.5941.00
21_E55_N0.5861.00
10_G42_N0.5831.00
41_P44_K0.5731.00
30_V65_I0.5721.00
14_I47_V0.5721.00
41_P72_I0.5701.00
57_S60_K0.5651.00
95_A98_D0.5641.00
86_E89_D0.5591.00
63_L99_F0.5591.00
12_L37_Y0.5531.00
4_I9_T0.5511.00
38_L75_K0.5501.00
3_V14_I0.5491.00
71_E74_K0.5461.00
55_N60_K0.5451.00
17_R90_E0.5391.00
94_E98_D0.5371.00
12_L34_L0.5371.00
51_L54_F0.5361.00
33_W47_V0.5351.00
30_V33_W0.5341.00
12_L33_W0.5321.00
21_E57_S0.5281.00
77_K80_K0.5241.00
5_F37_Y0.5221.00
93_L96_G0.5171.00
59_S95_A0.5141.00
19_I23_A0.5121.00
64_D68_K0.5061.00
49_F96_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dghA 4 0.9091 26.7 0.874 Contact Map
3eikA 2 0.404 19.7 0.882 Contact Map
3mcbB 1 0.3434 17.3 0.885 Contact Map
3lloA 1 0.8485 17.3 0.885 Contact Map
4b0aA 1 0.404 17 0.885 Contact Map
1ytbA 1 0.404 16.9 0.885 Contact Map
1rm1A 1 0.404 13.9 0.89 Contact Map
2o8rA 2 0.9394 10.5 0.895 Contact Map
1aisA 1 0.3737 10.3 0.896 Contact Map
4dgfA 1 0.9091 9.7 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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