GREMLIN Database
NuA4 - Histone acetyltransferase subunit NuA4
PFAM: PF09340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (77)
Sequences: 604 (452)
Seq/√Len: 51.5
META: 0.407

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_L21_E3.4211.00
10_K14_E2.8371.00
27_L30_S2.7971.00
41_G46_G2.4821.00
33_E63_K2.2221.00
35_T42_N2.1411.00
32_L72_L2.0191.00
8_K12_E1.9821.00
4_R11_R1.9661.00
25_Y29_T1.9521.00
29_T71_R1.8780.99
35_T47_F1.7270.99
4_R8_K1.6840.99
42_N47_F1.6670.98
26_D80_S1.6040.98
23_Q27_L1.5670.98
66_F75_L1.4780.97
45_K70_D1.4600.96
47_F52_K1.4110.96
42_N46_G1.3960.95
2_E27_L1.3920.95
9_K23_Q1.3590.94
2_E69_E1.3330.94
22_K26_D1.3190.94
21_E77_S1.3140.93
25_Y71_R1.2960.93
39_S45_K1.2860.93
8_K14_E1.2700.92
18_A22_K1.2390.91
7_L15_E1.2390.91
31_Y46_G1.1840.89
20_L27_L1.1590.88
4_R26_D1.1410.87
35_T48_D1.1380.87
63_K66_F1.1230.87
66_F71_R1.1220.86
21_E79_T1.0980.85
43_I68_D1.0420.82
26_D30_S1.0290.81
53_S57_S1.0040.80
61_R66_F0.9980.79
8_K47_F0.9880.79
19_Q22_K0.9790.78
44_I72_L0.9690.77
11_R14_E0.9560.76
8_K64_R0.9450.75
15_E50_Y0.9140.73
24_I77_S0.9090.73
33_E79_T0.8970.72
75_L78_V0.8810.70
67_T70_D0.8660.69
44_I66_F0.8640.69
27_L75_L0.8500.67
40_G51_L0.8410.67
7_L60_D0.8380.66
31_Y47_F0.8170.64
48_D51_L0.8160.64
7_L10_K0.8120.64
13_L49_G0.8080.63
8_K58_A0.7940.62
40_G65_K0.7930.62
10_K21_E0.7930.62
4_R79_T0.7690.60
74_S77_S0.7690.60
29_T72_L0.7690.60
31_Y42_N0.7460.57
30_S42_N0.7400.57
32_L35_T0.7360.56
59_A70_D0.7180.54
31_Y41_G0.7150.54
17_L24_I0.7140.54
75_L80_S0.7120.54
9_K12_E0.7110.54
25_Y30_S0.6990.52
10_K47_F0.6960.52
11_R34_E0.6870.51
72_L75_L0.6800.50
10_K45_K0.6780.50
42_N76_S0.6700.49
32_L71_R0.6630.49
8_K39_S0.6520.48
54_S62_R0.6400.46
43_I52_K0.6350.46
18_A25_Y0.6210.44
35_T41_G0.6180.44
25_Y64_R0.6060.43
64_R80_S0.6040.43
33_E48_D0.5940.42
8_K78_V0.5880.41
38_S47_F0.5870.41
4_R51_L0.5810.40
19_Q54_S0.5800.40
9_K63_K0.5770.40
23_Q64_R0.5700.39
13_L45_K0.5640.39
23_Q69_E0.5590.38
14_E71_R0.5540.38
5_E33_E0.5530.37
22_K52_K0.5430.37
4_R65_K0.5420.36
16_E27_L0.5380.36
31_Y35_T0.5340.36
17_L41_G0.5330.36
38_S48_D0.5290.35
70_D76_S0.5210.34
5_E30_S0.5190.34
23_Q76_S0.5170.34
5_E62_R0.5150.34
55_K61_R0.5120.34
12_E16_E0.5090.33
15_E19_Q0.5070.33
62_R72_L0.5060.33
6_L22_K0.5050.33
39_S48_D0.5040.33
13_L38_S0.5030.33
34_E43_I0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ihfA 4 0.3125 28.6 0.862 Contact Map
1nkpB 1 0.375 14.9 0.879 Contact Map
2iu8A 3 0.35 14.9 0.879 Contact Map
3pmoA 3 0.3 14.3 0.88 Contact Map
3zidA 1 0.425 13.6 0.881 Contact Map
2wujA 2 0.2375 13.5 0.881 Contact Map
2yy0A 6 0.35 13.4 0.881 Contact Map
4e79A 3 0.4 13.3 0.882 Contact Map
3mtuE 2 0.65 13 0.883 Contact Map
3ra3B 1 0.3375 12.4 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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