GREMLIN Database
Gly_reductase - Glycine/sarcosine/betaine reductase component B subunits
PFAM: PF09338 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 426 (423)
Sequences: 1624 (913)
Seq/√Len: 44.4
META: 0.789

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_R270_D5.8731.00
198_A304_A4.9801.00
277_I299_A4.3971.00
259_V338_I4.3611.00
29_N32_E4.0731.00
19_T167_A3.7181.00
300_E331_A3.6551.00
103_V116_I3.6371.00
48_L134_L3.6091.00
56_S378_D3.5711.00
13_V134_L3.4441.00
100_A134_L3.2851.00
10_I21_V3.2741.00
166_E169_R3.2201.00
16_G27_T3.2041.00
181_L228_H2.9871.00
12_D52_R2.9791.00
330_K358_E2.9661.00
37_V160_A2.9031.00
31_E35_A2.8671.00
33_L160_A2.8661.00
198_A274_V2.7501.00
7_N98_K2.7451.00
406_V410_A2.6841.00
121_P124_E2.6801.00
15_F30_K2.6801.00
11_K24_G2.6741.00
307_A328_L2.6471.00
232_V260_I2.6221.00
230_N264_Y2.6171.00
28_V134_L2.6011.00
9_P174_D2.5621.00
250_T253_H2.5341.00
177_E261_L2.5291.00
77_G84_G2.5191.00
2_R178_V2.4691.00
119_S377_M2.4461.00
4_E93_R2.4231.00
82_V238_V2.3731.00
101_A131_T2.2611.00
177_E265_R2.2241.00
399_R405_E2.2151.00
15_F50_I2.2041.00
34_L38_L2.1971.00
93_R176_V2.1601.00
198_A307_A2.1531.00
52_R132_N2.1431.00
50_I134_L2.1111.00
121_P375_P2.1021.00
65_V103_V2.0570.99
30_K47_D2.0420.99
49_E137_V1.9750.99
322_M359_A1.9510.99
4_E178_V1.9420.99
103_V133_N1.9310.99
49_E379_R1.9200.99
326_K358_E1.9110.99
73_E93_R1.9090.99
196_R303_G1.8950.99
181_L230_N1.8870.99
6_G95_H1.8830.99
259_V310_T1.8470.99
214_V219_A1.8370.99
9_P98_K1.8150.99
51_A57_V1.8150.99
12_D25_V1.8050.98
182_P190_E1.8010.98
228_H264_Y1.7930.98
8_I168_A1.7890.98
274_V304_A1.7870.98
32_E163_Y1.7590.98
373_E405_E1.7400.98
227_L278_L1.7210.98
200_V295_A1.7210.98
13_V100_A1.7180.98
71_K94_T1.6910.98
160_A163_Y1.6640.97
179_Y261_L1.6630.97
14_Q25_V1.6530.97
200_V277_I1.6350.97
66_I157_G1.6320.97
45_S139_E1.6280.97
79_F255_Q1.6220.97
51_A59_I1.6090.97
215_Y231_E1.5890.96
20_K27_T1.5870.96
31_E34_L1.5780.96
72_V95_H1.5720.96
35_A39_E1.5630.96
56_S377_M1.5540.96
296_A327_K1.5510.96
8_I21_V1.5330.96
6_G173_P1.5080.95
373_E399_R1.5040.95
42_R152_A1.5030.95
33_L48_L1.4940.95
326_K356_D1.4930.95
296_A331_A1.4900.95
67_E98_K1.4890.95
36_L160_A1.4890.95
214_V227_L1.4860.95
65_V116_I1.4830.95
95_H168_A1.4570.94
201_Y260_I1.4530.94
327_K330_K1.4310.94
162_V166_E1.4110.93
51_A381_I1.4050.93
201_Y232_V1.4000.93
134_L164_L1.3910.93
52_R55_E1.3910.93
141_V144_L1.3910.93
307_A333_I1.3860.93
2_R180_E1.3820.93
62_V116_I1.3800.92
94_T234_D1.3760.92
96_V100_A1.3690.92
367_N370_E1.3560.92
42_R151_K1.3530.92
200_V299_A1.3390.91
200_V328_L1.3390.91
294_M297_K1.3360.91
388_D396_G1.3280.91
32_E36_L1.3260.91
44_A142_E1.3200.91
326_K330_K1.3160.91
196_R274_V1.3150.91
36_L46_V1.3140.90
40_D156_A1.3100.90
102_V164_L1.3070.90
38_L46_V1.3040.90
30_K34_L1.3040.90
100_A132_N1.2990.90
185_L188_A1.2960.90
14_Q27_T1.2910.90
34_L46_V1.2790.89
19_T32_E1.2710.89
328_L331_A1.2600.89
11_K23_D1.2570.88
13_V132_N1.2520.88
277_I304_A1.2440.88
8_I95_H1.2440.88
34_L47_D1.2350.87
275_G304_A1.2350.87
62_V103_V1.2200.87
343_A367_N1.2200.87
6_G93_R1.2120.86
66_I161_A1.2110.86
263_L271_L1.1780.85
123_A129_S1.1690.84
329_E335_T1.1570.84
334_K360_D1.1500.83
233_L261_L1.1500.83
28_V37_V1.1360.83
262_E265_R1.1360.83
11_K25_V1.1320.82
71_K234_D1.1260.82
56_S119_S1.1230.82
197_V306_G1.1080.81
219_A222_I1.1070.81
203_L237_I1.1070.81
214_V278_L1.1070.81
397_S404_I1.1050.81
292_S327_K1.1020.81
91_E300_E1.0890.80
36_L39_E1.0860.80
7_N96_V1.0820.79
8_I171_L1.0750.79
48_L136_L1.0740.79
28_V50_I1.0670.79
341_E364_S1.0640.78
73_E76_G1.0610.78
10_I14_Q1.0600.78
90_G234_D1.0530.78
88_T297_K1.0510.77
288_K316_N1.0400.77
200_V307_A1.0360.76
83_L162_V1.0320.76
207_G211_D1.0270.76
69_R256_N1.0230.76
79_F161_A1.0160.75
165_A168_A1.0090.75
50_I100_A1.0080.74
408_L415_T1.0000.74
55_E136_L1.0000.74
36_L159_K0.9980.74
355_A359_A0.9960.74
388_D394_F0.9930.73
227_L294_M0.9930.73
168_A171_L0.9870.73
254_H257_N0.9810.72
199_Y310_T0.9790.72
44_A139_E0.9770.72
296_A328_L0.9760.72
17_D29_N0.9730.72
376_P403_S0.9620.71
244_S314_G0.9610.71
225_T294_M0.9540.70
180_E264_Y0.9500.70
10_I168_A0.9360.69
79_F83_L0.9250.68
47_D139_E0.9220.68
322_M355_A0.9210.68
266_R271_L0.9190.67
90_G94_T0.9180.67
22_E27_T0.9150.67
24_G174_D0.9130.67
309_I325_C0.9120.67
55_E379_R0.9110.67
43_I152_A0.9100.67
258_P418_L0.9080.66
34_L45_S0.9080.66
4_E176_V0.9070.66
179_Y264_Y0.9070.66
44_A141_V0.9040.66
14_Q52_R0.9030.66
57_V119_S0.9010.66
198_A302_L0.9000.66
288_K341_E0.9000.66
52_R57_V0.8980.66
72_V76_G0.8870.65
241_N312_E0.8850.64
73_E145_E0.8850.64
104_T157_G0.8840.64
237_I278_L0.8820.64
37_V159_K0.8810.64
68_P102_V0.8780.64
154_R240_G0.8770.64
17_D24_G0.8740.63
206_Q312_E0.8730.63
36_L142_E0.8670.63
201_Y254_H0.8660.63
18_K22_E0.8650.63
215_Y236_A0.8610.62
206_Q316_N0.8600.62
19_T163_Y0.8580.62
196_R272_N0.8580.62
260_I273_F0.8550.62
15_F32_E0.8520.61
32_E164_L0.8490.61
106_G109_V0.8490.61
344_G347_G0.8470.61
150_E316_N0.8440.61
183_P303_G0.8430.61
341_E347_G0.8420.61
39_E159_K0.8410.60
232_V276_V0.8400.60
299_A304_A0.8380.60
207_G210_H0.8330.60
187_R196_R0.8330.60
181_L264_Y0.8290.59
292_S324_N0.8280.59
37_V136_L0.8250.59
409_Q415_T0.8240.59
383_G386_A0.8200.58
17_D31_E0.8170.58
233_L257_N0.8160.58
206_Q313_G0.8140.58
101_A133_N0.8140.58
280_N283_V0.8110.58
95_H173_P0.8090.57
314_G368_A0.8080.57
93_R172_E0.8070.57
6_G72_V0.8050.57
325_C359_A0.8040.57
253_H416_N0.8020.57
164_L423_L0.7980.56
232_V237_I0.7980.56
11_K17_D0.7960.56
394_F406_V0.7950.56
267_H272_N0.7950.56
78_V165_A0.7930.56
161_A255_Q0.7930.56
18_K32_E0.7910.56
67_E256_N0.7900.56
417_E420_F0.7900.56
64_D71_K0.7890.56
78_V89_V0.7890.56
206_Q248_K0.7870.55
172_E176_V0.7850.55
226_L302_L0.7850.55
199_Y257_N0.7840.55
293_N327_K0.7820.55
194_L267_H0.7820.55
248_K312_E0.7820.55
9_P175_E0.7810.55
140_P149_Y0.7810.55
72_V173_P0.7790.55
325_C337_L0.7780.54
204_Q281_E0.7770.54
206_Q254_H0.7760.54
297_K301_M0.7720.54
28_V33_L0.7710.54
61_P383_G0.7670.53
136_L156_A0.7640.53
119_S375_P0.7560.52
316_N344_G0.7560.52
97_L168_A0.7560.52
21_V27_T0.7540.52
7_N177_E0.7530.52
11_K18_K0.7530.52
15_F48_L0.7520.52
356_D359_A0.7520.52
13_V28_V0.7510.52
100_A131_T0.7500.52
135_V381_I0.7490.52
399_R403_S0.7470.51
224_P294_M0.7470.51
262_E266_R0.7470.51
345_R394_F0.7470.51
48_L100_A0.7470.51
75_P91_E0.7450.51
182_P187_R0.7400.51
311_E416_N0.7390.51
50_I132_N0.7380.51
233_L264_Y0.7360.50
231_E236_A0.7350.50
317_P349_S0.7320.50
43_I140_P0.7300.50
71_K90_G0.7290.50
289_E306_G0.7290.50
122_G129_S0.7270.50
24_G27_T0.7260.49
21_V167_A0.7260.49
232_V278_L0.7260.49
38_L45_S0.7230.49
208_L211_D0.7210.49
46_V156_A0.7210.49
316_N325_C0.7170.49
384_L387_A0.7160.49
202_Q309_I0.7160.49
7_N175_E0.7140.48
14_Q28_V0.7140.48
343_A370_E0.7140.48
22_E269_K0.7120.48
199_Y259_V0.7100.48
413_G416_N0.7080.48
292_S323_M0.7070.48
214_V222_I0.7060.48
227_L232_V0.7050.47
63_K317_P0.7030.47
192_P272_N0.7020.47
191_Y196_R0.7020.47
105_T137_V0.7020.47
48_L160_A0.7010.47
21_V24_G0.7010.47
63_K150_E0.7010.47
60_I387_A0.7000.47
155_L159_K0.6980.47
51_A55_E0.6970.47
319_T355_A0.6960.47
51_A135_V0.6950.46
311_E337_L0.6920.46
116_I133_N0.6920.46
393_G410_A0.6910.46
95_H165_A0.6890.46
340_D368_A0.6880.46
344_G369_N0.6870.46
181_L187_R0.6870.46
5_L69_R0.6850.46
78_V162_V0.6840.45
15_F18_K0.6830.45
242_C312_E0.6810.45
390_I410_A0.6810.45
397_S405_E0.6790.45
25_V31_E0.6780.45
19_T165_A0.6780.45
262_E270_D0.6780.45
89_V94_T0.6760.45
6_G171_L0.6750.45
393_G396_G0.6730.44
322_M356_D0.6730.44
204_Q248_K0.6710.44
37_V163_Y0.6700.44
14_Q20_K0.6690.44
185_L189_A0.6680.44
180_E183_P0.6640.44
12_D55_E0.6630.43
204_Q311_E0.6620.43
13_V48_L0.6620.43
322_M325_C0.6590.43
60_I383_G0.6590.43
253_H421_S0.6560.43
60_I198_A0.6560.43
37_V40_D0.6560.43
408_L423_L0.6560.43
95_H171_L0.6550.43
299_A333_I0.6530.42
186_E189_A0.6530.42
347_G351_S0.6500.42
49_E135_V0.6480.42
155_L238_V0.6480.42
122_G372_I0.6480.42
289_E326_K0.6470.42
78_V255_Q0.6450.42
183_P190_E0.6400.41
57_V379_R0.6390.41
207_G254_H0.6380.41
247_D314_G0.6370.41
247_D340_D0.6360.41
304_A333_I0.6360.41
128_F250_T0.6360.41
342_Y364_S0.6350.41
30_K38_L0.6350.41
96_V99_G0.6340.41
254_H312_E0.6330.41
194_L268_G0.6330.41
112_Q209_L0.6330.41
257_N289_E0.6330.41
94_T231_E0.6330.41
318_D353_A0.6330.41
381_I411_I0.6310.40
179_Y265_R0.6310.40
365_T417_E0.6300.40
124_E130_K0.6300.40
369_N409_Q0.6300.40
207_G212_T0.6280.40
194_L273_F0.6280.40
396_G406_V0.6270.40
72_V93_R0.6260.40
38_L43_I0.6250.40
411_I414_A0.6250.40
388_D395_A0.6230.40
70_V169_R0.6230.40
204_Q280_N0.6210.39
400_E403_S0.6190.39
198_A275_G0.6180.39
122_G374_L0.6180.39
225_T290_R0.6170.39
170_D305_D0.6170.39
99_G132_N0.6160.39
101_A255_Q0.6150.39
19_T29_N0.6150.39
138_A160_A0.6150.39
282_N291_S0.6140.39
340_D349_S0.6120.39
217_V222_I0.6120.39
206_Q285_L0.6110.39
261_L265_R0.6110.39
10_I27_T0.6090.38
12_D132_N0.6090.38
215_Y234_D0.6090.38
6_G10_I0.6080.38
376_P380_V0.6070.38
251_T255_Q0.6060.38
191_Y272_N0.6050.38
384_L388_D0.6050.38
311_E318_D0.6050.38
138_A153_V0.6050.38
115_I374_L0.6050.38
238_V251_T0.6030.38
226_L274_V0.6020.38
182_P185_L0.6010.38
2_R134_L0.6000.38
313_G317_P0.6000.38
128_F253_H0.5990.37
296_A324_N0.5980.37
198_A299_A0.5980.37
248_K316_N0.5960.37
153_V156_A0.5960.37
63_K213_Y0.5960.37
342_Y368_A0.5940.37
204_Q282_N0.5940.37
413_G418_L0.5930.37
198_A277_I0.5920.37
158_L238_V0.5920.37
279_T291_S0.5920.37
52_R334_K0.5910.37
161_A251_T0.5910.37
122_G136_L0.5910.37
10_I24_G0.5890.37
233_L307_A0.5890.37
49_E57_V0.5880.36
148_E152_A0.5880.36
226_L301_M0.5880.36
197_V385_E0.5860.36
401_D407_E0.5840.36
202_Q317_P0.5800.36
84_G135_V0.5790.36
209_L244_S0.5790.36
47_D137_V0.5780.36
112_Q313_G0.5770.36
42_R295_A0.5750.35
345_R349_S0.5750.35
36_L163_Y0.5750.35
85_P289_E0.5750.35
149_Y153_V0.5730.35
409_Q418_L0.5730.35
105_T149_Y0.5730.35
200_V279_T0.5710.35
202_Q290_R0.5700.35
39_E46_V0.5690.35
281_E311_E0.5680.35
208_L212_T0.5680.35
209_L212_T0.5670.35
107_K110_G0.5670.35
323_M326_K0.5670.35
248_K313_G0.5660.35
205_S282_N0.5660.35
130_K269_K0.5650.34
317_P340_D0.5640.34
281_E318_D0.5640.34
145_E148_E0.5630.34
106_G111_F0.5630.34
359_A362_V0.5620.34
248_K367_N0.5620.34
116_I239_S0.5620.34
127_P133_N0.5610.34
350_Q368_A0.5600.34
175_E178_V0.5600.34
314_G409_Q0.5600.34
245_A368_A0.5590.34
206_Q344_G0.5590.34
388_D404_I0.5590.34
404_I412_T0.5580.34
237_I249_N0.5580.34
362_V417_E0.5580.34
6_G70_V0.5570.34
187_R364_S0.5560.34
190_E272_N0.5550.34
225_T298_L0.5550.34
394_F403_S0.5540.33
395_A421_S0.5540.33
78_V233_L0.5540.33
266_R308_I0.5510.33
368_A391_A0.5510.33
414_A417_E0.5500.33
199_Y325_C0.5500.33
282_N319_T0.5500.33
92_G234_D0.5500.33
289_E327_K0.5490.33
391_A409_Q0.5480.33
187_R190_E0.5480.33
377_M397_S0.5470.33
18_K29_N0.5470.33
416_N421_S0.5460.33
314_G342_Y0.5460.33
183_P187_R0.5450.33
237_I386_A0.5450.33
299_A309_I0.5450.33
51_A56_S0.5450.33
387_A391_A0.5440.33
62_V65_V0.5430.33
203_L257_N0.5420.32
257_N319_T0.5420.32
113_E213_Y0.5410.32
180_E184_L0.5400.32
233_L255_Q0.5390.32
21_V174_D0.5380.32
283_V318_D0.5380.32
250_T412_T0.5380.32
225_T297_K0.5370.32
5_L94_T0.5370.32
204_Q344_G0.5370.32
350_Q353_A0.5360.32
104_T110_G0.5360.32
119_S378_D0.5360.32
20_K23_D0.5360.32
202_Q318_D0.5350.32
29_N163_Y0.5350.32
34_L48_L0.5340.32
9_P21_V0.5330.32
28_V67_E0.5320.32
224_P315_G0.5310.32
150_E241_N0.5310.32
271_L338_I0.5310.32
7_N167_A0.5300.31
14_Q46_V0.5300.31
202_Q205_S0.5300.31
9_P170_D0.5300.31
176_V307_A0.5300.31
207_G354_D0.5300.31
393_G397_S0.5300.31
243_V312_E0.5290.31
239_S248_K0.5290.31
197_V307_A0.5290.31
45_S193_G0.5280.31
7_N179_Y0.5280.31
104_T107_K0.5270.31
6_G176_V0.5270.31
50_I181_L0.5260.31
12_D27_T0.5260.31
77_G162_V0.5250.31
54_G58_R0.5250.31
103_V131_T0.5250.31
390_I394_F0.5250.31
153_V168_A0.5250.31
92_G231_E0.5220.31
94_T225_T0.5220.31
153_V160_A0.5210.31
306_G357_P0.5200.31
253_H306_G0.5190.31
106_G392_G0.5180.30
2_R17_D0.5180.30
37_V46_V0.5180.30
243_V247_D0.5170.30
218_D221_G0.5170.30
82_V201_Y0.5170.30
387_A394_F0.5170.30
200_V309_I0.5160.30
68_P255_Q0.5160.30
388_D398_L0.5160.30
199_Y273_F0.5160.30
224_P264_Y0.5150.30
55_E58_R0.5150.30
357_P360_D0.5150.30
187_R274_V0.5130.30
109_V242_C0.5120.30
223_L294_M0.5120.30
299_A328_L0.5110.30
205_S219_A0.5110.30
409_Q412_T0.5110.30
37_V43_I0.5110.30
33_L134_L0.5100.30
37_V45_S0.5100.30
70_V95_H0.5100.30
196_R271_L0.5090.30
239_S243_V0.5090.30
98_K175_E0.5080.30
223_L277_I0.5080.30
340_D343_A0.5080.30
300_E333_I0.5070.30
85_P303_G0.5060.30
37_V48_L0.5060.30
243_V342_Y0.5050.29
386_A389_V0.5040.29
21_V50_I0.5040.29
91_E296_A0.5030.29
101_A252_Y0.5030.29
254_H318_D0.5030.29
129_S177_E0.5020.29
280_N317_P0.5020.29
189_A192_P0.5010.29
63_K242_C0.5010.29
187_R228_H0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ra9B 1 0.2864 55.6 0.975 Contact Map
2hy5A 2 0.2136 17.2 0.981 Contact Map
1tr8A 4 0.1714 15.6 0.981 Contact Map
3x2fA 4 0.3967 14.5 0.982 Contact Map
3ofhA 2 0.1221 14.5 0.982 Contact Map
2cfuA 2 0.1573 14.3 0.982 Contact Map
3u12A 2 0.1197 14 0.982 Contact Map
3offA 1 0.1221 13.3 0.982 Contact Map
2himA 4 0.6315 10.5 0.983 Contact Map
3f02C 1 0.0869 10.5 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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