GREMLIN Database
SNARE_assoc - SNARE associated Golgi protein
PFAM: PF09335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (118)
Sequences: 88631 (57428)
Seq/√Len: 5286.6
META: 0.802

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_L96_F3.7581.00
95_P98_R2.9171.00
68_G102_A2.8281.00
15_G18_L2.6701.00
68_G98_R2.6671.00
32_L100_L2.6211.00
24_T108_L2.2561.00
36_L96_F2.2361.00
66_H69_K1.9691.00
28_V104_A1.9581.00
20_L112_L1.9371.00
24_T104_A1.8811.00
60_E64_E1.7281.00
36_L40_Y1.7151.00
97_R101_L1.6161.00
20_L115_V1.6061.00
38_G90_G1.5781.00
109_P112_L1.5731.00
28_V100_L1.5511.00
96_F100_L1.5431.00
45_R48_R1.5321.00
62_F70_A1.4711.00
75_R107_A1.4661.00
18_L22_L1.4601.00
46_L49_R1.3921.00
52_K55_R1.3841.00
51_L54_E1.3831.00
32_L36_L1.3441.00
54_E58_R1.3111.00
39_R93_R1.3101.00
45_R49_R1.2931.00
53_P57_E1.2881.00
34_A87_L1.2851.00
16_L20_L1.2771.00
47_R53_P1.2661.00
17_W20_L1.2651.00
46_L51_L1.2611.00
18_L21_L1.2271.00
31_A103_T1.2021.00
15_G19_G1.1811.00
57_E60_E1.1751.00
44_R48_R1.1711.00
97_R100_L1.1601.00
57_E61_R1.1591.00
74_A85_I1.1571.00
35_Y99_F1.1501.00
43_R60_E1.1301.00
98_R101_L1.1141.00
23_A115_V1.0921.00
61_R64_E1.0871.00
31_A75_R1.0691.00
22_L26_G1.0581.00
116_L119_Y1.0541.00
55_R58_R1.0541.00
45_R50_L1.0531.00
10_A19_G1.0471.00
44_R47_R1.0381.00
21_L24_T1.0351.00
24_T28_V1.0321.00
17_W21_L1.0291.00
36_L39_R1.0081.00
72_F105_L1.0071.00
82_R107_A0.9931.00
24_T111_T0.9841.00
82_R110_W0.9841.00
20_L24_T0.9801.00
100_L104_A0.9801.00
101_L105_L0.9791.00
23_A111_T0.9661.00
9_A12_A0.9381.00
76_F109_P0.9341.00
111_T115_V0.9261.00
47_R50_L0.9251.00
10_A14_F0.9201.00
53_P56_L0.9191.00
83_T86_N0.9181.00
14_F119_Y0.9071.00
69_K73_L0.9031.00
74_A89_A0.9001.00
72_F102_A0.8981.00
9_A13_L0.8861.00
75_R103_T0.8851.00
105_L109_P0.8801.00
17_W116_L0.8791.00
37_I41_L0.8711.00
44_R49_R0.8621.00
71_V102_A0.8601.00
46_L50_L0.8571.00
98_R102_A0.8471.00
7_L23_A0.8411.00
113_L116_L0.8331.00
107_A110_W0.8321.00
47_R51_L0.8221.00
72_F106_G0.8181.00
102_A106_G0.8131.00
71_V89_A0.8081.00
112_L115_V0.8071.00
59_A62_F0.8031.00
35_Y96_F0.8031.00
105_L108_L0.8021.00
25_L28_V0.8001.00
38_G91_L0.7991.00
101_L104_A0.7901.00
104_A108_L0.7851.00
20_L108_L0.7831.00
5_V8_L0.7761.00
60_E93_R0.7741.00
50_L53_P0.7691.00
4_E7_L0.7611.00
85_I88_V0.7571.00
33_L36_L0.7521.00
112_L116_L0.7491.00
21_L25_L0.7381.00
3_G7_L0.7341.00
61_R65_R0.7311.00
85_I89_A0.7311.00
63_F89_A0.7291.00
54_E57_E0.7181.00
75_R82_R0.7161.00
50_L55_R0.7151.00
89_A94_M0.7151.00
10_A23_A0.7121.00
48_R51_L0.7111.00
70_A74_A0.7101.00
4_E8_L0.6951.00
38_G87_L0.6941.00
34_A86_N0.6901.00
67_G98_R0.6851.00
16_L116_L0.6841.00
68_G94_M0.6801.00
8_L12_A0.6791.00
108_L112_L0.6731.00
60_E92_T0.6731.00
107_A111_T0.6651.00
51_L55_R0.6651.00
68_G72_F0.6601.00
49_R52_K0.6581.00
20_L116_L0.6561.00
47_R52_K0.6521.00
52_K56_L0.6471.00
63_F67_G0.6451.00
99_F103_T0.6391.00
26_G30_G0.6391.00
103_T107_A0.6371.00
5_V9_A0.6341.00
75_R86_N0.6291.00
94_M98_R0.6291.00
19_G115_V0.6241.00
73_L77_V0.6241.00
58_R62_F0.6181.00
4_E82_R0.6121.00
14_F19_G0.6101.00
51_L56_L0.6051.00
30_G34_A0.6041.00
27_A107_A0.6041.00
62_F66_H0.6031.00
48_R53_P0.6001.00
37_I40_Y0.5881.00
11_G118_G0.5821.00
50_L54_E0.5771.00
31_A86_N0.5741.00
75_R106_G0.5711.00
76_F82_R0.5681.00
50_L56_L0.5641.00
27_A31_A0.5581.00
10_A13_L0.5511.00
47_R56_L0.5471.00
113_L117_L0.5441.00
72_F109_P0.5341.00
34_A83_T0.5321.00
27_A111_T0.5251.00
11_G19_G0.5231.00
88_V92_T0.5191.00
46_L53_P0.5181.00
58_R61_R0.5071.00
53_P58_R0.5071.00
4_E114_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.8667 28.7 0.849 Contact Map
3qnqA 2 0.475 26.5 0.852 Contact Map
2jlnA 1 0.6 18.9 0.862 Contact Map
3tdsE 3 0.4583 7.9 0.883 Contact Map
4ev6A 3 0.3667 5.6 0.891 Contact Map
4humA 1 0.4583 5.2 0.892 Contact Map
4i0uA 4 0.35 5.2 0.893 Contact Map
4x5mA 2 0.425 5.1 0.893 Contact Map
4fc4A 3 0.3667 5 0.893 Contact Map
4dveA 3 0.9083 4.9 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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