GREMLIN Database
ATG_C - Autophagy-related protein C terminal domain
PFAM: PF09333 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (85)
Sequences: 1184 (890)
Seq/√Len: 96.5
META: 0.476

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K39_E4.3301.00
33_I60_A3.1671.00
22_L71_A3.0011.00
68_A72_V2.7051.00
74_K77_E2.6181.00
32_G59_G2.5961.00
10_D82_T2.5961.00
71_A75_T2.5601.00
21_S74_K2.5411.00
41_A49_F2.3661.00
45_G48_G2.3021.00
66_I69_T1.9771.00
50_V54_G1.9091.00
18_G71_A1.8671.00
54_G58_P1.8271.00
13_E17_S1.8241.00
58_P62_V1.7061.00
36_K55_K1.6701.00
44_E51_K1.5711.00
17_S74_K1.4991.00
48_G52_G1.4751.00
11_V79_I1.4691.00
40_G48_G1.3990.99
12_R16_A1.2770.99
18_G78_G1.2330.99
52_G59_G1.2250.99
40_G52_G1.1850.98
17_S22_L1.1840.98
40_G44_E1.1840.98
69_T76_L1.1820.98
70_D73_S1.1750.98
29_G67_G1.1560.98
44_E55_K1.1190.97
77_E80_R1.0950.97
78_G81_N1.0250.96
26_L68_A1.0200.95
27_A31_T1.0140.95
22_L68_A1.0060.95
32_G56_G0.9770.94
30_V60_A0.9340.93
28_S63_K0.9190.92
54_G57_V0.9180.92
37_P41_A0.9060.92
65_V69_T0.9020.92
57_V60_A0.8810.91
41_A46_A0.8600.89
32_G36_K0.8550.89
52_G56_G0.8500.89
58_P61_V0.8380.88
34_V37_P0.8370.88
25_G70_D0.8190.87
85_P88_R0.8150.87
56_G59_G0.8100.86
19_Y71_A0.8010.86
72_V75_T0.8000.86
9_K13_E0.7920.85
72_V76_L0.7910.85
37_P51_K0.7900.85
14_G78_G0.7760.84
37_P67_G0.7730.84
25_G62_V0.7700.84
29_G56_G0.7680.83
25_G63_K0.7590.83
23_G27_A0.7440.81
29_G32_G0.7330.80
36_K40_G0.7240.80
31_T35_A0.7220.79
61_V68_A0.7180.79
11_V15_L0.7040.78
25_G29_G0.6980.77
63_K67_G0.6970.77
10_D16_A0.6910.76
22_L25_G0.6870.76
4_Y7_Q0.6810.75
48_G51_K0.6800.75
12_R18_G0.6690.74
64_P68_A0.6660.74
56_G67_G0.6510.72
19_Y23_G0.6490.72
37_P56_G0.6470.72
47_G66_I0.6400.71
5_A11_V0.6370.70
66_I74_K0.6310.70
80_R85_P0.6290.69
20_K23_G0.6290.69
34_V43_K0.6290.69
16_A60_A0.6220.69
75_T78_G0.6210.69
49_F53_V0.6200.68
29_G37_P0.6190.68
16_A22_L0.6150.68
15_L38_I0.6130.68
20_K57_V0.6120.67
73_S77_E0.6010.66
79_I82_T0.6000.66
38_I56_G0.6000.66
46_A49_F0.5920.65
45_G49_F0.5910.65
61_V64_P0.5870.64
17_S20_K0.5870.64
25_G71_A0.5820.64
63_K70_D0.5760.63
13_E33_I0.5690.62
19_Y22_L0.5590.60
84_D87_N0.5570.60
10_D13_E0.5550.60
68_A73_S0.5530.60
21_S76_L0.5490.59
58_P71_A0.5470.59
63_K78_G0.5440.58
11_V14_G0.5410.58
26_L83_L0.5360.57
49_F86_D0.5350.57
17_S77_E0.5350.57
4_Y22_L0.5350.57
32_G45_G0.5310.57
34_V39_E0.5300.56
26_L50_V0.5280.56
67_G70_D0.5230.55
22_L26_L0.5180.55
36_K66_I0.5170.55
45_G56_G0.5130.54
23_G85_P0.5130.54
12_R82_T0.5130.54
5_A62_V0.5060.53
21_S71_A0.5010.52
70_D83_L0.5000.52
46_A50_V0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3godA 4 0.9062 6.1 0.908 Contact Map
2z86A 2 0.3438 5 0.912 Contact Map
4p9tA 3 0.9688 2.4 0.924 Contact Map
1okcA 1 0.75 2.4 0.925 Contact Map
3rf3A 2 1 2.3 0.926 Contact Map
4o5fA 2 0.7396 2.2 0.926 Contact Map
1dowA 1 0.9688 2.1 0.927 Contact Map
4bbjA 1 0.8125 2 0.928 Contact Map
2de0X 2 0.7604 1.9 0.928 Contact Map
4iuhA 1 0.3438 1.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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