GREMLIN Database
DUF1985 - Domain of unknown function (DUF1985)
PFAM: PF09331 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (136)
Sequences: 743 (553)
Seq/√Len: 47.4
META: 0.122

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_S28_E3.7421.00
131_S135_L3.3451.00
29_F131_S3.0221.00
55_F58_K2.8261.00
54_F58_K2.7641.00
14_W21_P2.5761.00
24_F29_F2.4571.00
53_K58_K2.1681.00
54_F57_K2.1611.00
34_G127_W2.1431.00
9_K12_E2.1291.00
23_R28_E2.1041.00
46_Y52_N1.8940.99
114_K117_D1.8630.99
27_R31_L1.8320.99
53_K57_K1.8240.99
118_D121_A1.8220.99
85_D88_K1.8130.99
33_T125_Y1.7820.99
74_M78_K1.7430.98
81_W92_L1.6960.98
95_L99_L1.6960.98
60_F66_V1.6520.98
51_K99_L1.6280.98
29_F33_T1.6070.97
38_G94_I1.5980.97
66_V71_L1.5720.97
14_W23_R1.5680.97
125_Y130_V1.5540.97
131_S134_K1.5530.97
14_W25_S1.5060.96
5_L16_V1.4990.96
68_V93_Y1.4180.95
130_V134_K1.4080.94
51_K55_F1.3630.93
46_Y51_K1.3610.93
62_K88_K1.3380.93
11_H133_D1.3330.92
21_P86_R1.3110.92
69_K73_K1.2950.91
47_E50_K1.2880.91
50_K55_F1.2780.91
85_D91_L1.2750.91
14_W28_E1.2530.90
132_F136_I1.2440.90
2_C5_L1.2400.89
75_L90_A1.2270.89
56_W60_F1.1800.87
51_K56_W1.1800.87
22_I116_V1.1440.85
26_L72_I1.1280.84
88_K116_V1.1210.84
52_N55_F1.1200.84
46_Y49_K1.1160.84
11_H118_D1.1090.83
42_D125_Y1.1040.83
100_L131_S1.0970.83
13_L136_I1.0900.82
114_K119_L1.0890.82
5_L13_L1.0880.82
85_D101_G1.0870.82
101_G125_Y1.0840.82
51_K58_K1.0680.81
25_S86_R1.0570.80
81_W85_D1.0500.80
77_K90_A1.0450.79
118_D133_D1.0320.79
89_L95_L1.0300.78
21_P28_E1.0210.78
71_L109_P1.0000.76
67_T96_D0.9970.76
21_P26_L0.9850.75
120_E124_K0.9750.75
130_V135_L0.9730.74
43_D125_Y0.9710.74
109_P116_V0.9680.74
100_L112_Y0.9550.73
12_E69_K0.9530.73
15_F25_S0.9480.72
131_S137_K0.9190.70
5_L11_H0.9130.70
89_L97_G0.9130.70
15_F133_D0.9110.69
109_P117_D0.9100.69
92_L95_L0.9030.69
32_I106_S0.8930.68
60_F85_D0.8890.67
50_K54_F0.8870.67
100_L134_K0.8810.67
34_G89_L0.8750.66
115_M122_F0.8700.66
25_S131_S0.8610.65
20_Q32_I0.8560.65
3_R10_K0.8550.64
48_K77_K0.8550.64
26_L37_C0.8520.64
52_N56_W0.8490.64
34_G128_G0.8460.64
3_R9_K0.8420.63
94_I104_K0.8420.63
2_C15_F0.8320.62
122_F129_R0.8230.61
12_E26_L0.8200.61
66_V74_M0.8100.60
114_K118_D0.8060.60
129_R132_F0.8000.59
130_V133_D0.7930.59
24_F100_L0.7930.59
17_F120_E0.7920.58
30_A36_N0.7850.58
89_L116_V0.7800.57
18_G132_F0.7780.57
12_E23_R0.7730.57
49_K56_W0.7660.56
32_I69_K0.7630.56
78_K81_W0.7580.55
2_C20_Q0.7550.55
89_L101_G0.7530.55
62_K65_K0.7530.55
11_H15_F0.7340.53
95_L122_F0.7330.53
7_T12_E0.7280.52
67_T71_L0.7250.52
31_L83_D0.7190.51
53_K64_K0.7130.51
63_K73_K0.6990.49
71_L88_K0.6990.49
10_K118_D0.6970.49
29_F122_F0.6970.49
93_Y97_G0.6960.49
29_F100_L0.6960.49
60_F71_L0.6950.49
97_G106_S0.6940.49
35_L59_L0.6890.48
37_C122_F0.6880.48
128_G132_F0.6870.48
65_K71_L0.6870.48
8_K20_Q0.6860.48
101_G114_K0.6850.48
13_L16_V0.6840.48
90_A96_D0.6840.48
13_L71_L0.6750.47
2_C8_K0.6730.47
29_F96_D0.6640.46
37_C129_R0.6630.46
18_G29_F0.6620.46
48_K55_F0.6620.46
5_L36_N0.6580.45
133_D137_K0.6570.45
16_V21_P0.6550.45
121_A130_V0.6500.44
12_E76_K0.6430.44
40_Y129_R0.6400.43
68_V76_K0.6390.43
67_T87_L0.6370.43
71_L103_S0.6360.43
92_L125_Y0.6340.43
39_P101_G0.6280.42
65_K70_D0.6230.42
25_S135_L0.6230.42
32_I108_I0.6230.42
37_C86_R0.6220.42
20_Q29_F0.6220.42
28_E86_R0.6200.41
26_L30_A0.6170.41
50_K58_K0.6110.41
42_D136_I0.5990.39
39_P42_D0.5950.39
2_C17_F0.5900.39
15_F93_Y0.5870.38
8_K18_G0.5840.38
8_K19_G0.5810.38
65_K124_K0.5760.37
66_V117_D0.5720.37
22_I31_L0.5720.37
58_K85_D0.5650.36
94_I109_P0.5600.36
108_I118_D0.5590.36
121_A124_K0.5540.35
55_F60_F0.5520.35
78_K136_I0.5500.35
47_E77_K0.5480.35
32_I123_E0.5460.35
102_K113_V0.5460.35
88_K122_F0.5440.34
63_K70_D0.5420.34
26_L104_K0.5410.34
94_I136_I0.5400.34
15_F98_V0.5340.33
119_L132_F0.5270.33
89_L94_I0.5270.33
6_V38_G0.5260.33
36_N129_R0.5250.33
8_K82_S0.5240.33
122_F135_L0.5220.32
43_D47_E0.5160.32
30_A37_C0.5100.31
45_E50_K0.5090.31
22_I130_V0.5080.31
57_K79_K0.5070.31
9_K87_L0.5060.31
109_P112_Y0.5050.31
54_F59_L0.5050.31
85_D116_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dmlA 1 0.5435 5.8 0.94 Contact Map
4ok4A 2 0.2174 4.6 0.943 Contact Map
2j6bA 2 0.3406 4.2 0.944 Contact Map
2xf7A 3 0.2029 4 0.944 Contact Map
1wt6A 3 0.2174 2.8 0.948 Contact Map
4ja8A 2 0.3696 2.6 0.949 Contact Map
4tq1A 1 0.8623 2.4 0.95 Contact Map
3p0uA 2 0.2319 2.1 0.952 Contact Map
2jx3A 1 0.5 2.1 0.952 Contact Map
1zx5A 1 0.7681 2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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