GREMLIN Database
DUF1983 - Domain of unknown function (DUF1983)
PFAM: PF09327 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (81)
Sequences: 1751 (1194)
Seq/√Len: 132.7
META: 0.681

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_V8_V4.2711.00
52_L59_A3.4691.00
19_Y36_F2.4331.00
60_I74_V2.3661.00
8_V11_L2.2691.00
10_D14_K2.1291.00
53_V58_F2.0991.00
36_F53_V2.0841.00
20_T39_G1.9941.00
50_Q57_R1.9191.00
36_F51_F1.9051.00
53_V60_I1.8111.00
23_V40_S1.7391.00
3_Q19_Y1.6561.00
74_V79_V1.5701.00
8_V12_D1.5421.00
34_A49_S1.5091.00
22_K37_G1.4481.00
5_S8_V1.4201.00
15_L39_G1.3581.00
61_V70_P1.3301.00
71_P74_V1.2791.00
7_A10_D1.2691.00
1_V7_A1.2611.00
57_R75_Q1.2441.00
43_N46_G1.2411.00
17_A25_V1.2301.00
51_F58_F1.2251.00
23_V38_L1.2121.00
54_L61_V1.2031.00
59_A73_V1.1930.99
56_D62_N1.1850.99
62_N65_G1.1600.99
60_I72_F1.1550.99
11_L15_L1.1480.99
62_N77_G1.1000.99
3_Q21_V1.0850.99
26_N30_Q1.0650.99
15_L18_Q1.0270.98
18_Q39_G1.0050.98
24_Q27_G0.9680.98
51_F55_A0.9620.98
1_V5_S0.9600.98
24_Q54_L0.9580.98
21_V36_F0.9500.97
50_Q59_A0.9490.97
34_A40_S0.9470.97
4_V11_L0.9310.97
52_L61_V0.9310.97
75_Q78_Q0.9280.97
73_V80_F0.9160.97
18_Q43_N0.9110.97
48_T57_R0.9060.97
17_A23_V0.9030.96
9_A13_G0.8890.96
42_N47_P0.8880.96
54_L63_P0.8880.96
7_A11_L0.8840.96
32_Y40_S0.8730.96
9_A15_L0.8590.95
25_V31_Y0.8280.94
20_T37_G0.8250.94
38_L51_F0.8230.94
70_P73_V0.8090.94
11_L14_K0.8010.93
25_V40_S0.7850.92
76_G80_F0.7700.92
41_E47_P0.7700.92
33_V53_V0.7560.91
1_V4_V0.7500.91
24_Q33_V0.7290.89
26_N31_Y0.7260.89
40_S49_S0.7210.89
24_Q31_Y0.6990.87
18_Q37_G0.6930.87
9_A12_D0.6910.87
2_Q22_K0.6880.87
59_A70_P0.6820.86
12_D16_S0.6740.85
1_V11_L0.6700.85
8_V16_S0.6700.85
56_D63_P0.6690.85
1_V9_A0.6660.85
2_Q5_S0.6610.84
60_I79_V0.6560.84
57_R61_V0.6490.83
16_S25_V0.6460.83
38_L49_S0.6180.80
23_V31_Y0.6150.80
6_T10_D0.6110.79
68_V71_P0.6090.79
59_A71_P0.6050.79
5_S9_A0.6020.78
43_N47_P0.6010.78
42_N48_T0.5950.78
4_V16_S0.5930.77
51_F60_I0.5900.77
63_P66_G0.5900.77
42_N46_G0.5870.77
66_G70_P0.5870.77
34_A55_A0.5860.77
34_A38_L0.5760.75
4_V12_D0.5720.75
75_Q80_F0.5710.75
33_V36_F0.5640.74
60_I69_T0.5520.72
68_V73_V0.5510.72
62_N76_G0.5470.72
25_V32_Y0.5380.70
69_T79_V0.5340.70
54_L64_S0.5320.69
31_Y48_T0.5140.67
5_S10_D0.5120.67
19_Y23_V0.5080.66
68_V77_G0.5080.66
11_L16_S0.5050.65
7_A12_D0.5040.65
40_S51_F0.5030.65
12_D15_L0.5030.65
44_N47_P0.5020.65
30_Q50_Q0.5000.65
54_L62_N0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k49A 1 0.3457 8.7 0.873 Contact Map
4pdcE 1 0.642 3.7 0.894 Contact Map
2k8eA 1 0.3827 2.7 0.901 Contact Map
3bidA 2 0.321 2.2 0.905 Contact Map
3a1mA 5 0.8395 2.2 0.906 Contact Map
3if8A 1 0.8272 1.8 0.91 Contact Map
1zruA 3 0.2222 1.8 0.91 Contact Map
1xgsA 2 0.4321 1.6 0.912 Contact Map
3ogiA 1 0 1.4 0.915 Contact Map
4qs4A 3 0.7901 1.4 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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