GREMLIN Database
DUF1981 - Domain of unknown function (DUF1981)
PFAM: PF09324 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (83)
Sequences: 877 (613)
Seq/√Len: 67.3
META: 0.502

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_R69_D4.9701.00
39_R77_L2.7921.00
59_I63_L2.4471.00
25_M62_V2.2341.00
25_M66_A2.1691.00
21_F54_S2.0331.00
22_E61_S2.0211.00
52_I59_I1.9281.00
5_K18_L1.8031.00
38_L81_I1.8021.00
14_Q55_G1.7731.00
2_F17_F1.7551.00
41_L62_V1.6150.99
38_L45_I1.5990.99
38_L42_S1.5920.99
41_L59_I1.5450.99
20_P55_G1.5210.99
13_F20_P1.4660.98
8_L13_F1.4540.98
7_E54_S1.4200.98
1_K5_K1.3930.98
17_F54_S1.3550.97
7_E13_F1.3380.97
42_S46_Q1.3380.97
66_A69_D1.2900.97
1_K4_E1.2630.96
8_L11_F1.2400.96
7_E11_F1.2340.96
70_S76_R1.2290.96
73_S83_E1.2110.95
36_L40_C1.2070.95
23_V27_N1.2030.95
18_L33_I1.2020.95
1_K10_N1.1770.94
66_A78_A1.1300.93
27_N64_T1.1270.93
5_K50_E1.1080.92
48_R64_T1.0690.91
2_F66_A1.0400.90
4_E33_I1.0330.89
4_E48_R1.0160.89
77_L81_I0.9960.88
44_M47_A0.9890.87
5_K12_N0.9650.86
22_E62_V0.9500.85
16_D43_Q0.9460.85
26_A50_E0.9290.84
20_P40_C0.9290.84
12_N58_T0.9270.83
40_C43_Q0.9250.83
18_L65_A0.9160.83
2_F32_D0.9150.83
24_I59_I0.8990.82
3_L11_F0.8940.81
13_F40_C0.8910.81
19_K41_L0.8800.80
26_A32_D0.8720.80
3_L52_I0.8560.78
25_M28_S0.8510.78
74_I78_A0.8460.77
63_L81_I0.8440.77
1_K12_N0.8430.77
44_M49_G0.8390.77
68_K71_S0.8350.77
50_E65_A0.8300.76
62_V79_F0.8170.75
48_R57_K0.8150.75
3_L6_E0.8140.75
72_E76_R0.7630.70
41_L80_E0.7630.70
37_V52_I0.7610.70
74_I81_I0.7580.69
47_A68_K0.7480.68
79_F83_E0.7420.68
31_P65_A0.7380.67
69_D75_V0.7350.67
8_L44_M0.7350.67
19_K22_E0.7290.66
30_S60_F0.7280.66
19_K75_V0.7170.65
39_R51_N0.7110.64
15_K22_E0.7110.64
4_E10_N0.6890.62
77_L80_E0.6880.62
4_E9_S0.6710.60
57_K62_V0.6650.59
5_K24_I0.6610.59
27_N40_C0.6600.59
43_Q46_Q0.6590.59
39_R45_I0.6380.56
30_S63_L0.6380.56
22_E28_S0.6320.55
74_I79_F0.6240.54
13_F17_F0.6180.54
38_L78_A0.6150.53
6_E12_N0.6140.53
21_F55_G0.6090.53
18_L72_E0.6060.52
22_E26_A0.5970.51
45_I49_G0.5870.50
19_K36_L0.5840.50
42_S81_I0.5830.50
14_Q17_F0.5820.49
36_L57_K0.5680.48
68_K82_V0.5660.48
16_D74_I0.5660.48
10_N15_K0.5640.47
76_R81_I0.5610.47
21_F24_I0.5600.47
27_N61_S0.5530.46
10_N16_D0.5500.46
14_Q36_L0.5480.45
42_S70_S0.5440.45
71_S76_R0.5360.44
7_E10_N0.5350.44
9_S40_C0.5340.44
51_N55_G0.5260.43
15_K53_K0.5210.42
19_K25_M0.5180.42
4_E73_S0.5170.42
14_Q67_A0.5100.41
19_K44_M0.5070.41
35_E39_R0.5040.40
24_I34_R0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qmhA 1 0.9157 76 0.806 Contact Map
1u6gC 1 0.9759 68.5 0.816 Contact Map
2qk2A 1 0.9277 65.9 0.819 Contact Map
2z6gA 1 1 59.7 0.826 Contact Map
4fddA 1 0.988 56.8 0.829 Contact Map
1wa5B 1 0.9398 56.7 0.829 Contact Map
3w3wA 1 0.9518 55.9 0.831 Contact Map
4g3aA 1 0.988 55.3 0.831 Contact Map
2qk1A 1 1 55.1 0.831 Contact Map
4qmiA 1 0.8795 53.9 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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