GREMLIN Database
DUF1980 - Domain of unknown function (DUF1980)
PFAM: PF09323 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (179)
Sequences: 735 (603)
Seq/√Len: 45.1
META: 0.382

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_N31_M3.6001.00
82_L86_F3.0481.00
153_Q156_I2.6591.00
13_L82_L2.6491.00
33_P37_F2.6151.00
154_D180_K2.6001.00
58_C61_H2.5731.00
133_Y139_Y2.4171.00
158_V166_T2.2791.00
31_M34_L2.2281.00
159_T162_N2.2051.00
173_Y177_F2.1681.00
15_F39_A2.1511.00
93_L98_A2.1181.00
5_L12_L2.1011.00
42_L46_A2.0991.00
45_L49_Q2.0410.99
3_R23_I1.9490.99
175_D178_E1.9330.99
42_L95_S1.9210.99
74_S78_F1.9160.99
85_G93_L1.8960.99
23_I32_S1.8730.99
10_F42_L1.8300.99
26_Y89_P1.7900.98
59_C62_D1.7400.98
10_F77_L1.7360.98
126_L129_D1.7140.98
34_L51_F1.7120.98
6_I41_V1.7070.98
130_T134_F1.6660.98
75_Y78_F1.6590.97
114_S119_P1.6350.97
18_H39_A1.6320.97
16_Y20_T1.6210.97
168_E172_L1.6150.97
6_I79_L1.6000.97
4_A46_A1.5990.97
6_I75_Y1.5940.97
112_S115_S1.5440.96
47_I58_C1.5440.96
169_E177_F1.5430.96
169_E173_Y1.5250.96
164_L177_F1.5240.96
116_S119_P1.5030.95
28_N34_L1.4570.95
116_S123_T1.4560.95
170_I174_P1.4540.94
71_K76_L1.4480.94
142_E146_L1.4470.94
156_I179_G1.4270.94
13_L85_G1.4010.93
28_N35_S1.3920.93
51_F54_F1.3690.92
28_N32_S1.3610.92
139_Y143_M1.3560.92
84_L88_L1.3400.92
18_H35_S1.3360.92
25_K31_M1.3120.91
14_L39_A1.3050.91
10_F13_L1.2810.90
158_V165_E1.2320.88
62_D77_L1.2310.88
58_C62_D1.2300.88
3_R180_K1.2300.88
42_L174_P1.1920.86
60_G68_K1.1840.86
82_L116_S1.1830.86
7_L180_K1.1580.84
27_I32_S1.1570.84
159_T165_E1.1550.84
85_G88_L1.1400.83
37_F41_V1.1300.83
86_F98_A1.1220.82
23_I94_D1.1090.82
31_M158_V1.1080.82
98_A101_K1.0700.79
2_I24_L1.0660.79
75_Y88_L1.0640.79
124_Q131_S1.0640.79
88_L91_A1.0510.78
14_L84_L1.0440.78
88_L172_L1.0380.77
28_N171_Y1.0340.77
144_A147_A1.0280.76
61_H64_S1.0240.76
76_L85_G1.0150.76
28_N46_A1.0090.75
17_L20_T1.0090.75
62_D66_K1.0060.75
50_L53_A1.0030.75
111_S114_S0.9950.74
3_R89_P0.9910.74
109_A123_T0.9730.72
150_L180_K0.9680.72
15_F52_R0.9660.72
50_L174_P0.9650.72
158_V169_E0.9640.72
114_S117_S0.9600.71
133_Y143_M0.9540.71
17_L28_N0.9530.71
11_A46_A0.9510.71
7_L75_Y0.9510.71
11_A39_A0.9490.71
145_K149_K0.9400.70
143_M146_L0.9350.69
83_L129_D0.9320.69
28_N90_D0.9270.69
22_K73_L0.9210.68
117_S120_G0.9140.68
115_S123_T0.9110.67
31_M78_F0.9090.67
34_L37_F0.9050.67
80_I116_S0.9020.67
114_S123_T0.8990.66
49_Q97_I0.8940.66
17_L102_G0.8870.65
63_H177_F0.8860.65
23_I27_I0.8790.65
121_T127_K0.8710.64
160_D176_E0.8650.63
59_C65_P0.8550.62
112_S118_D0.8500.62
3_R88_L0.8490.62
12_L16_Y0.8480.62
82_L163_F0.8470.62
108_S121_T0.8400.61
125_Y131_S0.8400.61
15_F23_I0.8370.61
15_F19_L0.8350.61
27_I49_Q0.8290.60
18_H28_N0.8280.60
27_I35_S0.8260.60
15_F43_L0.8220.59
2_I108_S0.8040.58
16_Y89_P0.7990.57
31_M37_F0.7950.57
35_S84_L0.7930.57
138_A141_K0.7920.56
77_L85_G0.7900.56
117_S126_L0.7870.56
74_S80_I0.7850.56
67_S71_K0.7840.56
4_A22_K0.7840.56
132_I138_A0.7800.55
78_F95_S0.7770.55
115_S118_D0.7750.55
8_L175_D0.7730.55
85_G89_P0.7640.54
15_F54_F0.7610.53
66_K70_K0.7600.53
18_H29_P0.7570.53
21_G102_G0.7550.53
6_I180_K0.7530.53
11_A48_V0.7520.53
8_L24_L0.7520.53
134_F172_L0.7510.53
40_V44_L0.7500.52
96_S156_I0.7480.52
26_Y129_D0.7470.52
140_D173_Y0.7380.51
132_I170_I0.7370.51
31_M35_S0.7280.50
51_F55_K0.7270.50
42_L77_L0.7240.50
60_G64_S0.7220.50
89_P173_Y0.7130.49
125_Y128_P0.7130.49
118_D122_Q0.7130.49
56_K68_K0.7090.48
104_N162_N0.7080.48
41_V83_L0.7050.48
13_L63_H0.7030.48
26_Y33_P0.7000.48
75_Y81_P0.6980.47
88_L92_T0.6950.47
46_A167_M0.6950.47
76_L121_T0.6940.47
111_S117_S0.6930.47
17_L27_I0.6930.47
18_H163_F0.6890.46
114_S120_G0.6880.46
14_L158_V0.6870.46
40_V60_G0.6720.45
90_D158_V0.6680.44
63_H81_P0.6670.44
39_A88_L0.6670.44
35_S166_T0.6640.44
117_S136_K0.6610.44
69_L82_L0.6480.43
33_P104_N0.6430.42
82_L147_A0.6410.42
27_I166_T0.6390.42
11_A171_Y0.6390.42
110_E117_S0.6380.42
12_L19_L0.6370.41
120_G124_Q0.6370.41
4_A47_I0.6340.41
93_L101_K0.6330.41
48_V78_F0.6310.41
14_L42_L0.6290.41
7_L49_Q0.6190.40
57_K69_L0.6170.40
50_L56_K0.6090.39
106_P109_A0.6090.39
143_M147_A0.6090.39
20_T107_L0.6060.39
7_L88_L0.6030.38
20_T67_S0.6030.38
4_A39_A0.6020.38
57_K86_F0.5970.38
133_Y137_D0.5960.38
50_L78_F0.5950.38
30_R82_L0.5860.37
62_D121_T0.5860.37
18_H36_Y0.5850.37
28_N74_S0.5830.36
12_L78_F0.5820.36
164_L167_M0.5810.36
110_E113_S0.5780.36
133_Y136_K0.5760.36
33_P42_L0.5750.36
124_Q127_K0.5650.35
11_A59_C0.5630.35
37_F44_L0.5600.34
147_A176_E0.5590.34
2_I167_M0.5590.34
17_L101_K0.5550.34
3_R75_Y0.5550.34
110_E137_D0.5510.34
110_E119_P0.5500.34
55_K163_F0.5500.34
44_L55_K0.5490.33
119_P161_E0.5490.33
13_L36_Y0.5480.33
38_A174_P0.5480.33
4_A101_K0.5460.33
164_L168_E0.5460.33
174_P178_E0.5390.33
132_I135_P0.5380.33
113_S119_P0.5380.33
6_I23_I0.5370.32
9_G176_E0.5350.32
98_A150_L0.5330.32
134_F143_M0.5310.32
112_S116_S0.5290.32
131_S140_D0.5290.32
43_L72_L0.5270.32
10_F23_I0.5230.31
12_L100_A0.5230.31
150_L158_V0.5220.31
10_F34_L0.5190.31
117_S145_K0.5190.31
62_D69_L0.5170.31
16_Y78_F0.5150.31
71_K78_F0.5140.31
73_L122_Q0.5140.31
18_H37_F0.5140.31
84_L158_V0.5130.30
113_S153_Q0.5050.30
66_K86_F0.5030.30
38_A49_Q0.5030.30
31_M171_Y0.5020.30
28_N93_L0.5010.29
68_K72_L0.5010.29
157_T173_Y0.5010.29
112_S117_S0.5000.29
65_P71_K0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyA 2 0.5333 16.8 0.933 Contact Map
3ixzA 1 0.5667 11.8 0.938 Contact Map
2zxeA 1 0.5667 10 0.94 Contact Map
3ar4A 1 0.5333 8.7 0.941 Contact Map
2w3zA 1 0.3167 8.4 0.942 Contact Map
4xtrG 1 0.1222 8.4 0.942 Contact Map
4b4aA 1 0.5389 8.2 0.942 Contact Map
3wdoA 1 0.7889 7.8 0.943 Contact Map
2wn4A 1 0.2722 7.8 0.943 Contact Map
3rqwA 4 0.4556 7.5 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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