DUF1980 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF1980 - Domain of unknown function (DUF1980)

PFAM:	PF09323	Sequences: MIRALILLGFALLLFYLHLTGKILKYINPRMSPLSYFAAVVLLLLAIVQLFRAFKKKCCGHDHSPKSKLKKLLSYLLFLIPLLLGFLLPDATLDSSIAAAKGFNFPLSAESSSSSSSDPGTQTQYLKPDTSIYFPKDAYDKEMAKLAKKLLKQDTITVTDENFLETMEEIYLYPDEFEGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	180 (179)
Sequences:	735 (603)
Seq/√Len:	45.1
META:	0.382

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_N	31_M	3.600	1.00
82_L	86_F	3.048	1.00
153_Q	156_I	2.659	1.00
13_L	82_L	2.649	1.00
33_P	37_F	2.615	1.00
154_D	180_K	2.600	1.00
58_C	61_H	2.573	1.00
133_Y	139_Y	2.417	1.00
158_V	166_T	2.279	1.00
31_M	34_L	2.228	1.00
159_T	162_N	2.205	1.00
173_Y	177_F	2.168	1.00
15_F	39_A	2.151	1.00
93_L	98_A	2.118	1.00
5_L	12_L	2.101	1.00
42_L	46_A	2.099	1.00
45_L	49_Q	2.041	0.99
3_R	23_I	1.949	0.99
175_D	178_E	1.933	0.99
42_L	95_S	1.921	0.99
74_S	78_F	1.916	0.99
85_G	93_L	1.896	0.99
23_I	32_S	1.873	0.99
10_F	42_L	1.830	0.99
26_Y	89_P	1.790	0.98
59_C	62_D	1.740	0.98
10_F	77_L	1.736	0.98
126_L	129_D	1.714	0.98
34_L	51_F	1.712	0.98
6_I	41_V	1.707	0.98
130_T	134_F	1.666	0.98
75_Y	78_F	1.659	0.97
114_S	119_P	1.635	0.97
18_H	39_A	1.632	0.97
16_Y	20_T	1.621	0.97
168_E	172_L	1.615	0.97
6_I	79_L	1.600	0.97
4_A	46_A	1.599	0.97
6_I	75_Y	1.594	0.97
112_S	115_S	1.544	0.96
47_I	58_C	1.544	0.96
169_E	177_F	1.543	0.96
169_E	173_Y	1.525	0.96
164_L	177_F	1.524	0.96
116_S	119_P	1.503	0.95
28_N	34_L	1.457	0.95
116_S	123_T	1.456	0.95
170_I	174_P	1.454	0.94
71_K	76_L	1.448	0.94
142_E	146_L	1.447	0.94
156_I	179_G	1.427	0.94
13_L	85_G	1.401	0.93
28_N	35_S	1.392	0.93
51_F	54_F	1.369	0.92
28_N	32_S	1.361	0.92
139_Y	143_M	1.356	0.92
84_L	88_L	1.340	0.92
18_H	35_S	1.336	0.92
25_K	31_M	1.312	0.91
14_L	39_A	1.305	0.91
10_F	13_L	1.281	0.90
158_V	165_E	1.232	0.88
62_D	77_L	1.231	0.88
58_C	62_D	1.230	0.88
3_R	180_K	1.230	0.88
42_L	174_P	1.192	0.86
60_G	68_K	1.184	0.86
82_L	116_S	1.183	0.86
7_L	180_K	1.158	0.84
27_I	32_S	1.157	0.84
159_T	165_E	1.155	0.84
85_G	88_L	1.140	0.83
37_F	41_V	1.130	0.83
86_F	98_A	1.122	0.82
23_I	94_D	1.109	0.82
31_M	158_V	1.108	0.82
98_A	101_K	1.070	0.79
2_I	24_L	1.066	0.79
75_Y	88_L	1.064	0.79
124_Q	131_S	1.064	0.79
88_L	91_A	1.051	0.78
14_L	84_L	1.044	0.78
88_L	172_L	1.038	0.77
28_N	171_Y	1.034	0.77
144_A	147_A	1.028	0.76
61_H	64_S	1.024	0.76
76_L	85_G	1.015	0.76
28_N	46_A	1.009	0.75
17_L	20_T	1.009	0.75
62_D	66_K	1.006	0.75
50_L	53_A	1.003	0.75
111_S	114_S	0.995	0.74
3_R	89_P	0.991	0.74
109_A	123_T	0.973	0.72
150_L	180_K	0.968	0.72
15_F	52_R	0.966	0.72
50_L	174_P	0.965	0.72
158_V	169_E	0.964	0.72
114_S	117_S	0.960	0.71
133_Y	143_M	0.954	0.71
17_L	28_N	0.953	0.71
11_A	46_A	0.951	0.71
7_L	75_Y	0.951	0.71
11_A	39_A	0.949	0.71
145_K	149_K	0.940	0.70
143_M	146_L	0.935	0.69
83_L	129_D	0.932	0.69
28_N	90_D	0.927	0.69
22_K	73_L	0.921	0.68
117_S	120_G	0.914	0.68
115_S	123_T	0.911	0.67
31_M	78_F	0.909	0.67
34_L	37_F	0.905	0.67
80_I	116_S	0.902	0.67
114_S	123_T	0.899	0.66
49_Q	97_I	0.894	0.66
17_L	102_G	0.887	0.65
63_H	177_F	0.886	0.65
23_I	27_I	0.879	0.65
121_T	127_K	0.871	0.64
160_D	176_E	0.865	0.63
59_C	65_P	0.855	0.62
112_S	118_D	0.850	0.62
3_R	88_L	0.849	0.62
12_L	16_Y	0.848	0.62
82_L	163_F	0.847	0.62
108_S	121_T	0.840	0.61
125_Y	131_S	0.840	0.61
15_F	23_I	0.837	0.61
15_F	19_L	0.835	0.61
27_I	49_Q	0.829	0.60
18_H	28_N	0.828	0.60
27_I	35_S	0.826	0.60
15_F	43_L	0.822	0.59
2_I	108_S	0.804	0.58
16_Y	89_P	0.799	0.57
31_M	37_F	0.795	0.57
35_S	84_L	0.793	0.57
138_A	141_K	0.792	0.56
77_L	85_G	0.790	0.56
117_S	126_L	0.787	0.56
74_S	80_I	0.785	0.56
67_S	71_K	0.784	0.56
4_A	22_K	0.784	0.56
132_I	138_A	0.780	0.55
78_F	95_S	0.777	0.55
115_S	118_D	0.775	0.55
8_L	175_D	0.773	0.55
85_G	89_P	0.764	0.54
15_F	54_F	0.761	0.53
66_K	70_K	0.760	0.53
18_H	29_P	0.757	0.53
21_G	102_G	0.755	0.53
6_I	180_K	0.753	0.53
11_A	48_V	0.752	0.53
8_L	24_L	0.752	0.53
134_F	172_L	0.751	0.53
40_V	44_L	0.750	0.52
96_S	156_I	0.748	0.52
26_Y	129_D	0.747	0.52
140_D	173_Y	0.738	0.51
132_I	170_I	0.737	0.51
31_M	35_S	0.728	0.50
51_F	55_K	0.727	0.50
42_L	77_L	0.724	0.50
60_G	64_S	0.722	0.50
89_P	173_Y	0.713	0.49
125_Y	128_P	0.713	0.49
118_D	122_Q	0.713	0.49
56_K	68_K	0.709	0.48
104_N	162_N	0.708	0.48
41_V	83_L	0.705	0.48
13_L	63_H	0.703	0.48
26_Y	33_P	0.700	0.48
75_Y	81_P	0.698	0.47
88_L	92_T	0.695	0.47
46_A	167_M	0.695	0.47
76_L	121_T	0.694	0.47
111_S	117_S	0.693	0.47
17_L	27_I	0.693	0.47
18_H	163_F	0.689	0.46
114_S	120_G	0.688	0.46
14_L	158_V	0.687	0.46
40_V	60_G	0.672	0.45
90_D	158_V	0.668	0.44
63_H	81_P	0.667	0.44
39_A	88_L	0.667	0.44
35_S	166_T	0.664	0.44
117_S	136_K	0.661	0.44
69_L	82_L	0.648	0.43
33_P	104_N	0.643	0.42
82_L	147_A	0.641	0.42
27_I	166_T	0.639	0.42
11_A	171_Y	0.639	0.42
110_E	117_S	0.638	0.42
12_L	19_L	0.637	0.41
120_G	124_Q	0.637	0.41
4_A	47_I	0.634	0.41
93_L	101_K	0.633	0.41
48_V	78_F	0.631	0.41
14_L	42_L	0.629	0.41
7_L	49_Q	0.619	0.40
57_K	69_L	0.617	0.40
50_L	56_K	0.609	0.39
106_P	109_A	0.609	0.39
143_M	147_A	0.609	0.39
20_T	107_L	0.606	0.39
7_L	88_L	0.603	0.38
20_T	67_S	0.603	0.38
4_A	39_A	0.602	0.38
57_K	86_F	0.597	0.38
133_Y	137_D	0.596	0.38
50_L	78_F	0.595	0.38
30_R	82_L	0.586	0.37
62_D	121_T	0.586	0.37
18_H	36_Y	0.585	0.37
28_N	74_S	0.583	0.36
12_L	78_F	0.582	0.36
164_L	167_M	0.581	0.36
110_E	113_S	0.578	0.36
133_Y	136_K	0.576	0.36
33_P	42_L	0.575	0.36
124_Q	127_K	0.565	0.35
11_A	59_C	0.563	0.35
37_F	44_L	0.560	0.34
147_A	176_E	0.559	0.34
2_I	167_M	0.559	0.34
17_L	101_K	0.555	0.34
3_R	75_Y	0.555	0.34
110_E	137_D	0.551	0.34
110_E	119_P	0.550	0.34
55_K	163_F	0.550	0.34
44_L	55_K	0.549	0.33
119_P	161_E	0.549	0.33
13_L	36_Y	0.548	0.33
38_A	174_P	0.548	0.33
4_A	101_K	0.546	0.33
164_L	168_E	0.546	0.33
174_P	178_E	0.539	0.33
132_I	135_P	0.538	0.33
113_S	119_P	0.538	0.33
6_I	23_I	0.537	0.32
9_G	176_E	0.535	0.32
98_A	150_L	0.533	0.32
134_F	143_M	0.531	0.32
112_S	116_S	0.529	0.32
131_S	140_D	0.529	0.32
43_L	72_L	0.527	0.32
10_F	23_I	0.523	0.31
12_L	100_A	0.523	0.31
150_L	158_V	0.522	0.31
10_F	34_L	0.519	0.31
117_S	145_K	0.519	0.31
62_D	69_L	0.517	0.31
16_Y	78_F	0.515	0.31
71_K	78_F	0.514	0.31
73_L	122_Q	0.514	0.31
18_H	37_F	0.514	0.31
84_L	158_V	0.513	0.30
113_S	153_Q	0.505	0.30
66_K	86_F	0.503	0.30
38_A	49_Q	0.503	0.30
31_M	171_Y	0.502	0.30
28_N	93_L	0.501	0.29
68_K	72_L	0.501	0.29
157_T	173_Y	0.501	0.29
112_S	117_S	0.500	0.29
65_P	71_K	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qjyA	2	0.5333	16.8	0.933	Contact Map
3ixzA	1	0.5667	11.8	0.938	Contact Map
2zxeA	1	0.5667	10	0.94	Contact Map
3ar4A	1	0.5333	8.7	0.941	Contact Map
2w3zA	1	0.3167	8.4	0.942	Contact Map
4xtrG	1	0.1222	8.4	0.942	Contact Map
4b4aA	1	0.5389	8.2	0.942	Contact Map
3wdoA	1	0.7889	7.8	0.943	Contact Map
2wn4A	1	0.2722	7.8	0.943	Contact Map
3rqwA	4	0.4556	7.5	0.943	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.