GREMLIN Database
DUF1977 - Domain of unknown function (DUF1977)
PFAM: PF09320 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (100)
Sequences: 681 (534)
Seq/√Len: 53.4
META: 0.379

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_E29_P3.2861.00
9_Y52_V3.2011.00
75_I89_L2.9141.00
18_T34_P2.9131.00
96_P101_E2.8341.00
90_K94_A2.7661.00
21_R45_L2.6461.00
78_A92_A2.5131.00
74_L95_M2.3281.00
101_E104_E2.2381.00
32_V36_F2.1611.00
44_K47_R1.9801.00
28_V53_E1.9511.00
67_E98_P1.7990.99
92_A97_M1.7260.99
59_N63_E1.6460.98
71_K97_M1.5950.98
36_F40_Y1.5750.98
60_L102_R1.5040.97
88_K91_K1.4980.97
10_S29_P1.4840.97
87_E90_K1.4590.97
8_S11_F1.4430.96
78_A89_L1.4380.96
9_Y14_S1.4280.96
67_E97_M1.4270.96
81_W84_G1.4250.96
78_A97_M1.4130.96
30_Y49_E1.3500.95
33_N36_F1.3470.95
57_V103_L1.3450.95
70_Q74_L1.2600.93
6_D33_N1.2390.92
80_G85_D1.2200.91
71_K93_R1.2130.91
85_D88_K1.1870.90
67_E78_A1.1790.90
49_E65_E1.1770.90
73_R77_R1.1520.89
21_R66_R1.1230.88
90_K93_R1.0840.86
31_Y79_R1.0760.85
74_L91_K1.0740.85
10_S14_S1.0730.85
75_I93_R1.0720.85
97_M101_E1.0700.85
31_Y47_R1.0690.85
19_V27_K1.0350.83
66_R70_Q1.0100.81
23_T99_S0.9810.79
54_E61_R0.9760.79
92_A95_M0.9640.78
25_N50_R0.9630.78
79_R98_P0.9510.77
30_Y41_S0.9510.77
14_S18_T0.9370.76
42_G50_R0.9210.75
47_R51_S0.9190.75
13_P31_Y0.9110.74
74_L88_K0.8890.72
14_S17_Y0.8860.72
84_G89_L0.8810.72
82_F85_D0.8730.71
18_T67_E0.8690.70
6_D16_P0.8660.70
63_E67_E0.8630.70
38_S50_R0.8620.70
86_E90_K0.8570.69
9_Y55_D0.8370.68
100_C103_L0.8340.67
34_P42_G0.8280.67
60_L99_S0.8230.66
28_V56_Y0.8110.65
17_Y39_E0.8030.64
45_L49_E0.7930.63
27_K47_R0.7860.63
56_Y102_R0.7770.62
24_P49_E0.7670.61
50_R55_D0.7580.60
77_R102_R0.7550.60
22_T29_P0.7540.59
19_V34_P0.7400.58
15_P104_E0.7260.57
9_Y40_Y0.7130.55
89_L93_R0.7100.55
67_E92_A0.7080.55
13_P20_E0.7060.54
62_N104_E0.6990.54
12_T59_N0.6940.53
31_Y55_D0.6930.53
30_Y86_E0.6920.53
65_E73_R0.6900.53
11_F80_G0.6870.52
38_S60_L0.6710.51
9_Y17_Y0.6680.50
48_L52_V0.6680.50
34_P76_Y0.6670.50
37_V49_E0.6650.50
40_Y51_S0.6590.50
64_C100_C0.6590.50
19_V46_R0.6570.49
63_E99_S0.6560.49
72_E76_Y0.6520.49
36_F45_L0.6510.49
41_S93_R0.6430.48
48_L89_L0.6410.48
38_S70_Q0.6390.47
21_R30_Y0.6350.47
16_P52_V0.6170.45
24_P46_R0.6140.45
56_Y97_M0.6130.45
61_R92_A0.6110.44
55_D63_E0.6090.44
11_F54_E0.6080.44
40_Y48_L0.6040.44
37_V40_Y0.5940.43
87_E94_A0.5900.42
31_Y57_V0.5840.42
87_E99_S0.5830.42
5_S9_Y0.5820.41
81_W85_D0.5820.41
60_L103_L0.5760.41
41_S49_E0.5760.41
24_P62_N0.5660.40
36_F81_W0.5520.38
59_N66_R0.5510.38
87_E91_K0.5480.38
48_L82_F0.5480.38
58_S104_E0.5430.38
22_T26_L0.5360.37
75_I79_R0.5360.37
21_R68_K0.5290.36
67_E81_W0.5260.36
8_S17_Y0.5250.36
33_N65_E0.5240.36
25_N38_S0.5230.36
67_E95_M0.5210.35
30_Y34_P0.5200.35
61_R71_K0.5190.35
11_F33_N0.5180.35
56_Y60_L0.5170.35
79_R82_F0.5120.34
35_D87_E0.5120.34
22_T32_V0.5110.34
39_E55_D0.5110.34
86_E89_L0.5100.34
70_Q91_K0.5090.34
30_Y64_C0.5060.34
13_P36_F0.5050.34
57_V69_Q0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4recA 2 0.7238 2.2 0.933 Contact Map
3bbnE 1 0.0381 2.1 0.934 Contact Map
1a9xA 3 0.5714 2.1 0.934 Contact Map
2yvqA 2 0.4 2 0.935 Contact Map
4b9gA 1 0.5048 1.8 0.936 Contact Map
1mlwA 1 0.4762 1.7 0.937 Contact Map
4r8aA 1 0.7429 1.6 0.938 Contact Map
4n78D 1 0.4857 1.6 0.938 Contact Map
3plwA 1 0 1.5 0.939 Contact Map
3dinE 1 0.3714 1.3 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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