Mmp37 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Mmp37 - Mitochondrial matrix Mmp37

PFAM:	PF09139	Sequences: LRQILSQFPAPIRYAFAYGSGVFPQSGYSSSSKKKMIDFIFAVDDPQHWHSENLKQNPDHYSFLLRSLGSKAISRVQDKFGAGVYFNPYVPVNGRLIKYGVVSTDTLCRDLLDWDTLYLAGRLHKPVKILRDPDPRVRLANQVNLKSALRAALLLLPESFTEEELYETIAGLSYMGDFRMLFPGENPNKVSNIVKGQLPHFRELYAPLLENLPNVVFLDSSSSDSQGTLEQDMSPEARGNLLRRLPKTLRQKLYFQYQKKGKNRDEEEILRIASDPDLAEVVRQAIRKIVRWSSTTQSLKGILTAGLVKSVRYSSEKLKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	320 (316)
Sequences:	525 (356)
Seq/√Len:	20.0
META:	0.236

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
102_V	119_L	6.095	1.00
186_N	192_N	4.953	1.00
162_E	202_R	4.918	1.00
145_L	204_L	4.020	1.00
54_L	73_I	3.726	1.00
83_G	106_T	3.534	1.00
123_L	127_V	3.444	1.00
178_F	294_S	3.379	1.00
58_P	66_R	3.191	1.00
299_L	303_L	3.074	0.99
46_P	103_S	3.068	0.99
162_E	166_Y	2.953	0.99
123_L	141_N	2.872	0.99
8_F	41_F	2.725	0.98
170_A	201_F	2.719	0.98
155_L	168_T	2.629	0.98
178_F	184_G	2.553	0.98
157_P	160_F	2.508	0.97
28_Y	186_N	2.487	0.97
53_N	61_Y	2.434	0.97
12_I	41_F	2.311	0.96
28_Y	35_K	2.287	0.95
108_C	137_V	2.280	0.95
109_R	115_D	2.250	0.95
120_A	149_L	2.215	0.95
317_K	320_K	2.120	0.93
62_S	85_Y	2.117	0.93
77_Q	300_K	2.093	0.93
53_N	57_N	1.998	0.91
22_V	25_Q	1.990	0.91
156_L	160_F	1.970	0.90
298_S	302_I	1.964	0.90
50_H	61_Y	1.952	0.90
22_V	37_I	1.915	0.89
265_D	268_E	1.912	0.89
21_G	25_Q	1.862	0.87
298_S	304_T	1.848	0.87
297_Q	306_G	1.815	0.86
118_Y	297_Q	1.785	0.85
145_L	201_F	1.780	0.85
163_E	195_K	1.779	0.85
48_H	51_S	1.761	0.84
102_V	106_T	1.759	0.84
153_L	231_Q	1.746	0.84
78_D	106_T	1.740	0.83
162_E	201_F	1.737	0.83
62_S	87_N	1.710	0.82
300_K	305_A	1.694	0.82
232_D	235_P	1.693	0.82
117_L	204_L	1.666	0.81
46_P	49_W	1.659	0.80
300_K	306_G	1.655	0.80
84_V	119_L	1.646	0.80
88_P	91_P	1.636	0.79
313_Y	317_K	1.624	0.79
118_Y	306_G	1.610	0.78
111_L	114_W	1.608	0.78
73_I	307_L	1.594	0.78
45_D	48_H	1.584	0.77
108_C	172_L	1.581	0.77
124_H	164_E	1.576	0.77
81_G	298_S	1.561	0.76
82_A	102_V	1.544	0.75
78_D	299_L	1.544	0.75
172_L	286_I	1.539	0.75
262_K	265_D	1.532	0.75
266_E	269_I	1.531	0.75
41_F	49_W	1.528	0.74
149_L	208_L	1.519	0.74
141_N	145_L	1.510	0.74
52_E	56_Q	1.500	0.73
60_H	87_N	1.485	0.72
5_L	130_L	1.476	0.72
173_S	176_G	1.435	0.70
118_Y	300_K	1.430	0.69
36_M	69_G	1.396	0.67
249_L	289_I	1.392	0.67
140_A	152_A	1.386	0.67
54_L	66_R	1.379	0.66
71_K	120_A	1.376	0.66
103_S	106_T	1.363	0.66
60_H	99_Y	1.362	0.65
113_D	166_Y	1.350	0.65
20_S	25_Q	1.328	0.63
49_W	266_E	1.318	0.63
89_Y	309_K	1.317	0.63
178_F	295_T	1.306	0.62
253_L	286_I	1.304	0.62
262_K	266_E	1.304	0.62
50_H	60_H	1.299	0.62
50_H	53_N	1.291	0.61
100_G	173_S	1.265	0.60
65_L	85_Y	1.256	0.59
43_V	49_W	1.253	0.59
194_V	201_F	1.252	0.59
82_A	300_K	1.240	0.58
301_G	306_G	1.237	0.58
22_V	42_A	1.227	0.57
21_G	35_K	1.222	0.57
75_R	149_L	1.218	0.57
174_Y	177_D	1.217	0.57
306_G	310_S	1.214	0.56
14_Y	129_I	1.212	0.56
75_R	79_K	1.204	0.56
118_Y	180_M	1.195	0.55
54_L	198_L	1.184	0.54
105_D	136_R	1.176	0.54
40_I	63_F	1.172	0.54
86_F	95_R	1.168	0.53
42_A	107_L	1.165	0.53
168_T	283_R	1.163	0.53
300_K	304_T	1.162	0.53
85_Y	300_K	1.158	0.53
44_D	104_T	1.154	0.52
156_L	231_Q	1.149	0.52
4_I	86_F	1.147	0.52
24_P	196_G	1.146	0.52
263_N	266_E	1.146	0.52
167_E	191_S	1.145	0.52
184_G	197_Q	1.139	0.52
191_S	195_K	1.132	0.51
174_Y	179_R	1.119	0.50
49_W	254_Y	1.110	0.50
273_A	278_L	1.101	0.49
13_R	139_L	1.098	0.49
19_G	25_Q	1.088	0.48
157_P	231_Q	1.087	0.48
160_F	231_Q	1.081	0.48
146_K	211_N	1.077	0.48
127_V	204_L	1.077	0.48
61_Y	176_G	1.074	0.47
85_Y	306_G	1.059	0.46
17_A	289_I	1.055	0.46
5_L	9_P	1.055	0.46
305_A	310_S	1.046	0.46
297_Q	301_G	1.044	0.45
39_F	97_I	1.039	0.45
201_F	306_G	1.032	0.45
117_L	172_L	1.029	0.44
184_G	312_R	1.026	0.44
85_Y	305_A	1.024	0.44
311_V	315_S	1.020	0.44
102_V	210_E	1.018	0.44
170_A	190_V	1.012	0.43
265_D	269_I	1.012	0.43
134_D	139_L	1.004	0.43
122_R	189_K	0.997	0.42
313_Y	320_K	0.997	0.42
48_H	52_E	0.995	0.42
249_L	285_A	0.991	0.42
13_R	48_H	0.990	0.42
77_Q	85_Y	0.989	0.42
88_P	309_K	0.986	0.42
98_K	189_K	0.985	0.42
35_K	186_N	0.984	0.42
307_L	318_L	0.983	0.41
26_S	86_F	0.971	0.41
102_V	199_P	0.971	0.41
60_H	126_P	0.965	0.40
76_V	303_L	0.963	0.40
123_L	187_P	0.960	0.40
106_T	166_Y	0.958	0.40
87_N	126_P	0.951	0.39
65_L	68_L	0.949	0.39
118_Y	305_A	0.947	0.39
179_R	189_K	0.946	0.39
170_A	212_L	0.945	0.39
98_K	122_R	0.943	0.39
71_K	152_A	0.943	0.39
178_F	298_S	0.942	0.39
159_S	228_T	0.939	0.39
17_A	231_Q	0.928	0.38
18_Y	25_Q	0.927	0.38
292_W	296_T	0.923	0.38
160_F	180_M	0.922	0.38
125_K	189_K	0.919	0.38
57_N	92_V	0.916	0.37
298_S	306_G	0.910	0.37
122_R	179_R	0.904	0.37
62_S	285_A	0.901	0.36
304_T	307_L	0.899	0.36
40_I	287_R	0.899	0.36
78_D	103_S	0.895	0.36
95_R	124_H	0.895	0.36
98_K	179_R	0.892	0.36
297_Q	313_Y	0.891	0.36
94_G	101_V	0.891	0.36
287_R	290_V	0.887	0.36
74_S	282_V	0.883	0.35
197_Q	283_R	0.879	0.35
18_Y	38_D	0.878	0.35
115_D	120_A	0.877	0.35
122_R	125_K	0.876	0.35
98_K	125_K	0.864	0.34
119_L	248_T	0.861	0.34
19_G	38_D	0.860	0.34
166_Y	202_R	0.860	0.34
121_G	144_N	0.858	0.34
40_I	86_F	0.857	0.34
50_H	99_Y	0.857	0.34
149_L	209_L	0.855	0.34
50_H	114_W	0.853	0.34
4_I	8_F	0.851	0.33
100_G	176_G	0.841	0.33
100_G	313_Y	0.832	0.32
125_K	179_R	0.827	0.32
27_G	196_G	0.823	0.32
188_N	191_S	0.822	0.32
199_P	284_Q	0.822	0.32
108_C	190_V	0.820	0.32
86_F	100_G	0.818	0.32
46_P	127_V	0.815	0.31
109_R	188_N	0.815	0.31
63_F	66_R	0.814	0.31
237_A	242_L	0.813	0.31
298_S	305_A	0.813	0.31
112_L	234_S	0.811	0.31
110_D	120_A	0.810	0.31
165_L	193_I	0.807	0.31
169_I	194_V	0.807	0.31
164_E	167_E	0.805	0.31
270_L	299_L	0.800	0.31
168_T	316_E	0.797	0.30
38_D	43_V	0.794	0.30
85_Y	294_S	0.794	0.30
149_L	165_L	0.789	0.30
161_T	234_S	0.788	0.30
6_S	13_R	0.787	0.30
185_E	189_K	0.787	0.30
121_G	189_K	0.783	0.30
260_K	284_Q	0.776	0.29
9_P	104_T	0.775	0.29
264_R	267_E	0.772	0.29
132_D	138_R	0.771	0.29
312_R	316_E	0.769	0.29
81_G	103_S	0.767	0.29
3_Q	7_Q	0.766	0.29
21_G	178_F	0.765	0.29
184_G	314_S	0.765	0.29
174_Y	189_K	0.758	0.28
49_W	129_I	0.757	0.28
42_A	104_T	0.757	0.28
20_S	38_D	0.756	0.28
130_L	157_P	0.750	0.28
10_A	56_Q	0.750	0.28
53_N	176_G	0.748	0.28
85_Y	118_Y	0.748	0.28
159_S	315_S	0.748	0.28
150_R	241_L	0.748	0.28
76_V	161_T	0.747	0.28
307_L	310_S	0.747	0.28
82_A	298_S	0.746	0.28
149_L	282_V	0.746	0.28
122_R	185_E	0.746	0.28
242_L	250_R	0.743	0.28
173_S	313_Y	0.742	0.28
229_L	237_A	0.737	0.27
181_L	187_P	0.735	0.27
82_A	184_G	0.731	0.27
114_W	144_N	0.731	0.27
228_T	260_K	0.730	0.27
98_K	121_G	0.729	0.27
289_I	294_S	0.729	0.27
140_A	158_E	0.728	0.27
112_L	237_A	0.725	0.27
98_K	185_E	0.723	0.27
104_T	209_L	0.722	0.26
190_V	194_V	0.721	0.26
120_A	233_M	0.716	0.26
17_A	36_M	0.716	0.26
286_I	314_S	0.715	0.26
78_D	81_G	0.714	0.26
262_K	267_E	0.714	0.26
153_L	245_L	0.714	0.26
34_K	45_D	0.713	0.26
76_V	301_G	0.713	0.26
122_R	174_Y	0.713	0.26
108_C	123_L	0.709	0.26
56_Q	142_Q	0.709	0.26
9_P	44_D	0.709	0.26
207_P	285_A	0.709	0.26
305_A	309_K	0.707	0.26
180_M	186_N	0.705	0.26
88_P	305_A	0.704	0.26
159_S	230_E	0.703	0.26
209_L	215_V	0.702	0.25
159_S	314_S	0.702	0.25
98_K	174_Y	0.702	0.25
77_Q	82_A	0.700	0.25
13_R	134_D	0.700	0.25
172_L	290_V	0.699	0.25
150_R	244_R	0.699	0.25
121_G	179_R	0.694	0.25
249_L	286_I	0.692	0.25
81_G	116_T	0.692	0.25
179_R	185_E	0.688	0.25
300_K	310_S	0.688	0.25
171_G	188_N	0.687	0.25
77_Q	170_A	0.687	0.25
166_Y	198_L	0.685	0.25
11_P	42_A	0.685	0.25
7_Q	149_L	0.682	0.25
297_Q	305_A	0.680	0.24
57_N	172_L	0.679	0.24
48_H	70_S	0.671	0.24
177_D	189_K	0.669	0.24
8_F	21_G	0.668	0.24
109_R	202_R	0.666	0.24
117_L	290_V	0.666	0.24
164_E	290_V	0.666	0.24
157_P	180_M	0.666	0.24
4_I	39_F	0.666	0.24
121_G	125_K	0.665	0.24
33_K	55_K	0.659	0.23
114_W	121_G	0.658	0.23
125_K	185_E	0.656	0.23
289_I	309_K	0.656	0.23
5_L	232_D	0.655	0.23
311_V	319_K	0.653	0.23
86_F	312_R	0.649	0.23
94_G	171_G	0.647	0.23
202_R	282_V	0.647	0.23
42_A	49_W	0.646	0.23
86_F	153_L	0.646	0.23
310_S	314_S	0.644	0.23
6_S	45_D	0.641	0.23
181_L	184_G	0.640	0.23
124_H	167_E	0.637	0.22
69_G	76_V	0.637	0.22
125_K	174_Y	0.637	0.22
115_D	248_T	0.636	0.22
14_Y	42_A	0.636	0.22
46_P	120_A	0.634	0.22
99_Y	126_P	0.632	0.22
150_R	231_Q	0.632	0.22
21_G	77_Q	0.632	0.22
34_K	251_Q	0.631	0.22
3_Q	6_S	0.631	0.22
241_L	253_L	0.631	0.22
182_F	294_S	0.629	0.22
29_S	57_N	0.629	0.22
139_L	143_V	0.628	0.22
100_G	190_V	0.628	0.22
117_L	286_I	0.628	0.22
259_K	282_V	0.627	0.22
153_L	156_L	0.626	0.22
34_K	227_G	0.626	0.22
106_T	187_P	0.624	0.22
138_R	202_R	0.623	0.22
122_R	177_D	0.623	0.22
175_M	287_R	0.622	0.22
17_A	160_F	0.620	0.22
8_F	12_I	0.619	0.22
44_D	105_D	0.618	0.22
201_F	204_L	0.615	0.21
98_K	177_D	0.615	0.21
2_R	130_L	0.615	0.21
55_K	182_F	0.614	0.21
166_Y	201_F	0.614	0.21
130_L	296_T	0.613	0.21
2_R	5_L	0.613	0.21
99_Y	180_M	0.611	0.21
151_A	290_V	0.610	0.21
38_D	61_Y	0.603	0.21
65_L	76_V	0.603	0.21
13_R	70_S	0.602	0.21
87_N	99_Y	0.602	0.21
45_D	104_T	0.601	0.21
73_I	191_S	0.600	0.21
6_S	57_N	0.600	0.21
180_M	306_G	0.599	0.21
9_P	45_D	0.598	0.21
116_T	192_N	0.598	0.21
231_Q	241_L	0.598	0.21
86_F	132_D	0.594	0.21
158_E	164_E	0.593	0.20
117_L	289_I	0.591	0.20
83_G	141_N	0.591	0.20
80_F	307_L	0.587	0.20
194_V	306_G	0.586	0.20
82_A	103_S	0.586	0.20
46_P	191_S	0.585	0.20
142_Q	187_P	0.585	0.20
11_P	83_G	0.584	0.20
262_K	270_L	0.580	0.20
13_R	104_T	0.580	0.20
311_V	316_E	0.579	0.20
83_G	86_F	0.578	0.20
97_I	303_L	0.578	0.20
38_D	50_H	0.578	0.20
43_V	62_S	0.577	0.20
147_S	232_D	0.573	0.20
125_K	245_L	0.573	0.20
7_Q	315_S	0.573	0.20
46_P	155_L	0.571	0.20
173_S	177_D	0.570	0.20
62_S	65_L	0.570	0.20
65_L	72_A	0.569	0.19
297_Q	300_K	0.569	0.19
188_N	269_I	0.568	0.19
65_L	303_L	0.564	0.19
45_D	52_E	0.563	0.19
35_K	123_L	0.562	0.19
193_I	231_Q	0.562	0.19
71_K	172_L	0.561	0.19
102_V	251_Q	0.559	0.19
112_L	143_V	0.559	0.19
83_G	165_L	0.558	0.19
50_H	176_G	0.558	0.19
243_R	271_R	0.557	0.19
86_F	214_N	0.554	0.19
125_K	177_D	0.552	0.19
10_A	52_E	0.551	0.19
171_G	287_R	0.551	0.19
180_M	192_N	0.550	0.19
65_L	293_S	0.549	0.19
157_P	193_I	0.549	0.19
132_D	231_Q	0.547	0.19
173_S	189_K	0.546	0.19
82_A	296_T	0.545	0.19
114_W	148_A	0.544	0.18
188_N	311_V	0.543	0.18
197_Q	238_R	0.542	0.18
187_P	241_L	0.539	0.18
184_G	320_K	0.538	0.18
54_L	118_Y	0.538	0.18
47_Q	52_E	0.538	0.18
233_M	238_R	0.536	0.18
11_P	137_V	0.535	0.18
162_E	168_T	0.535	0.18
166_Y	310_S	0.535	0.18
105_D	143_V	0.535	0.18
83_G	257_Y	0.530	0.18
151_A	299_L	0.530	0.18
89_Y	141_N	0.530	0.18
99_Y	114_W	0.529	0.18
21_G	94_G	0.529	0.18
6_S	48_H	0.529	0.18
116_T	304_T	0.528	0.18
50_H	148_A	0.528	0.18
69_G	73_I	0.526	0.18
84_V	124_H	0.525	0.18
297_Q	310_S	0.525	0.18
223_S	227_G	0.523	0.18
36_M	118_Y	0.522	0.18
17_A	22_V	0.522	0.18
62_S	303_L	0.521	0.18
132_D	136_R	0.521	0.18
42_A	108_C	0.520	0.18
189_K	246_P	0.519	0.18
15_A	170_A	0.519	0.18
103_S	178_F	0.516	0.17
121_G	185_E	0.516	0.17
113_D	155_L	0.515	0.17
119_L	190_V	0.515	0.17
116_T	120_A	0.514	0.17
296_T	300_K	0.512	0.17
81_G	231_Q	0.511	0.17
3_Q	218_L	0.509	0.17
301_G	304_T	0.508	0.17
121_G	174_Y	0.508	0.17
21_G	160_F	0.507	0.17
45_D	168_T	0.506	0.17
182_F	188_N	0.506	0.17
69_G	77_Q	0.506	0.17
228_T	251_Q	0.505	0.17
4_I	201_F	0.503	0.17
122_R	173_S	0.502	0.17
86_F	301_G	0.502	0.17
73_I	79_K	0.501	0.17
12_I	254_Y	0.501	0.17
17_A	25_Q	0.501	0.17
124_H	258_Q	0.500	0.17
182_F	287_R	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1knyA	2	0.6	27.4	0.972	Contact Map
3jywF	1	0.3875	16.6	0.974	Contact Map
2zkrw	1	0.3812	12.8	0.976	Contact Map
4ebjA	2	0.6562	11.5	0.976	Contact Map
2pbeA	1	0.6562	11.4	0.976	Contact Map
4w20F	1	0.3812	10.2	0.977	Contact Map
2aqjA	2	0.1969	8.8	0.977	Contact Map
1no5A	4	0.275	8.8	0.977	Contact Map
2rffA	1	0.2531	8.2	0.978	Contact Map
1vigA	1	0.2031	7.1	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.