GREMLIN Database
Mmp37 - Mitochondrial matrix Mmp37
PFAM: PF09139 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 320 (316)
Sequences: 525 (356)
Seq/√Len: 20.0
META: 0.236

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_V119_L6.0951.00
186_N192_N4.9531.00
162_E202_R4.9181.00
145_L204_L4.0201.00
54_L73_I3.7261.00
83_G106_T3.5341.00
123_L127_V3.4441.00
178_F294_S3.3791.00
58_P66_R3.1911.00
299_L303_L3.0740.99
46_P103_S3.0680.99
162_E166_Y2.9530.99
123_L141_N2.8720.99
8_F41_F2.7250.98
170_A201_F2.7190.98
155_L168_T2.6290.98
178_F184_G2.5530.98
157_P160_F2.5080.97
28_Y186_N2.4870.97
53_N61_Y2.4340.97
12_I41_F2.3110.96
28_Y35_K2.2870.95
108_C137_V2.2800.95
109_R115_D2.2500.95
120_A149_L2.2150.95
317_K320_K2.1200.93
62_S85_Y2.1170.93
77_Q300_K2.0930.93
53_N57_N1.9980.91
22_V25_Q1.9900.91
156_L160_F1.9700.90
298_S302_I1.9640.90
50_H61_Y1.9520.90
22_V37_I1.9150.89
265_D268_E1.9120.89
21_G25_Q1.8620.87
298_S304_T1.8480.87
297_Q306_G1.8150.86
118_Y297_Q1.7850.85
145_L201_F1.7800.85
163_E195_K1.7790.85
48_H51_S1.7610.84
102_V106_T1.7590.84
153_L231_Q1.7460.84
78_D106_T1.7400.83
162_E201_F1.7370.83
62_S87_N1.7100.82
300_K305_A1.6940.82
232_D235_P1.6930.82
117_L204_L1.6660.81
46_P49_W1.6590.80
300_K306_G1.6550.80
84_V119_L1.6460.80
88_P91_P1.6360.79
313_Y317_K1.6240.79
118_Y306_G1.6100.78
111_L114_W1.6080.78
73_I307_L1.5940.78
45_D48_H1.5840.77
108_C172_L1.5810.77
124_H164_E1.5760.77
81_G298_S1.5610.76
82_A102_V1.5440.75
78_D299_L1.5440.75
172_L286_I1.5390.75
262_K265_D1.5320.75
266_E269_I1.5310.75
41_F49_W1.5280.74
149_L208_L1.5190.74
141_N145_L1.5100.74
52_E56_Q1.5000.73
60_H87_N1.4850.72
5_L130_L1.4760.72
173_S176_G1.4350.70
118_Y300_K1.4300.69
36_M69_G1.3960.67
249_L289_I1.3920.67
140_A152_A1.3860.67
54_L66_R1.3790.66
71_K120_A1.3760.66
103_S106_T1.3630.66
60_H99_Y1.3620.65
113_D166_Y1.3500.65
20_S25_Q1.3280.63
49_W266_E1.3180.63
89_Y309_K1.3170.63
178_F295_T1.3060.62
253_L286_I1.3040.62
262_K266_E1.3040.62
50_H60_H1.2990.62
50_H53_N1.2910.61
100_G173_S1.2650.60
65_L85_Y1.2560.59
43_V49_W1.2530.59
194_V201_F1.2520.59
82_A300_K1.2400.58
301_G306_G1.2370.58
22_V42_A1.2270.57
21_G35_K1.2220.57
75_R149_L1.2180.57
174_Y177_D1.2170.57
306_G310_S1.2140.56
14_Y129_I1.2120.56
75_R79_K1.2040.56
118_Y180_M1.1950.55
54_L198_L1.1840.54
105_D136_R1.1760.54
40_I63_F1.1720.54
86_F95_R1.1680.53
42_A107_L1.1650.53
168_T283_R1.1630.53
300_K304_T1.1620.53
85_Y300_K1.1580.53
44_D104_T1.1540.52
156_L231_Q1.1490.52
4_I86_F1.1470.52
24_P196_G1.1460.52
263_N266_E1.1460.52
167_E191_S1.1450.52
184_G197_Q1.1390.52
191_S195_K1.1320.51
174_Y179_R1.1190.50
49_W254_Y1.1100.50
273_A278_L1.1010.49
13_R139_L1.0980.49
19_G25_Q1.0880.48
157_P231_Q1.0870.48
160_F231_Q1.0810.48
146_K211_N1.0770.48
127_V204_L1.0770.48
61_Y176_G1.0740.47
85_Y306_G1.0590.46
17_A289_I1.0550.46
5_L9_P1.0550.46
305_A310_S1.0460.46
297_Q301_G1.0440.45
39_F97_I1.0390.45
201_F306_G1.0320.45
117_L172_L1.0290.44
184_G312_R1.0260.44
85_Y305_A1.0240.44
311_V315_S1.0200.44
102_V210_E1.0180.44
170_A190_V1.0120.43
265_D269_I1.0120.43
134_D139_L1.0040.43
122_R189_K0.9970.42
313_Y320_K0.9970.42
48_H52_E0.9950.42
249_L285_A0.9910.42
13_R48_H0.9900.42
77_Q85_Y0.9890.42
88_P309_K0.9860.42
98_K189_K0.9850.42
35_K186_N0.9840.42
307_L318_L0.9830.41
26_S86_F0.9710.41
102_V199_P0.9710.41
60_H126_P0.9650.40
76_V303_L0.9630.40
123_L187_P0.9600.40
106_T166_Y0.9580.40
87_N126_P0.9510.39
65_L68_L0.9490.39
118_Y305_A0.9470.39
179_R189_K0.9460.39
170_A212_L0.9450.39
98_K122_R0.9430.39
71_K152_A0.9430.39
178_F298_S0.9420.39
159_S228_T0.9390.39
17_A231_Q0.9280.38
18_Y25_Q0.9270.38
292_W296_T0.9230.38
160_F180_M0.9220.38
125_K189_K0.9190.38
57_N92_V0.9160.37
298_S306_G0.9100.37
122_R179_R0.9040.37
62_S285_A0.9010.36
304_T307_L0.8990.36
40_I287_R0.8990.36
78_D103_S0.8950.36
95_R124_H0.8950.36
98_K179_R0.8920.36
297_Q313_Y0.8910.36
94_G101_V0.8910.36
287_R290_V0.8870.36
74_S282_V0.8830.35
197_Q283_R0.8790.35
18_Y38_D0.8780.35
115_D120_A0.8770.35
122_R125_K0.8760.35
98_K125_K0.8640.34
119_L248_T0.8610.34
19_G38_D0.8600.34
166_Y202_R0.8600.34
121_G144_N0.8580.34
40_I86_F0.8570.34
50_H99_Y0.8570.34
149_L209_L0.8550.34
50_H114_W0.8530.34
4_I8_F0.8510.33
100_G176_G0.8410.33
100_G313_Y0.8320.32
125_K179_R0.8270.32
27_G196_G0.8230.32
188_N191_S0.8220.32
199_P284_Q0.8220.32
108_C190_V0.8200.32
86_F100_G0.8180.32
46_P127_V0.8150.31
109_R188_N0.8150.31
63_F66_R0.8140.31
237_A242_L0.8130.31
298_S305_A0.8130.31
112_L234_S0.8110.31
110_D120_A0.8100.31
165_L193_I0.8070.31
169_I194_V0.8070.31
164_E167_E0.8050.31
270_L299_L0.8000.31
168_T316_E0.7970.30
38_D43_V0.7940.30
85_Y294_S0.7940.30
149_L165_L0.7890.30
161_T234_S0.7880.30
6_S13_R0.7870.30
185_E189_K0.7870.30
121_G189_K0.7830.30
260_K284_Q0.7760.29
9_P104_T0.7750.29
264_R267_E0.7720.29
132_D138_R0.7710.29
312_R316_E0.7690.29
81_G103_S0.7670.29
3_Q7_Q0.7660.29
21_G178_F0.7650.29
184_G314_S0.7650.29
174_Y189_K0.7580.28
49_W129_I0.7570.28
42_A104_T0.7570.28
20_S38_D0.7560.28
130_L157_P0.7500.28
10_A56_Q0.7500.28
53_N176_G0.7480.28
85_Y118_Y0.7480.28
159_S315_S0.7480.28
150_R241_L0.7480.28
76_V161_T0.7470.28
307_L310_S0.7470.28
82_A298_S0.7460.28
149_L282_V0.7460.28
122_R185_E0.7460.28
242_L250_R0.7430.28
173_S313_Y0.7420.28
229_L237_A0.7370.27
181_L187_P0.7350.27
82_A184_G0.7310.27
114_W144_N0.7310.27
228_T260_K0.7300.27
98_K121_G0.7290.27
289_I294_S0.7290.27
140_A158_E0.7280.27
112_L237_A0.7250.27
98_K185_E0.7230.27
104_T209_L0.7220.26
190_V194_V0.7210.26
120_A233_M0.7160.26
17_A36_M0.7160.26
286_I314_S0.7150.26
78_D81_G0.7140.26
262_K267_E0.7140.26
153_L245_L0.7140.26
34_K45_D0.7130.26
76_V301_G0.7130.26
122_R174_Y0.7130.26
108_C123_L0.7090.26
56_Q142_Q0.7090.26
9_P44_D0.7090.26
207_P285_A0.7090.26
305_A309_K0.7070.26
180_M186_N0.7050.26
88_P305_A0.7040.26
159_S230_E0.7030.26
209_L215_V0.7020.25
159_S314_S0.7020.25
98_K174_Y0.7020.25
77_Q82_A0.7000.25
13_R134_D0.7000.25
172_L290_V0.6990.25
150_R244_R0.6990.25
121_G179_R0.6940.25
249_L286_I0.6920.25
81_G116_T0.6920.25
179_R185_E0.6880.25
300_K310_S0.6880.25
171_G188_N0.6870.25
77_Q170_A0.6870.25
166_Y198_L0.6850.25
11_P42_A0.6850.25
7_Q149_L0.6820.25
297_Q305_A0.6800.24
57_N172_L0.6790.24
48_H70_S0.6710.24
177_D189_K0.6690.24
8_F21_G0.6680.24
109_R202_R0.6660.24
117_L290_V0.6660.24
164_E290_V0.6660.24
157_P180_M0.6660.24
4_I39_F0.6660.24
121_G125_K0.6650.24
33_K55_K0.6590.23
114_W121_G0.6580.23
125_K185_E0.6560.23
289_I309_K0.6560.23
5_L232_D0.6550.23
311_V319_K0.6530.23
86_F312_R0.6490.23
94_G171_G0.6470.23
202_R282_V0.6470.23
42_A49_W0.6460.23
86_F153_L0.6460.23
310_S314_S0.6440.23
6_S45_D0.6410.23
181_L184_G0.6400.23
124_H167_E0.6370.22
69_G76_V0.6370.22
125_K174_Y0.6370.22
115_D248_T0.6360.22
14_Y42_A0.6360.22
46_P120_A0.6340.22
99_Y126_P0.6320.22
150_R231_Q0.6320.22
21_G77_Q0.6320.22
34_K251_Q0.6310.22
3_Q6_S0.6310.22
241_L253_L0.6310.22
182_F294_S0.6290.22
29_S57_N0.6290.22
139_L143_V0.6280.22
100_G190_V0.6280.22
117_L286_I0.6280.22
259_K282_V0.6270.22
153_L156_L0.6260.22
34_K227_G0.6260.22
106_T187_P0.6240.22
138_R202_R0.6230.22
122_R177_D0.6230.22
175_M287_R0.6220.22
17_A160_F0.6200.22
8_F12_I0.6190.22
44_D105_D0.6180.22
201_F204_L0.6150.21
98_K177_D0.6150.21
2_R130_L0.6150.21
55_K182_F0.6140.21
166_Y201_F0.6140.21
130_L296_T0.6130.21
2_R5_L0.6130.21
99_Y180_M0.6110.21
151_A290_V0.6100.21
38_D61_Y0.6030.21
65_L76_V0.6030.21
13_R70_S0.6020.21
87_N99_Y0.6020.21
45_D104_T0.6010.21
73_I191_S0.6000.21
6_S57_N0.6000.21
180_M306_G0.5990.21
9_P45_D0.5980.21
116_T192_N0.5980.21
231_Q241_L0.5980.21
86_F132_D0.5940.21
158_E164_E0.5930.20
117_L289_I0.5910.20
83_G141_N0.5910.20
80_F307_L0.5870.20
194_V306_G0.5860.20
82_A103_S0.5860.20
46_P191_S0.5850.20
142_Q187_P0.5850.20
11_P83_G0.5840.20
262_K270_L0.5800.20
13_R104_T0.5800.20
311_V316_E0.5790.20
83_G86_F0.5780.20
97_I303_L0.5780.20
38_D50_H0.5780.20
43_V62_S0.5770.20
147_S232_D0.5730.20
125_K245_L0.5730.20
7_Q315_S0.5730.20
46_P155_L0.5710.20
173_S177_D0.5700.20
62_S65_L0.5700.20
65_L72_A0.5690.19
297_Q300_K0.5690.19
188_N269_I0.5680.19
65_L303_L0.5640.19
45_D52_E0.5630.19
35_K123_L0.5620.19
193_I231_Q0.5620.19
71_K172_L0.5610.19
102_V251_Q0.5590.19
112_L143_V0.5590.19
83_G165_L0.5580.19
50_H176_G0.5580.19
243_R271_R0.5570.19
86_F214_N0.5540.19
125_K177_D0.5520.19
10_A52_E0.5510.19
171_G287_R0.5510.19
180_M192_N0.5500.19
65_L293_S0.5490.19
157_P193_I0.5490.19
132_D231_Q0.5470.19
173_S189_K0.5460.19
82_A296_T0.5450.19
114_W148_A0.5440.18
188_N311_V0.5430.18
197_Q238_R0.5420.18
187_P241_L0.5390.18
184_G320_K0.5380.18
54_L118_Y0.5380.18
47_Q52_E0.5380.18
233_M238_R0.5360.18
11_P137_V0.5350.18
162_E168_T0.5350.18
166_Y310_S0.5350.18
105_D143_V0.5350.18
83_G257_Y0.5300.18
151_A299_L0.5300.18
89_Y141_N0.5300.18
99_Y114_W0.5290.18
21_G94_G0.5290.18
6_S48_H0.5290.18
116_T304_T0.5280.18
50_H148_A0.5280.18
69_G73_I0.5260.18
84_V124_H0.5250.18
297_Q310_S0.5250.18
223_S227_G0.5230.18
36_M118_Y0.5220.18
17_A22_V0.5220.18
62_S303_L0.5210.18
132_D136_R0.5210.18
42_A108_C0.5200.18
189_K246_P0.5190.18
15_A170_A0.5190.18
103_S178_F0.5160.17
121_G185_E0.5160.17
113_D155_L0.5150.17
119_L190_V0.5150.17
116_T120_A0.5140.17
296_T300_K0.5120.17
81_G231_Q0.5110.17
3_Q218_L0.5090.17
301_G304_T0.5080.17
121_G174_Y0.5080.17
21_G160_F0.5070.17
45_D168_T0.5060.17
182_F188_N0.5060.17
69_G77_Q0.5060.17
228_T251_Q0.5050.17
4_I201_F0.5030.17
122_R173_S0.5020.17
86_F301_G0.5020.17
73_I79_K0.5010.17
12_I254_Y0.5010.17
17_A25_Q0.5010.17
124_H258_Q0.5000.17
182_F287_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1knyA 2 0.6 27.4 0.972 Contact Map
3jywF 1 0.3875 16.6 0.974 Contact Map
2zkrw 1 0.3812 12.8 0.976 Contact Map
4ebjA 2 0.6562 11.5 0.976 Contact Map
2pbeA 1 0.6562 11.4 0.976 Contact Map
4w20F 1 0.3812 10.2 0.977 Contact Map
2aqjA 2 0.1969 8.8 0.977 Contact Map
1no5A 4 0.275 8.8 0.977 Contact Map
2rffA 1 0.2531 8.2 0.978 Contact Map
1vigA 1 0.2031 7.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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