GREMLIN Database
TMA7 - Translation machinery associated TMA7
PFAM: PF09072 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (62)
Sequences: 560 (312)
Seq/√Len: 39.6
META: 0.436

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_F31_Q3.8361.00
29_Q32_K3.3841.00
29_Q33_E2.9801.00
36_K40_E2.3571.00
33_E37_A2.3291.00
39_K42_A2.1450.99
20_L28_K1.9540.99
31_Q35_Q1.7670.97
39_K43_A1.6650.96
28_K31_Q1.6400.96
51_L56_I1.5940.95
26_A29_Q1.5720.95
20_L25_L1.4930.93
38_L42_A1.4860.93
42_A46_A1.4100.91
56_I59_S1.4080.91
34_E38_L1.3800.90
25_L29_Q1.3480.89
38_L41_L1.3200.88
3_Q7_K1.3120.88
45_A49_G1.2870.87
32_K35_Q1.2800.86
20_L24_D1.2170.83
38_L45_A1.1830.81
36_K39_K1.1570.80
40_E44_K1.1330.79
51_L59_S1.1130.77
43_A46_A1.0820.75
41_L52_G1.0770.75
7_K12_A1.0740.75
35_Q39_K1.0700.74
23_D26_A1.0620.74
12_A15_K1.0450.73
33_E36_K0.9870.68
41_L44_K0.9750.67
32_K36_K0.9630.66
37_A40_E0.9520.65
40_E43_A0.9290.64
55_G59_S0.9200.63
41_L51_L0.9170.62
47_G53_G0.8600.58
3_Q36_K0.8520.57
35_Q38_L0.8270.55
55_G58_K0.8000.52
53_G58_K0.7940.52
50_P56_I0.7560.48
33_E40_E0.7450.47
51_L54_G0.7380.46
2_R47_G0.7280.46
4_G7_K0.7210.45
1_G31_Q0.7170.45
44_K49_G0.7110.44
7_K33_E0.6850.42
35_Q43_A0.6810.41
24_D58_K0.6710.40
13_P39_K0.6690.40
5_G8_K0.6650.40
16_E47_G0.6630.40
2_R15_K0.6580.39
2_R32_K0.6550.39
31_Q34_E0.6540.39
19_E23_D0.6220.36
5_G11_K0.6210.36
13_P36_K0.6160.36
56_I60_G0.6130.35
16_E23_D0.6100.35
17_K20_L0.6080.35
34_E37_A0.5980.34
7_K15_K0.5980.34
16_E25_L0.5830.33
17_K34_E0.5820.33
2_R7_K0.5760.32
57_K61_K0.5760.32
23_D27_F0.5740.32
35_Q40_E0.5640.31
22_E25_L0.5600.31
18_K40_E0.5560.31
1_G17_K0.5550.31
8_K11_K0.5530.31
32_K42_A0.5490.30
1_G7_K0.5480.30
28_K32_K0.5430.30
26_A46_A0.5390.30
30_K54_G0.5360.29
47_G51_L0.5310.29
18_K28_K0.5290.29
42_A50_P0.5270.29
46_A49_G0.5240.28
18_K44_K0.5160.28
12_A37_A0.5140.28
42_A58_K0.5140.28
17_K25_L0.5130.28
14_K22_E0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ou0A 4 0.3226 1.7 0.916 Contact Map
1f2vA 2 0.3387 1.7 0.917 Contact Map
3e7dA 2 0.3065 1.7 0.917 Contact Map
4au1A 2 0.3387 1.6 0.918 Contact Map
1jjrA 1 0 1.5 0.919 Contact Map
3avrB 1 0.2581 1.3 0.923 Contact Map
3p9dH 1 0 1 0.928 Contact Map
3izsv 1 0 0.9 0.929 Contact Map
4cj9A 1 0 0.9 0.93 Contact Map
3i44A 2 0.3387 0.9 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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