DUF1852 - PFAM28P - GREMLIN Contacts

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DUF1852 - Domain of unknown function (DUF1852)

PFAM:	PF08908	Sequences: MNKDFTFTIKSIRFDENYQPSDNTRITTNFANLARGESRQENLRNTLRMIDNRFNALAHWDNPKGDRYSVELEIISVEMDIDAEGNGDAFPLIEILKTNIVDHKTNERIEGIVGNNFSSYVRDYDFSVLLPEHNKNQPEFSIPDNFGDLHGKLFKHFVNSDAYKENFSKPPVICLSVSSSKTYHRTENQHPVLGVEYQQDESSLTDQYFKKMGLQVRYFMPPNSVAPLAFYFFGDLLNDYTNLELISTISTMETFQKIYRPEIYNANSAAGKCYQPSLKHQDYSLTQIVYDREERSQLAIEQGKFAEEHFIKPYQAILEQWSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	323 (323)
Sequences:	769 (272)
Seq/√Len:	15.1
META:	0.41

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
297_Q	301_E	6.043	1.00
199_Q	206_D	4.857	1.00
134_N	140_F	4.788	1.00
13_R	73_E	4.264	1.00
58_A	246_I	4.100	1.00
71_E	108_R	4.098	1.00
60_W	188_N	3.430	0.99
80_D	87_G	3.384	0.99
179_S	199_Q	3.377	0.99
179_S	206_D	3.334	0.99
199_Q	202_S	3.282	0.99
51_D	103_H	3.047	0.98
307_E	312_K	2.944	0.98
177_V	204_L	2.932	0.98
92_L	206_D	2.833	0.97
7_F	156_H	2.805	0.97
60_W	242_N	2.797	0.97
92_L	153_L	2.745	0.96
202_S	206_D	2.743	0.96
277_S	283_Y	2.740	0.96
202_S	207_Q	2.734	0.96
112_I	248_T	2.623	0.95
152_K	155_K	2.542	0.94
206_D	210_K	2.491	0.94
90_F	253_E	2.482	0.94
133_H	141_S	2.432	0.93
169_K	244_E	2.320	0.91
129_L	300_I	2.294	0.91
46_T	288_I	2.252	0.90
11_S	166_N	2.218	0.89
26_I	116_N	2.210	0.89
69_S	103_H	2.209	0.89
206_D	283_Y	2.192	0.88
148_D	152_K	2.178	0.88
158_V	233_F	2.131	0.87
17_N	40_Q	2.082	0.86
98_T	247_S	2.059	0.85
152_K	322_S	2.050	0.85
50_I	70_V	1.984	0.83
11_S	97_K	1.949	0.81
214_L	233_F	1.849	0.78
11_S	75_I	1.816	0.76
73_E	165_E	1.806	0.76
177_V	218_Y	1.781	0.75
187_E	272_K	1.749	0.74
46_T	90_F	1.695	0.71
293_E	297_Q	1.681	0.71
267_N	284_S	1.649	0.69
56_A	247_S	1.612	0.67
26_I	288_I	1.603	0.67
46_T	51_D	1.593	0.66
161_D	165_E	1.584	0.66
199_Q	233_F	1.564	0.65
179_S	210_K	1.552	0.64
40_Q	44_R	1.547	0.64
24_T	244_E	1.546	0.64
179_S	233_F	1.543	0.64
97_K	110_E	1.537	0.63
181_K	200_D	1.533	0.63
156_H	214_L	1.497	0.61
185_R	272_K	1.478	0.60
175_L	223_N	1.469	0.60
142_I	202_S	1.459	0.59
214_L	271_G	1.427	0.57
116_N	157_F	1.419	0.57
46_T	277_S	1.411	0.57
64_K	275_Q	1.404	0.56
98_T	113_V	1.391	0.55
180_S	233_F	1.370	0.54
41_E	107_E	1.369	0.54
92_L	199_Q	1.364	0.54
71_E	101_V	1.361	0.54
267_N	282_D	1.356	0.54
121_V	311_I	1.352	0.53
19_Q	26_I	1.343	0.53
188_N	242_N	1.343	0.53
98_T	175_L	1.342	0.53
12_I	22_D	1.335	0.52
180_S	199_Q	1.333	0.52
274_Y	277_S	1.325	0.52
76_S	228_L	1.321	0.52
92_L	180_S	1.315	0.51
129_L	145_N	1.306	0.51
105_T	238_N	1.300	0.50
181_K	199_Q	1.281	0.49
312_K	315_Q	1.273	0.49
314_Y	317_I	1.266	0.48
137_Q	140_F	1.261	0.48
206_D	231_Y	1.261	0.48
180_S	204_L	1.242	0.47
77_V	162_A	1.240	0.47
182_T	275_Q	1.238	0.47
142_I	204_L	1.231	0.46
134_N	138_P	1.224	0.46
84_E	152_K	1.220	0.46
153_L	206_D	1.219	0.46
9_I	162_A	1.213	0.45
158_V	214_L	1.209	0.45
206_D	233_F	1.207	0.45
101_V	108_R	1.201	0.45
88_D	101_V	1.199	0.45
73_E	139_E	1.187	0.44
152_K	181_K	1.183	0.44
121_V	310_F	1.179	0.44
23_N	26_I	1.169	0.43
26_I	198_Q	1.160	0.43
90_F	202_S	1.156	0.42
52_N	282_D	1.155	0.42
73_E	296_S	1.152	0.42
140_F	199_Q	1.149	0.42
13_R	40_Q	1.149	0.42
101_V	113_V	1.144	0.42
26_I	214_L	1.143	0.42
73_E	97_K	1.141	0.41
187_E	195_V	1.133	0.41
181_K	201_E	1.119	0.40
78_E	92_L	1.119	0.40
304_K	307_E	1.111	0.40
84_E	89_A	1.098	0.39
92_L	214_L	1.093	0.39
315_Q	319_E	1.085	0.38
175_L	301_E	1.083	0.38
134_N	137_Q	1.082	0.38
131_P	135_K	1.071	0.38
97_K	271_G	1.068	0.38
180_S	238_N	1.064	0.37
112_I	247_S	1.063	0.37
73_E	86_N	1.058	0.37
112_I	172_V	1.055	0.37
152_K	156_H	1.051	0.37
81_I	89_A	1.051	0.37
47_L	51_D	1.050	0.37
265_N	284_S	1.049	0.37
139_E	189_Q	1.041	0.36
51_D	104_K	1.040	0.36
189_Q	192_V	1.034	0.36
77_V	157_F	1.031	0.36
179_S	277_S	1.022	0.35
296_S	300_I	1.022	0.35
80_D	86_N	1.021	0.35
47_L	137_Q	1.019	0.35
297_Q	306_A	1.017	0.35
95_I	285_L	1.014	0.35
199_Q	210_K	1.003	0.34
72_L	157_F	1.002	0.34
51_D	155_K	1.002	0.34
175_L	322_S	0.996	0.34
106_N	109_I	0.992	0.34
9_I	37_E	0.989	0.33
97_K	166_N	0.988	0.33
156_H	301_E	0.988	0.33
142_I	206_D	0.987	0.33
46_T	59_H	0.981	0.33
38_S	300_I	0.980	0.33
146_F	228_L	0.979	0.33
223_N	269_A	0.978	0.33
2_N	26_I	0.977	0.33
315_Q	322_S	0.975	0.33
198_Q	222_P	0.975	0.33
40_Q	306_A	0.960	0.32
98_T	204_L	0.958	0.32
10_K	78_E	0.958	0.32
307_E	322_S	0.951	0.32
8_T	148_D	0.947	0.31
73_E	99_N	0.946	0.31
1_M	108_R	0.944	0.31
180_S	206_D	0.940	0.31
116_N	146_F	0.927	0.30
175_L	297_Q	0.926	0.30
24_T	169_K	0.924	0.30
24_T	97_K	0.923	0.30
280_H	319_E	0.922	0.30
202_S	218_Y	0.917	0.30
53_R	57_L	0.915	0.30
54_F	247_S	0.914	0.30
71_E	307_E	0.914	0.30
189_Q	222_P	0.905	0.29
6_T	107_E	0.897	0.29
110_E	168_S	0.893	0.29
223_N	237_L	0.889	0.29
48_R	214_L	0.886	0.28
40_Q	275_Q	0.884	0.28
301_E	322_S	0.884	0.28
92_L	181_K	0.881	0.28
99_N	277_S	0.874	0.28
31_A	34_A	0.874	0.28
204_L	233_F	0.872	0.28
9_I	277_S	0.870	0.28
241_T	275_Q	0.868	0.28
81_I	87_G	0.868	0.28
268_S	284_S	0.867	0.28
48_R	51_D	0.866	0.28
90_F	306_A	0.866	0.28
199_Q	207_Q	0.863	0.27
65_G	148_D	0.861	0.27
13_R	159_N	0.860	0.27
6_T	155_K	0.856	0.27
136_N	145_N	0.854	0.27
293_E	308_E	0.853	0.27
180_S	207_Q	0.853	0.27
215_Q	232_F	0.852	0.27
202_S	233_F	0.849	0.27
86_N	223_N	0.848	0.27
19_Q	152_K	0.847	0.27
187_E	198_Q	0.847	0.27
88_D	314_Y	0.846	0.27
128_V	131_P	0.844	0.27
164_K	168_S	0.842	0.27
206_D	277_S	0.841	0.26
207_Q	233_F	0.840	0.26
59_H	192_V	0.838	0.26
142_I	179_S	0.832	0.26
170_P	233_F	0.830	0.26
77_V	187_E	0.829	0.26
79_M	92_L	0.828	0.26
95_I	113_V	0.827	0.26
189_Q	274_Y	0.825	0.26
316_A	320_Q	0.824	0.26
46_T	253_E	0.823	0.26
267_N	277_S	0.817	0.25
69_S	247_S	0.814	0.25
90_F	251_T	0.812	0.25
134_N	141_S	0.812	0.25
92_L	283_Y	0.808	0.25
80_D	89_A	0.807	0.25
79_M	314_Y	0.803	0.25
152_K	301_E	0.803	0.25
30_F	34_A	0.801	0.25
144_D	308_E	0.798	0.25
246_I	250_S	0.793	0.24
104_K	280_H	0.792	0.24
179_S	238_N	0.790	0.24
106_N	166_N	0.789	0.24
17_N	268_S	0.788	0.24
12_I	24_T	0.785	0.24
225_V	250_S	0.785	0.24
195_V	228_L	0.784	0.24
157_F	220_M	0.783	0.24
23_N	201_E	0.781	0.24
12_I	41_E	0.778	0.24
75_I	275_Q	0.778	0.24
177_V	193_L	0.776	0.24
175_L	273_C	0.775	0.24
75_I	78_E	0.769	0.23
60_W	267_N	0.769	0.23
7_F	116_N	0.766	0.23
45_N	310_F	0.760	0.23
7_F	198_Q	0.757	0.23
131_P	145_N	0.757	0.23
132_E	141_S	0.757	0.23
200_D	214_L	0.755	0.23
44_R	71_E	0.755	0.23
181_K	216_V	0.750	0.23
210_K	306_A	0.749	0.23
179_S	215_Q	0.747	0.23
10_K	311_I	0.747	0.23
76_S	249_I	0.743	0.22
40_Q	164_K	0.742	0.22
46_T	301_E	0.741	0.22
19_Q	181_K	0.740	0.22
105_T	207_Q	0.740	0.22
75_I	304_K	0.736	0.22
138_P	247_S	0.736	0.22
222_P	268_S	0.734	0.22
99_N	287_Q	0.733	0.22
1_M	192_V	0.733	0.22
187_E	222_P	0.733	0.22
41_E	287_Q	0.731	0.22
3_K	168_S	0.730	0.22
80_D	85_G	0.730	0.22
182_T	273_C	0.730	0.22
46_T	187_E	0.729	0.22
139_E	316_A	0.723	0.22
184_H	273_C	0.723	0.22
200_D	206_D	0.723	0.22
19_Q	180_S	0.720	0.22
48_R	238_N	0.717	0.21
200_D	207_Q	0.716	0.21
304_K	323_A	0.714	0.21
90_F	148_D	0.712	0.21
284_S	287_Q	0.709	0.21
64_K	207_Q	0.708	0.21
182_T	215_Q	0.708	0.21
97_K	246_I	0.706	0.21
46_T	317_I	0.705	0.21
9_I	137_Q	0.704	0.21
271_G	280_H	0.703	0.21
274_Y	289_V	0.701	0.21
59_H	269_A	0.701	0.21
225_V	269_A	0.701	0.21
135_K	195_V	0.700	0.21
4_D	7_F	0.700	0.21
107_E	207_Q	0.700	0.21
56_A	269_A	0.699	0.21
51_D	69_S	0.699	0.21
93_I	120_Y	0.699	0.21
253_E	306_A	0.694	0.21
136_N	140_F	0.692	0.20
133_H	244_E	0.689	0.20
51_D	177_V	0.688	0.20
7_F	320_Q	0.687	0.20
280_H	322_S	0.685	0.20
95_I	112_I	0.684	0.20
81_I	145_N	0.684	0.20
179_S	283_Y	0.683	0.20
148_D	188_N	0.683	0.20
5_F	63_P	0.682	0.20
41_E	128_V	0.681	0.20
90_F	233_F	0.679	0.20
56_A	268_S	0.679	0.20
177_V	238_N	0.673	0.20
23_N	222_P	0.671	0.20
51_D	320_Q	0.670	0.20
76_S	232_F	0.670	0.20
4_D	314_Y	0.669	0.20
207_Q	210_K	0.667	0.20
192_V	207_Q	0.662	0.19
153_L	181_K	0.661	0.19
161_D	241_T	0.658	0.19
64_K	273_C	0.656	0.19
38_S	41_E	0.655	0.19
13_R	71_E	0.654	0.19
79_M	109_I	0.648	0.19
60_W	154_F	0.648	0.19
100_I	158_V	0.647	0.19
175_L	179_S	0.646	0.19
225_V	274_Y	0.644	0.19
210_K	233_F	0.643	0.19
103_H	214_L	0.638	0.19
168_S	285_L	0.636	0.18
180_S	198_Q	0.634	0.18
206_D	215_Q	0.632	0.18
1_M	4_D	0.632	0.18
216_V	237_L	0.631	0.18
88_D	148_D	0.630	0.18
93_I	244_E	0.630	0.18
19_Q	41_E	0.629	0.18
21_S	26_I	0.629	0.18
60_W	284_S	0.626	0.18
304_K	319_E	0.626	0.18
192_V	257_K	0.626	0.18
56_A	202_S	0.623	0.18
80_D	107_E	0.623	0.18
88_D	300_I	0.623	0.18
86_N	218_Y	0.620	0.18
268_S	281_Q	0.620	0.18
129_L	232_F	0.619	0.18
133_H	218_Y	0.619	0.18
201_E	308_E	0.618	0.18
77_V	159_N	0.617	0.18
228_L	247_S	0.617	0.18
200_D	254_T	0.613	0.18
12_I	48_R	0.613	0.18
162_A	181_K	0.612	0.18
141_S	246_I	0.610	0.18
268_S	301_E	0.610	0.18
152_K	180_S	0.608	0.18
142_I	218_Y	0.606	0.17
47_L	146_F	0.606	0.17
241_T	316_A	0.604	0.17
311_I	314_Y	0.604	0.17
156_H	297_Q	0.602	0.17
19_Q	65_G	0.602	0.17
116_N	248_T	0.600	0.17
257_K	274_Y	0.600	0.17
6_T	218_Y	0.599	0.17
144_D	159_N	0.597	0.17
21_S	185_R	0.597	0.17
25_R	28_T	0.596	0.17
292_R	295_R	0.595	0.17
100_I	243_L	0.593	0.17
3_K	87_G	0.592	0.17
5_F	47_L	0.592	0.17
46_T	254_T	0.592	0.17
2_N	5_F	0.592	0.17
90_F	131_P	0.592	0.17
51_D	70_V	0.591	0.17
269_A	316_A	0.591	0.17
73_E	246_I	0.591	0.17
41_E	52_N	0.591	0.17
308_E	312_K	0.590	0.17
210_K	280_H	0.589	0.17
8_T	117_F	0.589	0.17
95_I	132_E	0.588	0.17
45_N	268_S	0.586	0.17
4_D	202_S	0.586	0.17
45_N	274_Y	0.584	0.17
215_Q	247_S	0.584	0.17
29_N	35_R	0.582	0.17
23_N	301_E	0.582	0.17
192_V	242_N	0.581	0.17
98_T	244_E	0.581	0.17
6_T	59_H	0.579	0.17
73_E	100_I	0.578	0.17
137_Q	218_Y	0.578	0.17
200_D	215_Q	0.577	0.17
207_Q	215_Q	0.576	0.17
7_F	214_L	0.573	0.16
54_F	250_S	0.572	0.16
63_P	148_D	0.572	0.16
202_S	210_K	0.569	0.16
267_N	287_Q	0.566	0.16
202_S	283_Y	0.565	0.16
152_K	175_L	0.564	0.16
244_E	285_L	0.562	0.16
142_I	283_Y	0.561	0.16
19_Q	153_L	0.558	0.16
165_E	200_D	0.558	0.16
31_A	36_G	0.557	0.16
5_F	308_E	0.557	0.16
65_G	271_G	0.556	0.16
92_L	103_H	0.556	0.16
297_Q	314_Y	0.554	0.16
12_I	103_H	0.553	0.16
145_N	148_D	0.553	0.16
92_L	238_N	0.553	0.16
17_N	159_N	0.552	0.16
5_F	9_I	0.551	0.16
49_M	53_R	0.550	0.16
146_F	241_T	0.550	0.16
180_S	201_E	0.549	0.16
19_Q	92_L	0.547	0.16
2_N	301_E	0.546	0.16
101_V	175_L	0.545	0.16
73_E	182_T	0.544	0.16
48_R	95_I	0.543	0.16
80_D	275_Q	0.541	0.15
9_I	21_S	0.540	0.15
304_K	315_Q	0.540	0.15
170_P	241_T	0.539	0.15
214_L	309_H	0.539	0.15
61_D	173_I	0.536	0.15
62_N	284_S	0.535	0.15
92_L	268_S	0.534	0.15
17_N	107_E	0.534	0.15
52_N	287_Q	0.533	0.15
47_L	228_L	0.532	0.15
291_D	295_R	0.531	0.15
228_L	275_Q	0.531	0.15
22_D	38_S	0.531	0.15
56_A	223_N	0.528	0.15
106_N	247_S	0.527	0.15
112_I	253_E	0.527	0.15
161_D	222_P	0.527	0.15
129_L	273_C	0.526	0.15
188_N	237_L	0.525	0.15
177_V	199_Q	0.525	0.15
179_S	202_S	0.525	0.15
184_H	198_Q	0.524	0.15
17_N	85_G	0.524	0.15
9_I	128_V	0.521	0.15
80_D	88_D	0.521	0.15
89_A	223_N	0.521	0.15
105_T	195_V	0.520	0.15
20_P	27_T	0.519	0.15
12_I	73_E	0.518	0.15
62_N	188_N	0.518	0.15
145_N	184_H	0.518	0.15
132_E	164_K	0.517	0.15
204_L	238_N	0.516	0.15
199_Q	232_F	0.516	0.15
241_T	309_H	0.515	0.15
187_E	214_L	0.515	0.15
253_E	300_I	0.515	0.15
165_E	238_N	0.515	0.15
51_D	170_P	0.514	0.15
170_P	315_Q	0.511	0.15
214_L	238_N	0.511	0.15
110_E	223_N	0.510	0.15
110_E	307_E	0.509	0.15
92_L	179_S	0.509	0.15
64_K	200_D	0.509	0.15
222_P	225_V	0.508	0.15
115_N	143_P	0.508	0.15
103_H	187_E	0.504	0.14
48_R	101_V	0.504	0.14
281_Q	287_Q	0.503	0.14
180_S	200_D	0.503	0.14
104_K	131_P	0.502	0.14
233_F	283_Y	0.502	0.14
21_S	135_K	0.502	0.14
285_L	301_E	0.501	0.14
177_V	180_S	0.501	0.14
64_K	238_N	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ocxA	3	0.2198	6	0.987	Contact Map
3nz2A	4	0.226	5.1	0.987	Contact Map
2bc4B	1	0.1827	4.9	0.987	Contact Map
4gowA	1	0.0805	4.8	0.987	Contact Map
4ca9A	5	0.2012	3.8	0.988	Contact Map
1krrA	3	0.226	3.5	0.988	Contact Map
3j65o	1	0.195	3.4	0.988	Contact Map
3fttA	3	0.2012	3.2	0.988	Contact Map
1cq3A	2	0.4211	3.2	0.989	Contact Map
2p2oA	3	0.2198	3	0.989	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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