GREMLIN Database
DUF1852 - Domain of unknown function (DUF1852)
PFAM: PF08908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 323 (323)
Sequences: 769 (272)
Seq/√Len: 15.1
META: 0.41

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_Q301_E6.0431.00
199_Q206_D4.8571.00
134_N140_F4.7881.00
13_R73_E4.2641.00
58_A246_I4.1001.00
71_E108_R4.0981.00
60_W188_N3.4300.99
80_D87_G3.3840.99
179_S199_Q3.3770.99
179_S206_D3.3340.99
199_Q202_S3.2820.99
51_D103_H3.0470.98
307_E312_K2.9440.98
177_V204_L2.9320.98
92_L206_D2.8330.97
7_F156_H2.8050.97
60_W242_N2.7970.97
92_L153_L2.7450.96
202_S206_D2.7430.96
277_S283_Y2.7400.96
202_S207_Q2.7340.96
112_I248_T2.6230.95
152_K155_K2.5420.94
206_D210_K2.4910.94
90_F253_E2.4820.94
133_H141_S2.4320.93
169_K244_E2.3200.91
129_L300_I2.2940.91
46_T288_I2.2520.90
11_S166_N2.2180.89
26_I116_N2.2100.89
69_S103_H2.2090.89
206_D283_Y2.1920.88
148_D152_K2.1780.88
158_V233_F2.1310.87
17_N40_Q2.0820.86
98_T247_S2.0590.85
152_K322_S2.0500.85
50_I70_V1.9840.83
11_S97_K1.9490.81
214_L233_F1.8490.78
11_S75_I1.8160.76
73_E165_E1.8060.76
177_V218_Y1.7810.75
187_E272_K1.7490.74
46_T90_F1.6950.71
293_E297_Q1.6810.71
267_N284_S1.6490.69
56_A247_S1.6120.67
26_I288_I1.6030.67
46_T51_D1.5930.66
161_D165_E1.5840.66
199_Q233_F1.5640.65
179_S210_K1.5520.64
40_Q44_R1.5470.64
24_T244_E1.5460.64
179_S233_F1.5430.64
97_K110_E1.5370.63
181_K200_D1.5330.63
156_H214_L1.4970.61
185_R272_K1.4780.60
175_L223_N1.4690.60
142_I202_S1.4590.59
214_L271_G1.4270.57
116_N157_F1.4190.57
46_T277_S1.4110.57
64_K275_Q1.4040.56
98_T113_V1.3910.55
180_S233_F1.3700.54
41_E107_E1.3690.54
92_L199_Q1.3640.54
71_E101_V1.3610.54
267_N282_D1.3560.54
121_V311_I1.3520.53
19_Q26_I1.3430.53
188_N242_N1.3430.53
98_T175_L1.3420.53
12_I22_D1.3350.52
180_S199_Q1.3330.52
274_Y277_S1.3250.52
76_S228_L1.3210.52
92_L180_S1.3150.51
129_L145_N1.3060.51
105_T238_N1.3000.50
181_K199_Q1.2810.49
312_K315_Q1.2730.49
314_Y317_I1.2660.48
137_Q140_F1.2610.48
206_D231_Y1.2610.48
180_S204_L1.2420.47
77_V162_A1.2400.47
182_T275_Q1.2380.47
142_I204_L1.2310.46
134_N138_P1.2240.46
84_E152_K1.2200.46
153_L206_D1.2190.46
9_I162_A1.2130.45
158_V214_L1.2090.45
206_D233_F1.2070.45
101_V108_R1.2010.45
88_D101_V1.1990.45
73_E139_E1.1870.44
152_K181_K1.1830.44
121_V310_F1.1790.44
23_N26_I1.1690.43
26_I198_Q1.1600.43
90_F202_S1.1560.42
52_N282_D1.1550.42
73_E296_S1.1520.42
140_F199_Q1.1490.42
13_R40_Q1.1490.42
101_V113_V1.1440.42
26_I214_L1.1430.42
73_E97_K1.1410.41
187_E195_V1.1330.41
181_K201_E1.1190.40
78_E92_L1.1190.40
304_K307_E1.1110.40
84_E89_A1.0980.39
92_L214_L1.0930.39
315_Q319_E1.0850.38
175_L301_E1.0830.38
134_N137_Q1.0820.38
131_P135_K1.0710.38
97_K271_G1.0680.38
180_S238_N1.0640.37
112_I247_S1.0630.37
73_E86_N1.0580.37
112_I172_V1.0550.37
152_K156_H1.0510.37
81_I89_A1.0510.37
47_L51_D1.0500.37
265_N284_S1.0490.37
139_E189_Q1.0410.36
51_D104_K1.0400.36
189_Q192_V1.0340.36
77_V157_F1.0310.36
179_S277_S1.0220.35
296_S300_I1.0220.35
80_D86_N1.0210.35
47_L137_Q1.0190.35
297_Q306_A1.0170.35
95_I285_L1.0140.35
199_Q210_K1.0030.34
72_L157_F1.0020.34
51_D155_K1.0020.34
175_L322_S0.9960.34
106_N109_I0.9920.34
9_I37_E0.9890.33
97_K166_N0.9880.33
156_H301_E0.9880.33
142_I206_D0.9870.33
46_T59_H0.9810.33
38_S300_I0.9800.33
146_F228_L0.9790.33
223_N269_A0.9780.33
2_N26_I0.9770.33
315_Q322_S0.9750.33
198_Q222_P0.9750.33
40_Q306_A0.9600.32
98_T204_L0.9580.32
10_K78_E0.9580.32
307_E322_S0.9510.32
8_T148_D0.9470.31
73_E99_N0.9460.31
1_M108_R0.9440.31
180_S206_D0.9400.31
116_N146_F0.9270.30
175_L297_Q0.9260.30
24_T169_K0.9240.30
24_T97_K0.9230.30
280_H319_E0.9220.30
202_S218_Y0.9170.30
53_R57_L0.9150.30
54_F247_S0.9140.30
71_E307_E0.9140.30
189_Q222_P0.9050.29
6_T107_E0.8970.29
110_E168_S0.8930.29
223_N237_L0.8890.29
48_R214_L0.8860.28
40_Q275_Q0.8840.28
301_E322_S0.8840.28
92_L181_K0.8810.28
99_N277_S0.8740.28
31_A34_A0.8740.28
204_L233_F0.8720.28
9_I277_S0.8700.28
241_T275_Q0.8680.28
81_I87_G0.8680.28
268_S284_S0.8670.28
48_R51_D0.8660.28
90_F306_A0.8660.28
199_Q207_Q0.8630.27
65_G148_D0.8610.27
13_R159_N0.8600.27
6_T155_K0.8560.27
136_N145_N0.8540.27
293_E308_E0.8530.27
180_S207_Q0.8530.27
215_Q232_F0.8520.27
202_S233_F0.8490.27
86_N223_N0.8480.27
19_Q152_K0.8470.27
187_E198_Q0.8470.27
88_D314_Y0.8460.27
128_V131_P0.8440.27
164_K168_S0.8420.27
206_D277_S0.8410.26
207_Q233_F0.8400.26
59_H192_V0.8380.26
142_I179_S0.8320.26
170_P233_F0.8300.26
77_V187_E0.8290.26
79_M92_L0.8280.26
95_I113_V0.8270.26
189_Q274_Y0.8250.26
316_A320_Q0.8240.26
46_T253_E0.8230.26
267_N277_S0.8170.25
69_S247_S0.8140.25
90_F251_T0.8120.25
134_N141_S0.8120.25
92_L283_Y0.8080.25
80_D89_A0.8070.25
79_M314_Y0.8030.25
152_K301_E0.8030.25
30_F34_A0.8010.25
144_D308_E0.7980.25
246_I250_S0.7930.24
104_K280_H0.7920.24
179_S238_N0.7900.24
106_N166_N0.7890.24
17_N268_S0.7880.24
12_I24_T0.7850.24
225_V250_S0.7850.24
195_V228_L0.7840.24
157_F220_M0.7830.24
23_N201_E0.7810.24
12_I41_E0.7780.24
75_I275_Q0.7780.24
177_V193_L0.7760.24
175_L273_C0.7750.24
75_I78_E0.7690.23
60_W267_N0.7690.23
7_F116_N0.7660.23
45_N310_F0.7600.23
7_F198_Q0.7570.23
131_P145_N0.7570.23
132_E141_S0.7570.23
200_D214_L0.7550.23
44_R71_E0.7550.23
181_K216_V0.7500.23
210_K306_A0.7490.23
179_S215_Q0.7470.23
10_K311_I0.7470.23
76_S249_I0.7430.22
40_Q164_K0.7420.22
46_T301_E0.7410.22
19_Q181_K0.7400.22
105_T207_Q0.7400.22
75_I304_K0.7360.22
138_P247_S0.7360.22
222_P268_S0.7340.22
99_N287_Q0.7330.22
1_M192_V0.7330.22
187_E222_P0.7330.22
41_E287_Q0.7310.22
3_K168_S0.7300.22
80_D85_G0.7300.22
182_T273_C0.7300.22
46_T187_E0.7290.22
139_E316_A0.7230.22
184_H273_C0.7230.22
200_D206_D0.7230.22
19_Q180_S0.7200.22
48_R238_N0.7170.21
200_D207_Q0.7160.21
304_K323_A0.7140.21
90_F148_D0.7120.21
284_S287_Q0.7090.21
64_K207_Q0.7080.21
182_T215_Q0.7080.21
97_K246_I0.7060.21
46_T317_I0.7050.21
9_I137_Q0.7040.21
271_G280_H0.7030.21
274_Y289_V0.7010.21
59_H269_A0.7010.21
225_V269_A0.7010.21
135_K195_V0.7000.21
4_D7_F0.7000.21
107_E207_Q0.7000.21
56_A269_A0.6990.21
51_D69_S0.6990.21
93_I120_Y0.6990.21
253_E306_A0.6940.21
136_N140_F0.6920.20
133_H244_E0.6890.20
51_D177_V0.6880.20
7_F320_Q0.6870.20
280_H322_S0.6850.20
95_I112_I0.6840.20
81_I145_N0.6840.20
179_S283_Y0.6830.20
148_D188_N0.6830.20
5_F63_P0.6820.20
41_E128_V0.6810.20
90_F233_F0.6790.20
56_A268_S0.6790.20
177_V238_N0.6730.20
23_N222_P0.6710.20
51_D320_Q0.6700.20
76_S232_F0.6700.20
4_D314_Y0.6690.20
207_Q210_K0.6670.20
192_V207_Q0.6620.19
153_L181_K0.6610.19
161_D241_T0.6580.19
64_K273_C0.6560.19
38_S41_E0.6550.19
13_R71_E0.6540.19
79_M109_I0.6480.19
60_W154_F0.6480.19
100_I158_V0.6470.19
175_L179_S0.6460.19
225_V274_Y0.6440.19
210_K233_F0.6430.19
103_H214_L0.6380.19
168_S285_L0.6360.18
180_S198_Q0.6340.18
206_D215_Q0.6320.18
1_M4_D0.6320.18
216_V237_L0.6310.18
88_D148_D0.6300.18
93_I244_E0.6300.18
19_Q41_E0.6290.18
21_S26_I0.6290.18
60_W284_S0.6260.18
304_K319_E0.6260.18
192_V257_K0.6260.18
56_A202_S0.6230.18
80_D107_E0.6230.18
88_D300_I0.6230.18
86_N218_Y0.6200.18
268_S281_Q0.6200.18
129_L232_F0.6190.18
133_H218_Y0.6190.18
201_E308_E0.6180.18
77_V159_N0.6170.18
228_L247_S0.6170.18
200_D254_T0.6130.18
12_I48_R0.6130.18
162_A181_K0.6120.18
141_S246_I0.6100.18
268_S301_E0.6100.18
152_K180_S0.6080.18
142_I218_Y0.6060.17
47_L146_F0.6060.17
241_T316_A0.6040.17
311_I314_Y0.6040.17
156_H297_Q0.6020.17
19_Q65_G0.6020.17
116_N248_T0.6000.17
257_K274_Y0.6000.17
6_T218_Y0.5990.17
144_D159_N0.5970.17
21_S185_R0.5970.17
25_R28_T0.5960.17
292_R295_R0.5950.17
100_I243_L0.5930.17
3_K87_G0.5920.17
5_F47_L0.5920.17
46_T254_T0.5920.17
2_N5_F0.5920.17
90_F131_P0.5920.17
51_D70_V0.5910.17
269_A316_A0.5910.17
73_E246_I0.5910.17
41_E52_N0.5910.17
308_E312_K0.5900.17
210_K280_H0.5890.17
8_T117_F0.5890.17
95_I132_E0.5880.17
45_N268_S0.5860.17
4_D202_S0.5860.17
45_N274_Y0.5840.17
215_Q247_S0.5840.17
29_N35_R0.5820.17
23_N301_E0.5820.17
192_V242_N0.5810.17
98_T244_E0.5810.17
6_T59_H0.5790.17
73_E100_I0.5780.17
137_Q218_Y0.5780.17
200_D215_Q0.5770.17
207_Q215_Q0.5760.17
7_F214_L0.5730.16
54_F250_S0.5720.16
63_P148_D0.5720.16
202_S210_K0.5690.16
267_N287_Q0.5660.16
202_S283_Y0.5650.16
152_K175_L0.5640.16
244_E285_L0.5620.16
142_I283_Y0.5610.16
19_Q153_L0.5580.16
165_E200_D0.5580.16
31_A36_G0.5570.16
5_F308_E0.5570.16
65_G271_G0.5560.16
92_L103_H0.5560.16
297_Q314_Y0.5540.16
12_I103_H0.5530.16
145_N148_D0.5530.16
92_L238_N0.5530.16
17_N159_N0.5520.16
5_F9_I0.5510.16
49_M53_R0.5500.16
146_F241_T0.5500.16
180_S201_E0.5490.16
19_Q92_L0.5470.16
2_N301_E0.5460.16
101_V175_L0.5450.16
73_E182_T0.5440.16
48_R95_I0.5430.16
80_D275_Q0.5410.15
9_I21_S0.5400.15
304_K315_Q0.5400.15
170_P241_T0.5390.15
214_L309_H0.5390.15
61_D173_I0.5360.15
62_N284_S0.5350.15
92_L268_S0.5340.15
17_N107_E0.5340.15
52_N287_Q0.5330.15
47_L228_L0.5320.15
291_D295_R0.5310.15
228_L275_Q0.5310.15
22_D38_S0.5310.15
56_A223_N0.5280.15
106_N247_S0.5270.15
112_I253_E0.5270.15
161_D222_P0.5270.15
129_L273_C0.5260.15
188_N237_L0.5250.15
177_V199_Q0.5250.15
179_S202_S0.5250.15
184_H198_Q0.5240.15
17_N85_G0.5240.15
9_I128_V0.5210.15
80_D88_D0.5210.15
89_A223_N0.5210.15
105_T195_V0.5200.15
20_P27_T0.5190.15
12_I73_E0.5180.15
62_N188_N0.5180.15
145_N184_H0.5180.15
132_E164_K0.5170.15
204_L238_N0.5160.15
199_Q232_F0.5160.15
241_T309_H0.5150.15
187_E214_L0.5150.15
253_E300_I0.5150.15
165_E238_N0.5150.15
51_D170_P0.5140.15
170_P315_Q0.5110.15
214_L238_N0.5110.15
110_E223_N0.5100.15
110_E307_E0.5090.15
92_L179_S0.5090.15
64_K200_D0.5090.15
222_P225_V0.5080.15
115_N143_P0.5080.15
103_H187_E0.5040.14
48_R101_V0.5040.14
281_Q287_Q0.5030.14
180_S200_D0.5030.14
104_K131_P0.5020.14
233_F283_Y0.5020.14
21_S135_K0.5020.14
285_L301_E0.5010.14
177_V180_S0.5010.14
64_K238_N0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ocxA 3 0.2198 6 0.987 Contact Map
3nz2A 4 0.226 5.1 0.987 Contact Map
2bc4B 1 0.1827 4.9 0.987 Contact Map
4gowA 1 0.0805 4.8 0.987 Contact Map
4ca9A 5 0.2012 3.8 0.988 Contact Map
1krrA 3 0.226 3.5 0.988 Contact Map
3j65o 1 0.195 3.4 0.988 Contact Map
3fttA 3 0.2012 3.2 0.988 Contact Map
1cq3A 2 0.4211 3.2 0.989 Contact Map
2p2oA 3 0.2198 3 0.989 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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