GREMLIN Database
DUF1851 - Domain of unknown function (DUF1851)
PFAM: PF08906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (71)
Sequences: 3450 (2759)
Seq/√Len: 327.5
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_K60_E3.5991.00
40_E61_K3.1891.00
63_D66_E2.8451.00
43_G62_V2.4381.00
37_G40_E2.3471.00
43_G67_H2.3181.00
29_A59_L2.0231.00
40_E63_D1.8351.00
47_P71_L1.7531.00
6_E10_L1.7131.00
54_Y58_N1.6641.00
39_G63_D1.5241.00
44_F48_P1.4941.00
48_P54_Y1.4161.00
65_R69_S1.4071.00
34_G61_K1.3781.00
33_G42_Y1.3391.00
17_L21_L1.3371.00
17_L23_P1.3341.00
36_L42_Y1.3231.00
25_L44_F1.3071.00
29_A34_G1.2951.00
30_R35_P1.2541.00
32_K56_V1.2271.00
44_F59_L1.2081.00
18_D24_P1.2021.00
55_E58_N1.1861.00
67_H71_L1.1731.00
29_A42_Y1.1661.00
16_F20_W1.1491.00
36_L61_K1.1441.00
62_V66_E1.1301.00
4_R8_F1.1241.00
28_E56_V1.1071.00
30_R42_Y1.1011.00
69_S73_Q1.0821.00
30_R36_L1.0751.00
56_V59_L1.0731.00
11_L21_L1.0431.00
26_V30_R0.9771.00
8_F12_D0.9741.00
25_L59_L0.9561.00
68_L72_G0.9341.00
44_F54_Y0.9221.00
18_D23_P0.9021.00
24_P28_E0.8831.00
53_E58_N0.8591.00
70_L74_L0.8491.00
66_E70_L0.8411.00
5_E8_F0.8241.00
9_A12_D0.8191.00
24_P27_D0.8141.00
34_G45_K0.8041.00
12_D15_E0.8021.00
23_P27_D0.7981.00
27_D30_R0.7931.00
60_E66_E0.7881.00
66_E73_Q0.7861.00
47_P74_L0.7721.00
33_G61_K0.7721.00
6_E9_A0.7661.00
66_E69_S0.7550.99
13_D16_F0.7500.99
62_V67_H0.7470.99
68_L71_L0.7430.99
22_M54_Y0.7300.99
16_F19_D0.7240.99
37_G61_K0.7030.99
41_C64_L0.6860.99
59_L67_H0.6660.99
70_L73_Q0.6590.99
10_L14_D0.6560.99
26_V29_A0.6550.99
25_L28_E0.6530.99
25_L56_V0.6430.98
17_L20_W0.6390.98
6_E15_E0.6270.98
64_L72_G0.6160.98
41_C67_H0.6030.98
11_L17_L0.6000.97
8_F11_L0.5940.97
10_L15_E0.5940.97
8_F13_D0.5870.97
25_L54_Y0.5870.97
4_R7_F0.5800.97
44_F67_H0.5750.97
11_L14_D0.5710.97
4_R12_D0.5710.97
13_D17_L0.5660.96
14_D18_D0.5620.96
5_E9_A0.5580.96
9_A13_D0.5540.96
4_R11_L0.5500.96
65_R68_L0.5460.96
7_F11_L0.5340.95
43_G60_E0.5280.95
9_A14_D0.5240.94
63_D73_Q0.5210.94
20_W64_L0.5200.94
39_G65_R0.5190.94
18_D35_P0.5180.94
27_D31_A0.5110.94
20_W54_Y0.5090.94
64_L67_H0.5080.94
19_D22_M0.5060.93
5_E15_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
7ceiB 1 0.92 24.7 0.85 Contact Map
4uhqA 1 0.9867 13.1 0.867 Contact Map
1fr2B 1 0.92 11.5 0.871 Contact Map
1mgpA 1 0.92 7.8 0.88 Contact Map
4qkoB 2 0.9733 6.1 0.886 Contact Map
3v53A 1 0.4533 4.9 0.891 Contact Map
1q55A 2 0 4.5 0.893 Contact Map
3zfkA 1 0.9067 4.2 0.894 Contact Map
2prvA 2 0.36 3.9 0.896 Contact Map
4rh7A 1 1 3.6 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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