GREMLIN Database
DUF1849 - Domain of unknown function (DUF1849)
PFAM: PF08904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 248 (245)
Sequences: 2563 (1785)
Seq/√Len: 114.0
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_P193_P4.2221.00
139_A144_K3.9381.00
40_G76_G3.4711.00
194_R218_E3.0161.00
88_Y93_L2.9351.00
136_L166_T2.8981.00
11_R37_E2.8661.00
103_R108_G2.8581.00
192_L221_E2.8531.00
220_Y226_R2.7091.00
38_F130_T2.5511.00
127_L135_R2.4921.00
75_S79_K2.4871.00
127_L149_A2.3851.00
166_T199_I2.3741.00
164_T199_I2.3421.00
228_L239_G2.2391.00
141_R221_E2.1941.00
169_G196_P2.1391.00
135_R139_A2.1371.00
146_F165_L2.1061.00
139_A147_L2.0991.00
101_A128_F2.0781.00
109_T119_T2.0481.00
193_P221_E2.0261.00
138_E142_A1.9921.00
15_D33_R1.9771.00
6_E9_P1.9461.00
73_W82_R1.9261.00
19_A238_R1.8891.00
72_T81_F1.8691.00
30_A56_L1.8321.00
224_V246_L1.8091.00
11_R245_E1.7511.00
55_E65_L1.7431.00
111_K119_T1.7401.00
30_A237_I1.7101.00
15_D242_T1.7041.00
18_L21_A1.7001.00
83_F99_G1.6821.00
7_L137_I1.6721.00
93_L96_E1.6661.00
110_V122_L1.6661.00
140_A168_I1.6621.00
31_R55_E1.6531.00
241_L244_L1.6341.00
229_V238_R1.6261.00
109_T121_D1.6171.00
150_P163_D1.6151.00
146_F167_V1.6131.00
194_R220_Y1.6101.00
203_D212_D1.6051.00
96_E114_K1.5991.00
218_E226_R1.5921.00
224_V244_L1.5811.00
5_V138_E1.5771.00
86_R96_E1.5771.00
136_L197_V1.5661.00
231_D236_V1.5541.00
131_E135_R1.5481.00
29_G57_D1.5411.00
71_T84_N1.5031.00
232_Y235_F1.4921.00
37_E49_N1.4891.00
75_S80_S1.4501.00
229_V236_V1.4401.00
145_T170_K1.4161.00
8_A246_L1.3621.00
55_E63_V1.3571.00
53_V65_L1.3531.00
135_R147_L1.3481.00
51_R67_D1.3461.00
172_I218_E1.3191.00
79_K103_R1.2970.99
33_R53_V1.2820.99
17_S240_K1.2770.99
84_N98_D1.2710.99
45_G73_W1.2710.99
198_T214_E1.2580.99
103_R131_E1.2560.99
21_A25_S1.2430.99
8_A222_N1.2370.99
69_R86_R1.2250.99
35_V51_R1.2180.99
37_E48_L1.2150.99
47_T71_T1.2100.99
127_L131_E1.2020.99
13_V33_R1.2000.99
54_T237_I1.1970.99
37_E247_L1.1940.99
19_A229_V1.1890.99
86_R93_L1.1880.99
81_F133_T1.1860.99
10_H14_Y1.1850.99
8_A224_V1.1850.99
132_H153_D1.1730.99
69_R88_Y1.1720.99
137_I141_R1.1590.99
151_V164_T1.1580.99
140_A195_W1.1540.99
50_F230_L1.1510.99
25_S28_V1.1490.99
38_F50_F1.1440.99
123_P126_T1.1340.99
7_L38_F1.1300.99
218_E227_D1.1240.99
21_A26_G1.1230.99
122_L126_T1.1220.99
165_L200_S1.1200.99
30_A54_T1.1080.98
79_K106_D1.1070.98
206_S209_Q1.1030.98
188_A191_G1.0950.98
187_P190_A1.0920.98
19_A236_V1.0860.98
136_L199_I1.0850.98
149_A166_T1.0840.98
87_N95_E1.0770.98
135_R138_E1.0750.98
80_S100_E1.0730.98
132_H149_A1.0630.98
7_L36_Y1.0520.98
192_L220_Y1.0510.98
44_D73_W1.0470.98
242_T245_E1.0390.98
77_D116_E1.0280.97
46_Y152_F1.0180.97
41_S44_D1.0130.97
79_K105_G1.0120.97
134_R138_E0.9980.97
52_Q56_L0.9890.97
97_V112_L0.9890.97
103_R125_G0.9870.97
46_Y68_L0.9860.97
233_G236_V0.9810.97
200_S214_E0.9620.96
217_F228_L0.9530.96
118_K159_E0.9450.96
13_V35_V0.9440.96
78_G131_E0.9390.96
34_M50_F0.9330.95
26_G238_R0.9330.95
112_L160_K0.9300.95
217_F225_S0.9240.95
151_V201_Y0.9180.95
52_Q68_L0.9130.95
219_L230_L0.9050.95
106_D124_A0.9020.94
135_R149_A0.8980.94
148_E163_D0.8930.94
19_A22_R0.8800.94
207_G210_T0.8800.94
17_S238_R0.8710.93
132_H235_F0.8700.93
198_T216_S0.8650.93
47_T82_R0.8580.93
102_E109_T0.8540.93
5_V137_I0.8530.93
198_T231_D0.8480.92
81_F152_F0.8460.92
88_Y91_G0.8430.92
122_L161_V0.8380.92
36_Y52_Q0.8370.92
39_S47_T0.8360.92
98_D113_T0.8320.92
189_L222_N0.8300.92
197_V219_L0.8240.91
35_V54_T0.8230.91
213_Y232_Y0.8190.91
64_V90_N0.8180.91
225_S228_L0.8150.91
215_I225_S0.8140.91
148_E165_L0.8110.91
225_S239_G0.8080.91
110_V152_F0.8050.90
102_E111_K0.8050.90
40_G47_T0.8020.90
68_L87_N0.7970.90
84_N96_E0.7970.90
238_R243_S0.7960.90
162_Y215_I0.7910.90
120_F126_T0.7870.89
54_T164_T0.7870.89
230_L237_I0.7870.89
6_E17_S0.7710.88
36_Y50_F0.7710.88
21_A24_G0.7680.88
129_P231_D0.7590.88
14_Y32_G0.7580.88
219_L232_Y0.7530.87
16_L52_Q0.7470.87
7_L133_T0.7430.86
50_F232_Y0.7420.86
34_M201_Y0.7420.86
107_G125_G0.7400.86
107_G121_D0.7350.86
132_H166_T0.7340.86
126_T150_P0.7340.86
37_E51_R0.7340.86
130_T134_R0.7320.86
28_V59_G0.7320.86
36_Y219_L0.7290.85
133_T219_L0.7290.85
64_V241_L0.7240.85
83_F101_A0.7190.85
112_L120_F0.7180.85
9_P38_F0.7170.84
153_D228_L0.7170.84
57_D63_V0.7140.84
76_G152_F0.7130.84
99_G152_F0.7120.84
83_F110_V0.7100.84
89_V213_Y0.7090.84
80_S102_E0.7090.84
79_K104_D0.7070.84
58_S66_S0.7060.84
214_E218_E0.7050.83
34_M52_Q0.7030.83
84_N90_N0.7030.83
20_K23_G0.7010.83
8_A244_L0.7010.83
219_L225_S0.7000.83
8_A192_L0.7000.83
73_W80_S0.6960.83
23_G26_G0.6940.83
137_I140_A0.6930.82
52_Q213_Y0.6890.82
40_G51_R0.6870.82
182_A185_G0.6840.82
167_V198_T0.6820.81
126_T161_V0.6820.81
123_P204_A0.6810.81
27_I58_S0.6750.81
104_D107_G0.6740.81
30_A84_N0.6680.80
149_A163_D0.6660.80
190_A220_Y0.6640.80
78_G128_F0.6610.79
106_D191_G0.6610.79
216_S229_V0.6610.79
168_I195_W0.6610.79
10_H202_F0.6570.79
136_L186_A0.6550.79
71_T98_D0.6500.78
164_T167_V0.6490.78
112_L158_G0.6480.78
6_E141_R0.6470.78
69_R219_L0.6460.78
68_L160_K0.6460.78
12_A241_L0.6430.77
11_R33_R0.6420.77
155_S241_L0.6390.77
113_T177_A0.6370.77
185_G188_A0.6370.77
215_I235_F0.6370.77
172_I175_G0.6360.77
112_L200_S0.6360.77
116_E177_A0.6350.77
137_I195_W0.6290.76
82_R100_E0.6280.76
173_A177_A0.6220.75
103_R126_T0.6220.75
112_L157_D0.6210.75
162_Y230_L0.6130.74
72_T222_N0.6120.74
224_V245_E0.6110.74
132_H199_I0.6110.74
153_D201_Y0.6090.74
57_D97_V0.6070.73
83_F112_L0.6070.73
49_N141_R0.6050.73
16_L37_E0.6050.73
27_I30_A0.6040.73
87_N225_S0.6040.73
125_G183_A0.6030.73
230_L235_F0.6030.73
186_A224_V0.6000.72
9_P14_Y0.5990.72
156_D160_K0.5940.72
142_A177_A0.5920.71
175_G191_G0.5900.71
227_D238_R0.5870.71
68_L230_L0.5870.71
100_E111_K0.5800.70
139_A168_I0.5800.70
6_E11_R0.5780.70
237_I244_L0.5750.69
90_N95_E0.5740.69
34_M194_R0.5740.69
189_L244_L0.5720.69
66_S165_L0.5720.69
152_F158_G0.5710.69
197_V235_F0.5710.69
44_D221_E0.5710.69
134_R137_I0.5700.69
129_P233_G0.5700.69
3_A20_K0.5680.68
120_F152_F0.5680.68
142_A175_G0.5680.68
37_E142_A0.5670.68
132_H155_S0.5670.68
132_H136_L0.5630.68
54_T99_G0.5620.68
201_Y217_F0.5580.67
113_T180_D0.5580.67
66_S133_T0.5570.67
184_A187_P0.5560.67
63_V71_T0.5560.67
139_A142_A0.5520.66
132_H164_T0.5510.66
137_I230_L0.5500.66
15_D18_L0.5500.66
93_L107_G0.5500.66
156_D220_Y0.5500.66
154_G222_N0.5490.66
213_Y230_L0.5490.66
177_A190_A0.5480.66
185_G206_S0.5470.65
183_A186_A0.5460.65
112_L220_Y0.5460.65
203_D234_D0.5450.65
80_S240_K0.5410.65
70_S112_L0.5400.65
133_T200_S0.5400.65
16_L239_G0.5370.64
173_A193_P0.5370.64
127_L176_A0.5350.64
175_G178_A0.5330.64
6_E27_I0.5330.64
188_A244_L0.5330.64
92_E238_R0.5320.63
177_A180_D0.5300.63
42_A46_Y0.5300.63
96_E136_L0.5270.63
16_L78_G0.5260.62
198_T237_I0.5250.62
215_I218_E0.5240.62
110_V165_L0.5240.62
133_T214_E0.5230.62
151_V245_E0.5230.62
140_A213_Y0.5220.62
53_V67_D0.5220.62
52_Q66_S0.5210.62
192_L246_L0.5210.62
125_G173_A0.5200.62
88_Y121_D0.5190.61
243_S247_L0.5190.61
9_P132_H0.5190.61
70_S160_K0.5180.61
47_T73_W0.5180.61
209_Q214_E0.5160.61
40_G112_L0.5150.61
40_G50_F0.5140.61
77_D104_D0.5110.60
11_R35_V0.5100.60
33_R242_T0.5090.60
101_A110_V0.5060.60
44_D142_A0.5060.60
133_T150_P0.5040.59
89_V94_T0.5030.59
171_P174_P0.5030.59
44_D47_T0.5020.59
108_G188_A0.5010.59
66_S230_L0.5010.59
77_D141_R0.5010.59
128_F217_F0.5010.59
10_H224_V0.5000.59
165_L198_T0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k7iA 2 0.2379 7.1 0.964 Contact Map
2r39A 1 0.4234 5.7 0.966 Contact Map
3bidA 2 0.246 5.7 0.966 Contact Map
4a8jC 1 0.254 4.7 0.967 Contact Map
1u00A 1 0.4516 4.5 0.968 Contact Map
1v95A 1 0.2419 4.4 0.968 Contact Map
2o2aA 4 0.254 3.8 0.969 Contact Map
4oevA 1 0.7823 3.3 0.97 Contact Map
2mhgA 2 0.1573 3 0.97 Contact Map
2op6A 1 0.4677 2.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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