GREMLIN Database
DUF1847 - Protein of unknown function (DUF1847)
PFAM: PF08901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (157)
Sequences: 3095 (2054)
Seq/√Len: 163.9
META: 0.907

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_F156_V2.8481.00
58_L82_F2.7711.00
43_V73_L2.5691.00
41_T44_E2.5301.00
135_L147_F2.5161.00
103_D110_G2.5031.00
61_A125_L2.2011.00
35_E52_K2.1231.00
150_S154_V2.0651.00
57_K83_E1.9571.00
60_I74_A1.9311.00
16_E19_D1.8981.00
36_G40_K1.8591.00
130_T133_N1.8531.00
57_K85_V1.8131.00
133_N150_S1.7951.00
147_F154_V1.7661.00
14_L98_E1.7011.00
73_L77_L1.6981.00
46_I140_V1.6631.00
40_K48_E1.6551.00
132_L144_S1.6461.00
73_L136_L1.6431.00
97_E106_K1.6331.00
50_A82_F1.6261.00
134_I155_T1.6231.00
74_A78_E1.6101.00
47_I80_H1.6031.00
43_V157_L1.5991.00
144_S147_F1.5801.00
91_V120_G1.5741.00
64_I88_C1.5691.00
56_K131_D1.5681.00
126_N151_K1.5671.00
103_D106_K1.5541.00
123_E151_K1.5471.00
47_I76_I1.5331.00
51_K80_H1.4771.00
50_A58_L1.4761.00
46_I134_I1.4741.00
58_L134_I1.4611.00
16_E123_E1.4521.00
60_I73_L1.4471.00
25_F49_F1.4411.00
22_N149_Y1.4351.00
102_P105_E1.4291.00
15_E18_E1.4141.00
33_E37_Y1.4111.00
77_L134_I1.4031.00
24_E28_A1.3801.00
55_Y131_D1.3751.00
130_T150_S1.3641.00
119_I145_L1.3621.00
119_I149_Y1.3401.00
68_K71_R1.3241.00
56_K83_E1.3091.00
85_V128_A1.2981.00
66_L137_G1.2941.00
12_E123_E1.2811.00
6_E127_E1.2671.00
62_F67_R1.2561.00
146_F150_S1.2421.00
62_F86_S1.2341.00
23_R27_R1.2201.00
135_L156_V1.2151.00
9_L13_A1.2051.00
12_E127_E1.1951.00
50_A132_L1.1871.00
133_N152_A1.1811.00
24_E27_R1.1681.00
18_E23_R1.1621.00
44_E48_E1.1561.00
94_I117_N1.1431.00
61_A146_F1.1431.00
28_A31_I1.1371.00
73_L157_L1.1191.00
93_G114_A1.0941.00
14_L94_I1.0901.00
19_D22_N1.0740.99
31_I105_E1.0690.99
130_T152_A1.0640.99
32_V40_K1.0570.99
96_K113_E1.0550.99
123_E127_E1.0410.99
22_N148_K1.0390.99
99_I115_M1.0370.99
62_F70_A1.0370.99
31_I52_K1.0220.99
28_A53_M1.0210.99
129_G151_K1.0050.99
140_V144_S1.0040.99
28_A32_V1.0020.99
44_E80_H1.0000.99
124_L128_A0.9920.99
68_K72_I0.9900.99
148_K151_K0.9880.99
47_I77_L0.9850.99
27_R31_I0.9810.99
66_L136_L0.9740.99
48_E52_K0.9660.99
11_E14_L0.9630.99
91_V124_L0.9540.99
71_R75_E0.9360.99
108_R111_T0.9350.99
25_F153_P0.9310.99
76_I80_H0.9280.98
97_E103_D0.9230.98
30_A33_E0.9210.98
16_E149_Y0.9120.98
26_A99_I0.9040.98
106_K109_P0.9000.98
18_E98_E0.8960.98
73_L134_I0.8940.98
13_A123_E0.8800.98
46_I50_A0.8760.98
47_I51_K0.8600.98
144_S153_P0.8470.97
25_F32_V0.8470.97
145_L149_Y0.8410.97
94_I98_E0.8410.97
123_E126_N0.8400.97
87_V91_V0.8390.97
33_E96_K0.8280.97
10_I120_G0.8110.96
126_N152_A0.8060.96
4_K7_P0.8010.96
46_I73_L0.7870.96
10_I14_L0.7780.96
59_G125_L0.7710.95
21_E24_E0.7660.95
55_Y132_L0.7630.95
106_K112_F0.7550.95
106_K110_G0.7510.95
11_E15_E0.7500.95
87_V125_L0.7490.95
8_E11_E0.7450.94
26_A115_M0.7450.94
37_Y65_G0.7410.94
22_N119_I0.7400.94
148_K153_P0.7310.94
33_E65_G0.7310.94
67_R88_C0.7270.94
95_P114_A0.7260.94
135_L150_S0.7110.93
9_L127_E0.7060.93
101_L115_M0.7050.93
16_E119_I0.7020.92
46_I136_L0.6990.92
37_Y96_K0.6950.92
50_A140_V0.6940.92
144_S156_V0.6920.92
31_I102_P0.6900.92
10_I91_V0.6890.92
48_E51_K0.6850.91
135_L154_V0.6790.91
72_I75_E0.6770.91
138_L146_F0.6760.91
33_E113_E0.6750.91
7_P11_E0.6730.91
57_K129_G0.6710.91
64_I108_R0.6710.91
32_V36_G0.6690.90
7_P15_E0.6670.90
31_I35_E0.6650.90
77_L84_V0.6640.90
134_I157_L0.6620.90
144_S155_T0.6560.90
36_G48_E0.6520.89
33_E36_G0.6510.89
87_V124_L0.6500.89
75_E79_A0.6470.89
94_I120_G0.6450.89
6_E128_A0.6420.89
20_P23_R0.6400.88
60_I136_L0.6380.88
53_M132_L0.6310.88
43_V77_L0.6260.87
26_A30_A0.6210.87
95_P98_E0.6170.87
111_T114_A0.6170.87
72_I76_I0.6160.86
40_K62_F0.6160.86
29_A49_F0.6130.86
95_P112_F0.6070.86
16_E22_N0.6040.85
123_E149_Y0.6030.85
47_I81_G0.6020.85
40_K44_E0.5970.85
43_V76_I0.5950.85
64_I67_R0.5940.84
29_A33_E0.5890.84
11_E18_E0.5880.84
90_K96_K0.5870.84
6_E9_L0.5850.84
103_D109_P0.5840.83
139_C142_H0.5840.83
19_D24_E0.5780.83
70_A136_L0.5780.83
12_E15_E0.5780.83
32_V48_E0.5720.82
49_F53_M0.5710.82
67_R70_A0.5710.82
109_P112_F0.5700.82
46_I77_L0.5680.82
13_A92_G0.5650.81
28_A52_K0.5620.81
119_I123_E0.5600.81
6_E124_L0.5520.80
9_L120_G0.5510.80
126_N129_G0.5470.79
32_V35_E0.5470.79
9_L12_E0.5400.78
6_E11_E0.5350.78
46_I58_L0.5340.78
37_Y113_E0.5330.78
24_E53_M0.5300.77
10_I13_A0.5300.77
108_R112_F0.5300.77
150_S153_P0.5290.77
35_E105_E0.5270.77
78_E81_G0.5270.77
49_F55_Y0.5250.77
9_L14_L0.5250.77
21_E148_K0.5250.77
12_E16_E0.5200.76
20_P24_E0.5200.76
101_L113_E0.5140.75
17_Y22_N0.5130.75
124_L127_E0.5130.75
22_N145_L0.5100.74
6_E14_L0.5070.74
65_G69_E0.5030.73
40_K45_E0.5020.73
14_L18_E0.5010.73
26_A29_A0.5010.73
126_N130_T0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k77A 1 0.7834 61.2 0.937 Contact Map
3m3pA 1 0.6497 58.1 0.938 Contact Map
3ngfA 1 0.8217 36.5 0.946 Contact Map
2ywjA 1 0.5605 24.4 0.95 Contact Map
1qtwA 1 0.7643 23.6 0.951 Contact Map
1fy2A 1 0.8217 22.9 0.951 Contact Map
3lzdA 2 0.6879 22 0.951 Contact Map
3u0hA 3 0.7516 20.7 0.952 Contact Map
3gonA 1 0.5669 20.5 0.952 Contact Map
2ywdA 1 0.586 19.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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