GREMLIN Database
DUF1845 - Domain of unknown function (DUF1845)
PFAM: PF08900 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 215 (209)
Sequences: 640 (471)
Seq/√Len: 32.6
META: 0.655

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_D174_G4.1001.00
200_D206_R3.8881.00
56_D61_D3.4191.00
199_Q203_S3.4171.00
207_R211_A2.8261.00
25_R36_I2.8131.00
62_W198_P2.7881.00
43_A113_F2.7811.00
175_V180_F2.6921.00
61_D177_R2.6821.00
75_R127_D2.6181.00
52_A170_Y2.6091.00
132_V153_L2.5771.00
145_S148_E2.5611.00
207_R212_P2.4721.00
208_S211_A2.4330.99
179_D184_N2.4290.99
42_F121_A2.2310.99
184_N187_A2.2090.99
56_D177_R2.1960.99
13_L22_W2.1680.99
200_D205_T2.0770.98
176_T179_D2.0520.98
52_A57_D2.0360.98
43_A118_G1.9670.97
160_L163_L1.9490.97
178_D182_A1.9470.97
14_H115_S1.9400.97
63_W66_R1.8870.97
111_L122_A1.8720.97
77_E159_A1.8190.96
65_L201_V1.7980.96
178_D181_A1.7900.96
139_H149_A1.7880.96
100_V137_T1.7580.95
183_N188_R1.7420.95
193_K197_L1.7380.95
15_T18_A1.7010.94
69_E206_R1.6780.94
158_R162_S1.6170.92
57_D173_S1.5860.92
188_R191_I1.5810.92
63_W170_Y1.5770.91
36_I161_R1.5580.91
58_P61_D1.5260.90
190_A194_M1.4910.89
66_R169_R1.4890.89
117_Y208_S1.4800.89
135_V149_A1.4780.88
78_L131_L1.4250.87
52_A60_A1.4010.86
158_R169_R1.3980.85
42_F167_A1.3710.84
49_I141_V1.3460.83
27_A71_L1.3440.83
14_H133_R1.3410.83
181_A184_N1.3360.83
103_S106_P1.3320.83
42_F136_L1.3280.82
52_A111_L1.3250.82
164_F209_R1.3040.81
68_E209_R1.3030.81
52_A172_F1.2930.81
119_Y137_T1.2900.80
50_W62_W1.2880.80
191_I196_E1.2660.79
66_R166_L1.2610.79
53_A61_D1.2360.78
14_H95_G1.2360.78
86_D134_K1.2140.76
116_P119_Y1.1920.75
180_F187_A1.1890.75
188_R192_E1.1860.74
157_G161_R1.1820.74
53_A64_L1.1700.73
46_L118_G1.1700.73
39_L42_F1.1700.73
183_N187_A1.1470.72
208_S212_P1.1380.71
123_Y143_L1.1380.71
42_F57_D1.1340.71
46_L116_P1.1320.71
22_W39_L1.1260.71
187_A192_E1.1240.70
125_L160_L1.1180.70
70_A162_S1.1150.70
14_H19_Q1.0900.68
85_L135_V1.0770.67
19_Q167_A1.0680.66
125_L163_L1.0600.66
22_W118_G1.0500.65
50_W111_L1.0330.64
35_A41_G1.0200.63
86_D90_A1.0190.63
185_A189_A1.0180.63
128_Y201_V1.0040.62
182_A200_D0.9960.61
39_L121_A0.9850.60
38_G42_F0.9830.60
46_L121_A0.9820.60
147_D151_R0.9790.60
22_W134_K0.9780.59
27_A35_A0.9770.59
21_L160_L0.9760.59
133_R137_T0.9740.59
181_A185_A0.9740.59
184_N190_A0.9730.59
101_A140_H0.9730.59
117_Y137_T0.9680.59
196_E199_Q0.9660.59
21_L115_S0.9620.58
149_A153_L0.9600.58
59_Y195_G0.9430.57
58_P177_R0.9400.56
22_W43_A0.9390.56
39_L119_Y0.9300.56
180_F184_N0.9190.55
36_I41_G0.9180.55
46_L67_I0.9140.54
51_R55_Q0.9090.54
68_E125_L0.9090.54
178_D191_I0.9050.54
17_Q22_W0.9030.53
98_I144_I0.9020.53
76_A160_L0.8980.53
71_L83_E0.8970.53
81_L84_Q0.8960.53
7_S167_A0.8850.52
17_Q136_L0.8820.52
132_V152_W0.8790.51
44_A51_R0.8730.51
61_D207_R0.8700.51
121_A164_F0.8620.50
49_I60_A0.8620.50
14_H22_W0.8610.50
64_L137_T0.8610.50
37_I154_R0.8500.49
25_R35_A0.8480.49
117_Y134_K0.8450.49
94_K130_Q0.8440.49
111_L198_P0.8390.48
61_D179_D0.8230.47
186_R189_A0.8200.47
82_I98_I0.8170.46
75_R120_R0.8170.46
95_G130_Q0.8120.46
39_L125_L0.8080.46
180_F209_R0.8030.45
42_F46_L0.8030.45
87_A91_Q0.7980.45
113_F122_A0.7940.44
178_D199_Q0.7930.44
60_A64_L0.7870.44
22_W115_S0.7800.43
46_L170_Y0.7780.43
11_L126_A0.7770.43
4_A80_E0.7760.43
42_F67_I0.7720.43
5_L15_T0.7720.43
142_G188_R0.7620.42
57_D136_L0.7600.42
50_W116_P0.7590.42
13_L153_L0.7550.41
158_R166_L0.7530.41
113_F117_Y0.7520.41
74_A163_L0.7520.41
17_Q170_Y0.7510.41
178_D187_A0.7480.41
109_V169_R0.7460.41
62_W66_R0.7440.40
128_Y160_L0.7380.40
24_G161_R0.7340.40
75_R133_R0.7290.39
43_A50_W0.7230.39
25_R161_R0.7220.39
186_R200_D0.7190.38
134_K137_T0.7190.38
75_R123_Y0.7190.38
6_R104_V0.7160.38
76_A83_E0.7160.38
2_P133_R0.7140.38
111_L133_R0.7070.37
46_L100_V0.7050.37
127_D142_G0.7010.37
195_G208_S0.6990.37
82_I86_D0.6950.37
6_R162_S0.6930.36
118_G138_A0.6930.36
98_I126_A0.6920.36
79_Q127_D0.6900.36
159_A162_S0.6880.36
21_L77_E0.6830.36
143_L162_S0.6810.35
137_T141_V0.6810.35
182_A188_R0.6790.35
183_N186_R0.6740.35
187_A191_I0.6730.35
17_Q112_F0.6700.35
72_E76_A0.6700.35
147_D201_V0.6630.34
20_R44_A0.6620.34
50_W122_A0.6610.34
25_R28_D0.6600.34
67_I96_L0.6580.34
71_L148_E0.6550.34
79_Q132_V0.6500.33
176_T180_F0.6500.33
81_L144_I0.6480.33
113_F119_Y0.6470.33
18_A24_G0.6470.33
49_I108_R0.6430.33
36_I109_V0.6420.33
60_A175_V0.6410.32
98_I136_L0.6410.32
184_N212_P0.6390.32
18_A133_R0.6380.32
18_A177_R0.6360.32
17_Q137_T0.6290.32
94_K127_D0.6270.31
147_D205_T0.6270.31
124_L156_G0.6250.31
20_R59_Y0.6250.31
91_Q96_L0.6240.31
11_L41_G0.6220.31
78_L167_A0.6200.31
136_L140_H0.6200.31
12_T15_T0.6190.31
73_E191_I0.6160.31
49_I67_I0.6120.30
18_A21_L0.6120.30
87_A151_R0.6090.30
85_L175_V0.6090.30
89_L145_S0.6090.30
171_R174_G0.6070.30
68_E93_P0.6060.30
68_E131_L0.6040.30
71_L192_E0.6030.30
87_A110_P0.6010.30
4_A153_L0.6000.30
114_R210_F0.6000.30
64_L122_A0.6000.30
89_L138_A0.5970.29
120_R142_G0.5950.29
88_L125_L0.5930.29
39_L43_A0.5890.29
103_S113_F0.5890.29
59_Y175_V0.5880.29
185_A193_K0.5820.28
30_G162_S0.5810.28
181_A202_L0.5810.28
96_L193_K0.5800.28
163_L166_L0.5800.28
146_R150_E0.5800.28
115_S171_R0.5760.28
156_G160_L0.5690.27
162_S167_A0.5690.27
95_G119_Y0.5670.27
57_D138_A0.5670.27
178_D183_N0.5670.27
40_P96_L0.5640.27
86_D143_L0.5640.27
24_G36_I0.5630.27
128_Y157_G0.5620.27
95_G133_R0.5610.27
145_S209_R0.5610.27
130_Q145_S0.5600.27
46_L164_F0.5600.27
142_G149_A0.5590.27
60_A129_D0.5590.27
16_R33_K0.5580.27
17_Q128_Y0.5580.27
59_Y90_A0.5580.27
155_E158_R0.5570.27
64_L117_Y0.5560.27
47_R50_W0.5540.27
53_A119_Y0.5540.27
111_L137_T0.5520.26
83_E155_E0.5500.26
173_S194_M0.5490.26
71_L163_L0.5480.26
107_V111_L0.5470.26
191_I203_S0.5460.26
176_T182_A0.5420.26
133_R189_A0.5400.26
61_D138_A0.5370.25
56_D207_R0.5360.25
10_T114_R0.5360.25
122_A208_S0.5350.25
71_L188_R0.5340.25
119_Y139_H0.5330.25
127_D137_T0.5330.25
155_E201_V0.5290.25
96_L135_V0.5290.25
68_E161_R0.5290.25
39_L67_I0.5280.25
74_A157_G0.5270.25
9_V137_T0.5260.25
60_A177_R0.5250.25
175_V184_N0.5210.24
90_A182_A0.5200.24
128_Y132_V0.5180.24
59_Y187_A0.5180.24
14_H109_V0.5130.24
53_A132_V0.5130.24
201_V208_S0.5120.24
9_V19_Q0.5110.24
26_R67_I0.5100.24
138_A152_W0.5080.24
22_W113_F0.5080.24
20_R29_E0.5050.23
56_D131_L0.5040.23
73_E200_D0.5020.23
135_V152_W0.5000.23
76_A80_E0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r25A 1 0.3907 27.7 0.946 Contact Map
1pp9F 1 0.2651 18.7 0.95 Contact Map
4eukB 1 0.4279 16.5 0.952 Contact Map
3iqtA 1 0.3674 15.4 0.952 Contact Map
2cw9A 1 0.3116 14 0.953 Contact Map
3myfA 3 0.3721 13.6 0.953 Contact Map
3j20D 1 0.4326 9.9 0.956 Contact Map
4u4cA 1 0.707 9.7 0.956 Contact Map
4pacA 1 0.414 9.2 0.957 Contact Map
4a4zA 1 0.7023 8.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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