GREMLIN Database
DUF1844 - Domain of unknown function (DUF1844)
PFAM: PF08899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (72)
Sequences: 15131 (8678)
Seq/√Len: 1022.7
META: 0.986

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E63_E2.7241.00
44_A70_R2.6721.00
59_E63_E2.5681.00
64_N68_E2.2401.00
56_P60_R2.2301.00
20_E72_R2.1601.00
17_H39_T1.8491.00
56_P59_E1.8151.00
22_P27_G1.7781.00
23_D26_T1.7751.00
11_A65_V1.7691.00
32_D35_L1.6201.00
67_Y71_M1.5751.00
60_R64_N1.5301.00
54_L59_E1.4981.00
47_E51_K1.4841.00
35_L39_T1.4511.00
41_D44_A1.4341.00
48_E51_K1.4241.00
17_H35_L1.3661.00
51_K54_L1.3641.00
8_L12_T1.3521.00
47_E59_E1.3151.00
44_A48_E1.2891.00
22_P29_P1.2661.00
9_S13_Q1.2471.00
68_E72_R1.2101.00
6_L10_L1.2031.00
47_E70_R1.1671.00
4_S61_L1.1531.00
14_A39_T1.1431.00
23_D27_G1.1121.00
37_R41_D1.1051.00
2_D5_T1.0871.00
38_Q42_L1.0491.00
23_D30_E1.0491.00
44_A47_E1.0281.00
67_Y70_R1.0181.00
39_T42_L1.0171.00
51_K59_E0.9931.00
6_L45_M0.9901.00
15_L20_E0.9791.00
6_L42_L0.9461.00
43_L62_L0.9451.00
13_Q39_T0.9431.00
26_T30_E0.9351.00
66_L70_R0.9301.00
57_E60_R0.9211.00
13_Q16_M0.9021.00
13_Q17_H0.8951.00
50_T53_N0.8901.00
44_A66_L0.8851.00
5_T8_L0.8811.00
55_T58_E0.8731.00
49_K58_E0.8731.00
11_A15_L0.8611.00
45_M49_K0.8601.00
5_T9_S0.8301.00
15_L72_R0.8241.00
3_F54_L0.8231.00
3_F7_V0.8211.00
35_L38_Q0.7951.00
60_R63_E0.7931.00
12_T16_M0.7901.00
22_P28_K0.7821.00
4_S8_L0.7431.00
10_L39_T0.7401.00
14_A69_L0.7381.00
13_Q35_L0.7031.00
26_T29_P0.7011.00
7_V43_L0.6921.00
50_T54_L0.6891.00
4_S57_E0.6821.00
6_L46_L0.6741.00
18_L36_A0.6731.00
8_L11_A0.6691.00
42_L45_M0.6641.00
14_A18_L0.6541.00
42_L46_L0.6461.00
11_A68_E0.6411.00
63_E67_Y0.6371.00
65_V68_E0.6291.00
22_P26_T0.6151.00
9_S16_M0.6031.00
15_L21_I0.5921.00
7_V65_V0.5891.00
34_E37_R0.5881.00
10_L42_L0.5841.00
12_T21_I0.5831.00
19_G32_D0.5821.00
2_D6_L0.5791.00
25_E28_K0.5741.00
47_E54_L0.5731.00
19_G36_A0.5631.00
5_T38_Q0.5511.00
3_F62_L0.5461.00
61_L65_V0.5411.00
12_T15_L0.5361.00
18_L33_L0.5321.00
54_L62_L0.5221.00
33_L73_Y0.5211.00
47_E62_L0.5201.00
7_V62_L0.5141.00
9_S12_T0.5091.00
43_L66_L0.5061.00
54_L58_E0.5051.00
16_M25_E0.5051.00
13_Q38_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nwzA 3 0.4247 10.9 0.875 Contact Map
3j60S 1 0.9589 9.2 0.878 Contact Map
4ga6A 2 0.9315 9.1 0.879 Contact Map
3kp7A 2 0.8767 8.9 0.879 Contact Map
2wh5A 1 0.6027 8.3 0.881 Contact Map
2h5nA 5 0.7123 6.9 0.885 Contact Map
3u0hA 3 0.6849 6.8 0.885 Contact Map
2ou3A 2 0.863 6.5 0.886 Contact Map
3bddA 2 0.9726 6.2 0.888 Contact Map
3j38S 1 0.8904 6.1 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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