GREMLIN Database
DUF1843 - Domain of unknown function (DUF1843)
PFAM: PF08898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (51)
Sequences: 635 (435)
Seq/√Len: 60.9
META: 0.879

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_S18_E3.4421.00
23_A40_L2.7951.00
27_E44_K2.2681.00
2_L6_A2.1911.00
13_S22_L1.7891.00
29_H33_H1.7500.99
29_H36_V1.7290.99
7_I11_I1.7170.99
33_H36_V1.6510.99
18_E21_A1.5200.98
15_D18_E1.5170.98
42_A45_A1.4960.98
34_G37_R1.4660.98
2_L29_H1.3950.97
2_L25_Q1.2590.95
28_K32_E1.2130.94
6_A10_A1.2080.94
7_I19_M1.1980.93
2_L26_A1.1950.93
6_A22_L1.1660.92
16_L47_I1.1380.91
16_L20_K1.1330.91
35_D38_A1.1330.91
2_L10_A1.1320.91
22_L25_Q1.1110.90
30_L40_L1.0900.89
22_L26_A1.0880.89
8_Q39_A1.0710.89
41_E45_A1.0540.88
33_H37_R1.0390.87
19_M23_A1.0280.86
9_E18_E0.9430.81
20_K23_A0.9270.80
28_K31_A0.8900.77
21_A25_Q0.8730.76
6_A9_E0.8660.75
35_D41_E0.8640.75
20_K24_A0.8570.75
10_A18_E0.8460.74
27_E31_A0.8030.70
11_I45_A0.7800.68
45_A48_A0.7620.66
8_Q46_E0.7540.65
24_A28_K0.7300.62
43_L47_I0.7120.60
14_G20_K0.7000.59
17_A24_A0.6950.59
10_A22_L0.6890.58
19_M43_L0.6860.58
11_I36_V0.6850.57
23_A31_A0.6840.57
32_E36_V0.6540.54
34_G41_E0.6310.51
4_G10_A0.6250.51
8_Q12_A0.6230.51
37_R51_E0.6200.50
22_L29_H0.6080.49
20_K41_E0.6050.48
41_E44_K0.5920.47
24_A37_R0.5910.47
33_H38_A0.5890.47
16_L30_L0.5830.46
37_R41_E0.5780.45
32_E42_A0.5750.45
23_A44_K0.5680.44
26_A47_I0.5610.44
39_A42_A0.5560.43
17_A21_A0.5430.42
14_G19_M0.5360.41
29_H40_L0.5310.40
1_P5_V0.5310.40
19_M26_A0.5250.40
25_Q43_L0.5250.40
5_V8_Q0.5150.39
5_V9_E0.5060.38
35_D48_A0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ra1A 1 0.9615 44.6 0.807 Contact Map
2a26A 4 0.9038 33.4 0.821 Contact Map
2hg7A 1 0.0769 27.6 0.828 Contact Map
3bbpD 2 0.6923 23.7 0.833 Contact Map
3t5vB 1 0.9808 20.5 0.838 Contact Map
1kd8A 1 0.6731 18.9 0.841 Contact Map
4cr2S 1 0.9231 18.7 0.841 Contact Map
1ysmA 1 0.8654 17.6 0.843 Contact Map
2iu8A 3 0.8654 15.1 0.847 Contact Map
3x2dB 3 0.9423 14.7 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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