GREMLIN Database
DUF1841 - Domain of unknown function (DUF1841)
PFAM: PF08897 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 135 (134)
Sequences: 4542 (2796)
Seq/√Len: 241.5
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_D101_E2.8881.00
15_K26_E2.7271.00
116_E120_S2.4611.00
109_C132_C2.4231.00
12_A30_A2.3981.00
16_H34_A2.2491.00
106_M133_L2.2061.00
5_V9_F2.2001.00
14_R18_A2.1351.00
96_L105_A2.0971.00
7_R11_D2.0891.00
80_D86_R2.0811.00
17_R44_E2.0761.00
74_R103_E2.0391.00
73_I106_M2.0291.00
112_E116_E1.9921.00
88_A133_L1.9311.00
32_V67_L1.8791.00
86_R90_E1.7731.00
88_A134_R1.7651.00
89_Y106_M1.7601.00
89_Y99_A1.7511.00
87_A91_R1.6741.00
88_A91_R1.6671.00
30_A34_A1.6661.00
28_L71_L1.6101.00
99_A103_E1.6091.00
8_F29_A1.5951.00
4_Q7_R1.5571.00
27_A31_D1.5411.00
42_L54_Y1.5391.00
11_D14_R1.5341.00
69_L107_M1.5311.00
131_E134_R1.4771.00
89_Y93_A1.4671.00
55_T58_G1.4661.00
9_F68_S1.4301.00
31_D35_E1.4201.00
7_R50_L1.4191.00
10_F49_A1.3951.00
85_I133_L1.3541.00
33_I43_L1.3421.00
80_D87_A1.2831.00
23_T26_E1.2781.00
52_R60_E1.2751.00
1_S4_Q1.2651.00
16_H30_A1.2641.00
77_L89_Y1.2381.00
42_L60_E1.2271.00
22_L30_A1.2201.00
93_A102_A1.2141.00
32_V74_R1.2121.00
5_V68_S1.2021.00
3_D51_D1.1881.00
56_P59_G1.1801.00
116_E122_R1.1721.00
101_E105_A1.1641.00
81_Q126_E1.1491.00
113_M132_C1.1491.00
1_S5_V1.1451.00
14_R20_E1.1451.00
116_E132_C1.1351.00
46_P50_L1.1311.00
41_A44_E1.1211.00
93_A99_A1.1171.00
28_L74_R1.1161.00
45_D48_A1.0761.00
76_Q129_Y1.0761.00
90_E94_A1.0721.00
24_P27_A1.0671.00
73_I107_M1.0331.00
13_W16_H1.0141.00
69_L111_G1.0071.00
35_E99_A1.0061.00
31_D74_R1.0021.00
24_P28_L0.9821.00
87_A90_E0.9801.00
31_D34_A0.9581.00
117_A124_P0.9551.00
54_Y60_E0.9541.00
80_D83_P0.9511.00
88_A92_L0.9491.00
80_D84_G0.9441.00
10_F46_P0.9421.00
84_G130_L0.9171.00
77_L99_A0.9151.00
16_H19_G0.8941.00
93_A96_L0.8861.00
89_Y103_E0.8850.99
127_A134_R0.8820.99
2_R53_D0.8810.99
115_W119_R0.8710.99
35_E74_R0.8640.99
28_L79_I0.8610.99
113_M124_P0.8590.99
8_F12_A0.8430.99
22_L27_A0.8370.99
42_L49_A0.8290.99
112_E132_C0.8240.99
12_A16_H0.8240.99
7_R46_P0.8230.99
5_V29_A0.8210.99
71_L79_I0.8050.99
5_V8_F0.8050.99
74_R99_A0.8010.99
10_F43_L0.7910.99
13_W40_H0.7830.99
13_W44_E0.7790.99
16_H31_D0.7710.99
15_K20_E0.7670.99
21_P24_P0.7400.98
9_F67_L0.7350.98
4_Q11_D0.7350.98
54_Y59_G0.7330.98
117_A123_P0.7250.98
116_E128_A0.7210.98
123_P126_E0.7190.98
130_L134_R0.7160.98
5_V10_F0.7090.98
66_H104_H0.7080.98
28_L78_S0.7080.98
70_H100_H0.7060.98
108_E111_G0.7020.97
28_L31_D0.6960.97
91_R94_A0.6900.97
56_P61_T0.6870.97
52_R58_G0.6840.97
90_E99_A0.6810.97
21_P27_A0.6710.97
89_Y102_A0.6610.96
85_I106_M0.6580.96
8_F23_T0.6570.96
58_G61_T0.6550.96
74_R89_Y0.6480.96
96_L102_A0.6470.96
128_A132_C0.6460.96
20_E23_T0.6460.96
113_M128_A0.6440.96
97_G102_A0.6430.96
43_L67_L0.6410.96
125_D128_A0.6380.96
96_L101_E0.6340.95
28_L75_E0.6330.95
77_L86_R0.6320.95
9_F29_A0.6320.95
107_M113_M0.6310.95
11_D23_T0.6270.95
29_A71_L0.6260.95
113_M116_E0.6220.95
23_T28_L0.6210.95
102_A105_A0.6180.95
93_A98_D0.6160.95
110_L114_L0.6120.94
32_V103_E0.6090.94
68_S72_A0.6080.94
25_L28_L0.6030.94
29_A68_S0.5980.94
2_R13_W0.5970.94
70_H104_H0.5940.94
11_D15_K0.5930.93
103_E107_M0.5920.93
68_S114_L0.5920.93
41_A45_D0.5900.93
40_H44_E0.5860.93
12_A33_I0.5790.93
126_E130_L0.5780.93
5_V72_A0.5780.93
127_A131_E0.5660.92
10_F16_H0.5650.92
85_I130_L0.5650.92
88_A106_M0.5640.92
48_A51_D0.5630.92
113_M126_E0.5590.91
99_A106_M0.5580.91
66_H70_H0.5580.91
35_E98_D0.5550.91
74_R78_S0.5520.91
16_H20_E0.5520.91
31_D99_A0.5510.91
56_P114_L0.5480.90
115_W118_Q0.5470.90
72_A77_L0.5450.90
74_R100_H0.5450.90
111_G124_P0.5430.90
94_A134_R0.5430.90
35_E103_E0.5410.90
83_P113_M0.5330.89
113_M117_A0.5310.89
81_Q114_L0.5310.89
72_A81_Q0.5290.89
45_D49_A0.5280.89
14_R46_P0.5270.89
48_A52_R0.5250.89
93_A131_E0.5250.89
33_I67_L0.5220.88
69_L103_E0.5220.88
7_R10_F0.5180.88
55_T60_E0.5080.87
15_K19_G0.5050.87
39_Y110_L0.5030.86
29_A32_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ashA 1 0.9333 39.2 0.917 Contact Map
1mbaA 1 0.9185 32.2 0.921 Contact Map
4d0h0 3 0.8889 31.1 0.921 Contact Map
2zs0D 1 0.9185 22.4 0.927 Contact Map
1x9fD 3 0.8889 21.3 0.927 Contact Map
1ecaA 1 0.8815 21.2 0.927 Contact Map
1x9fB 1 0.8963 20.6 0.928 Contact Map
1yhuA 2 0.9037 19.5 0.929 Contact Map
3wctC 1 0.8815 19.2 0.929 Contact Map
3wctD 1 0.8889 18.1 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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