GREMLIN Database
DUF1840 - Domain of unknown function (DUF1840)
PFAM: PF08895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (105)
Sequences: 3797 (2733)
Seq/√Len: 266.7
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_E97_R5.5131.00
10_A95_M2.5891.00
46_L93_I2.4191.00
38_L41_D2.3911.00
16_F19_V2.3351.00
47_A51_A2.3141.00
38_L105_D2.1101.00
26_L52_A2.0791.00
42_L100_A2.0771.00
96_L106_V2.0001.00
17_G21_R1.9771.00
84_S87_Q1.9631.00
44_A48_A1.9081.00
29_K32_T1.8911.00
53_I89_A1.7911.00
4_T12_D1.7541.00
57_E86_R1.7081.00
39_A105_D1.6341.00
8_K104_A1.6341.00
42_L96_L1.5811.00
9_A104_A1.5731.00
94_E98_R1.5191.00
2_L17_G1.4561.00
40_E105_D1.4431.00
9_A98_R1.4381.00
99_A106_V1.4151.00
7_S99_A1.3581.00
43_P100_A1.3521.00
3_V20_A1.3461.00
39_A42_L1.3411.00
51_A55_A1.3341.00
49_L93_I1.3321.00
89_A92_L1.3111.00
100_A103_G1.2941.00
22_R56_E1.2901.00
23_L89_A1.2661.00
40_E103_G1.2621.00
10_A98_R1.2511.00
37_I45_A1.2461.00
9_A102_A1.2351.00
6_K12_D1.2191.00
7_S10_A1.2111.00
22_R25_K1.1851.00
21_R31_G1.1851.00
44_A47_A1.1841.00
50_E54_A1.1541.00
26_L85_L1.1371.00
47_A50_E1.1361.00
87_Q90_W1.1341.00
19_V22_R1.1091.00
42_L46_L1.1051.00
7_S104_A1.0971.00
23_L92_L1.0801.00
21_R25_K1.0771.00
27_M37_I1.0421.00
55_A59_A1.0411.00
46_L96_L1.0231.00
54_A57_E0.9731.00
46_L100_A0.9561.00
13_V92_L0.9391.00
32_T35_G0.9381.00
4_T14_I0.9291.00
56_E59_A0.9111.00
13_V95_M0.9091.00
23_L85_L0.9041.00
29_K37_I0.8861.00
58_A61_A0.8811.00
29_K35_G0.8751.00
65_D68_D0.8631.00
59_A62_A0.8410.99
8_K105_D0.8390.99
97_R101_A0.8300.99
97_R100_A0.8110.99
20_A23_L0.8100.99
46_L97_R0.7950.99
62_A66_E0.7910.99
2_L14_I0.7880.99
94_E97_R0.7810.99
90_W94_E0.7770.99
76_D79_E0.7760.99
3_V21_R0.7740.99
62_A65_D0.7710.99
53_I93_I0.7690.99
17_G33_V0.7540.99
37_I105_D0.7530.99
26_L56_E0.7520.99
41_D44_A0.7480.99
46_L50_E0.7370.99
88_R91_P0.7370.99
29_K41_D0.7330.99
30_S34_P0.7250.99
93_I97_R0.7150.98
36_I107_V0.7150.98
43_P46_L0.7090.98
43_P47_A0.7010.98
15_M19_V0.6870.98
81_P84_S0.6870.98
48_A51_A0.6840.98
78_P81_P0.6830.98
66_E73_E0.6780.98
56_E60_P0.6760.98
10_A94_E0.6750.98
92_L96_L0.6700.98
27_M45_A0.6690.97
35_G108_W0.6660.97
98_R101_A0.6650.97
37_I96_L0.6640.97
52_A56_E0.6620.97
18_D22_R0.6610.97
26_L53_I0.6560.97
2_L16_F0.6480.97
22_R85_L0.6460.97
3_V16_F0.6460.97
25_K41_D0.6410.97
73_E78_P0.6270.96
25_K31_G0.6230.96
10_A13_V0.6230.96
69_A73_E0.6120.96
63_A67_A0.6100.96
69_A77_E0.6080.96
79_E82_P0.5990.95
73_E77_E0.5960.95
67_A78_P0.5940.95
3_V6_K0.5920.95
55_A58_A0.5890.95
36_I92_L0.5870.95
61_A65_D0.5840.95
60_P64_E0.5800.94
74_G79_E0.5800.94
77_E80_E0.5750.94
74_G77_E0.5730.94
95_M106_V0.5730.94
15_M23_L0.5720.94
20_A24_L0.5720.94
24_L29_K0.5710.94
53_I57_E0.5710.94
38_L42_L0.5680.94
19_V83_V0.5550.93
57_E60_P0.5500.93
54_A58_A0.5460.92
21_R24_L0.5440.92
96_L100_A0.5430.92
6_K103_G0.5370.92
22_R26_L0.5350.92
75_E79_E0.5350.92
39_A43_P0.5340.92
27_M92_L0.5310.91
26_L48_A0.5280.91
74_G78_P0.5160.90
49_L89_A0.5130.90
64_E77_E0.5120.90
14_I17_G0.5100.90
39_A103_G0.5090.90
11_G94_E0.5090.90
42_L93_I0.5040.89
8_K102_A0.5030.89
73_E76_D0.5000.89
69_A76_D0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ga8A 1 0.3241 16.8 0.908 Contact Map
3ph9A 1 0.5463 14.4 0.911 Contact Map
3fk8A 1 0.4722 9.5 0.918 Contact Map
3ihsA 1 0.4907 9.4 0.918 Contact Map
1kklH 1 0.5463 9.2 0.918 Contact Map
3cptA 1 0.4537 7.8 0.921 Contact Map
1ka5A 1 0.5463 6.9 0.923 Contact Map
4ifdD 1 0.5278 6.4 0.924 Contact Map
3iraA 1 0.713 6.3 0.924 Contact Map
1pchA 1 0.5556 6.2 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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