GREMLIN Database
DUF1838 - Protein of unknown function (DUF1838)
PFAM: PF08894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 236 (224)
Sequences: 1422 (1016)
Seq/√Len: 67.9
META: 0.897

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_P204_A4.7781.00
76_E175_K4.1461.00
152_D155_L3.9281.00
14_G73_W3.5411.00
70_E75_G3.4121.00
70_E77_T3.2351.00
149_D159_P3.0671.00
26_G63_G2.9831.00
68_T77_T2.8751.00
203_R207_E2.8021.00
68_T79_E2.5821.00
69_W174_M2.5491.00
205_Y209_N2.5481.00
193_D197_E2.5161.00
26_G58_T2.4741.00
106_V150_L2.3951.00
226_E230_T2.3621.00
194_S197_E2.3291.00
23_P60_P2.2921.00
146_S149_D2.2731.00
149_D152_D2.2671.00
128_R175_K2.2621.00
157_S191_K2.2521.00
23_P26_G2.1561.00
19_E22_K2.1091.00
105_T146_S2.0381.00
207_E214_L1.9851.00
17_P180_P1.9771.00
101_V147_L1.9521.00
16_V19_E1.9421.00
121_A124_G1.9071.00
129_E232_F1.8961.00
28_E58_T1.8491.00
162_G189_G1.8411.00
67_D209_N1.8061.00
59_D62_T1.7981.00
40_D46_G1.7461.00
11_T23_P1.7311.00
5_V32_V1.6820.99
118_N131_G1.6500.99
192_L197_E1.6010.99
26_G60_P1.6000.99
16_V180_P1.5840.99
149_D155_L1.5750.99
201_D204_A1.5660.99
123_P130_S1.5610.99
226_E231_Y1.5430.99
60_P63_G1.5260.99
204_A208_K1.5160.99
155_L158_A1.4710.99
147_L151_L1.4680.99
67_D205_Y1.4650.99
41_G46_G1.4640.99
7_W28_E1.4340.98
115_F134_T1.4090.98
200_P203_R1.4030.98
30_M206_I1.3860.98
74_T176_M1.3860.98
76_E128_R1.3700.98
38_V48_R1.3610.98
38_V46_G1.3530.98
117_P134_T1.3140.97
19_E73_W1.3110.97
145_G158_A1.2870.97
12_V183_L1.2640.96
64_E201_D1.2580.96
106_V147_L1.2540.96
205_Y208_K1.2510.96
121_A127_P1.2400.96
22_K73_W1.2390.96
126_Y233_K1.2310.96
24_L69_W1.2150.95
85_N166_R1.1900.95
105_T161_T1.1860.95
153_P156_T1.1780.94
124_G127_P1.1630.94
155_L159_P1.1600.94
71_N176_M1.1550.94
195_F203_R1.1530.94
168_S185_Y1.1470.94
71_N74_T1.1270.93
53_E85_N1.1250.93
14_G22_K1.1190.93
123_P132_G1.0940.92
14_G24_L1.0920.92
104_D148_A1.0910.92
228_S231_Y1.0890.92
11_T26_G1.0790.91
95_F99_W1.0730.91
99_W103_G1.0690.91
55_G83_V1.0690.91
139_E166_R1.0680.91
94_P99_W1.0610.91
116_Y141_F1.0450.90
65_I205_Y1.0400.90
56_F206_I1.0350.90
31_N53_E1.0340.90
204_A207_E1.0210.89
84_A210_Y1.0200.89
69_W78_V1.0190.89
129_E175_K1.0170.89
57_Y171_L1.0120.89
31_N51_S1.0120.89
57_Y164_W1.0100.88
5_V195_F1.0100.88
198_L206_I0.9780.87
78_V175_K0.9780.87
126_Y175_K0.9760.87
16_V73_W0.9670.86
140_L186_H0.9670.86
195_F207_E0.9590.86
126_Y129_E0.9520.85
67_D82_H0.9510.85
34_R216_A0.9490.85
58_T201_D0.9410.85
97_L103_G0.9390.85
106_V145_G0.9350.84
12_V25_F0.9320.84
55_G187_A0.9300.84
167_I182_H0.9280.84
95_F98_P0.9170.83
72_P176_M0.9170.83
27_V187_A0.9150.83
107_W144_F0.9140.83
123_P178_G0.9120.83
56_F65_I0.9110.83
52_R86_D0.9110.83
14_G170_W0.9070.82
52_R164_W0.8970.82
36_V50_V0.8940.81
14_G19_E0.8910.81
227_T230_T0.8900.81
150_L158_A0.8780.80
230_T233_K0.8730.80
174_M183_L0.8700.80
8_W29_G0.8660.79
104_D146_S0.8630.79
64_E204_A0.8630.79
111_D140_L0.8610.79
48_R91_R0.8610.79
170_W181_G0.8570.79
123_P126_Y0.8540.78
53_E87_P0.8540.78
15_R21_D0.8530.78
167_I184_V0.8500.78
12_V185_Y0.8500.78
96_P99_W0.8410.77
169_P177_G0.8400.77
218_P221_D0.8330.77
125_E233_K0.8270.76
52_R217_P0.8230.76
101_V106_V0.8210.76
205_Y210_Y0.8150.75
48_R220_D0.8140.75
138_S184_V0.8120.75
59_D63_G0.8060.74
225_N230_T0.8020.74
108_L143_F0.7900.73
198_L203_R0.7900.73
85_N139_E0.7860.72
51_S90_G0.7840.72
203_R214_L0.7770.72
195_F214_L0.7760.71
112_I141_F0.7740.71
52_R166_R0.7670.71
85_N89_N0.7630.70
9_S28_E0.7600.70
16_V22_K0.7580.70
169_P178_G0.7540.69
15_R182_H0.7520.69
196_D214_L0.7510.69
164_W185_Y0.7510.69
127_P130_S0.7500.69
24_L73_W0.7490.69
111_D186_H0.7490.69
54_V213_Y0.7470.69
56_F202_L0.7460.68
5_V8_W0.7460.68
8_W55_G0.7450.68
7_W61_K0.7420.68
206_I210_Y0.7390.68
163_S186_H0.7320.67
70_E74_T0.7320.67
145_G191_K0.7290.67
200_P208_K0.7280.67
108_L117_P0.7280.67
24_L170_W0.7220.66
90_G110_F0.7220.66
123_P131_G0.7210.66
27_V35_C0.7130.65
170_W176_M0.7110.65
224_P230_T0.7090.65
100_Q103_G0.7050.64
57_Y166_R0.6980.63
9_S100_Q0.6960.63
74_T78_V0.6930.63
52_R85_N0.6930.63
196_D203_R0.6920.63
168_S228_S0.6910.63
83_V164_W0.6840.62
73_W170_W0.6820.62
219_E222_E0.6810.61
158_A191_K0.6790.61
226_E232_F0.6740.61
202_L206_I0.6720.60
58_T65_I0.6720.60
94_P97_L0.6720.60
128_R134_T0.6710.60
135_Y164_W0.6710.60
194_S198_L0.6680.60
86_D116_Y0.6640.59
105_T110_F0.6640.59
165_T184_V0.6590.59
53_E172_P0.6580.59
33_R47_Y0.6580.59
124_G133_P0.6560.59
16_V20_R0.6560.59
118_N121_A0.6530.58
118_N130_S0.6510.58
194_S199_P0.6500.58
103_G107_W0.6470.57
215_E218_P0.6430.57
120_L164_W0.6430.57
166_R185_Y0.6410.57
140_L163_S0.6410.57
58_T63_G0.6370.56
85_N88_V0.6370.56
54_V203_R0.6370.56
85_N185_Y0.6340.56
86_D89_N0.6320.56
67_D208_K0.6310.56
66_L170_W0.6300.55
160_A189_G0.6280.55
49_L90_G0.6260.55
85_N164_W0.6240.55
225_N231_Y0.6230.55
67_D79_E0.6220.55
112_I116_Y0.6210.54
5_V192_L0.6200.54
170_W179_R0.6190.54
52_R141_F0.6190.54
34_R50_V0.6170.54
141_F166_R0.6160.54
134_T177_G0.6150.54
72_P181_G0.6130.53
118_N127_P0.6110.53
31_N141_F0.6090.53
227_T233_K0.6090.53
38_V41_G0.6060.53
103_G152_D0.6050.53
116_Y119_P0.6040.52
105_T144_F0.6030.52
102_L107_W0.6010.52
166_R172_P0.5990.52
80_V173_W0.5970.52
69_W80_V0.5950.51
72_P150_L0.5930.51
61_K190_R0.5910.51
26_G29_G0.5900.51
140_L184_V0.5900.51
74_T179_R0.5880.50
86_D139_E0.5880.50
131_G178_G0.5880.50
85_N174_M0.5880.50
103_G197_E0.5870.50
187_A206_I0.5840.50
97_L110_F0.5840.50
15_R184_V0.5830.50
24_L232_F0.5820.50
75_G94_P0.5810.50
97_L108_L0.5800.50
50_V89_N0.5790.49
70_E76_E0.5790.49
32_V195_F0.5790.49
163_S189_G0.5790.49
37_P47_Y0.5780.49
71_N181_G0.5780.49
5_V9_S0.5780.49
12_V27_V0.5780.49
31_N85_N0.5780.49
123_P133_P0.5770.49
47_Y145_G0.5740.49
11_T60_P0.5700.48
57_Y228_S0.5670.48
99_W104_D0.5640.48
31_N52_R0.5600.47
57_Y185_Y0.5590.47
76_E179_R0.5580.47
124_G130_S0.5560.47
148_A154_D0.5520.46
131_G135_Y0.5480.46
136_H182_H0.5480.46
53_E174_M0.5460.45
222_E227_T0.5450.45
103_G106_V0.5420.45
119_P177_G0.5420.45
51_S189_G0.5410.45
142_T186_H0.5400.45
176_M179_R0.5390.45
127_P131_G0.5380.45
110_F143_F0.5370.44
86_D166_R0.5330.44
145_G150_L0.5320.44
51_S84_A0.5310.44
89_N164_W0.5280.43
6_Y33_R0.5280.43
100_Q107_W0.5280.43
226_E229_W0.5270.43
166_R171_L0.5260.43
193_D215_E0.5250.43
165_T186_H0.5250.43
94_P102_L0.5230.43
8_W31_N0.5220.43
49_L143_F0.5220.43
222_E230_T0.5220.43
34_R53_E0.5210.43
113_P132_G0.5210.43
99_W169_P0.5180.42
160_A163_S0.5180.42
225_N229_W0.5180.42
145_G149_D0.5160.42
102_L105_T0.5160.42
139_E164_W0.5150.42
61_K154_D0.5150.42
107_W188_A0.5150.42
87_P137_A0.5150.42
25_F69_W0.5130.42
17_P130_S0.5120.41
214_L219_E0.5120.41
137_A166_R0.5110.41
118_N135_Y0.5100.41
36_V48_R0.5050.41
90_G165_T0.5050.41
100_Q146_S0.5020.40
81_V231_Y0.5000.40
159_P193_D0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pjoK 1 0.178 9.6 0.96 Contact Map
3elgA 1 0.2034 8.8 0.961 Contact Map
4dsdA 1 0.1949 7 0.962 Contact Map
1wizA 1 0.322 5.2 0.965 Contact Map
3db7A 2 0.2034 5.1 0.965 Contact Map
4qoaA 2 0.1992 5 0.965 Contact Map
2gu3A 1 0.2627 4.8 0.965 Contact Map
2mxeA 1 0.1568 4.6 0.966 Contact Map
4cfgA 2 0 3.4 0.968 Contact Map
2o4aA 1 0.2542 3.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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