GREMLIN Database
DUF1839 - Domain of unknown function (DUF1839)
PFAM: PF08893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 312 (310)
Sequences: 900 (692)
Seq/√Len: 39.3
META: 0.821

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_A247_H5.4511.00
132_R151_D5.2451.00
100_V122_I4.5081.00
135_G142_Y4.4111.00
41_A60_P3.6721.00
114_R148_E3.4161.00
249_R267_R3.3791.00
43_G247_H3.2471.00
204_F237_L3.2361.00
58_F239_A3.1451.00
43_G187_A3.1101.00
266_F306_A3.0491.00
97_L121_T2.9771.00
31_L41_A2.9401.00
249_R263_A2.9391.00
129_P150_F2.9371.00
184_R254_H2.9101.00
102_S120_T2.8701.00
87_A129_P2.8181.00
145_L153_L2.8161.00
83_E150_F2.7431.00
134_L145_L2.6961.00
30_L95_L2.6601.00
16_T270_A2.5661.00
88_E210_R2.5331.00
201_D206_R2.5081.00
210_R214_D2.5071.00
135_G144_E2.4591.00
208_A300_A2.3511.00
67_A193_R2.3471.00
86_V124_I2.2811.00
208_A296_L2.2361.00
71_I171_V2.1770.99
133_R146_E2.1720.99
140_A143_F2.1550.99
46_L244_A2.1490.99
262_A309_A2.0890.99
31_L71_I2.0630.99
304_D308_A2.0510.99
198_R311_A2.0430.99
90_L127_I1.9550.99
102_S118_V1.9510.99
27_W73_V1.8850.98
125_N142_Y1.8420.98
191_L247_H1.8360.98
178_L186_A1.8070.98
157_G160_D1.7350.97
44_F61_P1.7280.97
30_L123_A1.7220.97
102_S112_S1.7180.97
198_R307_M1.7070.97
76_L170_F1.7050.97
157_G162_P1.7000.97
48_Q240_A1.7000.97
41_A69_Y1.6940.97
26_L120_T1.6730.96
208_A297_D1.6310.96
37_E40_A1.5800.95
179_S182_E1.5760.95
104_Y152_G1.5710.95
221_R225_F1.5650.95
205_A300_A1.5260.94
71_I170_F1.4800.93
265_A305_R1.4760.93
185_A189_A1.4730.93
245_A266_F1.4730.93
27_W31_L1.4460.92
8_H38_P1.4270.91
26_L123_A1.4220.91
112_S116_E1.4170.91
268_R305_R1.4170.91
272_G299_M1.4160.91
133_R144_E1.4060.91
241_F269_I1.4050.91
205_A304_D1.4020.91
24_V44_F1.3850.90
86_V154_F1.3650.89
19_E140_A1.3580.89
51_E89_Q1.3500.89
100_V105_L1.3420.89
226_F277_Q1.3280.88
155_R162_P1.3240.88
161_P164_L1.3210.88
190_L194_H1.3090.87
10_L28_I1.3090.87
241_F306_A1.3010.87
40_A43_G1.2980.87
265_A268_R1.2910.87
111_T115_R1.2870.86
97_L123_A1.2830.86
268_R302_A1.2820.86
48_Q55_W1.2750.86
23_Y57_F1.2650.85
188_R192_R1.2460.84
83_E127_I1.2310.84
217_W221_R1.1990.82
155_R163_V1.1780.81
194_H197_R1.1780.81
137_F142_Y1.1640.80
104_Y148_E1.1610.80
302_A305_R1.1560.80
226_F278_F1.1550.80
66_E197_R1.1460.79
69_Y103_F1.1420.79
218_L225_F1.1410.79
16_T267_R1.1390.79
71_I173_F1.1390.79
49_D206_R1.1310.78
151_D156_L1.1260.78
279_K286_R1.1210.78
34_L173_F1.1120.77
273_A299_M1.0930.76
78_I168_A1.0890.75
269_I302_A1.0800.75
112_S118_V1.0730.74
8_H11_H1.0620.74
162_P166_P1.0490.73
255_G258_G1.0480.73
2_P144_E1.0440.72
161_P166_P1.0430.72
77_A233_T1.0410.72
50_F72_D1.0320.71
126_A135_G1.0300.71
45_T58_F1.0270.71
44_F58_F1.0250.71
89_Q97_L1.0250.71
116_E228_A1.0220.71
120_T152_G1.0180.70
252_A259_L1.0100.70
180_G186_A1.0060.69
82_L154_F1.0030.69
7_P13_E1.0030.69
130_E133_R1.0030.69
127_I165_P0.9980.69
161_P165_P0.9960.69
132_R148_E0.9890.68
237_L273_A0.9800.67
242_E246_S0.9610.66
268_R298_P0.9520.65
145_L154_F0.9510.65
37_E254_H0.9500.65
36_L177_R0.9470.65
12_G15_R0.9460.65
61_P194_H0.9450.65
260_A264_A0.9440.64
217_W225_F0.9440.64
51_E56_T0.9410.64
77_A232_A0.9400.64
62_L73_V0.9320.63
204_F241_F0.9270.63
83_E154_F0.9260.63
160_D163_V0.9220.63
55_W80_R0.9210.63
201_D209_A0.9150.62
2_P135_G0.9100.62
118_V165_P0.8990.61
247_H251_L0.8980.61
268_R271_E0.8970.60
268_R272_G0.8940.60
88_E91_A0.8900.60
46_L191_L0.8890.60
159_P163_V0.8850.59
202_N300_A0.8820.59
182_E186_A0.8820.59
186_A189_A0.8790.59
23_Y59_K0.8790.59
8_H39_L0.8740.58
22_C59_K0.8730.58
301_A304_D0.8730.58
94_R172_K0.8700.58
204_F269_I0.8700.58
211_F296_L0.8690.58
57_F99_E0.8660.58
49_D53_D0.8650.58
87_A127_I0.8640.58
124_I134_L0.8610.57
297_D301_A0.8570.57
155_R166_P0.8510.56
42_L194_H0.8450.56
39_L246_S0.8450.56
267_R271_E0.8360.55
77_A122_I0.8330.55
176_P180_G0.8330.55
139_N197_R0.8320.55
112_S122_I0.8290.54
48_Q244_A0.8280.54
55_W244_A0.8270.54
27_W236_Q0.8260.54
216_P220_E0.8230.54
18_P140_A0.8210.54
155_R159_P0.8210.54
104_Y114_R0.8200.54
126_A133_R0.8190.54
234_L276_L0.8160.53
43_G190_L0.8150.53
59_K231_F0.8120.53
115_R120_T0.8110.53
184_R188_R0.8110.53
261_A264_A0.8110.53
214_D217_W0.8050.52
53_D56_T0.8050.52
80_R210_R0.8040.52
15_R246_S0.8020.52
80_R84_E0.8020.52
89_Q123_A0.7950.51
30_L171_V0.7930.51
194_H198_R0.7930.51
7_P140_A0.7900.51
229_Y280_L0.7900.51
175_R222_G0.7880.51
164_L167_Y0.7880.51
120_T123_A0.7840.50
188_R260_A0.7830.50
17_W236_Q0.7830.50
244_A266_F0.7830.50
52_G88_E0.7810.50
249_R260_A0.7770.50
202_N304_D0.7760.50
277_Q286_R0.7750.50
104_Y162_P0.7740.49
157_G161_P0.7740.49
42_L45_T0.7720.49
66_E72_D0.7710.49
26_L270_A0.7680.49
189_A192_R0.7680.49
59_K167_Y0.7660.49
55_W79_W0.7660.49
120_T139_N0.7640.49
84_E129_P0.7620.48
245_A249_R0.7610.48
123_A141_G0.7600.48
94_R230_A0.7590.48
181_A185_A0.7570.48
303_W307_M0.7560.48
284_V287_K0.7550.48
178_L182_E0.7530.48
80_R165_P0.7490.47
59_K75_E0.7470.47
22_C227_H0.7460.47
90_L124_I0.7460.47
76_L110_G0.7440.47
244_A247_H0.7430.47
100_V120_T0.7400.46
274_K278_F0.7380.46
58_F207_F0.7350.46
32_H37_E0.7350.46
83_E86_V0.7340.46
272_G302_A0.7340.46
286_R292_L0.7330.46
29_E32_H0.7310.46
189_A200_A0.7290.45
100_V168_A0.7280.45
155_R161_P0.7240.45
77_A279_K0.7240.45
31_L36_L0.7230.45
17_W277_Q0.7230.45
22_C57_F0.7200.45
89_Q94_R0.7190.44
61_P85_H0.7180.44
131_A146_E0.7180.44
188_R258_G0.7140.44
59_K119_K0.7130.44
45_T244_A0.7110.44
211_F234_L0.7100.44
142_Y237_L0.7030.43
2_P5_Y0.7010.43
300_A304_D0.7010.43
127_I230_A0.7000.43
49_D61_P0.6990.43
8_H40_A0.6980.43
55_W232_A0.6970.43
22_C231_F0.6940.42
65_L296_L0.6930.42
119_K227_H0.6930.42
24_V27_W0.6880.42
190_L304_D0.6880.42
67_A189_A0.6880.42
51_E172_K0.6870.42
173_F177_R0.6840.41
27_W36_L0.6820.41
286_R289_P0.6790.41
125_N137_F0.6780.41
46_L247_H0.6780.41
162_P165_P0.6750.41
168_A229_Y0.6750.41
127_I241_F0.6740.40
79_W217_W0.6740.40
97_L171_V0.6720.40
158_A162_P0.6710.40
73_V208_A0.6690.40
188_R264_A0.6690.40
280_L284_V0.6690.40
227_H231_F0.6690.40
122_I134_L0.6690.40
66_E79_W0.6660.40
78_I170_F0.6610.39
43_G55_W0.6590.39
6_R12_G0.6590.39
225_F228_A0.6580.39
97_L229_Y0.6550.39
232_A240_A0.6540.39
190_L239_A0.6530.39
146_E264_A0.6520.39
291_D294_P0.6520.39
61_P65_L0.6510.38
247_H250_W0.6480.38
275_A279_K0.6480.38
157_G164_L0.6470.38
274_K281_A0.6460.38
57_F231_F0.6450.38
81_P153_L0.6450.38
91_A301_A0.6450.38
50_F53_D0.6430.38
119_K231_F0.6420.38
80_R214_D0.6420.38
294_P297_D0.6420.38
60_P226_F0.6380.37
126_A144_E0.6380.37
83_E129_P0.6380.37
194_H206_R0.6380.37
280_L286_R0.6370.37
22_C119_K0.6370.37
75_E119_K0.6360.37
181_A216_P0.6350.37
153_L271_E0.6310.37
17_W27_W0.6290.37
77_A170_F0.6280.37
24_V77_A0.6280.37
232_A303_W0.6270.36
263_A267_R0.6250.36
262_A265_A0.6250.36
51_E94_R0.6240.36
13_E18_P0.6240.36
184_R258_G0.6230.36
125_N135_G0.6190.36
134_L142_Y0.6190.36
143_F234_L0.6170.36
57_F118_V0.6170.36
206_R215_L0.6170.36
72_D174_D0.6170.36
28_I32_H0.6110.35
172_K240_A0.6100.35
19_E22_C0.6100.35
47_A168_A0.6070.35
95_L123_A0.6030.34
209_A213_A0.6020.34
289_P298_P0.5990.34
205_A213_A0.5970.34
163_V166_P0.5940.34
82_L98_V0.5930.34
22_C25_D0.5920.34
37_E183_L0.5910.33
299_M303_W0.5890.33
30_L177_R0.5890.33
272_G295_A0.5840.33
20_T167_Y0.5830.33
185_A213_A0.5830.33
263_A310_L0.5820.33
145_L195_L0.5810.33
148_E152_G0.5800.33
59_K227_H0.5790.32
50_F207_F0.5790.32
20_T89_Q0.5760.32
298_P301_A0.5760.32
74_Q121_T0.5750.32
119_K167_Y0.5750.32
64_D172_K0.5750.32
12_G18_P0.5730.32
81_P84_E0.5700.32
80_R266_F0.5690.32
266_F291_D0.5670.32
280_L292_L0.5670.32
278_F286_R0.5660.31
300_A303_W0.5640.31
184_R256_E0.5630.31
191_L207_F0.5630.31
78_I236_Q0.5620.31
10_L208_A0.5610.31
104_Y229_Y0.5600.31
182_E308_A0.5590.31
155_R160_D0.5590.31
90_L96_V0.5580.31
291_D306_A0.5580.31
5_Y8_H0.5580.31
207_F233_T0.5570.31
57_F167_Y0.5570.31
205_A209_A0.5570.31
246_S249_R0.5560.31
57_F119_K0.5530.30
176_P186_A0.5520.30
173_F241_F0.5490.30
64_D140_A0.5490.30
224_A270_A0.5460.30
124_I163_V0.5450.30
85_H121_T0.5440.30
299_M307_M0.5440.30
184_R253_A0.5430.30
13_E16_T0.5430.30
257_A260_A0.5420.30
112_S278_F0.5420.30
42_L243_L0.5410.30
236_Q252_A0.5400.29
174_D272_G0.5380.29
261_A265_A0.5380.29
260_A263_A0.5370.29
83_E156_L0.5370.29
240_A244_A0.5360.29
80_R232_A0.5360.29
283_A290_F0.5340.29
102_S139_N0.5340.29
255_G259_L0.5330.29
262_A272_G0.5330.29
82_L228_A0.5320.29
245_A267_R0.5300.29
184_R255_G0.5290.29
55_W290_F0.5270.28
76_L239_A0.5250.28
57_F139_N0.5250.28
87_A130_E0.5250.28
102_S155_R0.5240.28
237_L247_H0.5240.28
21_N25_D0.5230.28
39_L253_A0.5230.28
274_K279_K0.5220.28
77_A286_R0.5210.28
79_W240_A0.5210.28
234_L277_Q0.5200.28
181_A263_A0.5180.28
198_R240_A0.5180.28
208_A299_M0.5180.28
307_M311_A0.5170.28
81_P98_V0.5160.28
246_S267_R0.5150.28
97_L124_I0.5150.28
36_L69_Y0.5140.28
32_H156_L0.5110.27
145_L245_A0.5110.27
295_A306_A0.5110.27
28_I186_A0.5100.27
57_F75_E0.5090.27
204_F273_A0.5090.27
97_L170_F0.5080.27
104_Y112_S0.5080.27
67_A186_A0.5080.27
51_E57_F0.5080.27
239_A243_L0.5070.27
78_I120_T0.5070.27
92_R209_A0.5060.27
224_A228_A0.5060.27
89_Q92_R0.5060.27
81_P183_L0.5060.27
50_F55_W0.5050.27
78_I283_A0.5050.27
240_A277_Q0.5050.27
43_G61_P0.5050.27
111_T154_F0.5050.27
195_L311_A0.5050.27
63_E96_V0.5040.27
102_S116_E0.5030.27
49_D199_P0.5020.27
11_H29_E0.5020.27
264_A309_A0.5010.27
208_A212_A0.5010.27
170_F240_A0.5010.27
96_V168_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e0gA 1 0.141 19.9 0.979 Contact Map
4c18A 2 0.1827 16.2 0.98 Contact Map
1i76A 1 0.2115 12.9 0.981 Contact Map
4p72C 2 0.234 11.6 0.981 Contact Map
1b7yA 2 0.2404 10.9 0.981 Contact Map
3pcoA 2 0.2308 9.8 0.982 Contact Map
1y93A 1 0.2083 9.5 0.982 Contact Map
2jz1A 2 0.2051 9 0.982 Contact Map
3stqA 2 0.1731 7.9 0.982 Contact Map
4mhlA 1 0.4167 7.8 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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