GREMLIN Database
YqcI_YcgG - YqcI/YcgG family
PFAM: PF08892 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 215 (206)
Sequences: 1666 (1250)
Seq/√Len: 87.1
META: 0.639

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_Q95_D6.3241.00
33_Y48_D4.3561.00
125_V145_L4.0371.00
53_V123_F3.8661.00
34_D71_E3.6151.00
78_S81_E3.5981.00
15_P174_D3.2681.00
42_D89_R3.2541.00
136_K179_Q2.7781.00
31_G48_D2.5961.00
29_R55_E2.5911.00
155_R160_T2.5211.00
46_A118_F2.4771.00
31_G66_L2.4741.00
171_R182_I2.2111.00
106_S111_D2.1991.00
45_L68_A2.0811.00
50_L119_G2.0791.00
164_E167_R2.0571.00
93_L118_F2.0541.00
91_Q94_H2.0301.00
57_R121_E1.9501.00
83_E203_R1.9351.00
196_E200_Y1.9151.00
105_V115_S1.9011.00
86_L90_L1.8951.00
30_Y69_F1.8831.00
42_D93_L1.8461.00
69_F144_A1.8231.00
53_V119_G1.8201.00
6_R10_L1.7631.00
94_H101_W1.7621.00
136_K177_L1.7531.00
190_G199_Q1.6771.00
33_Y68_A1.6601.00
43_L96_L1.6501.00
33_Y45_L1.6431.00
4_E141_P1.6361.00
185_M198_R1.6011.00
104_R121_E1.5991.00
115_S196_E1.5841.00
211_K215_H1.5721.00
175_E182_I1.5141.00
5_F69_F1.5141.00
38_S41_D1.4961.00
102_D122_A1.4860.99
193_S197_A1.4690.99
22_A28_L1.4640.99
165_R169_K1.4120.99
41_D44_R1.3720.99
140_F144_A1.3500.99
50_L98_A1.3440.99
49_L147_F1.3430.99
46_A50_L1.3190.99
147_F153_F1.3000.99
36_L85_L1.2980.99
40_A99_E1.2960.99
212_C215_H1.2790.98
45_L93_L1.2770.98
30_Y67_V1.2690.98
67_V144_A1.2650.98
102_D105_V1.2550.98
15_P137_A1.2510.98
3_E7_A1.2500.98
118_F149_P1.2420.98
69_F142_Y1.2130.98
5_F9_I1.2090.98
49_L118_F1.2050.98
92_S96_L1.1810.97
79_E134_S1.1530.97
48_D66_L1.1500.97
45_L89_R1.1370.97
60_P64_T1.1320.97
115_S154_E1.0950.96
171_R175_E1.0800.96
94_H214_F1.0750.95
189_F196_E1.0710.95
18_G166_M1.0670.95
105_V117_S1.0640.95
165_R168_E1.0580.95
9_I13_D1.0580.95
81_E85_L1.0550.95
150_H157_R1.0470.95
88_Q92_S1.0400.95
89_R92_S1.0200.94
3_E6_R1.0120.94
190_G193_S0.9950.93
42_D92_S0.9940.93
202_G210_W0.9930.93
101_W214_F0.9900.93
32_F69_F0.9890.93
56_Y149_P0.9890.93
6_R23_L0.9830.93
190_G196_E0.9830.93
96_L118_F0.9820.93
42_D45_L0.9770.93
150_H190_G0.9740.92
180_G183_N0.9740.92
208_D211_K0.9730.92
8_F14_F0.9650.92
33_Y66_L0.9610.92
171_R188_D0.9570.92
175_E181_S0.9560.92
174_D180_G0.9490.91
14_F18_G0.9430.91
188_D191_E0.9370.91
90_L125_V0.9360.91
149_P167_R0.9320.91
44_R47_R0.9310.91
54_D119_G0.9280.91
70_F145_L0.9230.90
28_L67_V0.9210.90
54_D211_K0.9180.90
4_E11_D0.9180.90
109_P183_N0.9150.90
6_R30_Y0.9150.90
37_G85_L0.9140.90
150_H200_Y0.9110.90
56_Y121_E0.9070.89
198_R205_V0.8980.89
167_R188_D0.8970.89
23_L28_L0.8940.89
10_L23_L0.8930.89
18_G23_L0.8930.89
77_L131_A0.8900.89
90_L116_F0.8800.88
73_P85_L0.8780.88
65_S147_F0.8740.88
82_F129_H0.8740.88
29_R66_L0.8710.87
51_E78_S0.8610.87
126_V147_F0.8600.87
137_A146_V0.8540.86
47_R51_E0.8530.86
183_N202_G0.8520.86
5_F67_V0.8510.86
84_R107_S0.8420.86
106_S113_H0.8350.85
126_V152_Q0.8310.85
72_P76_D0.8290.85
196_E199_Q0.8290.85
35_D42_D0.8210.84
39_P92_S0.8160.84
129_H201_S0.8150.84
187_A191_E0.8090.83
169_K172_E0.8030.83
5_F155_R0.8010.83
4_E8_F0.8010.83
126_V146_V0.8000.83
96_L99_E0.7950.82
46_A96_L0.7940.82
153_F199_Q0.7920.82
40_A96_L0.7890.82
37_G72_P0.7810.81
84_R100_P0.7790.81
79_E129_H0.7780.81
152_Q174_D0.7740.81
105_V122_A0.7730.80
115_S186_L0.7560.79
23_L30_Y0.7460.78
162_R169_K0.7430.78
37_G89_R0.7420.78
121_E149_P0.7400.77
15_P19_A0.7400.77
67_V146_V0.7360.77
123_F149_P0.7360.77
90_L101_W0.7330.77
124_F130_P0.7310.77
141_P144_A0.7300.77
65_S122_A0.7300.77
77_L85_L0.7280.76
182_I185_M0.7270.76
82_F127_G0.7240.76
148_N152_Q0.7230.76
87_W97_D0.7220.76
46_A64_T0.7210.76
18_G124_F0.7160.75
137_A174_D0.7140.75
63_F102_D0.7130.75
183_N201_S0.7110.75
14_F149_P0.7040.74
49_L66_L0.7030.74
192_A198_R0.7020.74
86_L127_G0.7010.74
52_F66_L0.7000.73
7_A10_L0.6980.73
33_Y70_F0.6970.73
94_H116_F0.6960.73
129_H134_S0.6830.72
16_C19_A0.6830.72
133_A180_G0.6730.71
48_D68_A0.6730.71
43_L99_E0.6690.70
83_E210_W0.6620.69
83_E129_H0.6580.69
79_E201_S0.6570.69
128_L146_V0.6490.68
100_P120_G0.6450.67
150_H189_F0.6380.66
95_D214_F0.6360.66
28_L212_C0.6310.66
105_V190_G0.6310.66
70_F143_P0.6270.65
109_P197_A0.6260.65
148_N153_F0.6260.65
108_D111_D0.6240.65
24_A166_M0.6230.65
39_P43_L0.6220.65
130_P167_R0.6220.65
7_A110_D0.6200.64
19_A147_F0.6190.64
73_P107_S0.6180.64
65_S126_V0.6170.64
77_L81_E0.6170.64
117_S200_Y0.6170.64
129_H203_R0.6160.64
83_E166_M0.6150.64
27_Q192_A0.6150.64
148_N156_L0.6140.64
189_F199_Q0.6140.64
29_R145_L0.6120.63
51_E208_D0.6110.63
8_F140_F0.6110.63
43_L47_R0.6100.63
14_F22_A0.6090.63
137_A177_L0.6080.63
38_S42_D0.6070.63
91_Q214_F0.6040.62
18_G21_S0.6030.62
128_L183_N0.6020.62
177_L181_S0.6000.62
166_M170_I0.5990.62
31_G44_R0.5990.62
56_Y151_D0.5980.61
86_L201_S0.5950.61
102_D149_P0.5940.61
103_P211_K0.5920.61
135_R183_N0.5890.60
186_L190_G0.5860.60
193_S198_R0.5860.60
23_L162_R0.5840.60
53_V121_E0.5830.60
70_F89_R0.5830.60
75_E80_E0.5830.60
32_F71_E0.5830.60
58_A124_F0.5820.59
92_S99_E0.5820.59
160_T163_Y0.5820.59
14_F124_F0.5790.59
81_E84_R0.5790.59
17_V23_L0.5780.59
129_H148_N0.5770.59
205_V210_W0.5750.58
102_D117_S0.5750.58
23_L26_G0.5720.58
116_F171_R0.5710.58
24_A173_R0.5700.58
170_I193_S0.5640.57
152_Q201_S0.5630.57
146_V151_D0.5620.57
22_A65_S0.5610.57
80_E103_P0.5590.56
6_R100_P0.5580.56
82_F135_R0.5580.56
164_E168_E0.5570.56
17_V20_K0.5570.56
43_L92_S0.5520.55
56_Y66_L0.5510.55
174_D177_L0.5490.55
150_H199_Q0.5490.55
17_V124_F0.5480.55
34_D37_G0.5460.55
26_G47_R0.5450.55
111_D142_Y0.5440.54
38_S99_E0.5440.54
148_N180_G0.5420.54
180_G201_S0.5410.54
126_V148_N0.5400.54
107_S168_E0.5340.53
167_R187_A0.5340.53
115_S150_H0.5320.53
14_F126_V0.5310.53
46_A85_L0.5310.53
4_E51_E0.5300.52
204_D211_K0.5290.52
127_G152_Q0.5280.52
52_F94_H0.5270.52
19_A156_L0.5270.52
113_H212_C0.5250.52
163_Y189_F0.5240.52
150_H153_F0.5220.51
183_N210_W0.5200.51
20_K24_A0.5180.51
201_S210_W0.5170.51
143_P180_G0.5160.51
57_R61_G0.5150.50
19_A150_H0.5150.50
105_V154_E0.5130.50
50_L54_D0.5130.50
9_I88_Q0.5090.50
112_P120_G0.5070.49
105_V157_R0.5070.49
47_R75_E0.5060.49
85_L89_R0.5050.49
121_E167_R0.5040.49
72_P85_L0.5030.49
187_A192_A0.5020.49
6_R28_L0.5010.49
83_E205_V0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obuE 2 0.293 14.3 0.96 Contact Map
2dr1A 2 0.2837 10.9 0.962 Contact Map
3kgwA 2 0.2744 8.8 0.964 Contact Map
2hufA 2 0.2698 7.4 0.965 Contact Map
3k40A 2 0.2791 7.2 0.965 Contact Map
4p7xA 1 0.2977 5.8 0.966 Contact Map
2q2kA 3 0.2 5.4 0.967 Contact Map
4ritB 2 0.2698 5.4 0.967 Contact Map
2ch1A 2 0.2884 4.4 0.968 Contact Map
4l22A 1 0.3814 4.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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