GREMLIN Database
WbqC - WbqC-like protein family
PFAM: PF08889 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 217 (216)
Sequences: 12320 (10697)
Seq/√Len: 727.8
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_T181_E3.3241.00
14_I121_C2.8601.00
151_K176_A2.7571.00
78_L95_F2.7071.00
114_I132_R2.6741.00
150_C155_A2.3401.00
114_I118_R2.3181.00
19_V131_V2.3031.00
91_F95_F2.2871.00
79_K82_E2.2331.00
157_T179_E2.2091.00
4_Y77_H2.2081.00
106_W111_D2.2051.00
192_P211_C2.0951.00
66_E107_E2.0781.00
104_R115_A2.0711.00
82_E86_R2.0581.00
25_D133_S2.0521.00
53_K66_E1.9931.00
100_E119_A1.9491.00
29_T32_G1.9431.00
106_W115_A1.9211.00
19_V129_P1.8951.00
121_C130_I1.8701.00
97_L119_A1.8321.00
144_E172_L1.8071.00
108_N111_D1.7821.00
97_L123_Y1.7571.00
75_K79_K1.7461.00
38_R45_P1.7311.00
140_G148_D1.7271.00
25_D145_R1.7201.00
99_E103_E1.7001.00
119_A123_Y1.6861.00
94_Y123_Y1.6801.00
169_D172_L1.6791.00
28_Y35_N1.6631.00
66_E108_N1.6511.00
78_L99_E1.6421.00
148_D152_A1.6411.00
19_V153_L1.5911.00
22_L114_I1.5841.00
22_L130_I1.5621.00
194_L210_N1.5591.00
82_E99_E1.5531.00
171_E175_E1.5381.00
148_D151_K1.5321.00
12_D183_Q1.5261.00
170_E180_L1.4751.00
31_R58_G1.4581.00
68_D71_Q1.4561.00
147_L172_L1.4551.00
77_H102_Y1.4421.00
79_K83_Q1.4401.00
57_S60_Q1.4381.00
61_L64_E1.4051.00
119_A122_E1.3941.00
12_D16_A1.3921.00
207_L211_C1.3891.00
60_Q65_V1.3811.00
95_F99_E1.3751.00
124_L204_I1.3591.00
22_L117_I1.3421.00
113_N116_L1.3341.00
41_T84_N1.3321.00
24_D134_S1.3321.00
131_V135_E1.3281.00
212_G215_A1.3241.00
34_R62_I1.2881.00
29_T34_R1.2881.00
131_V136_L1.2781.00
23_L26_V1.2571.00
48_L77_H1.2491.00
21_V149_I1.2351.00
74_R105_E1.2291.00
46_Q80_T1.2281.00
147_L176_A1.2271.00
170_E182_F1.2201.00
21_V153_L1.2201.00
40_K195_H1.2161.00
53_K68_D1.1921.00
120_I204_I1.1901.00
101_I116_L1.1841.00
45_P199_V1.1821.00
93_E213_P1.1761.00
123_Y213_P1.1721.00
131_V153_L1.1701.00
165_R182_F1.1701.00
109_L113_N1.1561.00
211_C215_A1.1551.00
171_E174_E1.1501.00
39_I48_L1.1411.00
110_S114_I1.1351.00
88_A194_L1.1241.00
207_L215_A1.1201.00
170_E174_E1.1161.00
172_L175_E1.1071.00
90_Y93_E1.0981.00
41_T46_Q1.0901.00
136_L153_L1.0841.00
160_S168_L1.0821.00
13_L161_G1.0811.00
111_D132_R1.0801.00
50_V67_I1.0801.00
8_L200_P1.0761.00
38_R47_W1.0611.00
82_E95_F1.0591.00
67_I112_L1.0511.00
211_C214_E1.0431.00
160_S164_G1.0381.00
144_E148_D1.0381.00
165_R184_D1.0371.00
69_N74_R1.0371.00
39_I84_N1.0291.00
63_N134_S1.0271.00
76_K80_T1.0181.00
193_Q198_F1.0091.00
35_N49_T1.0051.00
94_Y208_L1.0011.00
43_N46_Q0.9951.00
90_Y212_G0.9891.00
138_L152_A0.9841.00
118_R130_I0.9821.00
132_R135_E0.9781.00
121_C128_T0.9771.00
143_T172_L0.9751.00
67_I109_L0.9721.00
72_D75_K0.9681.00
80_T83_Q0.9611.00
162_P165_R0.9561.00
172_L176_A0.9551.00
78_L103_E0.9521.00
50_V73_W0.9501.00
12_D15_A0.9481.00
44_G47_W0.9401.00
3_Y34_R0.9341.00
50_V112_L0.9291.00
83_Q86_R0.9221.00
23_L149_I0.9201.00
40_K196_G0.9111.00
60_Q64_E0.9101.00
106_W112_L0.9081.00
41_T44_G0.9071.00
137_G152_A0.9061.00
212_G216_I0.8951.00
21_V133_S0.8911.00
96_P99_E0.8841.00
162_P184_D0.8821.00
97_L122_E0.8701.00
207_L216_I0.8651.00
118_R121_C0.8611.00
31_R146_L0.8561.00
199_V202_L0.8551.00
3_Y10_Y0.8531.00
5_L116_L0.8531.00
42_P84_N0.8471.00
40_K199_V0.8391.00
10_Y20_F0.8351.00
168_L180_L0.8221.00
139_D148_D0.8221.00
5_L205_L0.8191.00
33_W38_R0.8191.00
122_E127_K0.8181.00
115_A119_A0.8161.00
101_I119_A0.8161.00
187_P190_E0.8161.00
78_L102_Y0.8151.00
75_K103_E0.8151.00
174_E179_E0.8081.00
94_Y209_F0.7981.00
138_L148_D0.7981.00
160_S182_F0.7971.00
32_G35_N0.7971.00
25_D61_L0.7931.00
61_L65_V0.7931.00
118_R122_E0.7921.00
143_T147_L0.7921.00
23_L145_R0.7911.00
91_F209_F0.7891.00
96_P100_E0.7881.00
94_Y97_L0.7871.00
165_R170_E0.7871.00
56_G60_Q0.7761.00
208_L216_I0.7751.00
187_P201_N0.7751.00
3_Y32_G0.7741.00
52_V65_V0.7721.00
16_A183_Q0.7681.00
94_Y119_A0.7671.00
115_A118_R0.7661.00
11_F117_I0.7631.00
39_I80_T0.7601.00
8_L207_L0.7601.00
133_S145_R0.7591.00
27_Q58_G0.7561.00
69_N105_E0.7521.00
100_E103_E0.7491.00
147_L151_K0.7481.00
11_F204_I0.7391.00
40_K194_L0.7351.00
3_Y29_T0.7341.00
97_L101_I0.7321.00
78_L91_F0.7321.00
93_E123_Y0.7311.00
141_K145_R0.7311.00
110_S132_R0.7241.00
10_Y117_I0.7211.00
3_Y13_L0.7181.00
15_A126_I0.7101.00
81_I98_L0.7101.00
147_L178_I0.7081.00
76_K79_K0.7061.00
10_Y14_I0.7061.00
121_C126_I0.7031.00
31_R35_N0.7031.00
3_Y7_W0.7021.00
74_R106_W0.6991.00
54_K57_S0.6921.00
125_G213_P0.6921.00
162_P183_Q0.6911.00
102_Y112_L0.6881.00
41_T80_T0.6841.00
93_E96_P0.6831.00
22_L118_R0.6821.00
40_K45_P0.6791.00
111_D114_I0.6781.00
27_Q59_N0.6721.00
23_L31_R0.6711.00
161_G164_G0.6681.00
118_R132_R0.6671.00
25_D63_N0.6661.00
81_I205_L0.6661.00
97_L100_E0.6621.00
168_L182_F0.6571.00
14_I130_I0.6511.00
28_Y52_V0.6511.00
113_N117_I0.6501.00
92_D96_P0.6481.00
90_Y213_P0.6481.00
100_E115_A0.6451.00
23_L133_S0.6441.00
143_T173_F0.6421.00
140_G143_T0.6391.00
45_P202_L0.6371.00
160_S180_L0.6351.00
80_T84_N0.6351.00
163_G166_D0.6351.00
34_R163_G0.6281.00
63_N132_R0.6271.00
16_A159_L0.6261.00
101_I115_A0.6211.00
41_T47_W0.6191.00
4_Y48_L0.6181.00
8_L188_H0.6131.00
82_E91_F0.6121.00
33_W37_N0.6101.00
101_I112_L0.6091.00
69_N106_W0.6091.00
35_N52_V0.6081.00
14_I128_T0.6061.00
69_N72_D0.6061.00
69_N107_E0.6031.00
137_G140_G0.6031.00
120_I208_L0.6011.00
13_L183_Q0.6011.00
123_Y208_L0.6001.00
125_G216_I0.6001.00
143_T169_D0.5971.00
94_Y213_P0.5961.00
92_D95_F0.5951.00
74_R102_Y0.5951.00
88_A210_N0.5921.00
22_L132_R0.5911.00
185_Y201_N0.5901.00
39_I81_I0.5891.00
168_L173_F0.5871.00
147_L173_F0.5841.00
86_R92_D0.5801.00
78_L82_E0.5761.00
185_Y189_P0.5741.00
14_I20_F0.5731.00
146_L168_L0.5701.00
94_Y98_L0.5681.00
13_L17_V0.5671.00
143_T146_L0.5601.00
38_R201_N0.5581.00
54_K66_E0.5571.00
70_D73_W0.5551.00
78_L98_L0.5551.00
141_K144_E0.5551.00
8_L185_Y0.5541.00
193_Q210_N0.5521.00
98_L209_F0.5491.00
190_E197_P0.5471.00
3_Y117_I0.5461.00
11_F124_L0.5441.00
160_S167_Y0.5431.00
136_L152_A0.5391.00
32_G163_G0.5381.00
159_L183_Q0.5371.00
42_P46_Q0.5361.00
63_N108_N0.5351.00
3_Y33_W0.5331.00
50_V113_N0.5321.00
100_E104_R0.5321.00
73_W77_H0.5311.00
117_I121_C0.5281.00
89_P192_P0.5261.00
30_K58_G0.5241.00
90_Y94_Y0.5241.00
105_E108_N0.5231.00
65_V109_L0.5231.00
11_F120_I0.5221.00
138_L145_R0.5191.00
92_D99_E0.5171.00
15_A128_T0.5131.00
136_L149_I0.5071.00
26_V145_R0.5071.00
50_V109_L0.5051.00
60_Q63_N0.5051.00
138_L141_K0.5040.99
41_T45_P0.5040.99
40_K193_Q0.5030.99
12_D159_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c1lA 2 0.4147 4.2 0.963 Contact Map
2b9iC 1 0.0645 3.7 0.964 Contact Map
3tk2A 1 0.212 3.4 0.964 Contact Map
2m19A 1 0.2488 3 0.965 Contact Map
3mw8A 1 0.2903 2.9 0.965 Contact Map
3onkA 1 0.3641 2.8 0.966 Contact Map
4ujpS 1 0.4424 2.7 0.966 Contact Map
4qb0A 1 0.2166 2.5 0.967 Contact Map
2g2nA 5 0.1751 2.4 0.967 Contact Map
3j60R 1 0.47 2.4 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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