WbqC - PFAM28P - GREMLIN Contacts

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WbqC - WbqC-like protein family

PFAM:	PF08889	Sequences: QPYYLPWLGYFDLIAAVDVFVLLDDVQYTKRGWRNRNRIKTPNGPQWLTVPVKKKGSGNQLINEVEIDNDQDWRKKHLKTIEQNYRKAPYFDEYFPLLEEIYEREWENLSDLNIALIRAICEYLGIKTPIVRSSELGLDGKKTERLLDICKALGATTYLSGPGGRDYLDEELFEEAGIELEFQDYSPHPEYPQLHGPFVPNLSILDLLFNCGPEAIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	217 (216)
Sequences:	12320 (10697)
Seq/√Len:	727.8
META:	0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_T	181_E	3.324	1.00
14_I	121_C	2.860	1.00
151_K	176_A	2.757	1.00
78_L	95_F	2.707	1.00
114_I	132_R	2.674	1.00
150_C	155_A	2.340	1.00
114_I	118_R	2.318	1.00
19_V	131_V	2.303	1.00
91_F	95_F	2.287	1.00
79_K	82_E	2.233	1.00
157_T	179_E	2.209	1.00
4_Y	77_H	2.208	1.00
106_W	111_D	2.205	1.00
192_P	211_C	2.095	1.00
66_E	107_E	2.078	1.00
104_R	115_A	2.071	1.00
82_E	86_R	2.058	1.00
25_D	133_S	2.052	1.00
53_K	66_E	1.993	1.00
100_E	119_A	1.949	1.00
29_T	32_G	1.943	1.00
106_W	115_A	1.921	1.00
19_V	129_P	1.895	1.00
121_C	130_I	1.870	1.00
97_L	119_A	1.832	1.00
144_E	172_L	1.807	1.00
108_N	111_D	1.782	1.00
97_L	123_Y	1.757	1.00
75_K	79_K	1.746	1.00
38_R	45_P	1.731	1.00
140_G	148_D	1.727	1.00
25_D	145_R	1.720	1.00
99_E	103_E	1.700	1.00
119_A	123_Y	1.686	1.00
94_Y	123_Y	1.680	1.00
169_D	172_L	1.679	1.00
28_Y	35_N	1.663	1.00
66_E	108_N	1.651	1.00
78_L	99_E	1.642	1.00
148_D	152_A	1.641	1.00
19_V	153_L	1.591	1.00
22_L	114_I	1.584	1.00
22_L	130_I	1.562	1.00
194_L	210_N	1.559	1.00
82_E	99_E	1.553	1.00
171_E	175_E	1.538	1.00
148_D	151_K	1.532	1.00
12_D	183_Q	1.526	1.00
170_E	180_L	1.475	1.00
31_R	58_G	1.458	1.00
68_D	71_Q	1.456	1.00
147_L	172_L	1.455	1.00
77_H	102_Y	1.442	1.00
79_K	83_Q	1.440	1.00
57_S	60_Q	1.438	1.00
61_L	64_E	1.405	1.00
119_A	122_E	1.394	1.00
12_D	16_A	1.392	1.00
207_L	211_C	1.389	1.00
60_Q	65_V	1.381	1.00
95_F	99_E	1.375	1.00
124_L	204_I	1.359	1.00
22_L	117_I	1.342	1.00
113_N	116_L	1.334	1.00
41_T	84_N	1.332	1.00
24_D	134_S	1.332	1.00
131_V	135_E	1.328	1.00
212_G	215_A	1.324	1.00
34_R	62_I	1.288	1.00
29_T	34_R	1.288	1.00
131_V	136_L	1.278	1.00
23_L	26_V	1.257	1.00
48_L	77_H	1.249	1.00
21_V	149_I	1.235	1.00
74_R	105_E	1.229	1.00
46_Q	80_T	1.228	1.00
147_L	176_A	1.227	1.00
170_E	182_F	1.220	1.00
21_V	153_L	1.220	1.00
40_K	195_H	1.216	1.00
53_K	68_D	1.192	1.00
120_I	204_I	1.190	1.00
101_I	116_L	1.184	1.00
45_P	199_V	1.182	1.00
93_E	213_P	1.176	1.00
123_Y	213_P	1.172	1.00
131_V	153_L	1.170	1.00
165_R	182_F	1.170	1.00
109_L	113_N	1.156	1.00
211_C	215_A	1.155	1.00
171_E	174_E	1.150	1.00
39_I	48_L	1.141	1.00
110_S	114_I	1.135	1.00
88_A	194_L	1.124	1.00
207_L	215_A	1.120	1.00
170_E	174_E	1.116	1.00
172_L	175_E	1.107	1.00
90_Y	93_E	1.098	1.00
41_T	46_Q	1.090	1.00
136_L	153_L	1.084	1.00
160_S	168_L	1.082	1.00
13_L	161_G	1.081	1.00
111_D	132_R	1.080	1.00
50_V	67_I	1.080	1.00
8_L	200_P	1.076	1.00
38_R	47_W	1.061	1.00
82_E	95_F	1.059	1.00
67_I	112_L	1.051	1.00
211_C	214_E	1.043	1.00
160_S	164_G	1.038	1.00
144_E	148_D	1.038	1.00
165_R	184_D	1.037	1.00
69_N	74_R	1.037	1.00
39_I	84_N	1.029	1.00
63_N	134_S	1.027	1.00
76_K	80_T	1.018	1.00
193_Q	198_F	1.009	1.00
35_N	49_T	1.005	1.00
94_Y	208_L	1.001	1.00
43_N	46_Q	0.995	1.00
90_Y	212_G	0.989	1.00
138_L	152_A	0.984	1.00
118_R	130_I	0.982	1.00
132_R	135_E	0.978	1.00
121_C	128_T	0.977	1.00
143_T	172_L	0.975	1.00
67_I	109_L	0.972	1.00
72_D	75_K	0.968	1.00
80_T	83_Q	0.961	1.00
162_P	165_R	0.956	1.00
172_L	176_A	0.955	1.00
78_L	103_E	0.952	1.00
50_V	73_W	0.950	1.00
12_D	15_A	0.948	1.00
44_G	47_W	0.940	1.00
3_Y	34_R	0.934	1.00
50_V	112_L	0.929	1.00
83_Q	86_R	0.922	1.00
23_L	149_I	0.920	1.00
40_K	196_G	0.911	1.00
60_Q	64_E	0.910	1.00
106_W	112_L	0.908	1.00
41_T	44_G	0.907	1.00
137_G	152_A	0.906	1.00
212_G	216_I	0.895	1.00
21_V	133_S	0.891	1.00
96_P	99_E	0.884	1.00
162_P	184_D	0.882	1.00
97_L	122_E	0.870	1.00
207_L	216_I	0.865	1.00
118_R	121_C	0.861	1.00
31_R	146_L	0.856	1.00
199_V	202_L	0.855	1.00
3_Y	10_Y	0.853	1.00
5_L	116_L	0.853	1.00
42_P	84_N	0.847	1.00
40_K	199_V	0.839	1.00
10_Y	20_F	0.835	1.00
168_L	180_L	0.822	1.00
139_D	148_D	0.822	1.00
5_L	205_L	0.819	1.00
33_W	38_R	0.819	1.00
122_E	127_K	0.818	1.00
115_A	119_A	0.816	1.00
101_I	119_A	0.816	1.00
187_P	190_E	0.816	1.00
78_L	102_Y	0.815	1.00
75_K	103_E	0.815	1.00
174_E	179_E	0.808	1.00
94_Y	209_F	0.798	1.00
138_L	148_D	0.798	1.00
160_S	182_F	0.797	1.00
32_G	35_N	0.797	1.00
25_D	61_L	0.793	1.00
61_L	65_V	0.793	1.00
118_R	122_E	0.792	1.00
143_T	147_L	0.792	1.00
23_L	145_R	0.791	1.00
91_F	209_F	0.789	1.00
96_P	100_E	0.788	1.00
94_Y	97_L	0.787	1.00
165_R	170_E	0.787	1.00
56_G	60_Q	0.776	1.00
208_L	216_I	0.775	1.00
187_P	201_N	0.775	1.00
3_Y	32_G	0.774	1.00
52_V	65_V	0.772	1.00
16_A	183_Q	0.768	1.00
94_Y	119_A	0.767	1.00
115_A	118_R	0.766	1.00
11_F	117_I	0.763	1.00
39_I	80_T	0.760	1.00
8_L	207_L	0.760	1.00
133_S	145_R	0.759	1.00
27_Q	58_G	0.756	1.00
69_N	105_E	0.752	1.00
100_E	103_E	0.749	1.00
147_L	151_K	0.748	1.00
11_F	204_I	0.739	1.00
40_K	194_L	0.735	1.00
3_Y	29_T	0.734	1.00
97_L	101_I	0.732	1.00
78_L	91_F	0.732	1.00
93_E	123_Y	0.731	1.00
141_K	145_R	0.731	1.00
110_S	132_R	0.724	1.00
10_Y	117_I	0.721	1.00
3_Y	13_L	0.718	1.00
15_A	126_I	0.710	1.00
81_I	98_L	0.710	1.00
147_L	178_I	0.708	1.00
76_K	79_K	0.706	1.00
10_Y	14_I	0.706	1.00
121_C	126_I	0.703	1.00
31_R	35_N	0.703	1.00
3_Y	7_W	0.702	1.00
74_R	106_W	0.699	1.00
54_K	57_S	0.692	1.00
125_G	213_P	0.692	1.00
162_P	183_Q	0.691	1.00
102_Y	112_L	0.688	1.00
41_T	80_T	0.684	1.00
93_E	96_P	0.683	1.00
22_L	118_R	0.682	1.00
40_K	45_P	0.679	1.00
111_D	114_I	0.678	1.00
27_Q	59_N	0.672	1.00
23_L	31_R	0.671	1.00
161_G	164_G	0.668	1.00
118_R	132_R	0.667	1.00
25_D	63_N	0.666	1.00
81_I	205_L	0.666	1.00
97_L	100_E	0.662	1.00
168_L	182_F	0.657	1.00
14_I	130_I	0.651	1.00
28_Y	52_V	0.651	1.00
113_N	117_I	0.650	1.00
92_D	96_P	0.648	1.00
90_Y	213_P	0.648	1.00
100_E	115_A	0.645	1.00
23_L	133_S	0.644	1.00
143_T	173_F	0.642	1.00
140_G	143_T	0.639	1.00
45_P	202_L	0.637	1.00
160_S	180_L	0.635	1.00
80_T	84_N	0.635	1.00
163_G	166_D	0.635	1.00
34_R	163_G	0.628	1.00
63_N	132_R	0.627	1.00
16_A	159_L	0.626	1.00
101_I	115_A	0.621	1.00
41_T	47_W	0.619	1.00
4_Y	48_L	0.618	1.00
8_L	188_H	0.613	1.00
82_E	91_F	0.612	1.00
33_W	37_N	0.610	1.00
101_I	112_L	0.609	1.00
69_N	106_W	0.609	1.00
35_N	52_V	0.608	1.00
14_I	128_T	0.606	1.00
69_N	72_D	0.606	1.00
69_N	107_E	0.603	1.00
137_G	140_G	0.603	1.00
120_I	208_L	0.601	1.00
13_L	183_Q	0.601	1.00
123_Y	208_L	0.600	1.00
125_G	216_I	0.600	1.00
143_T	169_D	0.597	1.00
94_Y	213_P	0.596	1.00
92_D	95_F	0.595	1.00
74_R	102_Y	0.595	1.00
88_A	210_N	0.592	1.00
22_L	132_R	0.591	1.00
185_Y	201_N	0.590	1.00
39_I	81_I	0.589	1.00
168_L	173_F	0.587	1.00
147_L	173_F	0.584	1.00
86_R	92_D	0.580	1.00
78_L	82_E	0.576	1.00
185_Y	189_P	0.574	1.00
14_I	20_F	0.573	1.00
146_L	168_L	0.570	1.00
94_Y	98_L	0.568	1.00
13_L	17_V	0.567	1.00
143_T	146_L	0.560	1.00
38_R	201_N	0.558	1.00
54_K	66_E	0.557	1.00
70_D	73_W	0.555	1.00
78_L	98_L	0.555	1.00
141_K	144_E	0.555	1.00
8_L	185_Y	0.554	1.00
193_Q	210_N	0.552	1.00
98_L	209_F	0.549	1.00
190_E	197_P	0.547	1.00
3_Y	117_I	0.546	1.00
11_F	124_L	0.544	1.00
160_S	167_Y	0.543	1.00
136_L	152_A	0.539	1.00
32_G	163_G	0.538	1.00
159_L	183_Q	0.537	1.00
42_P	46_Q	0.536	1.00
63_N	108_N	0.535	1.00
3_Y	33_W	0.533	1.00
50_V	113_N	0.532	1.00
100_E	104_R	0.532	1.00
73_W	77_H	0.531	1.00
117_I	121_C	0.528	1.00
89_P	192_P	0.526	1.00
30_K	58_G	0.524	1.00
90_Y	94_Y	0.524	1.00
105_E	108_N	0.523	1.00
65_V	109_L	0.523	1.00
11_F	120_I	0.522	1.00
138_L	145_R	0.519	1.00
92_D	99_E	0.517	1.00
15_A	128_T	0.513	1.00
136_L	149_I	0.507	1.00
26_V	145_R	0.507	1.00
50_V	109_L	0.505	1.00
60_Q	63_N	0.505	1.00
138_L	141_K	0.504	0.99
41_T	45_P	0.504	0.99
40_K	193_Q	0.503	0.99
12_D	159_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2c1lA	2	0.4147	4.2	0.963	Contact Map
2b9iC	1	0.0645	3.7	0.964	Contact Map
3tk2A	1	0.212	3.4	0.964	Contact Map
2m19A	1	0.2488	3	0.965	Contact Map
3mw8A	1	0.2903	2.9	0.965	Contact Map
3onkA	1	0.3641	2.8	0.966	Contact Map
4ujpS	1	0.4424	2.7	0.966	Contact Map
4qb0A	1	0.2166	2.5	0.967	Contact Map
2g2nA	5	0.1751	2.4	0.967	Contact Map
3j60R	1	0.47	2.4	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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