GREMLIN Database
Acetone_carb_G - Acetone carboxylase gamma subunit
PFAM: PF08882 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (110)
Sequences: 2015 (1114)
Seq/√Len: 106.2
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_Y79_Y3.5041.00
41_E45_L3.4301.00
78_F98_V3.0831.00
51_V74_R2.9081.00
25_R35_E2.8481.00
32_C83_C2.8161.00
47_A87_L2.4971.00
40_R107_D2.4011.00
100_H103_E2.3511.00
14_H31_D2.0411.00
53_D57_I1.9941.00
25_R37_G1.9071.00
42_N100_H1.9021.00
36_L47_A1.8811.00
80_C83_C1.8591.00
108_A112_R1.8511.00
32_C80_C1.8501.00
37_G46_G1.8011.00
30_C85_T1.7491.00
34_H82_G1.6931.00
48_L84_G1.6401.00
62_Y65_T1.6361.00
58_H91_Y1.5801.00
59_P67_A1.5521.00
44_K90_E1.5441.00
8_L29_K1.5231.00
64_Y67_A1.5191.00
29_K35_E1.4771.00
3_W16_Y1.4631.00
68_P73_V1.4341.00
54_P57_I1.4221.00
9_L17_I1.3601.00
49_V98_V1.3551.00
59_P64_Y1.3270.99
52_R77_E1.3230.99
32_C82_G1.3190.99
58_H68_P1.3140.99
63_P67_A1.2090.99
19_R24_E1.1650.99
49_V76_R1.1650.99
41_E46_G1.1490.98
20_K35_E1.1370.98
108_A111_R1.1190.98
78_F99_L1.1130.98
93_P96_Y1.0920.98
50_Y57_I1.0520.97
30_C83_C1.0420.97
79_Y86_L1.0280.97
62_Y67_A1.0270.97
13_E108_A1.0100.96
16_Y31_D1.0060.96
72_W90_E0.9990.96
86_L89_V0.9950.96
57_I75_I0.9910.96
88_E101_D0.9830.96
24_E40_R0.9710.95
6_Y19_R0.9610.95
24_E110_Y0.9560.95
106_I110_Y0.9360.94
27_V35_E0.9360.94
96_Y99_L0.9340.94
63_P66_F0.9240.94
76_R92_L0.9200.94
12_G101_D0.9120.94
54_P72_W0.8910.93
54_P58_H0.8670.92
21_G24_E0.8650.92
8_L26_W0.8640.92
36_L87_L0.8550.91
62_Y66_F0.8520.91
76_R98_V0.8520.91
66_F69_D0.8460.91
43_Y101_D0.8390.91
20_K23_G0.8250.90
75_I88_E0.8200.90
12_G88_E0.8190.89
27_V33_G0.8100.89
86_L112_R0.8050.89
4_T46_G0.8030.89
3_W9_L0.8010.88
43_Y47_A0.7870.88
58_H67_A0.7840.87
55_R70_P0.7750.87
3_W7_I0.7720.87
51_V76_R0.7690.86
74_R92_L0.7590.86
4_T112_R0.7530.85
47_A89_V0.7380.84
47_A102_I0.7380.84
30_C80_C0.7360.84
7_I10_P0.7360.84
72_W88_E0.7260.83
28_C37_G0.7220.83
92_L96_Y0.7170.82
68_P75_I0.7150.82
69_D73_V0.7150.82
43_Y102_I0.7100.82
73_V94_P0.7040.81
107_D111_R0.7040.81
65_T68_P0.6980.81
62_Y68_P0.6910.80
34_H46_G0.6790.79
90_E99_L0.6760.78
37_G45_L0.6750.78
7_I16_Y0.6710.78
67_A99_L0.6700.78
28_C31_D0.6680.78
62_Y76_R0.6580.76
19_R22_D0.6540.76
30_C33_G0.6510.76
49_V78_F0.6490.76
4_T111_R0.6440.75
10_P43_Y0.6430.75
31_D65_T0.6420.75
8_L13_E0.6330.74
25_R38_D0.6320.74
99_L103_E0.6280.73
73_V89_V0.6270.73
84_G89_V0.6210.72
82_G85_T0.6140.71
29_K85_T0.6130.71
103_E107_D0.6110.71
17_I39_A0.6100.71
27_V30_C0.6080.71
6_Y46_G0.6070.71
48_L86_L0.6000.70
6_Y10_P0.5980.69
52_R60_E0.5970.69
3_W35_E0.5960.69
73_V91_Y0.5940.69
55_R67_A0.5910.69
25_R34_H0.5850.68
92_L95_G0.5820.67
82_G87_L0.5800.67
3_W31_D0.5780.67
53_D82_G0.5760.67
35_E41_E0.5720.66
53_D72_W0.5610.65
45_L98_V0.5600.64
58_H70_P0.5510.63
93_P97_P0.5510.63
35_E89_V0.5510.63
39_A100_H0.5490.63
70_P74_R0.5490.63
44_K88_E0.5480.63
3_W104_P0.5460.62
75_I89_V0.5360.61
20_K24_E0.5340.61
51_V60_E0.5330.61
77_E92_L0.5320.61
26_W106_I0.5320.61
31_D85_T0.5290.60
50_Y77_E0.5280.60
77_E89_V0.5260.60
19_R26_W0.5240.59
34_H37_G0.5130.58
58_H61_I0.5130.58
70_P95_G0.5110.57
31_D84_G0.5100.57
39_A106_I0.5090.57
67_A70_P0.5060.57
50_Y84_G0.5050.57
52_R95_G0.5040.56
79_Y84_G0.5020.56
104_P110_Y0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bbjA 1 0.1228 42.9 0.907 Contact Map
1yuzA 2 0.4386 42.1 0.908 Contact Map
2kdxA 1 0.5789 40.9 0.909 Contact Map
1lkoA 3 0.5263 34.4 0.912 Contact Map
4l2nA 2 0.6754 26.7 0.917 Contact Map
4y97B 1 0.4561 24.6 0.918 Contact Map
5aunA 1 0.7632 22.9 0.92 Contact Map
3floB 1 0.6491 22.7 0.92 Contact Map
1yk4A 1 0.4561 22.3 0.92 Contact Map
4tpuA 3 0.5175 19.2 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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