GREMLIN Database
DUF1837 - Domain of unknown function (DUF1837)
PFAM: PF08878 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 230 (229)
Sequences: 2115 (1743)
Seq/√Len: 115.2
META: 0.765

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_D84_K6.5291.00
56_L104_G3.1041.00
3_L55_L2.9481.00
199_K203_K2.9111.00
196_E199_K2.8831.00
192_D196_E2.7091.00
53_E87_D2.6901.00
50_E76_K2.3871.00
85_G107_K2.3601.00
87_D105_E2.3271.00
119_A122_S2.3141.00
152_E156_K2.2801.00
85_G105_E2.2701.00
196_E200_K2.2561.00
113_K208_K2.2301.00
193_E197_E2.2231.00
147_D150_L2.2061.00
148_E152_E2.0671.00
111_D114_D2.0461.00
9_D31_L2.0411.00
201_E205_R2.0171.00
87_D107_K2.0011.00
209_F225_L1.9921.00
118_D121_K1.9401.00
49_G105_E1.9221.00
20_E35_E1.9161.00
72_K135_E1.9091.00
193_E196_E1.9031.00
121_K125_K1.8841.00
208_K211_K1.8731.00
156_K162_T1.8681.00
191_T194_Y1.8661.00
53_E105_E1.7741.00
190_S193_E1.7561.00
195_K199_K1.7491.00
49_G87_D1.7211.00
212_K215_K1.6881.00
37_A41_R1.6791.00
205_R208_K1.6731.00
29_A32_L1.6581.00
53_E107_K1.6081.00
194_Y201_E1.5781.00
64_L226_F1.5741.00
207_K211_K1.5731.00
37_A40_F1.5731.00
121_K124_K1.5611.00
64_L67_P1.5601.00
29_A33_L1.5511.00
28_D31_L1.5481.00
49_G53_E1.5231.00
6_F10_N1.5011.00
198_I202_I1.4971.00
194_Y198_I1.4891.00
68_P90_H1.4891.00
105_E122_S1.4811.00
109_Y115_A1.4731.00
200_K203_K1.4721.00
127_L173_I1.4671.00
191_T195_K1.4661.00
100_E172_A1.4541.00
76_K83_V1.4321.00
57_Y66_A1.4031.00
206_A210_F1.3861.00
109_Y118_D1.3591.00
50_E82_E1.3571.00
60_L174_P1.3451.00
92_V102_W1.3351.00
44_K48_R1.3331.00
131_Y136_L1.3181.00
25_K28_D1.3131.00
78_N81_D1.3041.00
49_G107_K1.3001.00
49_G52_G1.2961.00
94_D100_E1.2921.00
203_K207_K1.2860.99
197_E201_E1.2860.99
69_I91_I1.2820.99
223_F229_P1.2730.99
111_D117_D1.2710.99
177_L227_L1.2700.99
22_E25_K1.2570.99
200_K204_E1.2560.99
204_E208_K1.2500.99
22_E26_K1.2480.99
25_K29_A1.2430.99
21_I24_L1.2290.99
108_F178_G1.2170.99
52_G87_D1.2160.99
45_K48_R1.2090.99
50_E90_H1.2070.99
123_I175_I1.2040.99
59_L228_L1.2040.99
26_K30_S1.1600.99
191_T209_F1.1560.99
53_E85_G1.1400.99
46_G49_G1.1390.99
222_S225_L1.1330.99
43_D46_G1.1200.99
76_K105_E1.1170.99
66_A92_V1.1100.98
112_I205_R1.1010.98
49_G85_G1.0980.98
42_K134_R1.0890.98
172_A222_S1.0870.98
7_L54_L1.0850.98
198_I201_E1.0750.98
7_L55_L1.0640.98
76_K107_K1.0640.98
86_A126_H1.0520.98
178_G230_F1.0510.98
106_S122_S1.0410.98
112_I177_L1.0270.97
18_R22_E1.0270.97
59_L226_F1.0210.97
162_T166_D1.0200.97
205_R209_F1.0180.97
121_K196_E1.0060.97
28_D33_L1.0020.97
114_D117_D0.9970.97
36_A41_R0.9920.97
182_D186_K0.9920.97
195_K198_I0.9820.97
172_A224_H0.9810.97
77_T84_K0.9750.97
92_V100_E0.9730.96
106_S170_R0.9650.96
113_K204_E0.9630.96
72_K87_D0.9600.96
190_S209_F0.9570.96
52_G106_S0.9490.96
115_A177_L0.9480.96
205_R210_F0.9470.96
76_K85_G0.9430.96
202_I205_R0.9410.96
202_I206_A0.9380.96
198_I205_R0.9310.95
195_K202_I0.9310.95
44_K47_K0.9180.95
117_D212_K0.9150.95
28_D32_L0.9140.95
94_D97_G0.8960.94
68_P71_S0.8950.94
15_A73_I0.8950.94
58_L62_E0.8940.94
72_K105_E0.8930.94
89_V139_I0.8920.94
97_G170_R0.8900.94
53_E72_K0.8880.94
27_E32_L0.8750.94
207_K210_F0.8730.94
56_L72_K0.8720.94
128_S156_K0.8580.93
66_A90_H0.8560.93
201_E208_K0.8530.93
119_A175_I0.8500.93
211_K216_P0.8400.92
187_H191_T0.8380.92
65_G92_V0.8350.92
130_D133_K0.8350.92
68_P179_Y0.8350.92
114_D118_D0.8340.92
131_Y135_E0.8250.92
21_I33_L0.8220.91
190_S198_I0.8180.91
70_L138_L0.8140.91
75_L130_D0.8110.91
52_G105_E0.8100.91
206_A209_F0.8040.91
151_A155_K0.8020.90
30_S33_L0.8020.90
5_E27_E0.8010.90
200_K211_K0.7940.90
25_K32_L0.7910.90
24_L30_S0.7890.90
5_E26_K0.7880.90
35_E137_S0.7870.90
48_R86_A0.7860.90
61_E67_P0.7820.89
24_L34_K0.7780.89
9_D30_S0.7750.89
76_K87_D0.7740.89
142_K145_L0.7720.89
10_N13_E0.7640.88
89_V154_L0.7600.88
218_L221_I0.7600.88
101_L182_D0.7580.88
185_K188_T0.7530.87
212_K216_P0.7510.87
201_E209_F0.7480.87
5_E34_K0.7480.87
97_G153_K0.7480.87
21_I28_D0.7450.87
200_K207_K0.7440.87
182_D185_K0.7420.87
117_D208_K0.7380.86
73_I77_T0.7300.86
77_T83_V0.7290.86
14_Y83_V0.7270.86
103_L126_H0.7260.85
201_E204_E0.7240.85
57_Y61_E0.7240.85
216_P219_D0.7240.85
16_L20_E0.7220.85
78_N138_L0.7200.85
107_K122_S0.7200.85
190_S197_E0.7100.84
190_S195_K0.7080.84
186_K207_K0.7080.84
77_T138_L0.7010.83
2_D5_E0.7010.83
149_E154_L0.6910.83
148_E151_A0.6840.82
187_H197_E0.6840.82
67_P178_G0.6820.82
76_K122_S0.6820.82
186_K197_E0.6760.81
174_P178_G0.6750.81
83_V122_S0.6700.81
204_E207_K0.6700.81
24_L27_E0.6690.81
70_L173_I0.6680.80
191_T202_I0.6650.80
57_Y71_S0.6620.80
24_L29_A0.6620.80
213_I222_S0.6560.79
55_L178_G0.6560.79
9_D29_A0.6560.79
174_P177_L0.6530.79
181_S201_E0.6520.79
48_R82_E0.6510.79
60_L88_G0.6510.79
35_E38_K0.6500.79
204_E219_D0.6480.78
70_L85_G0.6480.78
197_E200_K0.6460.78
77_T81_D0.6440.78
76_K89_V0.6440.78
152_E155_K0.6420.78
84_K107_K0.6400.78
198_I208_K0.6390.77
57_Y86_A0.6380.77
50_E83_V0.6360.77
33_L37_A0.6360.77
214_K219_D0.6350.77
61_E68_P0.6330.77
188_T193_E0.6320.77
175_I225_L0.6320.77
122_S126_H0.6290.76
79_S138_L0.6250.76
208_K212_K0.6240.76
35_E39_K0.6240.76
219_D222_S0.6210.75
190_S201_E0.6210.75
39_K42_K0.6200.75
5_E9_D0.6150.75
210_F222_S0.6150.75
39_K141_N0.6110.74
21_I26_K0.6100.74
192_D200_K0.6090.74
13_E61_E0.6080.74
196_E207_K0.6070.74
5_E29_A0.6060.74
30_S34_K0.6040.73
59_L195_K0.6040.73
50_E78_N0.5990.73
60_L71_S0.5990.73
84_K105_E0.5980.73
7_L51_L0.5930.72
191_T198_I0.5920.72
10_N58_L0.5870.71
27_E34_K0.5870.71
4_A10_N0.5830.71
189_K219_D0.5800.70
68_P75_L0.5770.70
83_V105_E0.5740.70
86_A131_Y0.5730.69
220_G223_F0.5720.69
213_I218_L0.5710.69
109_Y114_D0.5700.69
200_K219_D0.5700.69
171_I174_P0.5690.69
225_L228_L0.5670.69
186_K189_K0.5670.69
56_L143_I0.5660.69
198_I206_A0.5650.68
44_K80_N0.5640.68
212_K217_K0.5640.68
110_K180_D0.5640.68
215_K219_D0.5620.68
75_L164_L0.5620.68
64_L178_G0.5610.68
156_K165_D0.5610.68
63_F172_A0.5590.68
15_A71_S0.5590.68
24_L31_L0.5570.67
145_L151_A0.5560.67
17_S73_I0.5560.67
194_Y205_R0.5550.67
77_T122_S0.5530.67
64_L88_G0.5530.67
108_F119_A0.5500.66
40_F73_I0.5480.66
197_E202_I0.5480.66
70_L105_E0.5480.66
20_E23_E0.5460.66
26_K32_L0.5460.66
218_L223_F0.5450.66
195_K201_E0.5440.65
203_K209_F0.5430.65
29_A34_K0.5430.65
65_G170_R0.5420.65
19_S144_D0.5420.65
194_Y209_F0.5390.65
215_K220_G0.5280.63
74_Y102_W0.5270.63
77_T85_G0.5250.63
72_K104_G0.5250.63
53_E76_K0.5250.63
24_L32_L0.5240.63
194_Y197_E0.5230.62
18_R61_E0.5220.62
7_L58_L0.5210.62
51_L176_L0.5210.62
25_K34_K0.5200.62
196_E203_K0.5200.62
100_E170_R0.5190.62
73_I153_K0.5190.62
13_E32_L0.5180.62
112_I116_I0.5180.62
193_E210_F0.5160.61
134_R137_S0.5140.61
206_A226_F0.5130.61
69_I75_L0.5130.61
89_V167_I0.5120.61
181_S198_I0.5120.61
208_K215_K0.5110.61
14_Y135_E0.5090.60
217_K220_G0.5090.60
116_I120_F0.5080.60
136_L140_T0.5070.60
121_K182_D0.5070.60
48_R84_K0.5070.60
214_K222_S0.5030.60
192_D211_K0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wlrB 1 0.3522 11.4 0.939 Contact Map
3katA 2 0.2826 4.9 0.949 Contact Map
3j9oB 7 0.3565 4.7 0.949 Contact Map
1ynfA 2 0.2348 4.6 0.949 Contact Map
2lu1A 1 0.2739 4 0.951 Contact Map
1ry2A 1 0.2391 3.7 0.952 Contact Map
2kl5A 1 0.1609 3.5 0.952 Contact Map
3fovA 2 0.4391 2.7 0.955 Contact Map
2kqzA 1 0.4522 2.5 0.955 Contact Map
1s03H 1 0.2565 2.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.