GREMLIN Database
DUF1833 - Domain of unknown function (DUF1833)
PFAM: PF08875 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (147)
Sequences: 1641 (1391)
Seq/√Len: 114.7
META: 0.857

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_D53_A5.7581.00
16_L33_V4.7191.00
35_D39_I4.2691.00
121_L133_G3.8671.00
57_E74_T3.0951.00
70_E134_T2.9121.00
139_D142_N2.8771.00
23_H26_F2.7441.00
20_E101_R2.6481.00
40_T45_T2.6301.00
123_N134_T2.2061.00
13_E106_S2.1381.00
74_T130_T2.1021.00
109_S112_A2.0151.00
24_P94_E1.9921.00
22_T29_P1.9911.00
83_V126_Y1.9901.00
22_T99_T1.7561.00
20_E31_R1.7401.00
107_D110_P1.6621.00
26_F85_A1.6381.00
72_Q134_T1.6361.00
105_S108_L1.5901.00
72_Q132_T1.5781.00
38_D50_T1.5721.00
42_R48_T1.5691.00
77_N80_R1.5641.00
71_L135_L1.5371.00
108_L111_P1.5271.00
43_G51_F1.5011.00
87_R126_Y1.4991.00
38_D45_T1.4771.00
18_L41_S1.4701.00
17_H34_N1.4621.00
38_D52_T1.4311.00
43_G49_V1.4271.00
124_V133_G1.3751.00
52_T81_E1.3661.00
7_A10_P1.3591.00
31_R44_E1.3551.00
5_A9_A1.3491.00
74_T132_T1.3321.00
64_D67_G1.3161.00
11_T14_V1.3121.00
17_H102_I1.2951.00
13_E105_S1.2780.99
59_T72_Q1.2770.99
103_Y111_P1.2740.99
97_T120_T1.2360.99
57_E130_T1.2270.99
20_E29_P1.2190.99
33_V39_I1.2140.99
86_I124_V1.2120.99
20_E51_F1.2020.99
40_T50_T1.1930.99
17_H100_Y1.1690.99
18_L51_F1.1470.99
106_S110_P1.1470.99
14_V105_S1.1450.99
122_R136_G1.1380.99
26_F89_A1.1170.99
31_R49_V1.0920.98
56_F75_I1.0910.98
19_L32_L1.0850.98
106_S111_P1.0760.98
19_L56_F1.0700.98
16_L35_D1.0630.98
119_L137_F1.0490.98
22_T97_T1.0360.98
41_S49_V1.0160.97
77_N83_V1.0130.97
39_I108_L1.0050.97
110_P114_E0.9990.97
18_L103_Y0.9910.97
80_R83_V0.9520.96
85_A88_A0.9470.96
102_I113_V0.9450.96
9_A12_D0.9300.95
21_I26_F0.9280.95
107_D111_P0.9260.95
17_H71_L0.9190.95
99_T118_T0.9070.95
30_I82_I0.9050.95
5_A13_E0.8940.94
32_L56_F0.8930.94
83_V87_R0.8860.94
41_S44_E0.8690.93
31_R47_E0.8630.93
32_L54_F0.8590.93
5_A14_V0.8530.93
26_F29_P0.8530.93
82_I85_A0.8470.93
30_I85_A0.8330.92
5_A11_T0.8320.92
20_E42_R0.8280.92
103_Y108_L0.8180.91
103_Y106_S0.8160.91
104_L112_A0.8120.91
45_T49_V0.8110.91
13_E108_L0.8090.91
70_E136_G0.8050.91
126_Y131_V0.7980.90
4_E7_A0.7880.90
54_F75_I0.7730.89
111_P114_E0.7700.88
101_R111_P0.7680.88
43_G47_E0.7640.88
63_D91_G0.7460.87
127_D130_T0.7430.87
108_L112_A0.7430.87
143_R150_Y0.7390.86
42_R46_G0.7350.86
46_G50_T0.7340.86
44_E51_F0.7250.85
41_S108_L0.7230.85
6_L9_A0.7220.85
8_A11_T0.7210.85
68_P141_L0.7110.84
83_V131_V0.7100.84
105_S111_P0.7060.84
34_N55_P0.6960.83
30_I50_T0.6860.82
101_R116_P0.6790.81
119_L139_D0.6740.81
6_L11_T0.6730.81
101_R104_L0.6680.80
63_D87_R0.6630.80
23_H89_A0.6630.80
90_L93_P0.6610.80
85_A133_G0.6500.78
42_R101_R0.6470.78
33_V36_T0.6450.78
137_F141_L0.6430.78
43_G46_G0.6420.78
140_L148_E0.6410.77
98_V105_S0.6410.77
41_S50_T0.6390.77
21_I86_I0.6330.77
5_A10_P0.6320.76
45_T52_T0.6290.76
68_P137_F0.6280.76
52_T57_E0.6240.76
54_F83_V0.6230.75
6_L15_F0.6160.75
112_A115_P0.6150.75
55_P76_D0.6140.74
36_T55_P0.6130.74
133_G145_F0.6090.74
71_L100_Y0.6090.74
6_L63_D0.6060.73
107_D112_A0.6050.73
6_L10_P0.6040.73
40_T48_T0.6010.73
21_I96_I0.5990.73
20_E103_Y0.5980.72
101_R106_S0.5970.72
24_P97_T0.5970.72
104_L107_D0.5950.72
105_S109_S0.5930.72
121_L139_D0.5920.72
113_V116_P0.5910.72
105_S110_P0.5880.71
30_I137_F0.5860.71
83_V127_D0.5820.70
98_V135_L0.5820.70
41_S45_T0.5810.70
79_D82_I0.5810.70
5_A8_A0.5810.70
98_V101_R0.5790.70
110_P113_V0.5770.70
76_D130_T0.5760.70
46_G49_V0.5740.69
27_A88_A0.5740.69
42_R109_S0.5740.69
34_N57_E0.5720.69
18_L101_R0.5690.69
6_L12_D0.5690.69
121_L124_V0.5640.68
69_P79_D0.5610.68
111_P116_P0.5600.68
18_L39_I0.5580.67
30_I75_I0.5580.67
41_S51_F0.5570.67
63_D66_D0.5560.67
55_P126_Y0.5550.67
33_V53_A0.5550.67
18_L144_P0.5540.67
104_L108_L0.5500.66
80_R144_P0.5470.66
56_F133_G0.5440.65
69_P136_G0.5420.65
103_Y109_S0.5420.65
125_S132_T0.5400.65
5_A15_F0.5370.64
32_L52_T0.5350.64
57_E117_L0.5350.64
121_L128_A0.5340.64
63_D70_E0.5310.63
55_P143_R0.5260.63
29_P49_V0.5250.63
26_F30_I0.5250.63
13_E21_I0.5240.62
61_P76_D0.5230.62
56_F87_R0.5220.62
70_E122_R0.5220.62
61_P119_L0.5210.62
7_A18_L0.5200.62
122_R138_E0.5170.61
143_R147_R0.5170.61
54_F127_D0.5160.61
44_E82_I0.5150.61
26_F131_V0.5130.61
57_E73_L0.5120.61
68_P71_L0.5080.60
21_I75_I0.5060.60
136_G141_L0.5050.60
23_H29_P0.5010.59
88_A99_T0.5010.59
31_R43_G0.5000.59
120_T139_D0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gs9A 3 0.46 6.1 0.933 Contact Map
2lezA 1 0.6467 5.9 0.933 Contact Map
2czyA 1 0.3667 5.6 0.934 Contact Map
1fr2A 1 0.4133 4 0.939 Contact Map
2f05A 1 0.3333 3.3 0.941 Contact Map
4fx9A 2 0.3 2.7 0.944 Contact Map
4fnqA 4 0.8 2.7 0.944 Contact Map
1ixmA 2 0.44 2.7 0.944 Contact Map
1gxgA 1 0.42 2.3 0.946 Contact Map
2uv9A 5 0 2 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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