GREMLIN Database
DUF1835 - Domain of unknown function (DUF1835)
PFAM: PF08874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (115)
Sequences: 4317 (3211)
Seq/√Len: 299.4
META: 0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_D30_R3.3891.00
6_G9_A3.0811.00
72_L75_L2.7081.00
77_E81_A2.4151.00
52_E56_E2.3431.00
5_F101_G2.2741.00
71_T75_L2.2321.00
8_S11_G2.2201.00
69_E73_A2.1081.00
8_S12_T2.0991.00
39_P49_A1.9891.00
7_D28_V1.9561.00
10_A28_V1.9411.00
25_E78_L1.9261.00
99_Q103_Y1.8891.00
65_E68_I1.8261.00
15_Q18_E1.7731.00
38_L46_G1.6591.00
17_L20_G1.6421.00
107_S110_K1.5571.00
72_L76_D1.5561.00
4_V13_L1.5031.00
11_G15_Q1.4821.00
75_L78_L1.4171.00
50_R54_L1.4081.00
77_E80_D1.4031.00
104_W107_S1.4001.00
11_G14_R1.3941.00
104_W108_Q1.3891.00
71_T74_E1.3871.00
70_E74_E1.3781.00
34_S97_H1.3741.00
74_E78_L1.3161.00
21_G24_G1.3151.00
10_A26_V1.2751.00
37_P53_W1.2721.00
61_D66_E1.2651.00
76_D80_D1.2481.00
70_E73_A1.2371.00
41_L49_A1.2101.00
99_Q102_L1.2031.00
12_T16_A1.2031.00
61_D64_G1.1901.00
64_G68_I1.1821.00
43_T47_R1.1781.00
13_L26_V1.1691.00
71_T78_L1.1531.00
79_L82_L1.1301.00
48_E52_E1.1091.00
31_D37_P1.0971.00
63_E68_I1.0951.00
13_L16_A1.0871.00
12_T17_L1.0731.00
105_L108_Q1.0671.00
43_T46_G1.0331.00
12_T15_Q1.0221.00
2_H89_V1.0211.00
95_D98_D1.0141.00
48_E51_A1.0121.00
53_W57_V1.0111.00
80_D112_F1.0091.00
9_A13_L1.0031.00
78_L81_A0.9971.00
75_L79_L0.9881.00
49_A52_E0.9851.00
46_G50_R0.9801.00
82_L85_G0.9731.00
73_A77_E0.9731.00
29_W104_W0.9611.00
101_G104_W0.9601.00
52_E55_A0.9571.00
25_E85_G0.9551.00
15_Q19_L0.9531.00
80_D83_P0.9471.00
41_L46_G0.9261.00
4_V28_V0.9131.00
72_L78_L0.9101.00
10_A14_R0.9001.00
2_H37_P0.8971.00
17_L26_V0.8841.00
74_E77_E0.8791.00
45_E49_A0.8761.00
31_D50_R0.8751.00
64_G67_D0.8681.00
71_T76_D0.8581.00
31_D100_L0.8401.00
54_L57_V0.8341.00
93_E98_D0.8321.00
62_Y66_E0.8171.00
56_E59_G0.8151.00
16_A19_L0.8121.00
82_L109_L0.8121.00
69_E75_L0.8021.00
5_F98_D0.7870.99
46_G49_A0.7850.99
90_L93_E0.7790.99
44_E73_A0.7740.99
68_I72_L0.7630.99
63_E67_D0.7560.99
34_S101_G0.7540.99
9_A12_T0.7530.99
62_Y65_E0.7520.99
105_L109_L0.7410.99
7_D10_A0.7340.99
100_L103_Y0.7330.99
29_W105_L0.7310.99
68_I76_D0.7300.99
48_E69_E0.7290.99
63_E66_E0.7180.99
50_R56_E0.7090.99
39_P45_E0.7060.99
98_D101_G0.7050.99
94_H99_Q0.6980.99
73_A76_D0.6920.99
47_R51_A0.6760.98
93_E97_H0.6720.98
51_A69_E0.6700.98
69_E72_L0.6620.98
88_V94_H0.6600.98
41_L104_W0.6590.98
9_A26_V0.6530.98
90_L101_G0.6520.98
5_F9_A0.6510.98
2_H31_D0.6480.98
4_V26_V0.6480.98
32_D95_D0.6470.98
33_L97_H0.6460.98
46_G53_W0.6430.98
4_V9_A0.6410.98
7_D11_G0.6400.98
65_E69_E0.6310.98
37_P50_R0.6300.97
27_L78_L0.6290.97
27_L35_V0.6280.97
55_A58_L0.6150.97
32_D97_H0.6150.97
4_V8_S0.6150.97
97_H101_G0.6120.97
96_L100_L0.6110.97
27_L75_L0.6100.97
40_D45_E0.6030.97
78_L82_L0.6010.97
30_R97_H0.6010.97
40_D46_G0.5990.97
43_T104_W0.5920.96
6_G33_L0.5910.96
112_F115_R0.5820.96
45_E48_E0.5810.96
33_L104_W0.5770.96
61_D67_D0.5760.96
72_L81_A0.5720.96
50_R58_L0.5610.95
42_D46_G0.5590.95
40_D43_T0.5590.95
42_D45_E0.5560.95
52_E65_E0.5350.94
76_D79_L0.5320.94
101_G105_L0.5290.93
31_D98_D0.5280.93
92_F96_L0.5260.93
5_F93_E0.5240.93
62_Y68_I0.5220.93
68_I71_T0.5190.93
30_R71_T0.5180.93
44_E49_A0.5170.93
35_V54_L0.5150.92
30_R92_F0.5120.92
1_L86_E0.5100.92
47_R69_E0.5090.92
6_G12_T0.5040.92
7_D12_T0.5040.92
5_F8_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mw9X 1 0.8595 15.5 0.897 Contact Map
4dduA 1 0.9587 9 0.907 Contact Map
1wy5A 4 0.4959 8.7 0.908 Contact Map
3qyfA 2 0.9504 6.9 0.912 Contact Map
3a2kA 1 0.4463 6.7 0.913 Contact Map
1k7cA 1 0.8017 6.5 0.913 Contact Map
4blpA 3 0.5372 5.6 0.916 Contact Map
1mgpA 1 0.9339 4.8 0.919 Contact Map
2gaiA 1 0.8512 4.7 0.919 Contact Map
1i7dA 1 0.9752 4.7 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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