GREMLIN Database
FRG - FRG domain
PFAM: PF08867 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (90)
Sequences: 18277 (15372)
Seq/√Len: 1620.3
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A69_L4.5531.00
8_Q13_W4.3131.00
17_P20_Y3.1821.00
4_L76_W2.6851.00
41_R60_W2.4111.00
65_Q71_T2.3501.00
10_D13_W2.3421.00
33_E72_R2.1011.00
9_S13_W2.0921.00
56_W59_E1.8021.00
15_L74_L1.7901.00
4_L78_E1.7601.00
9_S90_D1.6391.00
18_S65_Q1.6391.00
16_L24_G1.5291.00
39_E42_R1.5281.00
48_L51_P1.4701.00
85_Y89_E1.4381.00
61_L73_L1.4341.00
44_A48_L1.2621.00
16_L20_Y1.2481.00
61_L72_R1.2291.00
9_S89_E1.2211.00
8_Q14_P1.2071.00
39_E43_R1.1861.00
81_L84_L1.1731.00
41_R45_H1.1711.00
17_P74_L1.1621.00
54_S57_D1.1581.00
30_L34_R1.1411.00
8_Q15_L1.1331.00
33_E36_L1.1291.00
45_H48_L1.1231.00
21_R65_Q1.0931.00
4_L62_A1.0821.00
79_S82_V1.0681.00
61_L64_A1.0501.00
37_L64_A1.0481.00
40_F64_A1.0431.00
18_S70_P1.0411.00
60_W63_L1.0401.00
73_L77_T1.0401.00
81_L88_V1.0391.00
33_E40_F1.0271.00
38_R42_R1.0241.00
31_E35_R1.0231.00
63_L67_Y1.0201.00
65_Q75_D1.0041.00
40_F44_A0.9611.00
35_R39_E0.9591.00
44_A47_Y0.9301.00
80_P84_L0.9291.00
26_K29_K0.9241.00
36_L40_F0.8991.00
19_L72_R0.8931.00
37_L61_L0.8851.00
4_L64_A0.8781.00
15_L76_W0.8711.00
32_L35_R0.8671.00
62_A76_W0.8651.00
13_W21_R0.8641.00
79_S85_Y0.8541.00
44_A60_W0.8441.00
35_R38_R0.8311.00
20_Y65_Q0.8181.00
22_L26_K0.8111.00
3_L85_Y0.8061.00
34_R38_R0.8021.00
50_S53_D0.7971.00
25_K29_K0.7921.00
43_R46_P0.7861.00
42_R45_H0.7781.00
68_G85_Y0.7761.00
9_S91_A0.7681.00
53_D56_W0.7681.00
41_R55_D0.7581.00
22_L70_P0.7581.00
53_D57_D0.7581.00
17_P22_L0.7441.00
49_S52_P0.7441.00
72_R88_V0.7431.00
24_G28_S0.7431.00
37_L41_R0.7351.00
72_R76_W0.7331.00
8_Q21_R0.7301.00
36_L69_L0.7291.00
22_L25_K0.7291.00
66_H75_D0.7261.00
77_T82_V0.7231.00
77_T85_Y0.7191.00
66_H71_T0.7171.00
23_G27_L0.7011.00
36_L70_P0.6951.00
72_R81_L0.6901.00
84_L88_V0.6831.00
43_R47_Y0.6751.00
12_S15_L0.6661.00
65_Q86_F0.6601.00
64_A72_R0.6581.00
72_R85_Y0.6541.00
46_P50_S0.6501.00
18_S71_T0.6351.00
52_P60_W0.6351.00
8_Q11_A0.6341.00
75_D86_F0.6271.00
77_T81_L0.6191.00
48_L52_P0.6161.00
20_Y23_G0.6001.00
8_Q12_S0.5981.00
47_Y50_S0.5941.00
61_L71_T0.5901.00
77_T83_A0.5851.00
37_L40_F0.5821.00
73_L76_W0.5821.00
42_R46_P0.5811.00
5_F83_A0.5761.00
13_W16_L0.5731.00
8_Q18_S0.5711.00
65_Q68_G0.5651.00
31_E34_R0.5611.00
80_P85_Y0.5571.00
61_L70_P0.5521.00
40_F63_L0.5521.00
62_A71_T0.5451.00
48_L55_D0.5421.00
41_R46_P0.5381.00
52_P57_D0.5351.00
51_P54_S0.5351.00
63_L76_W0.5271.00
10_D14_P0.5271.00
79_S84_L0.5271.00
40_F48_L0.5091.00
55_D58_L0.5061.00
88_V91_A0.5051.00
52_P56_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kxiA 1 0.8958 45.8 0.851 Contact Map
1urjA 1 0.8646 4.1 0.91 Contact Map
4qb0A 1 0.6667 3.7 0.912 Contact Map
4innA 1 0.0938 3.1 0.915 Contact Map
4tlvA 4 0.6458 3.1 0.915 Contact Map
1tiiA 1 0.7396 3 0.916 Contact Map
4k6lG 1 0.6458 2.9 0.916 Contact Map
3rmrA 5 0.2604 2.8 0.917 Contact Map
4yo7A 1 0 2.4 0.919 Contact Map
4pgiA 1 0.2708 2.3 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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