GREMLIN Database
DUF1830 - Domain of unknown function (DUF1830)
PFAM: PF08865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (65)
Sequences: 712 (444)
Seq/√Len: 55.1
META: 0.73

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R33_L3.1231.00
2_C32_R2.9171.00
4_V32_R2.6351.00
10_I28_F2.5341.00
27_V45_I2.2591.00
23_F33_L2.2051.00
14_R22_Y1.8020.99
42_Q58_T1.7920.99
17_N21_W1.7880.99
15_I18_I1.7400.99
1_C5_N1.5260.98
18_I21_W1.5100.98
7_T40_E1.5070.98
31_Q47_T1.3910.96
13_A45_I1.3030.94
7_T11_Q1.2690.93
46_H55_L1.2670.93
2_C12_I1.2550.93
4_V25_R1.2410.93
4_V7_T1.2360.93
51_A57_D1.2030.91
17_N41_A1.1500.90
14_R44_E1.1490.89
55_L58_T1.1440.89
19_P58_T1.1360.89
59_I64_L1.1350.89
41_A45_I1.1270.89
21_W33_L1.1240.88
60_P63_R1.1050.88
47_T51_A1.0590.85
15_I41_A1.0400.84
34_L65_Q1.0300.84
49_M52_G1.0200.83
24_E41_A1.0180.83
53_A58_T0.9710.80
40_E44_E0.9710.80
15_I46_H0.9700.80
13_A43_L0.9690.80
48_G52_G0.9660.79
11_Q15_I0.9540.79
12_I26_V0.9540.79
15_I23_F0.9390.77
18_I41_A0.8990.74
19_P65_Q0.8780.73
16_T41_A0.8750.72
17_N20_N0.8720.72
12_I57_D0.8680.72
37_A61_C0.8620.71
28_F32_R0.8580.71
34_L48_G0.8450.70
10_I52_G0.8360.69
31_Q52_G0.8310.68
14_R39_P0.8290.68
31_Q48_G0.8220.68
7_T43_L0.8050.66
56_S64_L0.8000.65
30_G50_M0.8000.65
2_C33_L0.7960.65
1_C61_C0.7730.63
9_R49_M0.7680.62
10_I38_P0.7450.60
45_I50_M0.7440.60
40_E63_R0.7380.59
40_E62_D0.7290.58
62_D65_Q0.7240.58
38_P45_I0.7100.56
8_S50_M0.7090.56
12_I51_A0.6940.54
3_Y35_F0.6920.54
16_T61_C0.6820.53
7_T33_L0.6730.52
15_I61_C0.6690.52
61_C64_L0.6580.51
25_R51_A0.6540.50
39_P62_D0.6420.49
37_A45_I0.6380.48
7_T36_E0.6350.48
23_F44_E0.6320.48
11_Q61_C0.6160.46
6_A29_P0.6120.46
13_A38_P0.6110.46
16_T42_Q0.5910.43
26_V38_P0.5890.43
13_A27_V0.5880.43
25_R60_P0.5840.43
37_A43_L0.5720.41
53_A63_R0.5710.41
2_C23_F0.5670.41
49_M56_S0.5580.40
49_M54_I0.5570.40
43_L61_C0.5460.39
30_G37_A0.5440.39
13_A36_E0.5360.38
8_S30_G0.5210.36
38_P62_D0.5080.35
14_R53_A0.5070.35
17_N22_Y0.5010.34
6_A45_I0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wxsA 1 1 9.1 0.897 Contact Map
4ifdG 1 0.6667 8.3 0.898 Contact Map
5afbA 3 1 8.2 0.899 Contact Map
4xatA 1 1 8.1 0.899 Contact Map
1rm6B 1 0.9091 5.8 0.905 Contact Map
5amoA 2 1 5 0.908 Contact Map
3j8eG 3 0.9394 5 0.908 Contact Map
2z0rA 4 0.7727 4 0.913 Contact Map
2j4bA 1 0.4242 3.6 0.915 Contact Map
4d7cA 1 1 3.5 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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