GREMLIN Database
DUF1829 - Domain of unknown function DUF1829
PFAM: PF08862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (87)
Sequences: 1487 (1101)
Seq/√Len: 118.1
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_L80_I3.1841.00
62_D86_S2.9931.00
30_P60_L2.5851.00
19_Q55_K2.5241.00
32_R36_E2.4911.00
31_N34_T2.3871.00
2_K47_E2.3431.00
10_D25_Q2.2561.00
25_Q41_A2.1141.00
39_L43_I2.0171.00
21_E49_R1.9371.00
58_A75_L1.8641.00
42_W56_A1.7721.00
28_N61_N1.7511.00
38_F58_A1.6841.00
36_E40_F1.6471.00
13_I24_I1.6281.00
36_E41_A1.5921.00
39_L75_L1.5061.00
76_R79_D1.4121.00
38_F56_A1.4011.00
33_D37_S1.3721.00
76_R81_K1.3591.00
23_I56_A1.3171.00
59_I82_P1.2991.00
29_R65_K1.2720.99
38_F42_W1.2660.99
35_A75_L1.2340.99
67_V84_L1.2310.99
57_Y81_K1.2060.99
30_P71_V1.2040.99
73_D76_R1.1920.99
43_I47_E1.1550.99
7_H41_A1.0950.98
13_I16_S1.0820.98
7_H36_E1.0680.98
84_L87_E1.0410.98
72_L84_L1.0390.98
35_A74_A1.0390.98
9_F41_A1.0370.98
67_V71_V1.0180.98
66_P72_L1.0080.97
27_I30_P1.0030.97
55_K81_K0.9970.97
16_S22_R0.9960.97
5_Y32_R0.9860.97
1_G4_G0.9730.97
9_F42_W0.9530.96
9_F35_A0.9490.96
25_Q38_F0.9420.96
60_L82_P0.9250.96
5_Y74_A0.9180.95
4_G61_N0.9170.95
10_D48_V0.9120.95
85_W88_R0.9030.95
2_K78_Y0.8850.94
18_K66_P0.8840.94
27_I38_F0.8620.94
24_I59_I0.8500.93
42_W54_S0.8480.93
28_N31_N0.8430.93
43_I77_N0.8400.93
14_P24_I0.8390.93
8_L15_K0.8290.92
76_R82_P0.8230.92
5_Y71_V0.8160.92
60_L84_L0.7980.91
55_K73_D0.7930.90
35_A39_L0.7850.90
3_S20_P0.7800.90
10_D26_A0.7780.90
9_F24_I0.7760.90
29_R63_S0.7750.89
9_F45_T0.7750.89
45_T54_S0.7670.89
70_D73_D0.7620.89
74_A78_Y0.7590.88
7_H40_F0.7500.88
81_K87_E0.7470.88
66_P87_E0.7170.85
4_G36_E0.7140.85
69_S87_E0.7110.85
40_F43_I0.7000.84
13_I85_W0.6860.83
50_P53_D0.6740.82
40_F78_Y0.6710.82
23_I54_S0.6680.81
32_R70_D0.6670.81
26_A60_L0.6660.81
34_T43_I0.6620.81
42_W83_V0.6600.80
41_A80_I0.6590.80
65_K76_R0.6580.80
70_D81_K0.6540.80
57_Y82_P0.6460.79
20_P55_K0.6420.79
31_N43_I0.6380.78
2_K63_S0.6260.77
66_P79_D0.6180.76
76_R87_E0.6170.76
6_D9_F0.6050.74
33_D76_R0.5970.73
21_E85_W0.5930.73
28_N69_S0.5930.73
9_F38_F0.5910.73
26_A66_P0.5880.72
36_E43_I0.5850.72
12_V16_S0.5850.72
16_S19_Q0.5840.72
6_D77_N0.5830.72
72_L82_P0.5750.71
14_P49_R0.5730.70
38_F61_N0.5700.70
72_L76_R0.5590.69
37_S68_S0.5580.68
23_I38_F0.5580.68
15_K53_D0.5580.68
51_P70_D0.5500.67
73_D79_D0.5480.67
27_I60_L0.5450.67
22_R57_Y0.5450.67
11_F26_A0.5410.66
8_L68_S0.5280.64
69_S76_R0.5230.63
67_V81_K0.5180.63
8_L63_S0.5140.62
51_P64_E0.5090.61
35_A71_V0.5060.61
18_K44_D0.5050.61
20_P62_D0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xbiA 1 0.8636 34.1 0.873 Contact Map
3j61c 1 0.8523 22.3 0.884 Contact Map
4c91A 2 0.8523 20.8 0.886 Contact Map
2fc3A 1 0.8977 19.2 0.888 Contact Map
2lbwA 1 0.8068 18.1 0.889 Contact Map
1vq8F 1 0.8977 17.6 0.89 Contact Map
3cpqA 2 0.75 16.7 0.891 Contact Map
1w41A 1 0.7614 14.2 0.894 Contact Map
3v7eA 1 0.6818 12.9 0.896 Contact Map
5by3A 1 0.8523 12 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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