GREMLIN Database
DUF1828 - Domain of unknown function DUF1828
PFAM: PF08861 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (90)
Sequences: 3713 (2983)
Seq/√Len: 314.4
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_V87_A3.4311.00
72_A80_A2.6671.00
61_V68_L2.5581.00
64_D69_V2.3301.00
49_Q53_E2.2321.00
7_D34_D2.0781.00
24_R69_V2.0611.00
11_I88_L2.0571.00
11_I89_L1.9381.00
24_R71_E1.7551.00
22_G71_E1.7181.00
76_N79_Q1.6721.00
62_E69_V1.6451.00
16_K24_R1.6291.00
70_V84_L1.6121.00
32_L63_L1.5661.00
15_L23_W1.5261.00
31_T88_L1.4991.00
63_L66_G1.4731.00
25_L84_L1.4721.00
52_L63_L1.4681.00
18_R24_R1.4491.00
62_E71_E1.4061.00
4_L10_H1.3701.00
77_F81_K1.3321.00
36_E41_D1.3241.00
56_L63_L1.2961.00
58_G90_A1.2931.00
26_T67_E1.2801.00
36_E66_G1.2761.00
53_E57_N1.2631.00
80_A83_N1.2471.00
73_T76_N1.2351.00
12_Q30_Y1.2091.00
76_N80_A1.1981.00
15_L25_L1.1841.00
84_L88_L1.1761.00
23_W74_P1.1651.00
79_Q83_N1.1361.00
39_G42_L1.1151.00
33_M66_G1.1121.00
24_R64_D1.1041.00
70_V80_A1.0841.00
72_A76_N1.0791.00
18_R22_G1.0771.00
86_Q89_L1.0551.00
5_D34_D1.0221.00
33_M36_E1.0211.00
32_L52_L1.0001.00
53_E63_L0.9941.00
5_D30_Y0.9871.00
68_L84_L0.9691.00
59_F86_Q0.9551.00
50_K54_N0.9551.00
16_K20_N0.9351.00
13_I81_K0.9221.00
56_L91_V0.9031.00
16_K26_T0.9011.00
47_K50_K0.8961.00
1_T4_L0.8861.00
29_G67_E0.8831.00
17_K20_N0.8741.00
81_K85_I0.8691.00
25_L81_K0.8601.00
52_L56_L0.8571.00
14_Y28_D0.8501.00
45_S49_Q0.8501.00
6_R34_D0.8301.00
70_V83_N0.8251.00
17_K23_W0.8251.00
6_R38_S0.8151.00
37_Y66_G0.8151.00
59_F90_A0.8111.00
33_M37_Y0.8071.00
55_I59_F0.7991.00
11_I31_T0.7881.00
47_K51_L0.7851.00
23_W77_F0.7831.00
61_V70_V0.7831.00
82_H85_I0.7761.00
5_D11_I0.7741.00
51_L54_N0.7600.99
4_L8_G0.7440.99
30_Y34_D0.7410.99
63_L68_L0.7370.99
13_I25_L0.7210.99
13_I84_L0.7190.99
3_F86_Q0.7160.99
73_T80_A0.7080.99
72_A77_F0.7070.99
78_P81_K0.7070.99
25_L80_A0.7000.99
30_Y33_M0.6990.99
56_L59_F0.6930.99
48_R51_L0.6860.99
66_G75_E0.6790.99
78_P82_H0.6730.99
85_I89_L0.6730.99
46_P50_K0.6650.98
55_I58_G0.6630.98
5_D12_Q0.6630.98
79_Q82_H0.6610.98
22_G73_T0.6580.98
86_Q91_V0.6430.98
46_P49_Q0.6360.98
3_F85_I0.6350.98
19_E24_R0.6340.98
63_L69_V0.6310.98
51_L55_I0.6310.98
55_I87_A0.6290.98
53_E62_E0.6090.97
77_F85_I0.6070.97
19_E62_E0.5990.97
25_L88_L0.5900.97
7_D37_Y0.5880.97
1_T5_D0.5840.97
61_V84_L0.5770.96
16_K28_D0.5700.96
13_I88_L0.5600.96
21_G73_T0.5590.96
52_L55_I0.5560.95
16_K19_E0.5450.95
1_T10_H0.5410.95
15_L72_A0.5350.94
71_E74_P0.5320.94
21_G74_P0.5310.94
30_Y37_Y0.5310.94
50_K53_E0.5300.94
58_G91_V0.5290.94
2_P13_I0.5250.94
2_P35_L0.5200.94
59_F83_N0.5050.93
8_G12_Q0.5030.92
9_D29_G0.5030.92
29_G35_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4es1A 2 0.6813 11.1 0.874 Contact Map
4qr2A 2 0.6264 9.9 0.877 Contact Map
2ivyA 2 0.6374 8.4 0.881 Contact Map
3excX 2 0.6044 7.7 0.883 Contact Map
4tnoA 2 0.6154 6.9 0.885 Contact Map
1zpwX 2 0.6484 6.9 0.885 Contact Map
3tewA 1 0.4725 6.1 0.888 Contact Map
3oq2A 3 0.6923 5.7 0.89 Contact Map
2ypvA 1 0.9231 5.5 0.891 Contact Map
3uf8A 1 0.9341 4.6 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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