GREMLIN Database
DGC - DGC domain
PFAM: PF08859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (103)
Sequences: 5171 (3086)
Seq/√Len: 304.1
META: 0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_G70_K4.3701.00
62_A80_V3.3191.00
55_A64_A3.2981.00
65_K69_E2.8391.00
80_V83_D2.5801.00
55_A68_L2.3431.00
62_A65_K2.1391.00
65_K78_H2.0541.00
98_E101_K2.0381.00
45_K49_S2.0281.00
45_K48_K1.9931.00
2_I28_A1.9821.00
21_K25_E1.9361.00
39_G71_A1.8771.00
42_G46_S1.7801.00
13_Q16_R1.7011.00
15_A56_I1.6251.00
19_A30_M1.6081.00
13_Q17_Q1.5901.00
52_P77_R1.5271.00
41_E45_K1.4861.00
87_E90_K1.4821.00
96_P100_E1.4821.00
40_V43_L1.4661.00
62_A78_H1.4471.00
16_R20_R1.4361.00
25_E103_V1.4271.00
69_E74_K1.3361.00
19_A56_I1.3321.00
3_Y31_S1.3171.00
21_K103_V1.2941.00
79_I84_L1.2891.00
35_G43_L1.2511.00
44_V48_K1.2141.00
18_A102_V1.2111.00
95_T98_E1.1681.00
57_D78_H1.1601.00
66_K69_E1.1351.00
17_Q96_P1.1301.00
54_I79_I1.1291.00
33_L64_A1.1201.00
37_G67_I1.1111.00
55_A78_H1.0941.00
97_E101_K1.0791.00
18_A22_L1.0771.00
84_L102_V1.0231.00
4_A19_A1.0201.00
29_E46_S1.0011.00
36_V68_L0.9961.00
91_T94_F0.9941.00
52_P76_D0.9921.00
94_F99_I0.9911.00
6_S30_M0.9881.00
10_N86_I0.9861.00
53_I73_I0.9831.00
7_G32_C0.9791.00
86_I98_E0.9381.00
62_A82_T0.9361.00
17_Q21_K0.9271.00
14_L86_I0.9241.00
35_G40_V0.9211.00
6_S16_R0.9111.00
89_G92_L0.8971.00
31_S47_A0.8941.00
24_R93_D0.8921.00
39_G44_V0.8891.00
21_K100_E0.8701.00
96_P99_I0.8661.00
10_N14_L0.8621.00
85_G88_K0.8481.00
57_D65_K0.8411.00
40_V44_V0.8361.00
3_Y53_I0.8291.00
4_A15_A0.8121.00
21_K24_R0.8101.00
68_L73_I0.8091.00
18_A103_V0.7981.00
3_Y68_L0.7971.00
1_L31_S0.7971.00
17_Q94_F0.7971.00
100_E103_V0.7931.00
66_K70_K0.7830.99
23_T30_M0.7780.99
86_I89_G0.7720.99
14_L99_I0.7700.99
93_D96_P0.7470.99
60_P82_T0.7440.99
23_T28_A0.7390.99
18_A81_L0.7340.99
69_E76_D0.7340.99
99_I103_V0.7330.99
53_I68_L0.7320.99
43_L47_A0.7310.99
38_G67_I0.7300.99
59_C63_C0.7270.99
35_G38_G0.7020.99
10_N13_Q0.7000.99
17_Q20_R0.6970.99
11_V82_T0.6940.99
91_T98_E0.6880.99
95_T99_I0.6850.99
31_S43_L0.6850.99
31_S35_G0.6780.99
3_Y47_A0.6720.98
31_S46_S0.6680.98
1_L53_I0.6650.98
53_I76_D0.6630.98
93_D99_I0.6510.98
43_L46_S0.6460.98
94_F98_E0.6460.98
91_T95_T0.6410.98
42_G61_L0.6320.98
96_P101_K0.6260.98
38_G66_K0.6160.97
41_E48_K0.6110.97
6_S13_Q0.6040.97
47_A73_I0.5990.97
67_I70_K0.5980.97
32_C88_K0.5950.97
23_T31_S0.5930.97
17_Q99_I0.5920.97
97_E100_E0.5900.96
11_V86_I0.5880.96
32_C35_G0.5850.96
98_E102_V0.5830.96
15_A19_A0.5820.96
34_A67_I0.5780.96
22_L28_A0.5720.96
14_L81_L0.5690.96
14_L18_A0.5690.96
54_I76_D0.5680.96
13_Q20_R0.5660.96
87_E91_T0.5640.95
90_K98_E0.5610.95
89_G98_E0.5600.95
44_V73_I0.5590.95
35_G61_L0.5570.95
35_G47_A0.5570.95
33_L67_I0.5360.94
41_E46_S0.5270.93
48_K73_I0.5240.93
39_G72_G0.5210.93
3_Y6_S0.5200.93
8_G33_L0.5180.93
55_A75_P0.5180.93
36_V73_I0.5180.93
15_A81_L0.5170.93
10_N16_R0.5160.93
95_T101_K0.5130.93
89_G95_T0.5070.92
33_L36_V0.5070.92
60_P83_D0.5000.92
32_C60_P0.5000.92
17_Q24_R0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zj8A 1 0.8679 58.4 0.852 Contact Map
2akjA 1 0.8491 57.2 0.853 Contact Map
3b0gA 1 0.8491 56.7 0.854 Contact Map
4g38A 1 0.8679 50.3 0.859 Contact Map
2l17A 1 0.9528 45.3 0.863 Contact Map
5c4iA 2 0.9717 39.7 0.868 Contact Map
4lrqA 2 1 33.4 0.873 Contact Map
3ju3A 4 0.9151 28 0.878 Contact Map
1yd7A 1 0 28 0.878 Contact Map
3jviA 1 0.9717 26.6 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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