GREMLIN Database
DUF1826 - Protein of unknown function (DUF1826)
PFAM: PF08856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 199 (195)
Sequences: 1871 (1554)
Seq/√Len: 111.3
META: 0.718

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_D123_Y6.0031.00
158_L164_A5.8151.00
129_E157_Q4.6431.00
159_P162_D4.3731.00
136_V180_V3.6881.00
132_P135_A3.3511.00
105_A108_P3.2461.00
129_E185_P3.1121.00
9_D12_Q3.0541.00
169_E176_G2.9371.00
22_R78_D2.7761.00
110_F155_I2.7601.00
24_L161_G2.6521.00
90_F117_C2.6101.00
99_L196_L2.5581.00
120_L195_L2.4391.00
126_P157_Q2.4271.00
20_W163_V2.4251.00
22_R123_Y2.3981.00
114_R170_L2.2381.00
79_I196_L2.1811.00
120_L197_T2.0751.00
166_L179_L1.9301.00
75_L79_I1.9081.00
31_W72_R1.8741.00
19_I158_L1.8691.00
17_L130_W1.8221.00
31_W71_G1.7861.00
31_W75_L1.7471.00
82_L163_V1.7331.00
145_N148_L1.7251.00
21_Q162_D1.6971.00
83_V95_V1.6831.00
140_K147_G1.6661.00
140_K146_S1.5841.00
97_L198_L1.5791.00
87_A95_V1.5501.00
81_E85_M1.5251.00
105_A187_A1.5071.00
114_R169_E1.4621.00
83_V198_L1.4471.00
107_C118_R1.4371.00
144_E147_G1.4251.00
17_L164_A1.4131.00
112_V169_E1.4101.00
98_R197_T1.3501.00
133_E177_A1.3401.00
6_V9_D1.3331.00
145_N149_Y1.3241.00
117_C171_W1.2990.99
17_L179_L1.2780.99
105_A186_I1.2730.99
102_L106_M1.2710.99
31_W73_D1.2200.99
31_W67_P1.2010.99
151_D154_D1.1990.99
4_P85_M1.1770.99
85_M88_C1.1750.99
166_L174_N1.1550.99
32_L124_R1.1540.99
67_P72_R1.1450.99
102_L108_P1.1400.99
25_P74_A1.1400.99
126_P191_E1.1160.98
69_G72_R1.1020.98
138_R142_G1.0990.98
10_I117_C1.0870.98
3_D6_V1.0830.98
30_D34_A1.0750.98
164_A179_L1.0700.98
4_P20_W1.0660.98
135_A154_D1.0640.98
107_C128_T1.0430.97
117_C165_L1.0380.97
186_I189_G1.0330.97
112_V178_G1.0320.97
36_L192_R1.0230.97
129_E182_R1.0120.97
16_N133_E1.0090.97
140_K148_L1.0050.97
10_I167_K1.0030.97
16_N167_K1.0000.97
28_L74_A0.9930.97
137_D141_L0.9890.96
135_A156_Q0.9860.96
53_E77_A0.9740.96
46_L49_S0.9680.96
29_A32_L0.9600.96
113_D128_T0.9600.96
47_L55_A0.9420.95
120_L142_G0.9420.95
142_G147_G0.9420.95
11_Y89_L0.9340.95
6_V18_A0.9330.95
84_D88_C0.9310.95
96_G199_D0.9290.95
43_L60_A0.9240.95
181_H193_R0.9150.95
115_V195_L0.9130.94
100_E197_T0.9120.94
48_R51_T0.9080.94
32_L194_L0.8950.94
183_S193_R0.8920.94
144_E148_L0.8830.93
33_D160_T0.8830.93
7_L18_A0.8820.93
107_C113_D0.8780.93
103_D192_R0.8640.93
169_E174_N0.8550.92
15_V18_A0.8530.92
140_K149_Y0.8480.92
138_R141_L0.8480.92
140_K143_A0.8470.92
158_L162_D0.8350.91
6_V20_W0.8300.91
82_L121_C0.8300.91
187_A190_G0.8290.91
148_L151_D0.8240.91
11_Y171_W0.8170.90
16_N174_N0.8150.90
188_G191_E0.8140.90
115_V169_E0.8070.90
59_L63_A0.7990.89
40_L124_R0.7930.89
17_L166_L0.7900.89
92_A117_C0.7890.89
96_G108_P0.7870.89
112_V116_P0.7870.89
80_A84_D0.7790.88
108_P185_P0.7790.88
171_W197_T0.7780.88
133_E138_R0.7730.88
142_G146_S0.7710.88
8_A11_Y0.7710.88
169_E178_G0.7600.87
132_P156_Q0.7560.87
25_P28_L0.7540.87
181_H184_P0.7530.86
11_Y96_G0.7530.86
109_R145_N0.7530.86
33_D124_R0.7520.86
186_I192_R0.7470.86
32_L36_L0.7460.86
3_D70_P0.7450.86
186_I190_G0.7450.86
17_L120_L0.7430.86
146_S149_Y0.7380.85
165_L171_W0.7370.85
133_E136_V0.7370.85
72_R76_I0.7360.85
16_N180_V0.7320.85
52_V57_A0.7310.85
174_N178_G0.7270.85
124_R127_G0.7230.84
52_V83_V0.7190.84
161_G164_A0.7130.83
79_I99_L0.7120.83
41_P124_R0.7120.83
62_L72_R0.7090.83
27_A74_A0.7040.83
40_L101_V0.7040.83
98_R171_W0.7030.83
47_L52_V0.7020.82
111_H125_G0.7010.82
111_H128_T0.6980.82
98_R115_V0.6980.82
105_A185_P0.6970.82
101_V156_Q0.6940.82
90_F171_W0.6920.82
24_L28_L0.6910.81
6_V88_C0.6910.81
135_A151_D0.6880.81
81_E88_C0.6860.81
54_P57_A0.6840.81
36_L101_V0.6800.80
126_P186_I0.6800.80
193_R196_L0.6790.80
8_A85_M0.6780.80
130_W156_Q0.6780.80
152_P155_I0.6720.80
102_L105_A0.6700.79
8_A88_C0.6670.79
11_Y90_F0.6670.79
90_F108_P0.6620.79
138_R180_V0.6600.78
28_L32_L0.6590.78
113_D181_H0.6580.78
4_P8_A0.6580.78
118_R168_G0.6560.78
88_C96_G0.6490.77
92_A95_V0.6470.77
122_T125_G0.6410.76
12_Q91_G0.6380.76
28_L71_G0.6370.76
31_W69_G0.6340.76
62_L66_L0.6330.75
120_L166_L0.6310.75
116_P164_A0.6310.75
140_K145_N0.6300.75
55_A60_A0.6260.75
26_P153_S0.6250.75
85_M96_G0.6240.74
16_N169_E0.6220.74
26_P30_D0.6170.74
6_V10_I0.6170.74
104_T108_P0.6170.74
22_R121_C0.6160.73
107_C122_T0.6140.73
86_F128_T0.6120.73
53_E56_L0.6110.73
107_C183_S0.6090.73
21_Q156_Q0.6070.72
47_L54_P0.6050.72
49_S53_E0.6010.72
82_L119_L0.6000.72
141_L178_G0.6000.72
139_S142_G0.5990.71
98_R183_S0.5940.71
97_L176_G0.5890.70
98_R108_P0.5860.70
109_R144_E0.5860.70
139_S143_A0.5850.70
13_P34_A0.5840.69
151_D155_I0.5840.69
35_L180_V0.5820.69
24_L74_A0.5820.69
43_L46_L0.5810.69
131_L178_G0.5800.69
60_A73_D0.5800.69
96_G106_M0.5790.69
119_L130_W0.5760.68
46_L55_A0.5750.68
64_A67_P0.5740.68
143_A146_S0.5700.68
83_V86_F0.5690.68
141_L180_V0.5680.67
107_C199_D0.5670.67
187_A191_E0.5660.67
65_G77_A0.5630.67
131_L156_Q0.5630.67
5_E61_L0.5620.67
109_R118_R0.5600.66
19_I162_D0.5580.66
52_V61_L0.5580.66
98_R106_M0.5520.65
111_H181_H0.5520.65
85_M90_F0.5510.65
146_S150_R0.5510.65
30_D56_L0.5490.65
130_W164_A0.5490.65
20_W82_L0.5490.65
116_P171_W0.5460.64
113_D118_R0.5460.64
51_T54_P0.5450.64
124_R192_R0.5440.64
121_C131_L0.5420.64
135_A150_R0.5420.64
13_P26_P0.5400.64
36_L124_R0.5390.63
34_A159_P0.5360.63
74_A77_A0.5340.63
28_L31_W0.5330.63
144_E149_Y0.5320.62
118_R128_T0.5310.62
115_V118_R0.5310.62
62_L67_P0.5290.62
121_C172_P0.5290.62
171_W175_E0.5280.62
105_A191_E0.5280.62
33_D150_R0.5270.62
29_A124_R0.5270.62
45_V195_L0.5270.62
23_Q41_P0.5270.62
11_Y117_C0.5250.61
145_N150_R0.5240.61
48_R55_A0.5210.61
46_L59_L0.5200.61
63_A72_R0.5200.61
131_L163_V0.5170.60
27_A70_P0.5160.60
49_S81_E0.5130.60
65_G68_D0.5120.59
96_G109_R0.5120.59
139_S150_R0.5100.59
173_G176_G0.5080.59
100_E106_M0.5070.59
31_W115_V0.5060.59
115_V170_L0.5050.58
32_L75_L0.5050.58
166_L195_L0.5020.58
31_W35_L0.5000.58
100_E167_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rdqA 1 0.9146 51.7 0.93 Contact Map
4xabA 1 0.9246 50.7 0.931 Contact Map
4xbzA 4 0.9045 45.8 0.932 Contact Map
4xaaA 1 0.9146 44.6 0.933 Contact Map
2opwA 1 0.9095 43.1 0.934 Contact Map
4nmiA 2 0.8945 32.7 0.938 Contact Map
4naoA 2 0.8643 27 0.94 Contact Map
4xcbA 4 0.8794 25.7 0.941 Contact Map
4mhrA 2 0.8744 21.9 0.943 Contact Map
4j25A 2 0.8291 17.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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