GREMLIN Database
DUF1825 - Domain of unknown function (DUF1825)
PFAM: PF08855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (101)
Sequences: 1405 (761)
Seq/√Len: 75.7
META: 0.944

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_E100_K2.7901.00
71_K74_I2.7511.00
77_S80_M2.5411.00
2_S5_D2.5251.00
69_E73_Q2.4111.00
10_R14_K2.3131.00
11_E14_K2.1971.00
74_I78_A2.1701.00
53_K90_D2.0901.00
34_D37_E2.0131.00
12_E54_I1.9551.00
22_E44_K1.9171.00
88_M92_M1.9091.00
72_E75_K1.8771.00
73_Q76_K1.7771.00
75_K78_A1.7691.00
37_E40_E1.7241.00
29_K32_S1.7121.00
78_A81_M1.6851.00
77_S81_M1.6581.00
53_K93_S1.5830.99
35_R39_L1.5790.99
89_F96_L1.5590.99
50_E53_K1.5450.99
6_S61_L1.5360.99
75_K79_G1.4810.99
95_T98_R1.4780.99
63_D67_A1.4540.99
72_E76_K1.4520.99
48_L52_Q1.4410.99
47_E51_K1.4160.99
15_E47_E1.4120.99
68_K72_E1.3830.99
74_I77_S1.3710.98
54_I57_T1.3610.98
66_E69_E1.3270.98
71_K75_K1.2920.98
76_K80_M1.2750.97
46_E97_E1.2720.97
76_K79_G1.2670.97
91_N94_K1.2600.97
62_S67_A1.2580.97
79_G82_G1.2330.97
35_R38_K1.1890.96
95_T99_M1.1230.95
98_R102_Q1.0840.94
50_E54_I1.0820.94
8_I12_E1.0580.93
98_R101_K1.0560.93
22_E40_E1.0130.91
14_K21_E1.0110.91
20_Q24_Y0.9900.90
90_D93_S0.9630.89
66_E73_Q0.9590.89
11_E18_E0.9500.88
75_K83_V0.9390.88
40_E43_E0.9310.87
90_D94_K0.9190.86
68_K71_K0.9160.86
97_E101_K0.9130.86
32_S35_R0.9110.86
63_D68_K0.8930.85
43_E100_K0.8880.85
30_F33_M0.8880.85
70_M74_I0.8850.84
94_K98_R0.8830.84
59_L71_K0.8810.84
6_S9_V0.8680.83
16_I48_L0.8650.83
87_Q101_K0.8590.83
10_R47_E0.8460.82
70_M73_Q0.8320.80
88_M95_T0.8290.80
38_K99_M0.8210.80
92_M96_L0.8170.79
13_L27_V0.7990.78
15_E51_K0.7960.77
94_K97_E0.7680.75
37_E43_E0.7680.75
11_E15_E0.7630.74
23_I93_S0.7610.74
96_L99_M0.7540.74
78_A82_G0.7520.73
2_S9_V0.7440.73
63_D69_E0.7420.72
67_A70_M0.7340.72
60_S71_K0.7330.71
73_Q78_A0.7200.70
55_F83_V0.7070.69
17_N21_E0.7060.69
49_L96_L0.7040.68
2_S46_E0.7010.68
20_Q52_Q0.7000.68
45_L96_L0.6980.68
75_K81_M0.6910.67
85_M88_M0.6900.67
13_L41_H0.6870.66
74_I79_G0.6840.66
17_N55_F0.6830.66
57_T61_L0.6810.66
8_I17_N0.6780.65
57_T91_N0.6760.65
59_L70_M0.6640.64
88_M91_N0.6640.64
5_D69_E0.6640.64
16_I20_Q0.6570.63
69_E72_E0.6550.63
75_K80_M0.6480.62
3_F67_A0.6480.62
12_E15_E0.6470.62
57_T60_S0.6330.60
15_E19_L0.6240.59
37_E55_F0.6160.58
20_Q49_L0.6150.58
19_L24_Y0.6120.58
77_S85_M0.5980.56
89_F95_T0.5980.56
48_L56_Y0.5970.56
16_I19_L0.5930.55
24_Y41_H0.5920.55
92_M100_K0.5910.55
37_E91_N0.5830.54
10_R70_M0.5820.54
22_E25_G0.5750.53
31_P44_K0.5690.52
9_V31_P0.5640.52
39_L53_K0.5500.50
30_F56_Y0.5470.49
34_D39_L0.5450.49
9_V55_F0.5450.49
83_V91_N0.5450.49
35_R62_S0.5410.49
7_E10_R0.5390.48
29_K33_M0.5370.48
5_D45_L0.5340.48
55_F73_Q0.5280.47
33_M41_H0.5270.47
89_F99_M0.5220.46
42_I92_M0.5210.46
30_F100_K0.5200.46
13_L93_S0.5200.46
41_H60_S0.5190.46
45_L89_F0.5170.46
24_Y27_V0.5120.45
76_K81_M0.5100.45
20_Q45_L0.5100.45
3_F51_K0.5100.45
31_P34_D0.5040.44
13_L55_F0.5040.44
20_Q63_D0.5040.44
95_T102_Q0.5020.44
88_M99_M0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onjA 1 0.7864 27.3 0.899 Contact Map
1vcsA 1 0.7864 18.7 0.907 Contact Map
2qywA 1 0.8252 14.1 0.912 Contact Map
1v2zA 2 0.699 13.8 0.912 Contact Map
1r5qA 2 0.5825 12.1 0.914 Contact Map
3zg1A 2 0.5243 11.1 0.916 Contact Map
2xxaA 1 0.8155 7.9 0.921 Contact Map
2p4fA 1 0 6.4 0.925 Contact Map
4kikA 2 0.8641 6.3 0.925 Contact Map
1tlqA 4 0.3786 6.3 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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