GREMLIN Database
DUF1822 - Protein of unknown function (DUF1822)
PFAM: PF08852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 368 (366)
Sequences: 741 (673)
Seq/√Len: 35.2
META: 0.483

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
303_L316_L3.9701.00
346_G350_E3.9371.00
334_R337_D3.8741.00
355_E362_S3.8351.00
301_V354_V3.7201.00
36_A119_A3.2451.00
322_D350_E3.1361.00
37_V79_C3.0271.00
185_N189_Q3.0191.00
227_L230_W2.9111.00
78_E104_G2.7801.00
186_L189_Q2.7211.00
14_F31_T2.5481.00
252_A255_G2.5081.00
39_P43_E2.4931.00
92_V130_L2.4781.00
322_D331_V2.4721.00
270_K274_L2.4421.00
226_S230_W2.3911.00
319_R355_E2.3871.00
345_S350_E2.3711.00
320_L328_F2.2640.99
125_T144_L2.2480.99
112_V119_A2.1930.99
329_Q344_F2.1910.99
23_K26_Q2.1140.99
303_L356_V2.0930.99
322_D328_F2.0740.99
334_R341_Q1.9910.98
329_Q342_L1.9730.98
71_I144_L1.9560.98
317_K330_E1.9440.98
3_L36_A1.9010.98
25_W83_E1.8930.98
90_V109_A1.8920.97
214_L218_R1.8470.97
238_L245_E1.8360.97
80_I93_P1.8310.97
101_D206_A1.8270.97
8_R116_L1.8260.97
329_Q337_D1.8250.97
91_R144_L1.8120.97
230_W235_V1.8010.97
108_V155_L1.7970.97
322_D346_G1.7800.96
333_A337_D1.7580.96
338_N341_Q1.7450.96
301_V344_F1.7360.96
341_Q344_F1.7290.96
337_D341_Q1.7280.96
251_A257_R1.7210.96
111_Q120_R1.7180.96
151_P155_L1.7130.95
244_W248_W1.7070.95
352_F367_F1.7070.95
150_I154_N1.7020.95
302_Q341_Q1.6810.95
230_W233_N1.6690.95
252_A256_A1.6590.95
320_L354_V1.6580.95
8_R112_V1.6520.94
3_L8_R1.6410.94
320_L345_S1.6010.93
329_Q343_K1.5960.93
247_R251_A1.5960.93
270_K365_E1.5920.93
37_V110_V1.5910.93
273_D278_L1.5770.93
266_V270_K1.5760.93
238_L242_L1.5720.93
25_W28_Y1.5680.93
17_Q61_S1.5560.92
301_V329_Q1.5550.92
187_L190_L1.5370.92
288_A315_G1.5340.92
247_R252_A1.5300.92
334_R338_N1.5290.92
331_V354_V1.5150.91
320_L329_Q1.5110.91
242_L245_E1.4900.91
78_E102_R1.4830.91
301_V320_L1.4820.90
305_P367_F1.4720.90
122_L149_L1.4450.89
329_Q345_S1.4270.89
302_Q337_D1.4230.89
18_Q27_V1.4090.88
214_L219_Q1.4020.88
273_D276_L1.3950.88
253_L256_A1.3930.87
229_Q232_Q1.3820.87
230_W234_G1.3720.87
90_V149_L1.3660.86
113_D117_E1.3640.86
307_G368_V1.3640.86
230_W236_S1.3560.86
7_A35_L1.3550.86
227_L231_L1.3440.86
339_Y342_L1.3430.85
127_H142_Y1.3410.85
246_T251_A1.3380.85
269_A272_I1.3330.85
239_A242_L1.3160.84
1_L43_E1.3030.84
320_L331_V1.3010.84
328_F339_Y1.2960.83
81_P110_V1.2930.83
212_Q215_Y1.2840.83
238_L244_W1.2740.82
273_D277_Q1.2720.82
298_S322_D1.2700.82
273_D334_R1.2650.82
299_I346_G1.2600.82
14_F56_W1.2590.82
77_L104_G1.2560.81
322_D329_Q1.2470.81
99_I142_Y1.2340.80
225_W230_W1.2330.80
76_R317_K1.2330.80
273_D337_D1.2260.80
338_N342_L1.2160.79
29_L112_V1.2160.79
15_S39_P1.2150.79
347_E350_E1.2140.79
243_G248_W1.2120.79
124_F152_D1.2110.79
226_S236_S1.2070.79
248_W251_A1.2000.78
3_L20_N1.2000.78
4_S46_I1.1940.78
37_V104_G1.1940.78
334_R344_F1.1890.78
44_M126_T1.1860.77
198_W202_E1.1860.77
211_R215_Y1.1710.77
65_D80_I1.1700.76
322_D353_S1.1700.76
331_V343_K1.1610.76
150_I156_L1.1580.76
225_W228_G1.1520.75
328_F358_L1.1490.75
44_M156_L1.1460.75
254_L258_S1.1440.75
288_A301_V1.1410.75
300_R339_Y1.1400.75
340_I343_K1.1350.74
158_V164_P1.1330.74
303_L363_I1.1330.74
38_L50_L1.1320.74
283_V316_L1.1310.74
67_A80_I1.1150.73
70_A76_R1.1080.72
68_D78_E1.1040.72
331_V345_S1.0950.72
344_F367_F1.0940.71
160_A163_L1.0930.71
361_A364_T1.0900.71
253_L258_S1.0850.71
29_L116_L1.0800.70
238_L241_T1.0750.70
79_C110_V1.0740.70
346_G352_F1.0740.70
96_W198_W1.0710.70
320_L342_L1.0700.70
38_L42_Q1.0680.70
268_R274_L1.0670.70
339_Y343_K1.0670.70
187_L265_G1.0630.69
215_Y218_R1.0610.69
262_P265_G1.0610.69
16_Q64_E1.0580.69
31_T55_S1.0570.69
355_E364_T1.0570.69
30_N81_P1.0560.69
245_E248_W1.0560.69
302_Q319_R1.0540.69
243_G249_L1.0530.68
228_G233_N1.0520.68
40_W112_V1.0450.68
183_A186_L1.0390.67
286_L320_L1.0390.67
112_V116_L1.0330.67
197_G200_T1.0290.67
302_Q338_N1.0240.66
333_A338_N1.0220.66
198_W201_W1.0210.66
108_V120_R1.0200.66
329_Q336_Q1.0190.66
253_L257_R1.0170.66
146_L192_N1.0150.66
174_P178_L1.0030.65
302_Q350_E1.0010.65
353_S366_N0.9990.64
257_R261_N0.9980.64
159_L163_L0.9960.64
21_P112_V0.9920.64
328_F336_Q0.9910.64
239_A243_G0.9910.64
269_A273_D0.9900.64
241_T244_W0.9870.63
299_I344_F0.9870.63
1_L39_P0.9860.63
15_S28_Y0.9850.63
248_W259_P0.9850.63
298_S343_K0.9840.63
34_L56_W0.9710.62
14_F61_S0.9710.62
322_D336_Q0.9650.62
329_Q350_E0.9590.61
144_L175_L0.9590.61
175_L202_E0.9570.61
109_A149_L0.9570.61
215_Y219_Q0.9540.61
286_L336_Q0.9540.61
86_D90_V0.9480.60
3_L11_A0.9470.60
267_R335_S0.9450.60
104_G107_Y0.9440.60
228_G237_Q0.9430.60
68_D102_R0.9400.60
320_L350_E0.9370.59
101_D156_L0.9320.59
281_Q342_L0.9320.59
352_F356_V0.9280.59
246_T250_A0.9250.58
302_Q329_Q0.9230.58
301_V322_D0.9220.58
8_R84_P0.9220.58
230_W237_Q0.9180.58
232_Q237_Q0.9150.57
92_V333_A0.9090.57
228_G232_Q0.9080.57
74_F156_L0.9060.57
288_A344_F0.9050.57
328_F338_N0.9020.56
344_F352_F0.9020.56
247_R250_A0.8990.56
228_G236_S0.8940.56
12_W16_Q0.8940.56
123_G316_L0.8880.55
225_W231_L0.8870.55
328_F331_V0.8850.55
149_L320_L0.8840.55
227_L233_N0.8830.55
27_V34_L0.8820.55
93_P149_L0.8780.54
41_L155_L0.8770.54
239_A245_E0.8760.54
121_L255_G0.8750.54
110_V318_L0.8750.54
354_V366_N0.8720.54
303_L347_E0.8700.54
11_A32_L0.8690.54
229_Q234_G0.8690.54
59_L62_L0.8670.53
243_G247_R0.8660.53
12_W24_A0.8540.52
241_T247_R0.8520.52
97_V130_L0.8520.52
227_L235_V0.8470.52
62_L76_R0.8420.51
234_G249_L0.8330.50
28_Y33_A0.8320.50
53_S56_W0.8300.50
244_W247_R0.8300.50
318_L331_V0.8300.50
68_D96_W0.8290.50
81_P154_N0.8280.50
84_P112_V0.8230.50
36_A115_E0.8190.49
227_L237_Q0.8180.49
1_L63_W0.8170.49
225_W229_Q0.8110.49
311_Y340_I0.8100.49
25_W116_L0.8100.49
7_A32_L0.8080.48
67_A78_E0.8070.48
283_V305_P0.8070.48
312_L333_A0.8060.48
329_Q339_Y0.8050.48
299_I352_F0.8050.48
34_L107_Y0.8040.48
83_E116_L0.8040.48
53_S102_R0.8030.48
25_W29_L0.8010.48
19_S27_V0.7990.48
363_I366_N0.7990.48
173_A176_P0.7990.48
288_A331_V0.7990.48
292_E298_S0.7820.46
78_E106_Y0.7810.46
50_L53_S0.7790.46
284_A349_G0.7750.46
204_L217_R0.7750.46
330_E337_D0.7740.45
3_L110_V0.7730.45
296_E350_E0.7720.45
258_S266_V0.7710.45
248_W252_A0.7690.45
114_E346_G0.7680.45
44_M106_Y0.7670.45
37_V67_A0.7660.45
272_I301_V0.7660.45
76_R354_V0.7630.44
49_D57_N0.7620.44
299_I367_F0.7590.44
23_K27_V0.7570.44
328_F337_D0.7570.44
180_L184_E0.7570.44
232_Q235_V0.7510.43
8_R25_W0.7510.43
11_A15_S0.7490.43
25_W112_V0.7490.43
301_V352_F0.7470.43
240_T246_T0.7460.43
271_L311_Y0.7460.43
140_R201_W0.7450.43
77_L250_A0.7430.43
225_W237_Q0.7430.43
50_L56_W0.7420.43
300_R338_N0.7410.43
39_P61_S0.7410.43
68_D95_E0.7390.42
94_Q99_I0.7350.42
15_S64_E0.7350.42
301_V328_F0.7320.42
228_G231_L0.7300.42
132_Q170_A0.7280.42
2_P108_V0.7270.41
125_T157_E0.7270.41
302_Q327_V0.7250.41
4_S9_Q0.7250.41
141_T356_V0.7240.41
226_S229_Q0.7230.41
320_L346_G0.7220.41
57_N149_L0.7220.41
152_D155_L0.7210.41
4_S116_L0.7200.41
251_A254_L0.7140.40
266_V274_L0.7100.40
226_S233_N0.7100.40
120_R127_H0.7090.40
225_W233_N0.7080.40
158_V161_Q0.7070.40
241_T245_E0.7070.40
332_Q360_D0.7060.40
143_E147_S0.7060.40
226_S234_G0.7040.40
240_T243_G0.7030.39
68_D106_Y0.7030.39
283_V356_V0.7020.39
225_W234_G0.7020.39
296_E322_D0.7010.39
27_V62_L0.6980.39
237_Q240_T0.6980.39
331_V337_D0.6960.39
65_D78_E0.6950.39
226_S231_L0.6940.39
94_Q100_P0.6920.39
235_V245_E0.6920.39
276_L363_I0.6920.39
239_A244_W0.6910.38
334_R343_K0.6900.38
238_L243_G0.6900.38
344_F363_I0.6890.38
229_Q235_V0.6890.38
43_E83_E0.6880.38
102_R106_Y0.6860.38
352_F363_I0.6840.38
78_E105_D0.6830.38
317_K332_Q0.6820.38
227_L238_L0.6780.37
3_L28_Y0.6770.37
1_L300_R0.6770.37
65_D68_D0.6740.37
235_V246_T0.6690.37
245_E254_L0.6670.37
228_G234_G0.6670.37
231_L237_Q0.6660.36
47_E59_L0.6660.36
353_S367_F0.6640.36
241_T246_T0.6630.36
82_V139_D0.6620.36
327_V346_G0.6620.36
239_A249_L0.6610.36
333_A367_F0.6610.36
286_L326_E0.6600.36
203_A335_S0.6570.36
99_I111_Q0.6560.36
109_A147_S0.6560.36
227_L232_Q0.6560.36
267_R296_E0.6550.36
66_V93_P0.6540.36
305_P308_G0.6530.35
308_G357_S0.6530.35
185_N200_T0.6510.35
299_I304_Y0.6480.35
329_Q341_Q0.6470.35
318_L337_D0.6460.35
255_G259_P0.6450.35
43_E112_V0.6450.35
85_L111_Q0.6430.35
5_P13_Q0.6420.35
286_L329_Q0.6420.35
211_R214_L0.6410.35
102_R124_F0.6400.34
184_E189_Q0.6380.34
183_A210_W0.6380.34
322_D326_E0.6380.34
50_L71_I0.6350.34
7_A39_P0.6350.34
327_V330_E0.6350.34
83_E112_V0.6340.34
227_L234_G0.6340.34
122_L159_L0.6330.34
28_Y36_A0.6320.34
233_N237_Q0.6300.34
188_S308_G0.6280.33
250_A254_L0.6270.33
336_Q343_K0.6270.33
267_R298_S0.6260.33
68_D198_W0.6260.33
142_Y145_P0.6200.33
325_G363_I0.6180.33
259_P262_P0.6170.33
323_E351_R0.6170.33
317_K357_S0.6160.33
80_I149_L0.6160.33
9_Q280_G0.6140.32
296_E345_S0.6140.32
305_P352_F0.6130.32
4_S7_A0.6120.32
227_L240_T0.6040.32
160_A303_L0.6040.32
238_L246_T0.6040.32
356_V363_I0.6030.32
61_S80_I0.6020.32
71_I174_P0.6010.31
33_A81_P0.6000.31
24_A99_I0.6000.31
190_L324_S0.5990.31
34_L101_D0.5990.31
65_D159_L0.5960.31
105_D128_V0.5950.31
290_T328_F0.5940.31
286_L343_K0.5920.31
79_C153_L0.5920.31
16_Q49_D0.5910.31
199_Q295_E0.5910.31
285_L337_D0.5870.30
76_R200_T0.5860.30
37_V108_V0.5850.30
28_Y76_R0.5810.30
55_S68_D0.5810.30
33_A207_P0.5810.30
254_L261_N0.5800.30
279_A328_F0.5800.30
251_A256_A0.5790.30
4_S126_T0.5790.30
28_Y32_L0.5780.30
228_G235_V0.5780.30
28_Y154_N0.5780.30
42_Q45_G0.5740.29
320_L338_N0.5740.29
361_A366_N0.5730.29
312_L352_F0.5730.29
17_Q156_L0.5710.29
14_F17_Q0.5700.29
229_Q236_S0.5660.29
225_W235_V0.5650.29
54_D66_V0.5650.29
197_G202_E0.5640.29
18_Q61_S0.5640.29
269_A364_T0.5630.29
42_Q48_T0.5630.29
8_R35_L0.5630.29
117_E121_L0.5610.29
11_A229_Q0.5610.29
298_S350_E0.5600.29
187_L198_W0.5590.28
284_A303_L0.5590.28
312_L367_F0.5590.28
244_W251_A0.5570.28
266_V276_L0.5560.28
14_F27_V0.5560.28
254_L292_E0.5550.28
348_P351_R0.5530.28
134_N240_T0.5530.28
293_S323_E0.5520.28
43_E64_E0.5510.28
285_L344_F0.5510.28
263_E273_D0.5500.28
248_W292_E0.5490.28
333_A355_E0.5470.28
106_Y198_W0.5470.28
341_Q345_S0.5460.28
257_R300_R0.5450.27
300_R342_L0.5420.27
197_G201_W0.5410.27
233_N236_S0.5400.27
337_D340_I0.5380.27
40_W44_M0.5370.27
319_R357_S0.5360.27
134_N138_S0.5350.27
296_E328_F0.5340.27
133_G138_S0.5340.27
42_Q109_A0.5320.27
240_T248_W0.5320.27
350_E354_V0.5320.27
283_V301_V0.5310.27
37_V129_Q0.5300.26
71_I309_Q0.5290.26
258_S262_P0.5280.26
170_A176_P0.5280.26
249_L254_L0.5260.26
140_R202_E0.5250.26
30_N67_A0.5250.26
29_L83_E0.5230.26
234_G237_Q0.5230.26
247_R259_P0.5230.26
154_N158_V0.5230.26
203_A366_N0.5230.26
156_L166_E0.5230.26
256_A269_A0.5230.26
165_E354_V0.5220.26
4_S8_R0.5220.26
27_V31_T0.5190.26
11_A14_F0.5190.26
358_L362_S0.5190.26
267_R288_A0.5180.26
207_P320_L0.5180.26
100_P142_Y0.5180.26
9_Q19_S0.5160.26
315_G335_S0.5140.25
27_V103_I0.5140.25
225_W238_L0.5130.25
210_W287_V0.5130.25
30_N80_I0.5130.25
244_W252_A0.5110.25
218_R222_P0.5090.25
105_D135_Y0.5080.25
171_A179_S0.5050.25
75_G78_E0.5040.25
244_W250_A0.5040.25
103_I289_L0.5030.25
113_D144_L0.5010.25
68_D99_I0.5010.25
121_L323_E0.5010.25
10_Q144_L0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sd2A 2 0.2174 7.2 0.973 Contact Map
3d33A 1 0.2391 5.6 0.974 Contact Map
3a4rA 1 0.0951 4.8 0.975 Contact Map
1p94A 2 0.1033 4.7 0.975 Contact Map
2xetA 1 0.1902 4.5 0.975 Contact Map
2k7pA 1 0.2391 3.8 0.976 Contact Map
2io1B 1 0.0815 3.7 0.976 Contact Map
2l76A 1 0.1332 3.7 0.976 Contact Map
3k6dA 1 0.1603 3.7 0.976 Contact Map
1irqA 2 0.1141 3.4 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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