GREMLIN Database
DUF1820 - Domain of unknown function (DUF1820)
PFAM: PF08850 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (95)
Sequences: 2626 (1368)
Seq/√Len: 140.3
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_I36_V3.6031.00
60_K76_E2.6111.00
20_S33_E2.4701.00
22_S25_D2.4461.00
9_N70_I2.3121.00
30_V72_I2.2181.00
19_R34_E2.1671.00
17_Y81_A2.1621.00
22_S27_Y2.1571.00
60_K74_E2.0841.00
13_V70_I2.0711.00
27_Y30_V1.9121.00
32_V64_I1.8991.00
18_A35_L1.8701.00
38_G49_E1.7981.00
19_R36_V1.7601.00
34_E60_K1.7431.00
18_A32_V1.7311.00
14_Y55_E1.6881.00
16_I35_L1.6821.00
58_G76_E1.6701.00
35_L62_T1.6681.00
62_T73_D1.6521.00
33_E61_R1.6171.00
39_E42_S1.6091.00
45_V50_E1.5631.00
25_D31_E1.4801.00
25_D63_Y1.4471.00
8_L70_I1.3821.00
59_V73_D1.3371.00
16_I81_A1.2901.00
63_Y74_E1.2691.00
12_K51_K1.2621.00
61_R74_E1.2501.00
52_L64_I1.1861.00
22_S33_E1.1731.00
44_V47_P1.1510.99
5_V32_V1.1510.99
16_I32_V1.1290.99
26_L63_Y1.1030.99
42_S82_K1.0970.99
49_E53_K1.0670.99
6_I70_I1.0500.99
22_S31_E1.0370.99
30_V69_V1.0180.99
24_S31_E1.0040.98
27_Y67_H0.9850.98
75_V79_G0.9740.98
40_R51_K0.9480.98
86_A90_G0.9250.97
12_K42_S0.9180.97
31_E61_R0.9090.97
23_Q52_L0.9020.97
27_Y66_M0.8930.97
8_L86_A0.8910.97
37_F49_E0.8840.97
23_Q27_Y0.8800.96
50_E53_K0.8760.96
11_G23_Q0.8730.96
31_E71_R0.8380.95
56_F70_I0.8360.95
23_Q30_V0.8260.95
14_Y59_V0.8240.95
85_D88_G0.8090.94
6_I13_V0.8030.94
38_G41_S0.8030.94
24_S27_Y0.8020.94
28_G65_P0.8010.94
60_K84_S0.7970.94
14_Y83_I0.7870.94
15_E29_F0.7820.93
5_V18_A0.7820.93
22_S63_Y0.7710.93
23_Q26_L0.7620.92
51_K85_D0.7540.92
37_F50_E0.7480.92
84_S91_N0.7480.92
4_K17_Y0.7410.91
80_V85_D0.7380.91
12_K85_D0.7330.91
10_Q13_V0.7310.91
8_L13_V0.7290.91
55_E71_R0.7250.90
16_I28_G0.7100.90
36_V39_E0.7040.89
8_L27_Y0.7030.89
25_D28_G0.7010.89
27_Y51_K0.7000.89
8_L12_K0.6970.89
22_S62_T0.6930.88
42_S54_S0.6880.88
74_E78_E0.6850.88
64_I73_D0.6790.87
90_G93_T0.6770.87
45_V53_K0.6760.87
85_D89_G0.6680.87
29_F46_D0.6580.86
18_A74_E0.6570.86
87_E90_G0.6570.86
40_R46_D0.6550.85
60_K95_F0.6430.84
52_L81_A0.6340.84
48_S53_K0.6340.84
54_S57_A0.6330.83
88_G94_P0.6270.83
44_V50_E0.6200.82
51_K83_I0.6190.82
4_K75_V0.6160.82
80_V86_A0.6080.81
31_E63_Y0.6070.81
61_R90_G0.6040.81
9_N55_E0.6030.80
91_N94_P0.6030.80
20_S34_E0.6000.80
43_V80_V0.5960.80
3_Y63_Y0.5960.80
84_S87_E0.5910.79
91_N95_F0.5900.79
21_V24_S0.5890.79
64_I69_V0.5780.78
89_G93_T0.5730.77
24_S35_L0.5700.77
85_D90_G0.5610.75
78_E81_A0.5610.75
77_K91_N0.5530.74
23_Q66_M0.5520.74
34_E62_T0.5430.73
81_A84_S0.5320.72
8_L11_G0.5260.71
16_I78_E0.5260.71
62_T69_V0.5250.71
43_V47_P0.5240.70
23_Q63_Y0.5190.70
12_K35_L0.5150.69
44_V51_K0.5100.68
46_D75_V0.5090.68
12_K27_Y0.5080.68
20_S25_D0.5060.68
27_Y55_E0.5050.68
26_L70_I0.5020.67
17_Y52_L0.5020.67
2_I6_I0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ay2A 1 0.3402 15 0.923 Contact Map
1nynA 1 0.9072 9.8 0.929 Contact Map
4hczA 1 0.2784 8.2 0.931 Contact Map
3ef4A 1 0.6186 6.3 0.934 Contact Map
2i4lA 2 0.866 5.7 0.936 Contact Map
1bxvA 1 0.3299 5 0.938 Contact Map
2ux6A 1 0.6289 5 0.938 Contact Map
3j26A 9 0.9691 4.9 0.938 Contact Map
3a32A 2 0.8763 4.8 0.938 Contact Map
3uh0A 2 0.9588 4.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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