GREMLIN Database
DUF1816 - Domain of unknown function (DUF1816)
PFAM: PF08846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (64)
Sequences: 936 (570)
Seq/√Len: 71.3
META: 0.785

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E55_K4.2461.00
32_K35_L2.4421.00
41_D45_E2.3871.00
12_E19_T1.9951.00
4_G26_L1.9901.00
33_E36_S1.5400.99
19_T64_I1.4240.99
15_Q48_Q1.4080.98
37_G59_P1.3940.98
25_F38_Y1.3910.98
7_W61_P1.3720.98
46_G62_L1.3300.98
22_F37_G1.3220.98
20_Y42_L1.3160.97
10_E57_C1.3150.97
45_E63_T1.3140.97
36_S40_E1.3040.97
37_G40_E1.2900.97
31_A59_P1.2760.97
29_R60_E1.2570.97
40_E59_P1.2310.96
9_A54_I1.2000.96
9_A58_K1.1940.96
21_Y31_A1.1630.95
1_N5_L1.1610.95
6_A56_R1.1540.95
12_E61_P1.1360.94
42_L47_A1.1300.94
9_A38_Y1.1070.93
3_L17_R1.0600.92
16_P45_E1.0540.91
6_A26_L1.0440.91
2_K36_S1.0420.91
21_Y38_Y1.0370.91
13_T45_E1.0310.91
16_P22_F1.0300.91
9_A31_A1.0080.90
27_T30_E1.0040.89
11_I18_C0.9990.89
1_N7_W0.9990.89
22_F40_E0.9740.88
40_E44_Q0.9520.87
59_P64_I0.9460.86
42_L50_I0.9460.86
22_F49_G0.9410.86
30_E38_Y0.9350.86
58_K61_P0.9270.85
47_A59_P0.8860.83
37_G47_A0.8800.82
43_E57_C0.8790.82
28_K32_K0.8760.82
2_K44_Q0.8730.82
28_K53_S0.8670.81
21_Y59_P0.8640.81
22_F59_P0.8620.81
53_S56_R0.8430.79
14_E51_K0.8350.79
54_I59_P0.8210.77
6_A58_K0.8160.77
39_I52_H0.8130.77
27_T43_E0.7860.74
11_I60_E0.7790.74
17_R44_Q0.7730.73
15_Q49_G0.7700.73
22_F54_I0.7520.71
26_L29_R0.7440.70
18_C37_G0.7420.70
36_S61_P0.7390.70
27_T51_K0.7160.67
15_Q35_L0.6970.65
41_D59_P0.6870.64
2_K29_R0.6870.64
53_S60_E0.6840.64
52_H56_R0.6790.63
25_F45_E0.6760.63
28_K35_L0.6710.62
13_T37_G0.6640.61
7_W12_E0.6620.61
22_F41_D0.6590.61
18_C31_A0.6460.59
39_I58_K0.6200.56
6_A24_P0.6010.54
12_E51_K0.6010.54
30_E59_P0.5960.53
13_T42_L0.5920.53
5_L26_L0.5900.53
7_W44_Q0.5790.51
17_R49_G0.5730.50
5_L33_E0.5690.50
24_P41_D0.5410.47
2_K51_K0.5380.46
2_K34_A0.5200.44
52_H55_K0.5150.43
33_E46_G0.5120.43
3_L6_A0.5040.42
36_S39_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lfvA 1 0.9062 35.7 0.877 Contact Map
2crhA 1 0.875 18.1 0.893 Contact Map
1x60A 1 0.7656 14.8 0.898 Contact Map
1utaA 1 0.7969 5.8 0.915 Contact Map
3si5X 1 0.2812 5.6 0.916 Contact Map
4knhA 1 0.6562 5.1 0.917 Contact Map
3eazA 1 0.7188 4.7 0.918 Contact Map
3hhmB 1 0.6406 4 0.921 Contact Map
1tdjA 2 0.2812 3.9 0.922 Contact Map
4bgdA 1 0.8438 3.5 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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