GREMLIN Database
CGGC - CGGC domain
PFAM: PF08821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (104)
Sequences: 3526 (1735)
Seq/√Len: 170.1
META: 0.907

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_K94_E3.7811.00
33_Y69_H2.9701.00
32_R100_K2.6651.00
20_F39_L2.6391.00
90_K103_E2.4331.00
23_L39_L2.4191.00
70_L93_I2.4061.00
23_L37_V2.3621.00
91_K95_K2.2881.00
16_G42_F2.0521.00
6_I11_R1.8511.00
24_R38_E1.7931.00
20_F42_F1.7781.00
40_V65_A1.7591.00
45_C83_C1.7371.00
58_E96_K1.7301.00
9_R47_G1.7121.00
21_K25_E1.6871.00
15_A56_R1.6781.00
67_V100_K1.6611.00
8_D44_T1.6051.00
57_P93_I1.5561.00
26_R36_E1.4921.00
87_E91_K1.4751.00
59_E62_K1.4741.00
8_D11_R1.4651.00
45_C48_C1.4461.00
69_H102_V1.3991.00
67_V102_V1.3841.00
87_E103_E1.3801.00
22_A27_E1.3801.00
94_E100_K1.3721.00
43_T56_R1.3351.00
29_A32_R1.3351.00
91_K94_E1.3181.00
61_K99_I1.3161.00
1_K38_E1.3141.00
26_R37_V1.2371.00
52_N55_Y1.2251.00
3_G41_G1.2231.00
33_Y67_V1.1871.00
50_G53_I1.1781.00
85_Y88_Y1.1601.00
48_C83_C1.1421.00
51_G81_P1.1411.00
86_I103_E1.1341.00
12_D44_T1.1171.00
54_E92_F1.1131.00
41_G65_A1.1121.00
26_R34_K1.1001.00
12_D46_G1.0831.00
7_C45_C1.0821.00
22_A28_G1.0631.00
74_I89_F1.0611.00
3_G60_M1.0300.99
23_L26_R1.0220.99
70_L74_I1.0120.99
52_N56_R0.9920.99
15_A59_E0.9810.99
88_Y91_K0.9610.99
7_C83_C0.9570.99
13_R55_Y0.9550.99
70_L90_K0.9490.99
6_I9_R0.9300.99
65_A68_I0.9210.99
75_V78_V0.9100.98
36_E39_L0.9010.98
3_G57_P0.8930.98
26_R35_E0.8620.98
8_D12_D0.8580.98
55_Y59_E0.8270.97
26_R33_Y0.8240.97
75_V103_E0.8130.97
4_I30_F0.7920.96
33_Y37_V0.7820.96
74_I86_I0.7800.96
20_F24_R0.7720.96
30_F33_Y0.7580.95
19_C33_Y0.7480.95
56_R61_K0.7440.95
3_G65_A0.7440.95
53_I93_I0.7430.95
58_E62_K0.7410.95
7_C48_C0.7250.94
1_K64_G0.7080.93
46_G50_G0.7050.93
92_F96_K0.7040.93
75_V79_G0.6860.92
2_I67_V0.6860.92
51_G55_Y0.6850.92
34_K37_V0.6850.92
18_K22_A0.6850.92
87_E90_K0.6850.92
92_F97_Y0.6820.92
86_I104_G0.6810.92
8_D46_G0.6760.92
2_I37_V0.6730.91
9_R12_D0.6720.91
41_G60_M0.6680.91
14_C19_C0.6640.91
88_Y92_F0.6560.90
11_R44_T0.6490.90
8_D47_G0.6480.90
91_K96_K0.6470.90
33_Y102_V0.6440.90
70_L86_I0.6410.89
2_I69_H0.6390.89
68_I99_I0.6310.89
17_G63_N0.6220.88
85_Y95_K0.6190.88
53_I89_F0.6140.87
22_A98_G0.6130.87
52_N59_E0.6130.87
19_C42_F0.6070.87
43_T60_M0.6070.87
2_I33_Y0.6040.86
50_G55_Y0.6020.86
61_K98_G0.5960.86
81_P85_Y0.5960.86
65_A99_I0.5940.86
4_I23_L0.5900.85
75_V86_I0.5900.85
99_I103_E0.5870.85
40_V64_G0.5870.85
20_F28_G0.5840.85
57_P68_I0.5830.84
53_I74_I0.5790.84
101_V106_H0.5780.84
50_G54_E0.5770.84
31_A100_K0.5760.84
5_I84_P0.5720.83
58_E92_F0.5700.83
34_K94_E0.5690.83
54_E96_K0.5690.83
16_G43_T0.5690.83
73_C105_T0.5620.82
69_H105_T0.5580.82
35_E66_D0.5580.82
69_H104_G0.5550.82
9_R44_T0.5530.81
1_K66_D0.5530.81
19_C22_A0.5490.81
70_L85_Y0.5390.80
95_K100_K0.5380.79
70_L103_E0.5360.79
20_F41_G0.5310.79
19_C93_I0.5300.78
1_K82_P0.5300.78
94_E103_E0.5260.78
11_R41_G0.5230.78
80_Y104_G0.5230.78
71_A74_I0.5140.76
21_K72_T0.5120.76
34_K91_K0.5080.76
9_R49_P0.5070.75
50_G60_M0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1geqA 1 0.6226 78.1 0.873 Contact Map
2xedA 1 0.8019 70.7 0.881 Contact Map
4fq5B 4 0.8019 70.7 0.881 Contact Map
4ht3A 1 0.7264 66.4 0.884 Contact Map
3vndA 3 0.7358 63.4 0.886 Contact Map
3thaA 2 0.6698 57.1 0.89 Contact Map
3ixlA 1 0.7736 55.7 0.891 Contact Map
2dgdA 4 0.7736 54.7 0.892 Contact Map
2ekcA 1 0.7264 54.6 0.892 Contact Map
2g0tA 3 0.8491 53.9 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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