GREMLIN Database
YtxC - YtxC-like family
PFAM: PF08812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 217 (215)
Sequences: 1213 (1005)
Seq/√Len: 68.5
META: 0.617

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E63_R5.3101.00
16_E94_Y4.9721.00
208_I216_V4.1891.00
7_L71_I4.0831.00
150_D154_N3.7991.00
70_K93_E3.5101.00
193_I205_I3.4051.00
24_I40_L3.3161.00
67_I91_L3.2041.00
94_Y98_L2.8241.00
124_Y184_I2.7471.00
24_I102_V2.6811.00
20_L43_A2.5781.00
134_D151_E2.5711.00
135_E190_K2.4711.00
11_I71_I2.2471.00
137_H194_H2.2451.00
124_Y181_S2.2191.00
31_F39_I2.1921.00
9_D64_K2.1821.00
43_A105_A2.1171.00
135_E192_I2.1071.00
139_V149_L2.0531.00
123_R213_E2.0261.00
125_F129_Q1.9731.00
103_D106_V1.8831.00
46_I105_A1.8271.00
63_R94_Y1.8171.00
28_Y106_V1.7891.00
138_V179_L1.7821.00
114_E211_V1.7351.00
138_V193_I1.7251.00
99_E102_V1.7211.00
85_G117_E1.6370.99
28_Y103_D1.6230.99
8_A68_L1.6010.99
7_L83_L1.5400.99
25_R36_R1.5390.99
137_H153_G1.5170.99
85_G194_H1.5130.99
124_Y129_Q1.4710.99
23_I98_L1.4700.99
20_L40_L1.4640.99
23_I102_V1.4480.98
172_E177_D1.4420.98
125_F181_S1.4420.98
134_D189_K1.4060.98
118_F181_S1.4020.98
161_L178_L1.3910.98
10_Y137_H1.3670.98
21_R40_L1.3430.97
131_P189_K1.3350.97
178_L181_S1.3240.97
198_P201_P1.3100.97
124_Y128_I1.2790.97
52_G56_D1.2790.97
74_Y81_L1.2490.96
173_I180_I1.2440.96
3_I46_I1.2420.96
46_I191_I1.2390.96
136_V150_D1.2170.95
42_I109_Y1.2020.95
118_F122_L1.1980.95
207_T211_V1.1870.95
30_Y106_V1.1770.95
87_I91_L1.1690.94
9_D13_E1.1460.94
137_H192_I1.1420.94
175_Y179_L1.1400.94
30_Y39_I1.1390.94
67_I71_I1.1340.93
49_G56_D1.1190.93
113_K121_L1.1140.93
8_A16_E1.1060.93
115_Y207_T1.1040.92
74_Y78_N1.0910.92
139_V189_K1.0830.92
117_E177_D1.0760.91
71_I144_G1.0750.91
119_I207_T1.0690.91
46_I123_R1.0680.91
177_D181_S1.0620.91
33_E37_E1.0570.91
135_E151_E1.0550.91
146_F179_L1.0390.90
121_L194_H1.0350.90
46_I108_E1.0320.90
85_G177_D1.0310.90
49_G54_D1.0260.89
30_Y107_D1.0250.89
117_E121_L1.0250.89
24_I67_I1.0230.89
183_L191_I1.0230.89
27_N30_Y1.0220.89
126_V216_V1.0210.89
50_E56_D1.0170.89
181_S184_I1.0130.89
45_S201_P1.0130.89
69_E73_E1.0070.89
206_E209_K1.0070.89
138_V205_I0.9880.88
107_D204_L0.9860.87
43_A145_E0.9860.87
74_Y86_F0.9840.87
176_E181_S0.9730.87
136_V156_I0.9650.86
96_E154_N0.9630.86
69_E136_V0.9620.86
4_A72_L0.9620.86
106_V110_L0.9510.86
80_E123_R0.9480.85
38_E102_V0.9470.85
85_G90_R0.9390.85
129_Q185_T0.9320.84
117_E194_H0.9310.84
182_A194_H0.9300.84
53_E56_D0.9290.84
188_P191_I0.9280.84
68_L72_L0.9210.84
33_E96_E0.9200.84
28_Y31_F0.9180.83
120_K124_Y0.9140.83
168_L173_I0.9100.83
106_V109_Y0.9090.83
74_Y204_L0.9030.82
177_D185_T0.9010.82
7_L36_R0.9000.82
82_N153_G0.8990.82
83_L189_K0.8970.82
118_F207_T0.8830.81
118_F125_F0.8830.81
70_K86_F0.8810.81
11_I19_L0.8790.81
177_D194_H0.8790.81
128_I185_T0.8730.80
85_G121_L0.8730.80
24_I74_Y0.8690.80
117_E184_I0.8680.80
19_L94_Y0.8660.80
58_L193_I0.8600.79
8_A77_E0.8600.79
46_I214_E0.8510.79
185_T207_T0.8470.78
16_E75_L0.8330.77
160_L176_E0.8330.77
71_I125_F0.8300.77
145_E151_E0.8200.76
50_E53_E0.8180.76
3_I139_V0.8180.76
36_R95_L0.8170.76
47_L94_Y0.8150.75
104_K108_E0.8090.75
121_L129_Q0.8040.74
13_E191_I0.8020.74
24_I28_Y0.7960.74
7_L67_I0.7920.73
15_Y204_L0.7900.73
5_N68_L0.7880.73
140_I195_T0.7860.73
19_L74_Y0.7860.73
107_D111_M0.7830.72
153_G211_V0.7800.72
195_T199_E0.7800.72
97_E121_L0.7770.72
172_E181_S0.7700.71
163_E167_E0.7680.71
25_R38_E0.7660.71
124_Y130_E0.7650.71
118_F121_L0.7640.71
35_E38_E0.7640.71
8_A97_E0.7620.70
10_Y20_L0.7590.70
83_L162_E0.7590.70
7_L15_Y0.7550.70
94_Y194_H0.7500.69
39_I98_L0.7480.69
129_Q181_S0.7460.69
210_N213_E0.7460.69
141_K210_N0.7370.68
98_L139_V0.7300.67
40_L211_V0.7290.67
96_E130_E0.7240.67
63_R97_E0.7220.66
195_T203_E0.7210.66
143_D193_I0.7170.66
207_T215_R0.7150.66
31_F107_D0.7110.65
49_G52_G0.7100.65
134_D156_I0.7030.64
85_G125_F0.7020.64
161_L179_L0.7000.64
123_R176_E0.7000.64
188_P212_F0.6990.64
116_Q203_E0.6980.64
119_I211_V0.6970.64
20_L102_V0.6960.63
170_D174_N0.6940.63
12_I101_I0.6890.63
48_N133_I0.6870.62
121_L181_S0.6850.62
82_N176_E0.6840.62
95_L136_V0.6830.62
76_E87_I0.6830.62
7_L81_L0.6810.62
7_L62_N0.6760.61
124_Y185_T0.6750.61
149_L153_G0.6720.61
146_F211_V0.6700.61
17_K199_E0.6670.60
4_A21_R0.6670.60
77_E138_V0.6670.60
71_I192_I0.6610.59
193_I209_K0.6590.59
109_Y207_T0.6590.59
81_L86_F0.6580.59
51_K55_E0.6570.59
205_I211_V0.6540.59
209_K214_E0.6490.58
38_E41_E0.6430.57
22_K87_I0.6420.57
117_E122_L0.6420.57
28_Y118_F0.6390.57
41_E147_I0.6380.57
171_I179_L0.6360.57
44_L109_Y0.6350.56
85_G181_S0.6330.56
116_Q210_N0.6310.56
118_F184_I0.6280.56
36_R150_D0.6280.56
28_Y35_E0.6250.55
123_R214_E0.6230.55
49_G57_S0.6200.55
21_R37_E0.6160.54
11_I22_K0.6160.54
27_N73_E0.6150.54
85_G89_F0.6140.54
99_E103_D0.6130.54
123_R205_I0.6130.54
78_N190_K0.6120.54
84_D123_R0.6090.53
58_L78_N0.6090.53
182_A201_P0.6080.53
3_I191_I0.6070.53
122_L207_T0.6020.53
104_K208_I0.6020.53
92_K136_V0.6010.52
9_D84_D0.5990.52
133_I215_R0.5980.52
181_S185_T0.5960.52
115_Y118_F0.5950.52
26_K92_K0.5940.52
161_L176_E0.5910.51
163_E166_A0.5910.51
181_S187_A0.5910.51
35_E51_K0.5890.51
140_I146_F0.5880.51
51_K56_D0.5880.51
15_Y180_I0.5870.51
124_Y180_I0.5850.50
122_L211_V0.5830.50
117_E129_Q0.5800.50
106_V162_E0.5800.50
107_D180_I0.5750.49
126_V163_E0.5750.49
80_E83_L0.5730.49
115_Y126_V0.5720.49
33_E106_V0.5660.48
84_D88_R0.5660.48
17_K84_D0.5640.48
122_L129_Q0.5640.48
19_L95_L0.5630.48
103_D214_E0.5630.48
151_E154_N0.5620.48
16_E98_L0.5610.48
106_V207_T0.5570.47
156_I177_D0.5550.47
167_E171_I0.5550.47
2_Y5_N0.5540.47
206_E214_E0.5520.47
17_K44_L0.5510.46
64_K97_E0.5500.46
74_Y85_G0.5500.46
96_E151_E0.5490.46
8_A12_I0.5480.46
50_E54_D0.5470.46
58_L173_I0.5460.46
111_M201_P0.5450.46
41_E156_I0.5450.46
49_G55_E0.5440.46
98_L189_K0.5430.45
138_V209_K0.5360.45
116_Q120_K0.5350.44
131_P187_A0.5340.44
66_K101_I0.5260.43
63_R208_I0.5250.43
162_E211_V0.5240.43
21_R36_R0.5230.43
186_L195_T0.5200.43
132_K213_E0.5190.43
2_Y6_A0.5190.43
24_I82_N0.5190.43
129_Q187_A0.5170.42
37_E152_N0.5160.42
145_E175_Y0.5140.42
6_A127_D0.5130.42
49_G84_D0.5130.42
72_L76_E0.5120.42
101_I120_K0.5100.42
147_I155_P0.5090.41
13_E151_E0.5080.41
6_A10_Y0.5070.41
90_R114_E0.5060.41
115_Y132_K0.5060.41
54_D156_I0.5060.41
57_S68_L0.5050.41
35_E109_Y0.5050.41
109_Y113_K0.5030.41
167_E178_L0.5020.41
205_I208_I0.5020.41
196_D205_I0.5010.41
99_E123_R0.5000.40
11_I177_D0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4peoA 2 0.4009 6.5 0.954 Contact Map
1tm9A 1 0.2673 4.1 0.958 Contact Map
3s44A 1 0.4286 3.8 0.959 Contact Map
3o1fA 1 0.1429 3.8 0.959 Contact Map
3mmiA 2 0.3041 3.1 0.96 Contact Map
1a0cA 4 0.3502 2.8 0.961 Contact Map
2adlA 2 0.2995 2.8 0.961 Contact Map
3j3wT 1 0.212 2.6 0.962 Contact Map
2hyvA 1 0.2903 2.6 0.962 Contact Map
4d2uA 3 0.5668 2.4 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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